Automatic control system for sterile production of injection stock solution

Abstract

The utility model relates to an automatic control system for sterile production of an injection stock solution. The automatic control system comprises an electronic scale; the liquid storage tank is arranged on the electronic scale, a filling liquid conveying pipe is arranged at the position, close to the lower end, of a tank body of the liquid storage tank, and a first electric valve is arranged on the filling liquid conveying pipe; the stock solution conveying pipe is communicated with the upper end of the solution storage tank, and a second electric valve is arranged on the stock solution conveying pipe; the return pipe is communicated with the bottom of the liquid storage tank, and a third electric valve, a high-temperature sterilization device and a first electric pump are sequentially arranged on the return pipe; the electronic scale, the first electric valve, the liquid storage tank, the second electric valve, the first electric pump, the third electric valve, the high-temperature sterilization device and the first electric pump are all connected with the PLC. Liquid medicine enters the liquid storage tank through the stock solution conveying pipe, the PLC is connected with the electronic scale to automatically recognize the weight of liquid in the liquid storage tank, and when the total weight of the liquid in the liquid storage tank reaches a set value, the first electric valve is automatically controlled to be closed, and the second electric valve on the filling liquid conveying pipe is opened, so that the liquid medicine enters a next filling production line. Meanwhile, after work, the PLC can control a first electric valve and a second electric valve to be kept in a closed state, a third electric valve, a first electric pump and a high-temperature sterilization device are opened at the same time, then high-temperature sterilization is conducted on residual liquid medicine in the liquid storage tank, the whole system works in a very closed environment, online operation is completely achieved, and the work efficiency is improved. The sterile production of the injection stock solution is ensured, the automation degree is greatly improved, and the labor intensity of personnel is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of aseptic production equipment for injections, in particular to an automatic control system for aseptic production of injection stock solutions. Background Art

[0002] In the previous injection production process, the raw liquid circulation system was that the preparation position would pressurize and transport the prepared liquid through a multi-stage pump. During the transportation process, the liquid was filtered through one 0.45μm and two 0.22μm filters into the liquid storage bottle for filling. The excess liquid was returned to the preparation pipe through the reflux system. During filling, the liquid in the liquid storage bottle was manually controlled within a certain range, and the liquid storage bottle was cleaned and sterilized offline after the shift.

[0003] The raw liquid infusion pipeline joints of this circulation system usually adopt a quick-connect connection method, and the position of the raw liquid in the glass storage bottle needs to be observed by naked eye to control the manual diaphragm pump on the raw liquid infusion tube, thereby controlling the total amount of liquid in the storage bottle. Finally, the operator seals the storage bottle with a silicone stopper before proceeding to the next filling step. The remaining raw liquid in the storage bottle is also sterilized offline. Not only does the entire system have a low degree of automation, but it also greatly increases the risk of raw liquid contamination. Utility Model Content

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the problems in the prior art of low automation level of injection stock solution circulation system and high risk factor of stock solution contamination.

[0005] In order to solve the above technical problems, the present invention provides an automatic control system for aseptic production of injection stock solution, comprising:

[0006] electronic scales;

[0007] A liquid storage tank is provided on the electronic scale, wherein a filling and infusion tube is provided near the lower end of the liquid storage tank, and a first electric valve is provided on the filling and infusion tube;

[0008] a raw liquid delivery pipe, which is connected to the upper end of the liquid storage tank, and a second electric valve is provided on the raw liquid delivery pipe;

[0009] a reflux pipe connected to the bottom of the liquid storage tank, wherein a third electric valve, a high-temperature sterilization device and a first electric pump are sequentially arranged on the reflux pipe;

[0010] A PLC controller is provided, wherein the electronic scale, the first electric valve, the liquid storage tank, the second electric valve, the first electric pump, the third electric valve, the high-temperature sterilization device and the first electric pump are all connected to the PLC controller.

[0011] In one embodiment of the present invention, a second electric pump and a multi-stage filter are further provided on the raw liquid delivery pipe, and the second electric pump is also connected to the PLC controller.

[0012] In one embodiment of the present invention, the second electric valve is arranged at a position where the raw liquid delivery pipe is close to the liquid storage tank, the second electric pump is arranged at a position where the raw liquid delivery pipe is away from the liquid storage tank, and the multi-stage filter is arranged between the second electric pump and the second electric valve.

[0013] The above technical solution of the utility model has the following advantages compared with the prior art:

[0014] The automatic control system for the aseptic production of injection stock solutions described in the present invention is designed so that the drug solution enters the liquid storage tank through the stock solution delivery pipe. The PLC controller automatically identifies the weight of the liquid in the liquid storage tank by connecting to an electronic scale. When the total weight of the liquid in the liquid storage tank reaches the set value, it automatically controls the first electric valve to close and opens the second electric valve on the filling infusion pipe to allow the drug solution to enter the next filling production line. At the same time, after the shift, the PLC controller controls the first and second electric valves to remain closed, while simultaneously opening the third electric valve, the first electric pump, and the high-temperature sterilization device to perform high-temperature sterilization on the residual drug solution in the liquid storage tank. The entire system is carried out in a very closed environment and fully realizes online operation, which not only ensures the aseptic production of injection stock solutions, but also greatly improves the degree of automation and reduces the labor intensity of personnel. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to make the content of the present invention more clearly understood, the present invention is further described in detail below based on the specific embodiments of the present invention and in conjunction with the accompanying drawings, wherein

[0016] Figure 1 This is a schematic diagram of the automatic control system for aseptic production of injection stock solution of the utility model.

[0017] Explanation of the reference numerals in the specification: 1. Electronic scale; 2. Liquid storage tank; 3. Filling infusion tube; 310. First electric valve; 4. Raw liquid delivery pipe; 410. Second electric valve; 5. Reflux pipe; 510. Third electric valve; 6. High-temperature sterilization device; 7. First electric pump; 8. PLC controller; 9. Second electric pump; 10. Multi-stage filter. DETAILED DESCRIPTION

[0018] The present invention will be further described below with reference to the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it. However, the embodiments are not intended to limit the present invention.

[0019] Reference Figure 1As shown, the utility model provides an automatic control system for aseptic production of injection stock solution, comprising:

[0020] Electronic scale 1;

[0021] A liquid storage tank 2 is provided on the electronic scale 1. A filling and infusion tube 3 is provided near the lower end of the liquid storage tank 2. A first electric valve 310 is provided on the filling and infusion tube 3.

[0022] A raw liquid delivery pipe 4 is connected to the upper end of the liquid storage tank 2 and is provided with a second electric valve 410;

[0023] A reflux pipe 5 is connected to the bottom of the liquid storage tank 2 and is provided with a third electric valve 510, a high-temperature sterilization device 6 and a first electric pump 7 in sequence;

[0024] The PLC controller 8 , the electronic scale 1 , the first electric valve 310 , the liquid storage tank 2 , the second electric valve 410 , the first electric pump 7 , the third electric valve 510 , the high-temperature sterilization device 6 and the first electric pump 7 are all connected to the PLC controller 8 .

[0025] This automatic control system for the aseptic production of injection stock solutions, in which the drug liquid enters the liquid storage tank 2 through the stock liquid delivery pipe 4, and the PLC controller 8 automatically identifies the weight of the liquid in the liquid storage tank 2 by connecting to an electronic scale. When the total weight of the liquid in the liquid storage tank 2 reaches the set value, it automatically controls the first electric valve 310 to close and opens the second electric valve 410 on the filling infusion pipe 3, so that the drug liquid can enter the next filling production line. At the same time, after the shift, the PLC controller 8 will control the first electric valve 310 and the second electric valve 410 to remain closed, while opening the third electric valve 510, the first electric pump 7, and the high-temperature sterilization device 6, thereby performing high-temperature sterilization on the residual drug liquid in the liquid storage tank 2. The entire system is carried out in a very closed environment and fully realizes online operation, which not only ensures the aseptic production of the injection stock solution, but also greatly improves the degree of automation and reduces the labor intensity of personnel.

[0026] Specifically, the liquid storage tank 2 and all pipelines are made of stainless steel, and the first electric valve 310, the second electric valve 410 and the third electric valve 510 are all electrically controlled pneumatic valves.

[0027] Furthermore, a second electric pump 9 and a multi-stage filter 10 are provided on the raw liquid delivery pipe 4 , and the second electric pump 9 is also connected to the PLC controller 8 .

[0028] Specifically, the second electric pump 9 is a multi-stage pump for providing power for the delivery of the raw liquid; the multi-stage filter 10 includes one 0.45 μm filter and two 0.22 μm filters for filtering the raw liquid.

[0029] Furthermore, the second electric valve 410 is arranged at a position of the raw liquid delivery pipe 4 close to the liquid storage tank 2, the second electric pump 9 is arranged at a position of the raw liquid delivery pipe 4 away from the liquid storage tank 2, and the multi-stage filter 10 is arranged between the second electric pump 9 and the second electric valve 410.

[0030] Obviously, the above embodiments are merely examples for clarity of explanation and are not intended to limit the implementation methods. Those skilled in the art will readily appreciate that other variations or modifications based on the above descriptions are possible. It is not necessary and impossible to enumerate all implementation methods here. Obvious variations or modifications arising therefrom remain within the scope of protection of the present invention.

Claims

1. An automatic control system for aseptic production of injection stock solution, characterized in that: include: electronic scales; A liquid storage tank is provided on the electronic scale, wherein a filling and infusion tube is provided near the lower end of the tank body of the liquid storage tank, and a first electric valve is provided on the filling and infusion tube; a raw liquid delivery pipe, which is connected to the upper end of the liquid storage tank, and a second electric valve is provided on the raw liquid delivery pipe; a reflux pipe connected to the bottom of the liquid storage tank, wherein a third electric valve, a high-temperature sterilization device and a first electric pump are sequentially arranged on the reflux pipe; A PLC controller is provided, wherein the electronic scale, the first electric valve, the liquid storage tank, the second electric valve, the first electric pump, the third electric valve, the high-temperature sterilization device and the first electric pump are all connected to the PLC controller.

2. The automatic control system for aseptic production of injection stock solution according to claim 1, characterized in that: The raw liquid delivery pipe is also provided with a second electric pump and a multi-stage filter, and the second electric pump is also connected to the PLC controller.

3. The automatic control system for aseptic production of injection stock solution according to claim 2, characterized in that: The second electric valve is arranged at a position of the raw liquid delivery pipe close to the liquid storage tank, the second electric pump is arranged at a position of the raw liquid delivery pipe away from the liquid storage tank, and the multi-stage filter is arranged between the second electric pump and the second electric valve.

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