High-precision digital slice rapid scanning device and scanning system based on rotary imaging

Abstract

The utility model discloses a high-precision digital slice rapid scanning device and scanning system based on rotary imaging. The high-precision digital slice rapid scanning device comprises a bottom plate assembly, a vertical plate arranged on the bottom plate assembly, a camera, a barrel lens, a lifting objective lens and a whole set of light source assembly, wherein the camera, the barrel lens, the lifting objective lens and the whole set of light source assembly are sequentially arranged on a plurality of installation positions to form a Z-axis light path; the XY translation platform is arranged between the lifting objective lens and the whole set of light source; the fluorescent mechanism and the panoramic camera are arranged between the barrel lens and the lifting objective lens; a plurality of mounting positions are arranged on the vertical plate in the height direction; a glass slide for placing a microstructure sample is arranged on the XY translation platform; wherein the fluorescent mechanism comprises a rotating sliding table, a rotating disc and a plurality of fluorescent assemblies, the rotating sliding table is arranged under the barrel lens in a sliding mode, the rotating disc is in a disc shape and is rotationally arranged on the rotating sliding table, and the fluorescent assemblies are arranged at an angle with the center of the disc. When single-color or multi-color fluorescence imaging needs to be carried out, the turntable can be rotated, so that the corresponding fluorescence color is rotated to the Z-axis light path for fluorescence imaging.

Description

Technical Field

[0001] The utility model belongs to the technical field of digital slice scanning equipment, and more specifically relates to a high-precision digital slice fast scanning device and a scanning system based on rotational imaging. Background Art

[0002] The high-precision digital slide intelligent scanner is a high-end instrument that can quickly and accurately obtain microscopic tissue structure information. Its primary purpose is to achieve high-fidelity restoration of tissue slide images, improve scanning speed and automation, optimize the digital slide scanner's operating system and software, and enable intelligent operation and data management. It has broad application prospects in fields such as materials science, biology, and medicine.

[0003] Currently, existing high-precision digital slide scanners are unable to switch between multiple imaging modes at any time when performing panoramic imaging, fluorescent monochrome and multi-channel imaging, and white bright field imaging.

[0004] It can be seen that how to provide a high-precision digital slice rapid scanning device that can switch between multiple imaging modes at any time is a technical problem that technical personnel in this field urgently need to solve. Utility Model Content

[0005] In response to the above-mentioned defects or improvement needs of the prior art, in a first aspect, the present invention provides a high-precision digital slice rapid scanning device based on rotational imaging, the rapid scanning device comprising: a base plate assembly, a vertical plate arranged on the base plate assembly, a camera arranged in sequence on a plurality of mounting positions to form a Z-axis optical path, a cylindrical lens, a lifting objective lens and a complete set of light source assemblies, and an XY translation platform arranged between the lifting objective lens and the complete set of light source assemblies;

[0006] The vertical plate is provided with a plurality of installation positions along the height direction;

[0007] A fluorescent mechanism and a panoramic camera provided between the cylindrical lens and the lifting objective lens;

[0008] A glass slide for placing microscopic tissue samples is provided on the XY translation platform;

[0009] Among them, the fluorescent mechanism includes a rotating slide, a turntable and several fluorescent components. The rotating slide is rotatably arranged on the mounting position on the vertical plate and is located directly below the cylindrical mirror. The turntable is disc-shaped and rotatably arranged on the rotating slide. Several fluorescent components are arranged at an angle with the center of the disc.

[0010] In the first aspect, the rotating platform is further provided with light-through holes, and the light-through holes are correspondingly arranged between adjacent fluorescent components.

[0011] In the first aspect, the panoramic camera is provided on the side of the fluorescent mechanism, and the lamp is provided adjacent to the panoramic camera;

[0012] The XY translation platform is also provided with a white light backlight source.

[0013] In the first aspect, the complete light source assembly includes a brake mounting plate, a motor, a light shield, a light source, and a pair of proximity switches;

[0014] The brake mounting plate includes an ear plate, a mounting space and a light-transmitting hole; the ear plate is connected to the mounting position, the light source is arranged in the mounting hole, and transmits light through the light-transmitting hole, and the light source is connected to a pair of the proximity switches and is controlled to be on and off by a pair of the proximity switches; a pair of the proximity switches are arranged at intervals on the brake mounting plate and are located around the light-transmitting hole, the motor is arranged on the brake mounting plate, and the output end of the motor is connected to one side of the light-shielding plate. When the motor rotates, it drives the light-shielding plate to pass through a pair of the proximity switches or the light-shielding hole to open or close the proximity switch.

[0015] In the first aspect, the motor is provided between a pair of the proximity switches, and the moving path of the light shielding plate forms contact with the pair of the proximity switches.

[0016] In the first aspect, the light-shielding plate includes a light-shielding portion and a trigger portion, and the light-shielding portion is adapted to the aperture of the light-transmitting hole. When the light-shielding portion completely covers the light-shielding hole, the trigger portion coincides with the position of one of the trigger switches. When the light-shielding portion is separated from the light-shielding hole, the light-shielding portion coincides with the position of the other trigger switch.

[0017] In the first aspect, the scanning device further includes an outer cover assembly, and the outer cover is arranged outside the base plate assembly and the vertical plate.

[0018] In the first aspect, the housing assembly includes a housing front cover, a housing frame, a housing rear cover, a touch panel, a lifting door, and a driving assembly;

[0019] The outer cover front cover, the outer cover frame and the outer cover rear cover form a cubic shell structure. The outer cover front cover is provided with a window. The window is opened and closed by the lifting door, and the lifting door is driven to move by a driving assembly.

[0020] In the first aspect, the drive assembly includes a motor, a gear and a rack, the rack is arranged on the switch door, and the extension direction of the rack is toward the direction in which the switch door slides open, the motor is arranged on the front cover of the outer cover, and the output end of the motor is coaxially arranged with the gear, and the gear is engaged with the rack.

[0021] In a second aspect, the present invention provides a digital slice scanning system, which includes any one of the high-precision digital slice rapid scanning devices based on rotational imaging described above.

[0022] In general, the above technical solutions conceived by the present invention can achieve the following beneficial effects compared with the prior art:

[0023] 1. The high-precision digital slice rapid scanning device based on rotational imaging of the present invention realizes monochrome or multi-color fluorescence photography and panoramic photography through the fluorescence mechanism and panoramic camera located between the tube lens and the lifting objective lens. At the same time, white light bright field imaging can be performed after the fluorescence mechanism is removed. The three can be freely switched according to imaging requirements.

[0024] 2. The camera, tube lens, lifting objective lens and a complete set of light source components form a Z-axis optical path on the vertically arranged vertical plate, and cooperate with the fluorescent mechanism located directly below the tube lens to perform monochrome or multi-color fluorescent imaging. The fluorescent mechanism consists of a rotating slide, a turntable and several fluorescent components. The turntable is disc-shaped and rotates on the rotating slide. Several fluorescent components are arranged at an angle with the center of the disc. When corresponding fluorescent color imaging is required, the corresponding fluorescent color can be rotated to the bottom of the tube lens to enter the Z-axis optical path to achieve corresponding dual-channel fluorescent imaging / monochrome fluorescent imaging. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of the structure of a high-precision digital slice rapid scanning device based on rotational imaging in an embodiment of the present utility model. Figure 1 ;

[0026] Figure 2 This is a schematic diagram of the structure of a high-precision digital slice rapid scanning device based on rotational imaging in an embodiment of the present utility model. Figure 2 ;

[0027] Figure 3 This is a schematic diagram of the structure of the fluorescent mechanism in the embodiment of the utility model

[0028] Figure 4 This is a structural diagram of the outer cover assembly in an embodiment of the present utility model;

[0029] Figure 5 This is a schematic structural diagram of the driving assembly and the touch panel in an embodiment of the present utility model;

[0030] Figure 6 This is a schematic diagram of the structure of the entire light source assembly in the embodiment of the utility model. Figure 1 ;

[0031] Figure 7 This is a schematic diagram of the structure of the entire light source assembly in the embodiment of the utility model. Figure 2 ;

[0032] Figure 8 This is a schematic diagram of the structure of the entire light source assembly in the embodiment of the utility model. Figure 3 ;

[0033] Figure 9 The structure diagram of the lifting objective lens in the embodiment of the utility model is shown as follows: Figure 1 ;

[0034] Figure 10 The structure diagram of the lifting objective lens in the embodiment of the utility model is shown as follows: Figure 2 .

[0035] Description of reference numerals:

[0036] 1. Bottom plate assembly;

[0037] 2. Vertical board;

[0038] 3. Camera;

[0039] 4. Tube mirror;

[0040] 5. Lifting objective lens;

[0041] 6. A complete set of light source components;

[0042] 7. Fluorescent mechanism; 701. Rotating slide; 702. Turntable; 703. Fluorescent component; 704. Light hole;

[0043] 8. Panoramic camera;

[0044] 9. XY translation platform;

[0045] 10. Lights;

[0046] 11. White light backlight;

[0047] 12. Outer cover assembly; 1201. Outer cover front cover; 1202. Outer cover frame; 1203. Outer cover back cover; 1204. Window; 1205. Lift door; 1206. Drive assembly; 12061. Motor; 12062. Gear; 12063. Rack; 1207. Touch panel. DETAILED DESCRIPTION

[0048] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present invention and are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

[0049] Example 1:

[0050] like Figure 1-10 As shown, the first embodiment of the present invention proposes that the present invention provides a high-precision digital slice rapid scanning device based on rotational imaging, the rapid scanning device comprising: a base plate assembly, a vertical plate 2 arranged on the base plate assembly, a camera 3 sequentially arranged on a plurality of mounting positions to form a Z-axis optical path, a tube lens 4, a lifting objective lens 5 and a complete set of light source components 6, and an XY translation platform 9 arranged between the lifting objective lens 5 and the complete set of light source components;

[0051] In which, the vertical plate 2 is provided with multiple mounting positions along the height direction; a fluorescent mechanism 7 and a panoramic camera 8 are provided between the tube lens 4 and the lifting objective lens 5; a slide for placing microscopic tissue samples is provided on the XY translation platform 9; in which, the fluorescent mechanism 7 includes a rotating slide 701, a turntable 702 and several fluorescent components 703, the rotating slide 701 rotates on the mounting position on the vertical plate and is located directly below the tube lens 4, the turntable 702 is disc-shaped and is rotatably provided on the rotating slide 701, and several fluorescent components 703 are arranged at an angle with the center of the disc.

[0052] In the above embodiment, the high-precision digital slide rapid scanning device based on rotational imaging of this embodiment realizes monochrome or multi-color fluorescence photography and panoramic photography through the fluorescence mechanism 7 and panoramic camera 8 located between the tube lens 4 and the lifting objective lens 5. At the same time, white bright field imaging can be performed after the fluorescence mechanism 7 is removed. The three can be freely switched according to imaging requirements. Specifically, the camera 3, the tube lens 4, the lifting objective lens 5 and the complete light source assembly 6 form a Z-axis optical path on the vertically arranged vertical plate 2. In conjunction with the fluorescence mechanism 7 located directly below the tube lens 4, monochrome or multi-color fluorescence imaging is performed. The fluorescence mechanism 7 consists of a rotating slide 701, a turntable 702 and a plurality of fluorescence assemblies 703. The turntable 702 is disc-shaped and rotatably mounted on the rotating slide 701. The plurality of fluorescence assemblies 703 are arranged at an angle with the center of the disc. When imaging of a corresponding fluorescence color is required, the corresponding fluorescence color can be rotated to the position directly below the tube lens 4 to enter the Z-axis optical path to achieve corresponding dual-channel fluorescence imaging / monochrome fluorescence imaging. At the same time, the rotating stage is also provided with light holes, which are arranged between adjacent fluorescent components 703 to transmit the signal light collected from the objective lens so as to be detected and imaged by the camera 3 .

[0053] At the same time, a panoramic camera 8 is installed on the side of the fluorescent structure 7, and a lamp 10 is installed adjacent to the panoramic camera 8; a white light backlight source 11 is also installed on the XY translation platform 9. When performing panoramic imaging, the XY translation platform 9 is moved so that the internal white light backlight source is directly below the panoramic camera 8. Then, the panoramic camera 8 and the lamp 10 are combined with the white light backlight source 11 on the XY platform to perform panoramic imaging, generating a complete slice cell image for cell positioning;

[0054] Also, when performing white bright field imaging, the fluorescent mechanism 7 is moved out of the Z-axis optical path, the xy translation stage drives the slide to be located between the lifting objective lens 5 and the entire light source assembly 6, the light source of the light source assembly is turned on, and the light source is used to illuminate the slide with white light, and then the image is formed through the lifting objective lens 5, the tube lens 4 and the camera 3 in sequence.

[0055] like Figure 6-8 As shown, in some preferred embodiments, the complete light source assembly 6 includes a brake mounting plate, a motor 12061, a light shield, a light source and a pair of proximity switches;

[0056] The brake mounting plate includes an ear plate, a mounting space and a light-transmitting hole; the ear plate is connected to the mounting position by bolts, the light source is arranged in the mounting space and transmits light through the light-transmitting hole, and the light source is connected to a pair of the proximity switches and is controlled on and off by a pair of the proximity switches; a pair of the proximity switches are arranged at intervals on the brake mounting plate and are located around the light-transmitting hole, the motor 12061 is arranged on the brake mounting plate, and the output end of the motor 12061 is connected to one side of the light shielding plate. When the motor 12061 rotates, it drives the light shielding plate through a pair of the proximity switches or the light shielding hole to open or close the proximity switch.

[0057] Furthermore, the motor 12061 is arranged between a pair of proximity switches, and the moving path of the light shielding plate forms an inductive contact with a pair of proximity switches. When the light shielding plate is driven by the motor 12061 to rotate through the contact switch on the corresponding side, the switch of the motor is triggered, causing the motor to stop rotating.

[0058] Furthermore, the shading plate includes a shading portion and a trigger portion, and the shading portion is adapted to the aperture of the light-transmitting hole. When the shading portion completely covers the light-transmitting hole, the trigger portion coincides with the position of one of the trigger switches to trigger the motor switch to stop the motor from rotating. When the shading portion is separated from the light-transmitting hole, the shading portion coincides with the position of the other trigger switch to trigger the motor switch to stop the motor from rotating.

[0059] In some preferred embodiments, Figure 4As shown, the scanning device further includes an outer cover assembly 12 , which is arranged outside the base plate assembly and the vertical plate 2 .

[0060] In some preferred embodiments, the outer cover assembly 12 includes an outer cover front cover 1201, an outer cover frame 1202, an outer cover back cover 1203, a motor 12061, a touch panel 1207, a lifting door 1205 and a driving assembly 1206; the outer cover front cover 1201, the outer cover frame 1202 and the outer cover back cover 1203 constitute a cubic shell structure, and a window 1204 is provided on the outer cover front cover 1201, and the window 1204 is controlled to open and close by the lifting door 1205, and the lifting door 1205 is driven to move by the driving assembly 1206. The lifting door 1205 is opposite to the placement position of the slide. When the slide needs to be replaced, the switch door can be opened. The driving component 1206 includes a motor 12061, a gear 12062 and a rack 12063. The rack 12063 is set on the switch door, and the extension direction of the rack 12063 is toward the direction of sliding opening of the switch door. The motor 12061 is set on the outer cover 1201, and the output end of the motor 12061 is coaxially arranged with the gear 12062, and the gear 12062 is engaged with the rack 12063.

[0061] The housing assembly 12 not only protects internal components but also optimizes the user experience. It comprises key components such as a front housing cover 1201, a frame 1202, a rear housing cover 1203, a touch panel 1207, a lift door 1205, and a drive assembly 1206. Together, they form a cubic shell structure, resulting in a simple and modern design while also achieving a high degree of automation and intelligence.

[0062] The front cover 1201 of the housing is specially designed with a window 1204 that directly faces the slide placement area. The opening and closing of window 1204 is controlled by a lift door 1205. This design not only protects the internal components from external environmental influences but also facilitates real-time monitoring of the device status. The opening and closing of lift door 1205 is controlled by a drive assembly 1206. This drive assembly 1206 uses a motor 12061 as its power source and achieves smooth movement of lift door 1205 through a precise gear 12062 and rack 12063 mechanism.

[0063] Furthermore, if Figure 5As shown, the detailed design of drive assembly 1206 is as follows: Motor 12061 is mounted on the sturdy front cover 1201 of the housing, ensuring stability and reliability during long-term operation. The output end of motor 12061 is coaxially arranged with gear 12062, ensuring efficient and accurate power transmission. Gear 12062 meshes with rack 12063 mounted on lift door 1205. The direction of rack 12063 extends in the same direction as the lift door 1205 slides open. This design ensures smoother movement of lift door 1205, reduces wear caused by friction, and extends the service life of the component. Furthermore, the integration of touch panel 1207 provides an intuitive user interface. Users can control the opening and closing of lift door 1205 and the start and stop of motor 12061 through simple touch operations, greatly enhancing operational convenience. The entire housing assembly 12 is designed with ergonomic principles in mind, ensuring user comfort and safety during use. During the slide change process, the user simply issues a command via the touch panel 1207, and the lift door 1205 automatically opens, revealing the slide placement area, allowing the user to easily change the slide. After the slide change is complete, the lift door 1205 automatically closes, ensuring that the device is sealed and prevents the intrusion of dust and impurities.

[0064] like Figure 9-10 As shown, in some preferred embodiments, the lifting objective lens 5 can be a single objective lens or multiple objective lenses. In the case of a single objective lens, it is arranged in the Z-axis optical path and can be raised and lowered for focusing and imaging slices of different thicknesses. In the case of multiple objective lenses, they are installed in a circular distribution on a disk. When an objective lens of a corresponding specification is needed, the objective lens is rotated into the Z-axis optical path by rotating the disk. The design of multiple objective lenses allows different objective lenses to be selected for different slice types, thereby obtaining better imaging results.

[0065] Example 2:

[0066] The present invention provides a digital slide scanning system, comprising any of the aforementioned high-precision digital slide rapid scanning devices based on rotational imaging. The scanning system of the second embodiment utilizes a fluorescence mechanism 7 and a panoramic camera 8, both located between a cylindrical lens 4 and an elevating objective lens 5 in the scanning device, to achieve monochrome or multicolor fluorescence imaging and panoramic imaging. Furthermore, white-light brightfield imaging can be achieved by removing the fluorescence mechanism 7. These three modes can be freely switched according to imaging requirements.

[0067] It is easy for those skilled in the art to understand that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A high-precision digital slice rapid scanning device based on rotational imaging, characterized in that: The rapid scanning device comprises: Base plate assembly; A vertical plate (2) provided on the base plate assembly, wherein the vertical plate (2) is provided with a plurality of mounting positions along a height direction; A camera (3), a tube lens (4), a lifting objective lens (5), and a complete set of light source components (6) are sequentially arranged on the plurality of mounting positions to form a Z-axis optical path, and a fluorescent mechanism (7) and a panoramic camera (8) are arranged between the tube lens (4) and the lifting objective lens (5); an XY translation platform (9) provided between the lifting objective lens (5) and the entire set of light source components, wherein a glass slide for placing a microscopic tissue sample is provided on the XY translation platform (9); The fluorescent mechanism (7) comprises a rotating slide (701), a rotating disk (702) and a plurality of fluorescent components (703); the rotating slide (701) is rotatably mounted on a mounting position on the vertical plate and is located directly below the cylindrical mirror (4); the rotating disk (702) is disc-shaped and rotatably mounted on the rotating slide (701); and the plurality of fluorescent components (703) are arranged at an angle with respect to the center of the disc.

2. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 1, characterized in that: The rotating slide is also provided with light holes, and the light holes are correspondingly arranged between adjacent fluorescent components (703).

3. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 1, characterized in that: The panoramic camera (8) is arranged on the side of the fluorescent mechanism (7), and a lamp (10) is arranged adjacent to the panoramic camera (8); A white light backlight source (11) is also provided on the XY translation platform (9).

4. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 1, characterized in that: The complete light source assembly (6) comprises a brake mounting plate, a motor (12061), a light shield, a light source and a pair of proximity switches; The brake mounting plate includes an ear plate, a mounting space and a light-transmitting hole; the ear plate is connected to the mounting position, the light source is arranged in the mounting space and transmits light through the light-transmitting hole, and the light source is connected to a pair of the proximity switches and is controlled to be on and off by a pair of the proximity switches; a pair of the proximity switches are arranged at intervals on the brake mounting plate and are located around the light-transmitting hole, the motor (12061) is arranged on the brake mounting plate, and the output end of the motor (12061) is connected to one side of the light shielding plate. When the motor (12061) rotates, it drives the light shielding plate to pass through a pair of the proximity switches or the light-transmitting hole to open or close the proximity switch.

5. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 4, characterized in that: The motor (12061) is arranged between a pair of proximity switches, and the moving path of the sunshade forms contact with the pair of proximity switches.

6. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 5, characterized in that: The shading plate includes a shading portion and a trigger portion, and the shading portion is adapted to the aperture of the light-transmitting hole. When the shading portion completely covers the light-transmitting hole, the trigger portion coincides with the position of one of the trigger switches. When the shading portion is separated from the light-transmitting hole, the shading portion coincides with the position of the other trigger switch.

7. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 1, characterized in that: The scanning device further comprises an outer cover component (12), which is arranged outside the base plate component and the vertical plate (2).

8. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 7, characterized in that: The outer cover assembly (12) includes an outer cover front cover (1201), an outer cover frame (1202), an outer cover rear cover (1203), a touch panel (1207), a lifting door (1205) and a driving assembly (1206); The outer cover front cover (1201), the outer cover frame (1202) and the outer cover rear cover (1203) form a cubic shell structure. A window (1204) is provided on the outer cover front cover (1201). The window (1204) is controlled to open and close by the lifting door (1205). The lifting door (1205) is driven to move by a driving assembly (1206).

9. The high-precision digital slice rapid scanning device based on rotational imaging according to claim 8, characterized in that: The driving assembly (1206) comprises a motor (12061), a gear (12062) and a rack (12063); the rack (12063) is arranged on the lifting door, and the extension direction of the rack (12063) is toward the direction in which the lifting door slides open; the motor (12061) is arranged on the outer cover (1201), and the output end of the motor (12061) is coaxially arranged with the gear (12062); the gear (12062) and the rack (12063) are meshed.

10. A digital slide scanning system, characterized by: The scanning system includes the high-precision digital slice rapid scanning device based on rotational imaging as described in any one of claims 1 to 9.

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