Disposable pipeline system

Abstract

The utility model relates to the technical field of biological pharmacy, in particular to a disposable pipeline system. The disposable pipeline system comprises a stock solution bag, an input pipeline, a delivery pump, a uniform mixing container, a sampling pipeline and a liquid outlet pipeline; the stock solution bag can be detachably connected with an inlet of the input pipeline, and an outlet of the input pipeline can be connected with the uniform mixing container; the conveying pump is arranged on the input pipeline; an inlet of the sampling pipeline and an inlet of the liquid outlet pipeline are respectively formed in the bottom of the uniform mixing container; the outlet of the sampling pipeline can be connected with at least two sampling bags, and the outlet of the liquid outlet pipeline can discharge the fluid in the blending container. In this way, writing and maintenance of pipelines in the stock solution preparation process can be provided in a detachable mode, meanwhile, the requirements for cleaning and sterility can be met, and the cost can also be reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, and in particular to a disposable piping system. Background Art

[0002] Currently, when preparing raw liquids in the biopharmaceutical field, stainless steel pipelines are used for transportation, which are high in cost and have high requirements for cleaning and sterility. At the same time, the pipelines are fixed and cannot be disassembled after installation, resulting in unchanged assembly and maintenance. Utility Model Content

[0003] The purpose of the present invention includes, for example, providing a disposable piping system that can be detachably provided for the writing and maintenance of piping during the preparation of the stock solution, while ensuring cleaning and sterility requirements and reducing costs.

[0004] The embodiment of the present utility model can be implemented as follows:

[0005] In a first aspect, the present invention provides a disposable piping system, comprising:

[0006] Original liquid bag, input pipeline, delivery pump, mixing container, sampling pipeline and liquid outlet pipeline;

[0007] The raw liquid bag can be detachably connected to the inlet of the input pipeline, and the outlet of the input pipeline can be connected to the mixing container; the delivery pump is provided on the input pipeline;

[0008] The inlet of the sampling pipeline and the inlet of the liquid outlet pipeline are respectively arranged at the bottom of the mixing container; the outlet of the sampling pipeline can be connected to at least two sampling bags, and the outlet of the liquid outlet pipeline can discharge the fluid in the mixing container.

[0009] In an optional embodiment, a disposable sterile connector is provided at the inlet of the input pipeline; and the delivery pump is located at an end of the disposable sterile connector away from the inlet of the input pipeline.

[0010] In an optional embodiment, a filter pipe is also provided on the input pipeline; along the length direction of the filter pipe, the filter pipe has a first end and a second end relative to each other, the first end is provided with a gas filter element, and the second end is arranged between the delivery pump and the mixing container.

[0011] In an optional embodiment, both ends of the delivery pump are connected to the input pipeline via double Y-shaped disposable hoses.

[0012] In an optional embodiment, a front-end pipeline is further included, and along the length direction of the front-end pipeline, both ends of the front-end pipeline are detachably connected to the raw liquid bag and the input pipeline respectively.

[0013] In an optional embodiment, a plurality of connecting holes are provided on the top of the mixing container, and the outlet of the input pipeline can be connected to any of the connecting holes.

[0014] In an optional embodiment, the mixing container includes a chamber and a cover, an opening is provided at the top of the chamber, and the cover can seal the opening.

[0015] In an optional embodiment, a temperature measuring sleeve is further included; the temperature measuring sleeve is detachably arranged on the mixing container.

[0016] In an optional embodiment, the liquid outlet pipeline includes a liquid outlet connector, a liquid outlet pipe and a liquid outlet valve connected in sequence; the liquid outlet connector is connected to the bottom of the mixing container.

[0017] In an optional embodiment, the sampling pipeline includes a sampling connector, a sampling tube and a sampling multi-way valve connected in sequence, the sampling connector is connected to the bottom of the mixing container, and the sampling multi-way valve can be connected to at least two sampling bags.

[0018] The beneficial effects of the embodiments of the present invention include, for example:

[0019] The disposable piping system of this solution includes a raw liquid bag, an input pipeline, a delivery pump, a mixing container, a sampling pipeline, and a liquid outlet pipeline. The raw liquid bag can be detachably connected to the inlet of the input pipeline, the outlet of the input pipeline can be connected to the mixing container, and the delivery pump is arranged on the input pipeline, which is conducive to the liquid medicine entering the mixing container along the input pipeline for mixing; and the sampling pipeline and the liquid outlet pipeline can realize the sampling and liquid outlet operations of the mixed liquid medicine. Because the two ends of the input pipeline are detachably connected to the raw liquid bag and the mixing container respectively, and the sampling pipeline and the liquid outlet pipeline are detachably connected to the mixing container, this simplifies the assembly and maintenance of the entire piping system, and this connection method can meet the requirements that the raw liquid bag, input pipeline, sampling pipeline, liquid outlet pipeline and the mixing container using the mixing bag are all disposable products, thereby providing sterility and convenience in the balancing of the liquid medicine, and significantly improving production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following is a brief introduction to the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1This is a schematic diagram of the assembly of a disposable piping system according to an embodiment of the present invention;

[0022] Figure 2 This is a schematic diagram of the assembly between the sampling pipeline and the sampling bag of the disposable pipeline system of an embodiment of the utility model;

[0023] Figure 3 This is a schematic diagram of the assembly of a sampling bag of a disposable piping system according to an embodiment of the present invention;

[0024] Figure 4 This is a schematic diagram of the heating assembly of the temperature measuring sleeve of the disposable piping system according to an embodiment of the present utility model.

[0025] Icons: 11- original liquid bag; 12- input pipeline; 13- transfer pump; 14- sampling bag; 15- disposable sterile connector; 16- double Y-type disposable hose; 17- front-end pipeline; 18- temperature measuring sleeve; 100- mixing container; 101- connecting hole; 110- chamber; 120- cover; 200- sampling pipeline; 210- sampling connector; 220- sampling tube; 230- sampling multi-way valve; 300- liquid outlet pipeline; 310- liquid outlet connector; 320- liquid outlet tube; 330- liquid outlet valve; 400- filtration pipeline; 410- first end; 420- second end; 510- first matching tube; 520- second matching tube. DETAILED DESCRIPTION

[0026] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.

[0027] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are also within the scope of protection of the present invention.

[0028] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0029] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the utility model product is usually placed when in use. It is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0030] In addition, the terms "first", "second", etc., if used, are merely used to distinguish and describe, and should not be understood as indicating or implying relative importance.

[0031] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention can be combined with each other.

[0032] Please refer to Figure 1 This embodiment provides a disposable pipeline system, including a raw liquid bag 11, an input pipeline 12, a delivery pump 13, a mixing container 100, a sampling pipeline 200 and a liquid outlet pipeline 300.

[0033] The stock liquid bag 11 can be detachably connected to the inlet of the input pipeline 12, and the outlet of the input pipeline 12 can be connected to the mixing container 100; the delivery pump 13 is provided on the input pipeline 12;

[0034] The inlet of the sampling pipeline 200 and the inlet of the liquid outlet pipeline 300 are respectively arranged at the bottom of the mixing container 100; the outlet of the sampling pipeline 200 can be connected to at least two sampling bags 14, and the outlet of the liquid outlet pipeline 300 can discharge the fluid in the mixing container 100.

[0035] The disposable piping system of this solution includes a stock solution bag 11, an input line 12, a delivery pump 13, a mixing container 100, a sampling line 200, and a liquid outlet line 300. The stock solution bag 11 can be detachably connected to the inlet of the input line 12, and the outlet of the input line 12 can be connected to the mixing container 100. The delivery pump 13 is installed on the input line 12, which facilitates the entry of the liquid medicine along the input line 12 into the mixing container 100 for mixing. The sampling line 200 and the liquid outlet line 300 enable sampling and liquid discharge of the mixed liquid medicine. Because the two ends of the input pipeline 12 are detachably connected to the raw liquid bag 11 and the mixing container 100, and the sampling pipeline 200 and the liquid outlet pipeline 300 are detachably connected to the mixing container 100, the assembly and maintenance operations of the entire pipeline system are simplified. Moreover, such a connection method can meet the requirement that the raw liquid bag 11, the input pipeline 12, the sampling pipeline 200, the liquid outlet pipeline 300 and the mixing container 100 using the mixing bag are all disposable products, thereby providing sterility and convenience in the balancing of the drug solution and significantly improving production efficiency.

[0036] Please continue reading Figure 1 、 Figure 2 、 Figure 3 and Figure 4 As can be seen from the figure, in an optional embodiment, a disposable sterile connector 15 is provided at the inlet of the input line 12; the delivery pump 13 is located at the end of the disposable sterile connector 15 away from the inlet of the input line 12. This ensures the sterility of the input line 12.

[0037] In an optional embodiment, a filter pipe 400 is further provided on the input pipe 12. Along its length, the filter pipe 400 has a first end 410 and a second end 420 that are opposite each other. The first end 410 is provided with a gas filter element, and the second end 420 is positioned between the delivery pump 13 and the mixing container 100. This ensures that the input pipe 12 can effectively balance the external air pressure, thereby facilitating the smooth operation of the delivery pump 13. The delivery pump 13 can optionally be a peristaltic pump.

[0038] In an optional embodiment, both ends of the delivery pump 13 are connected to the input pipeline 12 through double Y-shaped disposable hoses 16 .

[0039] In an optional embodiment, the disposable tubing system further includes a front-end tubing 17, with both ends of the front-end tubing 17 being detachably connected to the bulk bag 11 and the input tubing 12 along its length. The front-end tubing 17 further ensures the sterility between the bulk bag 11 and the input tubing 12, and this arrangement also ensures the integrity of the input tubing 12, preventing damage.

[0040] from Figure 1 It can also be seen that in an optional embodiment, a plurality of connection holes 101 are provided on the top of the mixing container 100, and the outlet of the input pipe 12 can be connected to any connection hole 101. In this embodiment, five connection holes 101 are provided on the top of the mixing container 100.

[0041] In an optional embodiment, the mixing container 100 includes a chamber 110 and a cover 120. The top of the chamber 110 is provided with an opening, and the cover 120 can seal the opening. This arrangement facilitates the maintenance of the mixing container 100 at any time and also facilitates the placement of the mixing bag into the chamber 110.

[0042] In an optional embodiment, the liquid outlet pipeline 300 includes a liquid outlet connector 310 , a liquid outlet pipe 320 , and a liquid outlet valve 330 that are connected in sequence; the liquid outlet connector 310 is connected to the bottom of the mixing container 100 .

[0043] See also Figure 1 、 Figure 2 and Figure 3As can be seen from the drawings, in an optional embodiment, the sampling pipeline 200 includes a sampling connector 210, a sampling tube 220 and a sampling multi-way valve 230 connected in sequence, the sampling connector 210 is connected to the bottom of the mixing container 100, and the sampling multi-way valve 230 can be connected to at least two sampling bags 14.

[0044] Furthermore, the sampling multi-way valve 230 has at least two connection ports connected to the sampling bag 14 .

[0045] The sampling bag 14 has two openings, one of which is connected to the sampling multi-way valve 230 via a first coupling tube 510; the other is connected to the 3D bag via a second coupling tube 520. This arrangement not only facilitates timely and efficient sampling operations with the sampling bag 14, but also enables operations such as liquid storage, thereby increasing the operational flexibility of the sampling line 200.

[0046] Optionally, the structures of the first matching tube 510 and the second matching tube 520 are substantially the same, except that the end of the second matching tube 520 away from the sampling bag 14 is further provided with a Luer connector and a cap body in sequence.

[0047] from Figure 4 It can also be seen that in an optional embodiment, the disposable piping system further includes a temperature measuring sleeve 18; the temperature measuring sleeve 18 is detachably provided on the mixing container 100. The temperature measuring sleeve 18 can monitor the temperature of the mixed liquid in real time, thereby ensuring the quality of the pharmaceutical mixing.

[0048] Optionally, a plurality of mating ports are provided at the bottom of the mixing container 100, one of which is connected to the liquid outlet pipe 300, another is connected to the sampling pipe 200, and another is connected to the temperature measuring sleeve 18. Compared with the prior art, which uses stainless steel pipes for transportation, the cost itself is high and the cleaning and sterility requirements are also high. Now the mixing system is enabled, using disposable liquid bags 11, disposable pipes and disposable mixing bags. The mixing bags can be directly used downstream, which significantly reduces production costs and is convenient. Under the premise of ensuring the sterility and integrity of the mixing experiment, the use of disposable pipeline equipment such as liquid bags 11, pipes, filters, etc. has the following three advantages:

[0049] ① Cheap and affordable: It is cheap and does not require cleaning and maintenance.

[0050] ②Safety: Ensure a sterile environment.

[0051] ③Flexibility: The materials to be used can be quickly replaced.

[0052] In summary, the embodiments of the present invention provide a disposable tubing system, which has at least the following advantages:

[0053] The beneficial effects of the embodiments of the present invention include, for example:

[0054] The disposable piping system of this solution includes a liquid bag 11, an input line 12, a delivery pump 13, a mixing container 100, a sampling line 200, and a liquid outlet line 300. The input line 12 is detachably connected to the liquid bag 11 and the mixing container 100 at both ends, and the sampling line 200 and the liquid outlet line 300 are also detachably connected to the mixing container 100. This simplifies the assembly and maintenance of the entire piping system. The use of disposable piping equipment and the liquid bag 11 is cost-effective, safe, efficient, and flexible.

[0055] The above are only specific embodiments of the present invention, but the scope of protection of the present invention is not limited to them. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in this utility model should be included in the scope of protection of the present utility model. Therefore, the scope of protection of the present utility model should be based on the scope of protection of the claims.

Claims

1. A disposable piping system, characterized in that: include: A raw liquid bag (11), an input pipeline (12), a delivery pump (13), a mixing container (100), a sampling pipeline (200) and a liquid outlet pipeline (300); The stock liquid bag (11) can be detachably connected to the inlet of the input pipeline (12), and the outlet of the input pipeline (12) can be connected to the mixing container (100); the delivery pump (13) is arranged on the input pipeline (12); The inlet of the sampling pipeline (200) and the inlet of the liquid outlet pipeline (300) are respectively arranged at the bottom of the mixing container (100); the outlet of the sampling pipeline (200) can be connected to at least two sampling bags (14), and the outlet of the liquid outlet pipeline (300) can discharge the fluid in the mixing container (100).

2. The disposable tubing system according to claim 1, characterized in that: A disposable sterile connector (15) is provided at the inlet of the input pipeline (12); the delivery pump (13) is located at an end of the disposable sterile connector (15) away from the inlet of the input pipeline (12).

3. The disposable tubing system according to claim 1, characterized in that: A filter pipe (400) is also provided on the input pipeline (12); along the length direction of the filter pipe (400), the filter pipe (400) has a first end (410) and a second end (420) opposite to each other, the first end (410) is provided with a gas filter element, and the second end (420) is located between the delivery pump (13) and the mixing container (100).

4. The disposable tubing system according to claim 1, characterized in that: Both ends of the delivery pump (13) are connected to the input pipeline (12) via double Y-shaped disposable hoses (16).

5. The disposable tubing system according to claim 1, characterized in that: It also includes a front-end pipeline (17), and along the length direction of the front-end pipeline (17), the two ends of the front-end pipeline (17) are detachably connected to the raw liquid bag (11) and the input pipeline (12) respectively.

6. The disposable tubing system according to claim 1, characterized in that: The top of the mixing container (100) is provided with a plurality of connecting holes (101), and the outlet of the input pipeline (12) can be connected to any of the connecting holes (101).

7. The disposable tubing system according to claim 1, characterized in that: The mixing container (100) comprises a chamber (110) and a cover (120). An opening is provided at the top of the chamber (110), and the cover (120) is capable of sealing the opening.

8. The disposable tubing system according to claim 1, characterized in that: It also includes a temperature measuring sleeve (18); the temperature measuring sleeve (18) is detachably arranged on the mixing container (100).

9. The disposable tubing system according to claim 1, characterized in that: The liquid outlet pipeline (300) comprises a liquid outlet connector (310), a liquid outlet pipe (320), and a liquid outlet valve (330) connected in sequence; the liquid outlet connector (310) is connected to the bottom of the mixing container (100).

10. The disposable tubing system according to claim 1, characterized in that: The sampling pipeline (200) comprises a sampling connector (210), a sampling tube (220) and a sampling multi-way valve (230) connected in sequence, wherein the sampling connector (210) is connected to the bottom of the mixing container (100), and the sampling multi-way valve (230) can be connected to at least two sampling bags (14).

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