Device for preparing multi-scale composite microspheres through sharp hole-pipeline flow

Abstract

The utility model provides a device for preparing multi-scale composite microspheres through sharp hole-pipeline flow. The device comprises a pipeline and an injector, the pipeline is a one-in and multiple-out pipeline; the injector is an injector with one inlet and multiple outlets; a main pipeline inlet of the pipeline is connected with the female seat; outlets of the three sub-pipelines of the pipeline are connected with the male seat; the sub-pipelines of the pipeline are connected with the inlet of the tee joint through the male seat; a branch opening of the tee joint is connected with a slurry outlet of the injector, and a sealing device is arranged at the branch opening; the injector comprises a needle cylinder and a plurality of needle tips; according to the utility model, the plurality of needle heads and the tee joint are connected in parallel, so that under the action of pipeline flow, the production efficiency of the composite microspheres is greatly improved, and the prepared composite microspheres are good in batch property and narrow in particle size distribution; a new idea is provided for preparation of the composite microspheres in the fields of biological medicines, energetic materials, food engineering, water treatment and the like.

Description

Technical Field

[0001] The utility model relates to the technical field related to microsphere production, and specifically to a device for preparing multi-scale composite microspheres by sharp hole-pipeline flow for microspheres in the fields of biomedicine, energetic materials, food industry, water treatment, etc. Background Art

[0002] With the development of society, microspheres play an important role in various fields. For example, in the field of biomedicine, microspheres can be used as drug carriers to improve the efficacy of drugs and reduce side effects by controlling their release rate; in the field of energetic materials, microspheres can not only improve the safety of energetic materials and facilitate transportation and storage, but also the morphology of microspheres can improve the fluidity and greatly improve the efficiency of drug loading; in the field of food industry, microsphere technology can be used to encapsulate sensitive nutrients such as vitamins, minerals, enzymes, antioxidants and probiotics, protect their stability during processing and storage, and improve their digestibility in the human body. Controlled release can be achieved during the chemical process. By encapsulating preservatives and antibacterial agents, the shelf life of food can be effectively extended, food waste can be reduced, and food safety can be improved. In the field of water treatment, microspheres can be used to remove organic pollutants, heavy metal ions, pathogenic microorganisms and other harmful substances in water, reducing water treatment costs and improving water treatment efficiency. The surface of the microspheres can also be functionally modified to increase their adsorption capacity and selectivity. In the above fields, microspheres have been widely used, but how to improve the efficiency of microsphere preparation and maintain the uniformity of particle size has always been a concern of scientific researchers.

[0003] Inspired by biomedicine, it was found that the sharp hole-coagulation bath has certain advantages in the preparation of microspheres, but it is only limited to the preparation of simple gel microspheres. There is less research on the preparation of microspheres with the addition of solid particles. This is because after too many microspheres with the addition of solid particles are prepared, the microspheres obtained in the coagulation bath will cause the level of the coagulation bath to rise, thereby affecting the morphology of the subsequently prepared microspheres. If the needle is too close to the liquid level of the coagulation bath, the needle will be immersed in the coagulation bath during the subsequent preparation of microspheres, resulting in the failure of the microsphere preparation, forcing humans to check the microsphere preparation process at any time to avoid this process. This increases the labor cost and causes certain troubles to the development of industrialization. Utility Model Content

[0004] In order to solve the problem that the existing composite microsphere preparation process cannot achieve continuous and batch production, the utility model provides a device for preparing multi-scale composite microspheres by using a sharp hole-pipe flow.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] A device for preparing multi-scale composite microspheres by orifice-pipe flow, comprising:

[0007] Tubes, syringes;

[0008] The pipe is a pipe with one input and multiple outputs; the syringe is a syringe with one input and multiple outputs;

[0009] The main pipe inlet of the pipeline is connected to the female socket;

[0010] The outlets of the three sub-pipelines of the pipeline are all connected to the male socket;

[0011] The sub-pipelines of the pipeline are all connected to the inlet of the tee through the male socket;

[0012] The branch port of the tee is connected to the slurry outlet of the syringe, and a sealing device is provided at the branch port;

[0013] The syringe includes a syringe barrel and multiple needle tips; a micro-injection pump is arranged in the syringe barrel, and the needle tips are the slurry outlets of the syringe.

[0014] Furthermore, the multiple sub-pipelines branched from the pipeline are all provided with water stop clamps.

[0015] Furthermore, a peristaltic pump is connected to the mother seat to maintain a uniform flow rate in the pipeline in order to improve the preparation efficiency of the microspheres and expand production efficiency.

[0016] Furthermore, the three connections are arranged in parallel and are all connected to the needle of the syringe, and the outlet of the three connections is connected to the collection device.

[0017] Furthermore, the sealing device is sealed with a nut; a nut is provided at the connection between the branch port of the tee and the needle, and the nut is equipped with a gasket, the needle can be inserted into the gasket, and the sealing of the tee is maintained.

[0018] Furthermore, the needle in the tee is set higher than the liquid level in the pipeline and cannot be immersed in the liquid level in the pipeline.

[0019] Furthermore, the lifting platform should be stably connected to the tee 4 so as to be able to accurately adjust the height of the tee from the needle.

[0020] Furthermore, the three-way valve can replace other multi-way valves, and the outlet needle of the syringe 5 is set accordingly.

[0021] Compared with the prior art, the present invention has the following significant advantages:

[0022] 1. It can realize the large-scale preparation of composite microspheres;

[0023] 2. The prepared composite microspheres have the characteristics of narrow particle size distribution;

[0024] 3. The prepared composite microspheres have good batch quality and consistency;

[0025] 4. The particle size of the composite microspheres is easy to control. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a partial structural diagram of the utility model.

[0027] Figure 2 This is a schematic diagram of the multi-needle structure of the utility model.

[0028] Figure 3 It is a schematic diagram of the three-way structure of the utility model.

[0029] Figure 4 This is a schematic diagram of the one-to-three channel structure of the utility model.

[0030] In the figure, 1. female socket; 2. water stop clamp; 3. nut; 4. tee; 5. syringe; 6. male socket; 7. pipe. DETAILED DESCRIPTION

[0031] In order to further illustrate the technical solution of the present invention, the present invention will be further described below through embodiments.

[0032] according to Figure 1-4 As shown in the schematic diagram,

[0033] A device for preparing multi-scale composite microspheres by sharp hole-pipe flow, the device comprising a female seat 1, a water stop clamp 2, a nut 3, a tee 4, a syringe 5, a male seat 6, and a pipe 7;

[0034] The pipe 7 is a pipe with one input and multiple outputs; the syringe 5 is a syringe with one input and multiple outputs;

[0035] The main pipe inlet of pipe 7 is connected to female socket 1;

[0036] The outlets of the three sub-pipelines of the pipeline 7 are all connected to the male socket 6;

[0037] The sub-pipes of the pipe 7 are all connected to the inlet of the tee 4 through the male socket 6;

[0038] The branch port of the tee 4 is connected to the outlet of the syringe 5; the syringe 5 includes a syringe and a needle tip;

[0039] Among them, the multiple sub-pipelines branched from the pipeline 7 are all provided with water stop clamps 2.

[0040] The device also includes a peristaltic pump, which is connected to the mother seat 1 to maintain a uniform flow rate in the pipeline in order to improve the preparation efficiency of the microspheres and expand production efficiency.

[0041] The branching openings of the tee 4 are sealed with a nut 3. The parallel tees connect to a single-inlet, multi-outlet syringe 5. The syringe 5, equipped with a microinjection pump, precisely controls the flow rate of the liquid within the syringe. Syringe 5 extrudes at an appropriate flow rate. The syringe is filled with a pre-prepared slurry. The slurry extruded from the needle reacts with the fluid in the pipeline flow, prompting the composite microspheres to form. The composite microspheres then flow into a collection device under the flow of the pipeline.

[0042] The branch port of the tee 4 of the utility model and the connection between the needle 5 are provided with a nut 3, and the nut 3 is equipped with a gasket. The needle 5 can be inserted into the gasket and maintain the sealing of the tee 4. The needle 5 in the tee 4 is set at a position higher than the liquid level of the pipeline flow and cannot be immersed in the liquid level of the pipeline flow.

[0043] The aperture of the needle of the utility model is adjustable within the range of 0.2-2 mm, including but not limited to plastic-steel needles, TT plastic bevel needles, coaxial needles, and the like.

[0044] In the present invention, the syringe 5 includes but is not limited to syringes of different capacities such as 5ml, 10ml, 30ml and other extrusion devices.

[0045] The pipe 7 of the present invention can be a silicone pipe or a PVC pipe, and is a multi-outlet pipe to ensure large-scale production of composite microspheres.

[0046] In the present invention, the inner diameter of the tee 4 is adjustable within a range of 5 mm to 30 mm, including but not limited to tee pipes connected in series, in parallel, and in other combinations.

[0047] In the present invention, the flow rate of the peristaltic pump is between 1-1000 mL / min, including but not limited to other devices for controlling the flow rate of the liquid.

[0048] In addition, in the present invention, the three-way valve 4 can replace other multi-way valves, and the outlet needle of the syringe 5 is correspondingly arranged.

[0049] The working process of the device is as follows: a metal salt solution of a certain concentration enters the pipe 1 under the action of the peristaltic pump, flows through the three sub-pipes of the pipe 7 through the tee 4 (the tee 4 is tightly connected to the pipe through the female seat 6 to ensure that the liquid does not leak), and the prepared suspension is extruded through the syringe 5 (the connection between the syringe 5 and the tee 4 must be sealed, and the nut 3 is the key part here). During the extrusion process, ensure that the needle does not immerse above the liquid level of the flowing liquid in the tee 4. By adjusting the extrusion rate of the suspension and the flow rate of the peristaltic pump, composite microspheres can be obtained.

[0050] The above description is merely a description of the preferred embodiments of the present invention and should not be construed as limiting the claims. The present invention is not limited to the above embodiments, and variations in the specific structure are permitted. In short, all variations within the scope of the independent claims of the present invention are also within the scope of protection of the present invention.

Claims

1. A device for preparing multi-scale composite microspheres by orifice-pipe flow, characterized in that: The device includes: Pipeline (7), syringe (5); The pipe (7) is a pipe with one input and multiple outputs; the syringe (5) is a syringe with one input and multiple outputs; The main pipeline inlet of the pipeline (7) is connected to the female seat (1); The outlets of the three sub-pipelines of the pipeline (7) are all connected to the male socket (6); The sub-pipes of the pipe (7) are all connected to the inlet of the tee (4) through the male socket (6); The branch port of the tee (4) is connected to the slurry outlet of the syringe (5), and a sealing device is provided at the branch port; The syringe (5) comprises a syringe and a plurality of needle tips; a microinjection pump is provided in the syringe, and the needle tips serve as slurry outlets of the syringe (5).

2. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 1, characterized in that: The plurality of sub-pipelines branched from the pipeline (7) are all provided with water stop clamps (2).

3. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 1, characterized in that: The device also includes a peristaltic pump connected to the mother seat (1) for maintaining a uniform flow rate in the pipeline in order to improve the preparation efficiency of the microspheres and expand production efficiency.

4. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 1, characterized in that: The three connections are arranged in parallel and are all connected to the needle of the syringe (5), and the outlet of the three connections (4) is connected to the collecting device.

5. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 4, characterized in that: The sealing device is sealed with a nut (3); a nut (3) is provided at the connection between the branch port of the tee (4) and the needle of the syringe (5); the nut (3) is equipped with a gasket, and the needle of the syringe (5) can be inserted into the gasket, thereby maintaining the sealing of the tee (4).

6. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 5, characterized in that: The needle of the syringe (5) in the tee (4) is arranged at a position higher than the liquid level in the pipeline and cannot be immersed in the liquid level in the pipeline.

7. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 1, characterized in that: The lifting platform should be stably connected to the tee (4) and can accurately adjust the height of the tee from the needle.

8. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 7, characterized in that: The aperture of the needle is 0.2-2mm.

9. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 1, characterized in that: The pipe (7) is a silicone pipe or a PVC pipe, and the inner diameter of the pipe (7) includes but is not limited to 5mm, 6mm, and 7mm.

10. The device for preparing multi-scale composite microspheres by orifice-pipe flow according to claim 1, characterized in that: The three-way connection (4) can replace other multi-way connections, and the outlet needle of the syringe (5) is set accordingly.

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