Automatic liquid preparation equipment

Abstract

The utility model discloses automatic liquid preparation equipment, which relates to the technical field of liquid preparation equipment and comprises an automatic weighing and sample adding system, a solution stirring and calibrating system and a solution sampling and subpackaging system. According to the utility model, the stirring container is used for directly performing large-capacity preparation treatment on the prepared solution, the raw materials for preparing the solution can be uniformly put into the large-capacity stirring container for stirring calibration after each raw material reagent is adjusted once or several times, and then the prepared solution is subjected to split charging treatment; the working efficiency is high, a large batch of solutions can be rapidly prepared, and the pipettor does not need to frequently and repeatedly move to carry out solution preparation operation; various solutions can be prepared more conveniently and quickly, equipment can be remotely controlled, multiple formulas are prepared in batches in sequence, and personnel operation is greatly reduced; multiple sensors are matched with whole-course data closed-loop processing, so that the solution preparation precision is ensured; and subpackaging, labeling and information inputting of containers of different specifications can be achieved, and use is convenient.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid dispensing equipment, in particular to automatic liquid dispensing equipment. Background Art

[0002] In response to the increasing demand for preparation of various solutions from biopharmaceutical companies and laboratories, manual preparation of solutions has the problems of low production efficiency, difficulty in controlling accuracy and consistency, and pollution problems easily caused by manual operation. The above problems indicate that manual preparation of solutions is gradually unable to meet the increasing production needs and industry environmental requirements. Therefore, in response to the above situation, some automatic liquid preparation equipment has emerged for solution preparation work within the laboratory.

[0003] Patent (CN219540343U) discloses an automatic liquid dispensing device for a laboratory, which relates to the technical field of liquid dispensing. The utility model includes an equipment frame, a collection box is provided inside the equipment frame, two first electric cylinders are fixedly installed on the inner wall of the equipment frame, the opposite sides of the two first electric cylinders are slidably connected with first sliders, the opposite sides of the two first sliders are fixedly connected to the collection box, a reinforcement frame is fixedly installed on the inner wall of the equipment frame, and a liquid dispensing table is provided inside the equipment frame; the liquid dispensing table is moved horizontally longitudinally or transversely by a moving mechanism, and the lower end of the pipette is connected to the first pipette head or the second pipette head by driving the pipette to descend vertically. The pipette, after being connected to the first pipette head or the second pipette head, draws solution from the liquid collection tube and injects the drawn solution into the liquid injection tube, thereby conveniently realizing the configuration of batch solutions, thereby effectively improving the convenience and efficiency of solution configuration.

[0004] The automatic liquid dispensing equipment in the laboratory in the above patent has a small capacity for preparing solutions. When large quantities of solutions need to be prepared, the pipette can only be moved repeatedly, which results in excessive workload and low work efficiency. Utility Model Content

[0005] The purpose of the present invention is to provide an automatic liquid dispensing device to solve the problems raised in the above background technology.

[0006] In order to solve the above technical problems, the utility model provides the following technical solutions: an automatic liquid dispensing equipment, including an automatic weighing and sampling system, a solution stirring and calibration system and a solution sampling and filling system, the solution stirring and calibration system is arranged between the automatic weighing and sampling system and the solution sampling and filling system, the solution sampling and filling system includes a filling pump, an empty bottle feeding and conveying mechanism, a filling and handling robot, a solution quantitative filling workstation, a sampling window and a full bottle discharge and conveying mechanism, the solution stirring and calibration system includes a stirring and weighing device, a stirring container, an injection water pump and a pH adjustment pump, the discharge pipe of the filling pump is connected to the filling pipe of the solution quantitative filling workstation, and the feed pipe of the filling pump extends to the bottom inner side of the stirring container.

[0007] Furthermore, the filling and transporting robot is arranged between the empty bottle feeding and conveying mechanism and the full bottle discharging and conveying mechanism, the solution quantitative filling workstation is arranged between the filling pump and the sampling window, the stirring container is arranged on the top of the stirring and weighing device, and the discharge pipes of the injection water pump and the pH adjustment pump extend to the top of the stirring container.

[0008] Furthermore, the automatic weighing and adding system includes a raw material and reagent placement station, a raw material and reagent code scanning and weighing station, a raw material and reagent shaking and dispersion station, a tooling storage quick change station, a sampling and weighing robot, a weighing station, a adding robot, a weighing container storage station, a pipetting head storage station, and a waste disposal station. The sampling and weighing robot and the adding robot are arranged in parallel.

[0009] Furthermore, the weighing station includes several scales and shock-absorbing platforms, the tool storage quick-change station includes reagent bottle clamping tooling and quantitative sample addition tooling, and the stirring container is provided with an integrated pH electrode and temperature sensor.

[0010] Furthermore, the packaging and handling robot is equipped with an end torque sensor, and the solution sampling and packaging system also includes a packaging bottle fixture and sampling fixture storage station, a bottle cap opening and closing station, a bottle cap picking and placing station, and a labeling and code scanning and verification station.

[0011] Furthermore, the automatic weighing and sampling system, the solution stirring and calibration system, and the solution sampling and packaging system are all provided with an equipment rack and a protective rack, and the solution sampling and packaging system is provided with a laminar flow hood on the top of the equipment rack and the protective rack.

[0012] Compared with the prior art, the beneficial effects achieved by the present invention are:

[0013] The utility model is provided with an automatic weighing and adding system, a solution stirring and calibration system and a solution sampling and filling system. The automatic liquid dispensing equipment in the utility model integrates the functions of automatic formula recognition, automatic material recognition, automatic sampling, weighing and adding, automatic stirring, pH calibration and volume determination, and automatic sampling and filling of the prepared solution; the utility model uses a stirring container to directly prepare a large volume of the prepared solution. Each raw material reagent only needs to be adjusted once or several times before the raw materials for the prepared solution can be uniformly put into the large-capacity stirring container for stirring and calibration, and then the prepared solution can be The device can be used for packaging, with high work efficiency, and can quickly prepare large quantities of solutions without the need for frequent and repeated movement of the pipette for liquid preparation operations. The utility model can use this device to prepare various solutions more conveniently and quickly. The device can be remotely controlled, and multiple formulas can be prepared in batches in sequence, which greatly reduces the need for human operation. Multiple sensors cooperate with the full data closed-loop processing to achieve precise control of each data and ensure the accuracy of solution preparation. The liquid preparation volume range is wide, and the replacement of standardized modules can achieve configurations of different specifications from ml to 500L. It can realize the packaging, labeling and information entry of containers of different specifications, which is convenient to use.

[0014] In the utility model, the automatic weighing and sampling system automatically identifies the raw materials and reagents, automatically samples, and automatically weighs and samples; the solution stirring and calibration system automatically stirs, calibrates the pH value, and performs constant volume processing on the prepared solution; the solution sampling and packaging system automatically samples and automatically packages the prepared solution; the stirring and weighing device weighs the stirring container and the solution inside it, the injection water pump transports the injection water into the stirring container to perform solution preparation and constant volume work, and the pH regulating pump regulates and calibrates the pH value of the solution inside the stirring container by transporting water; when the solution sampling and packaging system is working, the packaging and handling robot takes the solution configured inside the stirring container through the sampling bottle. The solution is sampled, and then the sampling bottle is placed at the sampling window. The staff samples the solution inside the sampling bottle through the sampling window for inspection. If the inspection fails, the solution stirring calibration system continues to work and adjusts the prepared solution. After the inspection is qualified, the filling pump is used to transport the prepared solution inside the stirring container to the solution quantitative filling workstation. The filling handling robot clamps the empty filling bottle transported from the empty bottle feeding and conveying mechanism and places it under the solution quantitative filling workstation. The solution quantitative filling workstation quantitatively fills the filling bottle with the prepared solution. After the filling is completed, the filling bottle is capped and then placed on the top of the full bottle discharging and conveying mechanism for transportation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0016] Figure 1 It is a schematic structural diagram of the utility model as a whole;

[0017] Figure 2 This is a schematic diagram of the structure of the utility model with the protective frame removed as a whole;

[0018] Figure 3 This utility model Figure 2 A top view of

[0019] Figure 4 This is a schematic structural diagram of the solution sampling and packaging system of the utility model without the protective frame;

[0020] Figure 5 This is a structural diagram of the automatic weighing and sample adding system of the utility model without the protective frame;

[0021] In the figure: 1. Automatic weighing and adding system; 101. Raw material and reagent placement station; 102. Raw material and reagent scanning and weighing station; 103. Raw material and reagent shaking and dispersion station; 104. Tool storage and quick change station; 105. Sampling and weighing robot; 106. Weighing station; 107. Adding robot; 108. Weighing container storage station; 109. Pipette head storage station; 110. Waste disposal station; 2. Solution stirring and calibration system; 201. Stirring and weighing device; 202. Stirring Mixing container; 203, injection water pump; 204, pH adjustment pump; 3, solution sampling and filling system; 301, filling pump; 302, empty bottle feeding and conveying mechanism; 303, filling and handling robot; 304, solution quantitative filling workstation; 305, sampling window; 306, full bottle discharge and conveying mechanism; 307, filling bottle fixture and sampling fixture storage station; 308, bottle cap opening and closing station; 309, bottle cap taking and placing station; 310, labeling and code scanning and verification station; 311, laminar flow hood. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] See also Figure 1-Figure 5The utility model provides a technical solution: an automatic liquid dispensing device, including an automatic weighing and adding system 1, a solution stirring and calibration system 2 and a solution sampling and filling system 3, wherein the solution stirring and calibration system 2 is arranged between the automatic weighing and adding system 1 and the solution sampling and filling system 3, and the solution sampling and filling system 3 includes a filling pump 301, an empty bottle feeding and conveying mechanism 302, a filling and handling robot 303, a solution quantitative filling workstation 304, a sampling window 305 and a full bottle discharging and conveying mechanism 306, and the solution stirring and calibration system System 2 includes a stirring and weighing device 201, a stirring container 202, an injection water pump 203 and a pH adjustment pump 204. The discharge pipe of the filling pump 301 is connected to the filling pipe of the solution quantitative filling workstation 304, and the feed pipe of the filling pump 301 extends to the bottom inside the stirring container 202; the empty bottle feeding conveying mechanism 302 and the full bottle discharging conveying mechanism 306 can both adopt a rotary crawler conveying mechanism; the stirring and weighing device 201 can use an electronic weighing device to weigh the stirring container 202 and the solution therein.

[0024] The packing and handling robot 303 is arranged between the empty bottle feeding and conveying mechanism 302 and the full bottle discharging and conveying mechanism 306, which makes it easier for the packing and handling robot 303 to take and place the reagent bottles between the empty bottle feeding and conveying mechanism 302 and the full bottle discharging and conveying mechanism 306; the solution quantitative filling workstation 304 is arranged between the packing pump 301 and the sampling window 305, and the sampling window 305 is used for external detection and sampling, which makes it easier for the staff to take the samples from the sampling window 305 and avoid the solution from being taken out of the container. The liquid quantitative filling workstation 304 obstructs the sampling window 305; the stirring container 202 is arranged on the top of the stirring and weighing device 201, and the discharge pipes of the injection water pump 203 and the pH adjustment pump 204 extend to the top of the stirring container 202. The stirring and weighing device 201 weighs the stirring container 202 and the solution therein to ensure that the injection water pump 203 delivers the injection water to the inside of the stirring container 202, and ensures that the pH adjustment pump 204 delivers the water or pH adjuster to the inside of the stirring container 202.

[0025] The automatic weighing and adding sample system 1 includes a raw material reagent placement station 101, a raw material reagent code scanning and weighing station 102, a raw material reagent shaking and dispersing station 103, a tool storage quick-change station 104, a sampling and weighing robot 105, a weighing station 106, a sample adding robot 107, a weighing container storage station 108, a pipetting head storage station 109, and a waste disposal station 110; the raw material reagent placement station 101 is used to carry and place the raw material reagents for preparing the solution; the raw material reagent code scanning and weighing station 102 is used to scan and weigh the raw material reagents for preparing the solution, Ensure the identification and processing of raw material reagents to avoid incorrect use of raw material reagents. The weighing operation weighs the raw material reagents before and after use, and measures the amount of raw material reagents used, thereby ensuring the accuracy of the raw material reagents in the solution preparation process; the raw material reagent shaking and dispersing station 103 is used to shake and disperse the raw material reagents to avoid stratification of the used raw material reagents, and ensure the stability and accuracy of the raw material reagents in the subsequent liquid preparation process; the tooling storage quick change station 104 is used to store and process the tooling used in the liquid preparation process, which is convenient for the sampling weighing robot 105 and the sampler The end of the robot 107 is used for quick tooling change; the sampling and weighing robot 105 is used to sample and weigh the raw materials and reagents; the weighing station 106 is used to weigh the amount of raw materials and reagents used in the solution preparation process; the sample adding robot 107 is used to add samples to the raw materials and reagents in the weighing station 106, so as to facilitate the weighing adjustment of the amount of raw materials and reagents used in the weighing station 106, thereby enhancing the accuracy of solution preparation; the weighing container storage station 108 is used to store the containers used for weighing the raw materials and reagents, so as to facilitate the sampling and weighing robot 105 to take out the weighing containers Taking operation; the pipette head storage station 109 is used to store and process the pipette heads, which is convenient for the sampling and weighing robot 105 and the adding robot 107 to automatically disassemble and assemble the pipette heads of the pipette; the waste disposal station 110 is used to centrally collect and process the waste in the liquid preparation process, as long as it is the used pipette head; the sampling and weighing robot 105 and the adding robot 107 are arranged in parallel to ensure that the sampling and weighing robot 105 and the adding robot 107 work together to fully cover the automatic weighing and adding system 1, making the operation in the solution preparation process more convenient.

[0026] The weighing station 106 includes several balances and shock-absorbing platforms, and is equipped with multiple platforms with different ranges, which is convenient for accurately weighing raw material solvents of different ranges; the tooling storage quick-change station 104 includes reagent bottle clamping tooling and quantitative sampling tooling. The reagent bottle clamping tooling is mainly equipped in the end effector of the sampling and weighing robot 105 and the sampling robot 107, and the quantitative sampling tooling is mainly used by the sampling robot 107 to perform quantitative sampling of raw material reagents; the inside of the stirring container 202 is provided with an integrated pH electrode and a temperature sensor. The integrated pH electrode is used to measure the pH value of the solution configured inside the stirring container 202, and the temperature sensor is used to measure the temperature of the solution configured inside the stirring container 202.

[0027] The packaging and handling robot 303 is equipped with an end torque sensor, so that the packaging and handling robot 303 can adaptively adjust the reagent bottles it clamps when in use, avoiding clamping damage to the reagent bottles and ensuring the stability of clamping of reagent bottles of different weights; the solution sampling and packaging system 3 also includes a packaging bottle clamp and sampling clamp storage station 307, a bottle cap opening and closing station 308, a bottle cap taking and placing station 309 and a labeling and code scanning and verification station 310; the packaging bottle clamp and sampling clamp storage station 307 is mainly used to provide a storage location for the packaging bottle clamp and the sampling clamp, so as to facilitate the packaging and handling robot 303 to quickly change the clamps; the bottle cap opening and closing station 308 is used to open and close the bottle caps of the packaging bottles; the bottle cap taking and placing station 309 is used to take and place the bottle caps; the labeling and code scanning and verification station 310 is used to label and scan the packaging bottles to ensure the accuracy of the packaging of the prepared solution.

[0028] The automatic weighing and sampling system 1, the solution stirring and calibration system 2, and the solution sampling and packaging system 3 are all equipped with an equipment rack and a protective rack, which are used to support and protect the automatic weighing and sampling system 1, the solution stirring and calibration system 2, and the solution sampling and packaging system 3; the solution sampling and packaging system 3 is provided with a laminar flow hood 311 on the top of the equipment rack and the protective rack, and the laminar flow hood 311 is used to ensure the high cleanliness of the equipment working area, thereby ensuring the safety of the solution preparation process and avoiding contamination of the prepared solution.

[0029] The working principle of this utility model:

[0030] Refer to the instruction manual Figure 1-Figure 5The utility model is provided with an automatic weighing and adding system 1, a solution stirring and calibration system 2 and a solution sampling and filling system 3. The automatic weighing and adding system 1 automatically identifies the raw materials and reagents, automatically samples, and automatically weighs and adds samples; the solution stirring and calibration system 2 automatically stirs, calibrates the pH value and fixes the volume of the prepared solution; the solution sampling and filling system 3 automatically samples and automatically fills the prepared solution; the stirring and weighing device 201 weighs the stirring container 202 and the solution therein, the injection water pump 203 transports the injection water to the stirring container 202 for solution preparation and volume fixing, and the pH regulating pump 204 regulates and calibrates the pH value of the solution in the stirring container 202 by transporting water; when the solution sampling and filling system 3 is working, the filling and handling robot 303 takes The sample bottle samples the solution configured in the stirring container 202, and then places the sampling bottle on the sampling window 305. The staff samples the solution in the sampling bottle through the sampling window 305 for inspection. If the inspection is unqualified, the solution stirring calibration system 2 continues to work and adjusts the prepared solution. After the inspection is qualified, the filling pump 301 is used to transport the prepared solution in the stirring container 202 to the solution quantitative filling workstation 304. The filling and transporting robot 303 clamps the empty filling bottle transported from the empty bottle feeding and conveying mechanism 302 and places it under the solution quantitative filling workstation 304. The solution quantitative filling workstation 304 quantitatively fills the filling bottle with the prepared solution. After the filling is completed, the filling bottle is capped and then placed on the top of the full bottle discharging and conveying mechanism 306 for transportation.

[0031] The automatic liquid dispensing equipment of the present invention integrates the functions of automatic formula recognition, automatic material recognition, automatic sampling, weighing and adding, automatic stirring, pH calibration and volume determination, and automatic sampling and subpackaging of the prepared solution; the present invention utilizes the stirring container 202 to directly perform large-capacity preparation processing on the prepared solution, and each raw material reagent only needs to be adjusted once or several times before the raw materials for the prepared solution can be uniformly added into the large-capacity stirring container 202 for stirring and calibration, and then the prepared solution can be subpacked, which has high work efficiency and can quickly prepare large quantities of solutions without the need for frequent and repeated movement of the pipette for liquid dispensing operations;

[0032] Working mode of this utility model:

[0033] 1. Manually place reagent raw materials, weighing containers, etc. in designated locations;

[0034] 2. Manually pre-install filling pipelines and filling containers;

[0035] 3. The device automatically recognizes the imported recipe information;

[0036] 4. Automatically grab the material and read the information according to the formula information. If the information is correct, sample, weigh and fill it into the preset container as needed;

[0037] 5. Repeat the previous step until all the ingredients are added;

[0038] 6. Add WFI (water for injection) while adding the sample, and use the top weighing sensor to control the pump speed to accurately determine the volume; while determining the volume, use the preset high-precision peristaltic pump to perform pH calibration;

[0039] 7. After the solution is prepared, the packaging robot automatically takes samples and places them in designated locations for manual testing;

[0040] 8. After passing the test, manual confirmation is performed again, and the packaging equipment begins to package according to the predetermined specifications;

[0041] 9. The sub-packaging container can be selected as needed, and the sub-packaging process uses a high-precision peristaltic pump combined with a weighing sensor to achieve high-precision packaging;

[0042] 10. After the subpackaging is completed, label the subpackaging container and enter the information;

[0043] Repeat the subpackaging steps until the subpackaging is completed;

[0044] The utility model utilizes this equipment to prepare various solutions more conveniently and quickly. The equipment can be remotely controlled, and multiple formulas can be prepared in batches in sequence, which greatly reduces the need for human operation. Multiple sensors cooperate with the full data closed-loop processing to achieve precise control of each data and ensure the accuracy of solution preparation (closed-loop measurement of weight changes of each material to improve sampling accuracy). The liquid preparation range is wide, and the replacement of standardized modules can achieve configurations of different specifications from ml to 500L. It can realize the packaging, labeling and information entry of containers of different specifications, which is convenient to use.

[0045] Finally, it should be noted that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein with equivalents. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. An automatic liquid dispensing device, comprising an automatic weighing and adding system (1), a solution stirring and calibration system (2) and a solution sampling and filling system (3), characterized in that: The solution stirring and calibration system (2) is arranged between the automatic weighing and adding system (1) and the solution sampling and filling system (3), the solution sampling and filling system (3) comprises a filling pump (301), an empty bottle feeding and conveying mechanism (302), a filling and transporting robot (303), a solution quantitative filling workstation (304), a sampling window (305) and a full bottle discharging and conveying mechanism (306), the solution stirring and calibration system (2) comprises a stirring and weighing device (201), a stirring container (202), an injection water pump (203) and a pH regulating pump (204), the discharge pipe of the filling pump (301) is connected to the filling pipe of the solution quantitative filling workstation (304), and the feed pipe of the filling pump (301) extends to the inner bottom of the stirring container (202).

2. The automatic liquid dispensing device according to claim 1, characterized in that: The filling and transporting robot (303) is arranged between the empty bottle feeding and conveying mechanism (302) and the full bottle discharging and conveying mechanism (306); the solution quantitative filling workstation (304) is arranged between the filling pump (301) and the sampling window (305); the stirring container (202) is arranged on the top of the stirring and weighing device (201); and the discharge pipes of the injection water pump (203) and the pH adjustment pump (204) extend above the stirring container (202).

3. The automatic liquid dispensing device according to claim 1, characterized in that: The automatic weighing and sample addition system (1) comprises a raw material and reagent placement station (101), a raw material and reagent code scanning and weighing station (102), a raw material and reagent shaking and dispersing station (103), a tool storage and quick-change station (104), a sampling and weighing robot (105), a weighing station (106), a sample addition robot (107), a weighing container storage station (108), a pipetting head storage station (109), and a waste disposal station (110). The sampling and weighing robot (105) and the sample addition robot (107) are arranged in parallel.

4. The automatic liquid dispensing device according to claim 3, characterized in that: The weighing station (106) includes several scales and shock-absorbing platforms, the tool storage quick-change station (104) includes a reagent bottle clamping tool and a quantitative sample addition tool, and the stirring container (202) is provided with an integrated pH electrode and a temperature sensor.

5. The automatic liquid dispensing device according to claim 1, characterized in that: The packaging and handling robot (303) is equipped with an end torque sensor, and the solution sampling and packaging system (3) further includes a packaging bottle fixture and sampling fixture storage station (307), a bottle cap opening and closing station (308), a bottle cap picking and placing station (309), and a labeling and code scanning and verification station (310).

6. The automatic liquid dispensing device according to claim 1, characterized in that: The automatic weighing and adding system (1), the solution stirring and calibration system (2), and the solution sampling and packaging system (3) are all provided with an equipment frame and a protective frame. The solution sampling and packaging system (3) is provided with a laminar flow hood (311) on the top of the equipment frame and the protective frame.

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