Separating type multi-channel chromatography device

Abstract

The utility model relates to the technical field of separated multi-channel chromatography, and particularly discloses a separated multi-channel chromatography device which comprises a base, a cabinet is fixedly connected to the surface of the base, a plurality of liquid inlet and outlet devices are mounted on one side of the cabinet, sample injection needles are mounted on the surfaces of the liquid inlet and outlet devices, and the liquid inlet and outlet devices are connected with the sample injection needles. A collecting needle is mounted on the surface of the liquid inlet and outlet device, a rectangular plate is fixedly connected to the surface of the base, a plurality of sample discs are fixedly connected to one side of the rectangular plate, a plurality of sample test tube bodies and liquid collecting test tubes are inserted into the inner walls of the sample discs, and a limiting structure is arranged on the surface of the rectangular plate. The limiting structure comprises a rectangular box, the rectangular box is fixedly connected with the surface of the rectangular plate, and an adjusting arm is slidably inserted into the inner wall of the rectangular box. According to the utility model, the problem that the insertion positions of the sample test tube and the collection liquid test tube are inconvenient to position in the insertion process of the sample injection needle and the collection needle is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of separated multi-channel chromatography, and specifically relates to a separated multi-channel chromatography device. Background Technique

[0002] Separated multi-channel chromatography is an analytical and separation technique mainly used for the separation and purification of chemical and biological samples. By utilizing the distribution differences of different components between the mobile phase and the stationary phase, separation is achieved. These components move at different speeds in the channels, thus achieving the separation purpose. By simultaneously processing multiple samples or different components of a sample through multiple channels, the processing capacity can be significantly improved.

[0003] A Chinese patent with the publication number CN219721988U discloses a multi-channel chromatography purification device. The key points of its technical solution are as follows: The multi-channel chromatography purification device is provided with a base. On the base, there are a buffer solution area, a sample and collection area, a chromatography column and its detection area, and an inlet valve group and pump area; the buffer solution area is provided with a cabinet and multiple storage containers; the sample and collection area is provided with multiple groups of independently controlled synchronous inlet and outlet liquid devices, sample test tubes, and collection liquid test tubes; the chromatography column and detection area are provided with a detection device and a chromatography column, and the inlet valve group and pump area are provided with a one-inlet multi-outlet flow cell and an injection pump valve integrated machine; the number of chromatography columns and injection pump valve integrated machines, as well as the number of liquid outlets of the one-inlet multi-outlet flow cell, are the same as the number of synchronous inlet and outlet liquid devices, and the number of one-inlet multi-outlet flow cells and the number of valve group buffer solution interfaces of the injection pump valve integrated machine are the same as the number of storage containers. The utility model can realize automatic multi-channel sample analysis and improve the protein purification analysis efficiency.

[0004] In the existing related technologies, the following defects often exist: When separating and purifying a sample, it is necessary to insert the sampling needle and the collection needle into the sample test tube body and the collection liquid test tube respectively to extract and drain the liquid. Since the sample test tube and the collection liquid test tube are usually made of glass, it is inconvenient to position the positions where the sampling needle and the collection needle are inserted into the sample test tube and the collection liquid test tube during the insertion process. As a result, the sample test tube or the collection liquid test tube may be broken, and sample loss and equipment damage will lead to repeated experiments, increasing the reagent and time costs.

[0005] Therefore, the utility model provides a separated multi-channel chromatography device. Summary of the Utility Model

[0006] The purpose of the utility model is to solve the defect in the existing technology that it is inconvenient to position the positions where the sampling needle and the collection needle are inserted into the sample test tube and the collection liquid test tube during the insertion process, and to propose a separated multi-channel chromatography device.

[0007] To achieve the above object, the present utility model adopts the following technical solution: A separable multi-channel chromatography device, including a base, a cabinet is fixedly connected to the surface of the base, several liquid inlet and outlet devices are installed on one side of the cabinet, a sampling needle is installed on the surface of the liquid inlet and outlet device, a collection needle is installed on the surface of the liquid inlet and outlet device, a rectangular plate is fixedly connected to the surface of the base, several sample trays are fixedly connected to one side of the rectangular plate, several sample test tube bodies and collection liquid test tubes are inserted into the inner wall of the sample tray, a limiting structure is arranged on the surface of the rectangular plate, the limiting structure includes a rectangular box, the rectangular box is fixedly connected to the surface of the rectangular plate, an adjusting arm is slidably inserted into the inner wall of the rectangular box, several limiting plates are fixedly connected to the surface of the adjusting arm, several limiting blocks are fixedly connected to the surface of the limiting plate, positioning holes are formed on the surface of the limiting block, a bracket is fixedly connected to the surface of the rectangular box, a pin is slidably penetrated through the surface of the bracket, several round holes are formed on the surface of the adjusting arm, and the size of the round hole is adapted to the size of the pin.

[0008] The effect achieved by the above components is: By setting the limiting structure, the sampling needle and the collection needle can be accurately inserted into the sample test tube body and the collection liquid test tube, avoiding the situation that the sampling needle and the collection needle collide with the sample test tube body and the collection liquid test tube body due to operation errors, thereby protecting the sample test tube body and the collection liquid test tube.

[0009] Preferably, limiting grooves are formed on both sides of the adjusting arm, limiting arms are slidably connected to the inner walls of the two limiting grooves, and the limiting arms are fixedly connected to the surface of the rectangular box.

[0010] The effect achieved by the above components is: When the adjusting arm moves, the limiting arm will slide along the inner wall of the limiting groove, and the limiting arm restricts the moving path of the adjusting arm, thereby avoiding the adjusting arm from slipping out of the rectangular box.

[0011] Preferably, a spring is sleeved on the arc surface of the pin, and the two ends of the spring are respectively fixedly connected to the pin and the bracket.

[0012] The effect achieved by the above components is: The spring improves the stability of inserting into the round hole and avoids the pin from slipping out of the round hole due to shaking.

[0013] Preferably, a pull ring is fixedly connected to the surface of the adjusting arm, a round groove is formed on the surface of the limiting block, and the round groove is communicated with the positioning hole.

[0014] The effect achieved by the above components is: The movement of the pull ring will drive the movement of the adjusting arm. The pull ring facilitates moving the position of the adjusting arm, and thus facilitates moving the position of the limiting block. The round groove further facilitates inserting the sampling needle and the collection needle into the sample test tube body and the collection liquid test tube.

[0015] Preferably, a conical tube is fixedly connected to one side of the limiting block close to the sample tray, and the conical tube is communicated with the positioning hole.

[0016] The effects achieved by the above components are as follows: The movement of the limiting block will drive the movement of the conical tube. When the conical tube moves to a suitable position, the conical tube will be inserted into the sample test tube body and the collection liquid test tube, and the conical block reaches the positions of the sample test tube body and the collection liquid test tube, so as to further facilitate the accurate insertion of the sampling needle and the collection needle into the sample test tube body and the collection liquid test tube.

[0017] Preferably, a rubber ring is fixedly connected to one side of the conical tube away from the limiting block, and the rubber ring is communicated with the positioning hole.

[0018] The effects achieved by the above components are as follows: After the sampling needle and the collection needle pass through the positioning hole and are inserted to a certain distance, they will pass through the rubber ring. The rubber ring will expand when it is squeezed, and the rubber ring will closely fit on the surfaces of the sampling needle and the collection needle. The rubber ring serves to scrape off the sample liquid adhering to the surfaces of the sampling needle and the collection needle when the sampling needle and the collection needle are taken out from the sample test tube body and the collection liquid test tube.

[0019] To sum up:

[0020] 1. In the present utility model, by setting the limiting structure, when the sampling needle and the collection needle are respectively inserted into the sample test tube body and the collection liquid test tube, first, several sample test tube bodies and collection liquid test tubes are placed in the sample tray, and then the adjustment arm is moved. The movement of the adjustment arm will drive the movement of several limiting plates. The movement of the limiting plates will move in the direction close to the sample tray. The movement of the limiting plates will drive the movement of several limiting blocks. When the limiting blocks move to a suitable position, the limiting blocks will be located directly above the sample test tube body and the collection liquid test tube. Then, the sampling needle and the collection needle are moved. When the sampling needle and the collection needle move to the appropriate positions, they will be inserted into the sample test tube body and the collection liquid test tube body, so that the sampling needle and the collection needle are accurately inserted into the sample test tube body and the collection liquid test tube, avoiding the situation that the sampling needle and the collection needle collide with the sample test tube body and the collection liquid test tube body due to operation errors, and thus protecting the sample test tube body and the collection liquid test tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a three-dimensional structural diagram of the present utility model;

[0022] Figure 2 is a structural diagram of another angle of the present utility model;

[0023] Figure 3 is a structural diagram of the rectangular plate of the present utility model;

[0024] Figure 4For the present utility model Figure 3 is an enlarged view of part A in the present utility model;

[0025] Figure 5 is a schematic structural view of the limit block of the present utility model.

[0026] Legend: 1. Base; 2. Cabinet; 3. Liquid inlet and outlet device; 4. Sampling needle; 5. Collection needle; 6. Sample tray; 7. Sample test tube body; 8. Collection liquid test tube; 9. Limit structure; 901. Rectangular box; 902. Adjusting arm; 903. Limit plate; 904. Limit block; 905. Positioning hole; 906. Bracket; 907. Plug; 908. Round hole; 909. Limit groove; 910. Limit arm; 911. Spring; 912. Pull ring; 913. Round groove; 914. Rubber ring; 915. Conical tube; 10. Rectangular plate. Specific embodiments

[0027] Referring to Figure 1 as shown, the present utility model provides a technical solution: a separable multi-channel chromatography device, including a base 1, a cabinet 2 fixedly connected to the surface of the base 1, several liquid inlet and outlet devices 3 installed on one side of the cabinet 2, a sampling needle 4 installed on the surface of the liquid inlet and outlet device 3, a collection needle 5 installed on the surface of the liquid inlet and outlet device 3, a rectangular plate 10 fixedly connected to the surface of the base 1, several sample trays 6 fixedly connected to one side of the rectangular plate 10, several sample test tube bodies 7 and collection liquid test tubes 8 inserted into the inner walls of the sample trays 6, and a limit structure 9 provided on the surface of the rectangular plate 10. By setting the limit structure 9, the sampling needle 4 and the collection needle 5 can be accurately inserted into the sample test tube body 7 and the collection liquid test tube 8, avoiding the situation that the sampling needle 4 and the collection needle 5 collide with the sample test tube body 7 and the collection liquid test tube 8 due to operation errors, thereby protecting the sample test tube body 7 and the collection liquid test tube 8.

[0028] Next, specifically describe the specific setting and function of its limit structure 9.

[0029] Referring to Figure 2 - Figure 5As shown in the figure, in this embodiment: The limiting structure 9 includes a rectangular box 901, which is fixedly connected to the surface of the rectangular plate 10. An adjusting arm 902 is slidably inserted into the inner wall of the rectangular box 901. A number of limiting plates 903 are fixedly connected to the surface of the adjusting arm 902. A number of limiting blocks 904 are fixedly connected to the surface of the limiting plates 903. A positioning hole 905 is formed on the surface of the limiting block 904. A bracket 906 is fixedly connected to the surface of the rectangular box 901. A pin 907 slidably penetrates through the surface of the bracket 906. A number of circular holes 908 are formed on the surface of the adjusting arm 902, and the size of the circular holes 908 is adapted to the size of the pin 907. Limiting grooves 909 are formed on both sides of the adjusting arm 902, and limiting arms 910 are slidably connected to the inner walls of the two limiting grooves 909. The limiting arms 910 are fixedly connected to the surface of the rectangular box 901. When the adjusting arm 902 moves, the limiting arms 910 will slide along the inner walls of the limiting grooves 909. The limiting arms 910 function to limit the movement path of the adjusting arm 902, thereby preventing the adjusting arm 902 from disengaging from the rectangular box 901. A spring 911 is sleeved on the arc surface of the pin 907, and the two ends of the spring 911 are respectively fixedly connected to the pin 907 and the bracket 906. The spring 911 functions to improve the stability of inserting into the circular hole 908 and prevent the pin 907 from disengaging from the circular hole 908 due to shaking. A pull ring 912 is fixedly connected to the surface of the adjusting arm 902. A circular groove 913 is formed on the surface of the limiting block 904, and the circular groove 913 communicates with the positioning hole 905. Moving the pull ring 912 will drive the adjusting arm 902 to move. The pull ring 912 functions to facilitate moving the position of the adjusting arm 902, and further facilitate moving the position of the limiting block 904. The circular groove 913 functions to further facilitate inserting the sampling needle 4 and the collection needle 5 into the sample test tube body 7 and the collection liquid test tube 8. A conical tube 915 is fixedly connected to the side of the limiting block 904 close to the sample tray 6, and the conical tube 915 communicates with the positioning hole 905. Moving the limiting block 904 will drive the conical tube 915 to move. When the conical tube 915 moves to a suitable position, the conical tube 915 will be inserted into the sample test tube body 7 and the collection liquid test tube 8. The conical block functions to position the sample test tube body 7 and the collection liquid test tube 8, thereby further facilitating accurately inserting the sampling needle 4 and the collection needle 5 into the sample test tube body 7 and the collection liquid test tube 8. A rubber ring 914 is fixedly connected to the side of the conical tube 915 away from the limiting block 904, and the rubber ring 914 communicates with the positioning hole 905. After the sampling needle 4 and the collection needle 5 pass through the positioning hole 905 and are inserted to a certain distance, they will pass through the rubber ring 914. When the rubber ring 914 is squeezed, it will expand, and the rubber ring 914 will closely adhere to the surfaces of the sampling needle 4 and the collection needle 5. The rubber ring 914 functions to scrape off the sample liquid adhering to the surfaces of the sampling needle 4 and the collection needle 5 when the sampling needle 4 and the collection needle 5 are taken out from the sample test tube body 7 and the collection liquid test tube 8.

[0030] Working principle: When the sampling needle 4 and the collection needle 5 need to be inserted into the sample test tube body 7 and the collection liquid test tube 8 respectively, first place several sample test tube bodies 7 and collection liquid test tubes 8 in the sample tray 6. Then pull the bolt 907. The movement of the bolt 907 will slide in the bracket 906 and gradually disengage from the round hole 908. When the bolt 907 moves, it will stretch the spring 911. When the bolt 907 disengages from the round hole 908, the spring 911 is in a stretched state at this time. Then press the pull ring 912. The movement of the pull ring 912 will drive the adjustment arm 902 to move. When the adjustment arm 902 moves, it will make the limit arm 910 slide along the inner wall of the limit groove 909. The limit arm 910 restricts the movement path of the adjustment arm 902, so as to prevent the adjustment arm 902 from disengaging from the rectangular box 901. The movement of the adjustment arm 902 will gradually insert into the rectangular box 901. The movement of the adjustment arm 902 will drive several limit plates 903 to move. The movement of the limit plates 903 will move towards the sample tray 6. The movement of the limit plates 903 will drive several limit blocks 904 to move. The movement of the limit blocks 904 will drive the conical tube 915 to move. When the conical tube 915 moves to a suitable position, the conical tube 915 will be inserted into the sample test tube body 7 and the collection liquid test tube 8. Then release the bolt 907. The bolt 907 will insert into the round hole 908 by the force of the spring 911 contracting. The bolt 907 reaches the position of restricting the adjustment arm 902, and then restricts the position of the limit block 904. The spring 911 improves the stability of inserting into the round hole 908 and prevents the bolt 907 from disengaging from the round hole 908 due to shaking. At this time, move the liquid inlet and outlet device 3. The movement of the liquid inlet and outlet device 3 will drive the sampling needle 4 and the collection needle 5 to move. When the sampling needle 4 and the collection needle 5 move to a suitable position, lower the liquid inlet and outlet device 3. The liquid inlet and outlet device 3 will drive the sampling needle 4 and the collection needle 5 to move towards the limit block 904. When the sampling needle 4 and the collection needle 5 move to a suitable position, they will pass through the round groove 913 and insert into the positioning hole 905. After the sampling needle 4 and the collection needle 5 pass through the positioning hole 905 and insert to a certain distance, they will pass through the rubber ring 914. The rubber ring 914 will expand when being squeezed. The rubber ring 914 will closely fit on the surfaces of the sampling needle 4 and the collection needle 5. The rubber ring 914 serves to scrape off the sample liquid attached to the surfaces of the sampling needle 4 and the collection needle 5 when the sampling needle 4 and the collection needle 5 are taken out from the sample test tube body 7 and the collection liquid test tube 8. When the sampling needle 4 and the collection needle 5 move to a suitable position, they will be inserted into the sample test tube body 7 and the collection liquid test tube 8, so that the sampling needle 4 and the collection needle 5 are accurately inserted into the sample test tube body 7 and the collection liquid test tube 8, avoiding the situation that the sampling needle 4 and the collection needle 5 collide with the sample test tube body 7 and the collection liquid test tube 8 due to operation errors, and thus protecting the sample test tube body 7 and the collection liquid test tube 8.

[0031] In the description of the present utility model, it should be noted that unless otherwise clearly specified and defined, the terms "installed", "connected", and "coupled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood through specific circumstances.

Claims

1. A separable multi-channel chromatography device, comprising a base (1), a cabinet (2) is fixedly connected to the surface of the base (1), several liquid inlet and outlet devices (3) are installed on one side of the cabinet (2), a sampling needle (4) is installed on the surface of the liquid inlet and outlet device (3), a collection needle (5) is installed on the surface of the liquid inlet and outlet device (3), a rectangular plate (10) is fixedly connected to the surface of the base (1), several sample trays (6) are fixedly connected to one side of the rectangular plate (10), several sample test tube bodies (7) and collection liquid test tubes (8) are inserted into the inner wall of the sample tray (6), and a limiting structure (9) is arranged on the surface of the rectangular plate (10), characterized in that: The limiting structure (9) includes a rectangular box (901), the rectangular box (901) is fixedly connected to the surface of the rectangular plate (10), an adjusting arm (902) is slidably inserted into the inner wall of the rectangular box (901), a plurality of limiting plates (903) are fixedly connected to the surface of the adjusting arm (902), a plurality of limiting blocks (904) are fixedly connected to the surface of the limiting plate (903), a positioning hole (905) is formed in the surface of the limiting block (904), a bracket (906) is fixedly connected to the surface of the rectangular box (901), a pin (907) slidably penetrates through the surface of the bracket (906), a plurality of circular holes (908) are formed in the surface of the adjusting arm (902), and the size of the circular hole (908) is adapted to the size of the pin (907).

2. The separated multi-channel chromatography device according to claim 1, characterized in that: Limiting grooves (909) are formed on both sides of the adjusting arm (902), and limiting arms (910) are slidably connected to the inner walls of the two limiting grooves (909), and the limiting arms (910) are fixedly connected to the surface of the rectangular box (901).

3. The separated multi-channel chromatography device according to claim 1, characterized in that: A spring (911) is sleeved on the arc surface of the pin (907), and the two ends of the spring (911) are respectively fixedly connected to the pin (907) and the bracket (906).

4. The separated multi-channel chromatography device according to claim 1, wherein: A pull ring (912) is fixedly connected to the surface of the adjusting arm (902), a circular groove (913) is formed in the surface of the limiting block (904), and the circular groove (913) is communicated with the positioning hole (905).

5. The separated multi-channel chromatography device according to claim 1, wherein: A conical tube (915) is fixedly connected to one side of the limiting block (904) close to the sample tray (6), and the conical tube (915) is communicated with the positioning hole (905).

6. The separated multi-channel chromatography device according to claim 5, wherein: A rubber ring (914) is fixedly connected to one side of the conical tube (915) away from the limiting block (904), and the rubber ring (914) is communicated with the positioning hole (905).

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