Modifiable immunohistochemical pen

Abstract

The utility model discloses a modifiable immunohistochemical pen which comprises a pen holder, the pen holder is a hollow tubular structural body, a first volume cavity and a second volume cavity are formed in the two ends of a tubular cavity of the pen holder respectively, a film-forming agent is packaged in the first volume cavity, and a solvent capable of dissolving and erasing the film-forming agent is packaged in the second volume cavity; a scribing pen point is formed at the outer end of the first volume cavity of the immunohistochemical pen, and the inner side of the scribing pen point is communicated with the first volume cavity; an erasing pen point is formed at the outer end of the first volume cavity of the immunohistochemical pen, and the inner side of the erasing pen point is communicated with the second volume cavity. According to the utility model, convenience, accuracy and stability of experimental operation are fully considered in design, sealing performance of a film-forming agent and a solvent is also considered, and an efficient and convenient experimental tool is provided for an experimenter.

Description

Technical Field

[0001] The utility model relates to an immunohistochemistry pen in laboratory equipment technology, in particular to a modifiable immunohistochemistry pen. Background Art

[0002] The immunohistochemistry pen is an important auxiliary tool in immunohistochemistry experiments, specifically used to accurately label tissue sections. This tool has a wide range of mature applications in detecting tumor markers, pathogens, and abnormal proteins, thereby facilitating accurate and personalized diagnosis. The immunohistochemistry pen has significant applications not only in the medical field, but also in drug research, drug efficacy evaluation, macromolecular interactions, and the detection of new biomarkers.

[0003] When conducting immunohistochemistry experiments, the tissue sections must first be dewaxed and hydrated, and then the excess liquid on the edge of the tissue on the slide must be gently absorbed with absorbent paper. Then, an immunohistochemistry pen is used to draw a circle around the sample to be tested on the slide and allowed to dry. A successful immunohistochemistry experiment not only depends on high-quality section preparation and precise staining techniques, but the correct use of the immunohistochemistry pen is also crucial. Currently, the immunohistochemistry pens on the market only have a drawing function. When the film-forming agent in the immunohistochemistry pen dries, the operator needs to use a cotton swab dipped in a strong solvent such as xylene or acetone to erase it. When the drawn circle line does not meet specific requirements, the user has to repeat the aforementioned drawing and erasing operations. This process is time-consuming and unsafe, which not only increases the complexity of the experiment, but may also have a negative impact on the experimental results. Utility Model Content

[0004] The technical problem solved by the present invention is to provide a modifiable immunohistochemistry pen, which can conveniently modify the drawn circle line, thereby improving the experimental efficiency and accuracy, so as to solve the defects in the above technical background.

[0005] The technical problem solved by the present invention is achieved by the following technical solutions:

[0006] A modifiable immunohistochemistry pen, comprising a pen holder, the pen holder being a hollow tubular structure, with a first volume cavity and a second volume cavity respectively formed at both ends of the tubular cavity of the pen holder, the first volume cavity encapsulating a film-forming agent, and the second volume cavity encapsulating a solvent capable of dissolving and erasing the film-forming agent;

[0007] The immunohistochemistry pen is formed with a marking pen tip at the outer end of the first volume cavity, and the inner side of the marking pen tip is communicated with the first volume cavity; the immunohistochemistry pen is formed with an erasing pen head at the outer end of the first volume cavity, and the inner side of the erasing pen head is communicated with the second volume cavity.

[0008] As a further limitation, the pen holder is formed of aluminum alloy.

[0009] As a further limitation, the film-forming agent and solvent in the first volume chamber and the second volume chamber are sealed at the outer ends by liquid sealing or piston means, and at the same time, a through hole is formed on the rod body between the first volume chamber and the second volume chamber to balance the air pressure in the pen tube cavity.

[0010] As a further limitation, a structural reinforcement liner is formed in the middle position inside the pen barrel, and the structural reinforcement liner is formed between the first volume cavity and the second volume cavity.

[0011] As a further limitation, the marking pen tip is a nylon pen tip with a capillary groove, and the capillary groove is connected to the first volume cavity through a capillary guide port on the inner side.

[0012] As a further limitation, the marking pen tip is a replaceable structure.

[0013] As a further limitation, the erasing pen tip is a pen tip made of an absorbent material, and the top surface of the pen tip is beveled.

[0014] As a further definition, the pen holder is formed with a transition connecting pipe section at the outer end of the first volume chamber and the outer end of the second volume chamber, respectively, and the transition connecting pipe section is a cone or a cone-like structure; the marking pen tip and the erasing pen tip are respectively assembled and connected to the pen holder through the transition connecting pipe sections at the corresponding ends;

[0015] The immunohistochemistry pen further includes a first pen cap and a second pen cap, which can be respectively buckled onto the transition connecting pipe section on the corresponding side to seal and cover the marking pen tip and the erasing pen tip;

[0016] An annular sealing ring is formed on the inner side of the first pen cap and / or the second pen cap corresponding to the inner side of the marking pen tip and / or the inner side of the base of the erasing pen tip.

[0017] Beneficial effects: The utility model is a modifiable immunohistochemistry pen that improves experimental efficiency and accuracy while also having the advantages of simple operation, safety, reliability, and easy maintenance. When in use, the experimenter can use the scribing pen tip to circle and draw lines at the tissue section position on the glass slide, and when an erroneous drawing operation occurs, the eraser pen tip can be used immediately to erase the error, so that the film-forming agent can be dissolved and erased through the solvent in the second volume chamber. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is an exploded view of the structure of a preferred embodiment of the present invention.

[0019] Figure 2 for Figure 1 Cross-sectional view of the pen cap structure.

[0020] Among them: 1. first pen cap; 2. marking pen tip; 3. first transition connecting pipe section; 4. pen body; 5. second transition connecting pipe section; 6. erasing pen tip; 7. second pen cap; 11. pen cap body; 12. annular sealing ring; 41. first volume chamber; 42. second volume chamber; 43. structural reinforcement lining block. DETAILED DESCRIPTION

[0021] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the present invention is further described below with reference to specific illustrations.

[0022] See also Figure 1 、 Figure 2 A preferred embodiment of a modifiable immunohistochemistry pen is provided. In this embodiment, the immunohistochemistry pen has a double-ended double-head structure, including a pen body 4 as a main body, one end of the pen body 4 corresponds to the marking pen tip 2, and the marking pen tip 2 is covered and protected by a first pen cap 1, while the other end corresponds to the erasing pen tip 6, and the erasing pen tip 6 is covered and protected by a second pen cap 7.

[0023] The penholder 4 is a hollow tubular structure formed from an aluminum alloy, offering excellent strength and corrosion resistance, ensuring the pen's durability. A structural reinforcement block 43 is formed in the middle of the penholder 4. This reinforcement block 43 not only provides internal structural support for the penholder 4, further improving its structural stability, compressive strength, and bending resistance, preventing material leakage due to structural deformation of the penholder 4 under stress, but also separates the lumen of the penholder 4 into a first volume chamber 41 and a second volume chamber 42.

[0024] The first volume chamber 41 is encapsulated with a film-forming agent for realizing the performance of the immunohistochemistry pen, and the type of the film-forming agent can be selected according to actual needs. The first volume chamber 41 is sealed by a liquid sealing medium on the side close to the structural reinforcement liner 43, and is end-face sealed with the first transition connecting pipe section 3 on the side close to the outer marking pen tip 2. The marking pen tip 2 is connected to the first volume chamber 41 on the inner side through the lumen of the first transition connecting pipe section 3.

[0025] In this embodiment, the marking pen tip 2 is a nylon tip with a capillary groove. The capillary groove is connected to the first volume chamber 41 via a capillary guide port on the inner side. The capillary groove design allows the film-forming agent to flow evenly from the first volume chamber 41 to the marking pen tip 2 through capillary action, thereby forming a clear and uniform circle line on the glass slide. In different embodiments, the tip of the marking pen tip 2 can be designed with a fine point shape according to actual needs to accommodate tissue sections of different sizes and shapes, ensuring that the experimenter can accurately draw the circle line.

[0026] When the internal sealing of the lumen of the pen shaft 4 is good, in order to balance the air pressure inside the lumen, the liquid sealing structure of the liquid sealing medium can push the film-forming agent in the first volume chamber 41 to continue to flow out under negative pressure conditions when the marking pen tip 2 continues to slide. A through hole is formed on the rod body of the pen shaft 4 between the first volume chamber 41 and the second volume chamber 42 to balance the internal and external air pressure of the pen shaft 4.

[0027] In this embodiment, the marking pen tip 2 is detachably mounted on the first transition connecting tube section 3 of the pen body 4. By replacing the marking pen tip 2 with a different size, lines of varying thicknesses can be drawn to suit different experimental requirements. Furthermore, the interchangeability of the marking pen tip 2 facilitates the experimenter to change the tip according to experimental requirements, thereby extending the service life of the immunohistochemistry pen.

[0028] The second volume chamber 42 contains a solvent capable of dissolving and erasing the film-forming agent. The type of solvent can also be selected based on actual needs. The second volume chamber 42 is also sealed with a liquid sealing medium on the side adjacent to the structural reinforcement liner 43. The second volume chamber 42 is end-sealed with the second transition connecting pipe section 5 on the side adjacent to the eraser tip 6. The eraser tip 6 is internally connected to the second volume chamber 42 through the lumen of the second transition connecting pipe section 5.

[0029] The eraser tip 6 is made of an absorbent material (nylon, polyester, or acrylic in different embodiments), and its top surface is beveled to increase the contact area with the slide and improve erasing efficiency. The eraser tip 6 is also designed to be replaceable, allowing the experimenter to replace the eraser tip 6 of different types and sizes according to different experimental needs.

[0030] In this embodiment, the first transition connecting pipe section 3 and the second transition connecting pipe section 5 are both two-step cone-shaped pyramidal structures. The first transition connecting pipe section 3 and the second transition connecting pipe section 5 are assembled with the pen body 4 through threaded surfaces at the bottom of the pyramidal structure and formed into one piece; and the marking pen tip 2 and the erasing pen tip 6 can be assembled and connected with the pen body 4 through the first transition connecting pipe section 3 or the second transition connecting pipe section 5 at the corresponding end, ensuring the close fit between the marking pen tip 2 / erasing pen tip 6 and the pen body 4, and preventing the leakage of the corresponding film-forming agent and solvent in the first volume chamber 41 and the second volume chamber 42.

[0031] Taking into account the organic material properties of the film-forming agent and the solvent, which have certain volatility, the immunohistochemistry pen also includes a first pen cap 1 and a second pen cap 7. The first pen cap 1 and the second pen cap 7 can be respectively used to be snapped onto the first transition connecting pipe section 3 and the second transition connecting pipe section 5 on the corresponding sides to seal and cover the marking pen tip 2 and the erasing pen tip 6.

[0032] In order to improve the sealing performance of the first pen cap 1 and the second pen cap 7, an annular sealing ring 12 is formed on the inner side of each of the first pen cap 1 and the second pen cap 7. When the first pen cap 1 or the second pen cap 7 is closed, the annular sealing ring 12 can be correspondingly and sealingly sleeved on the inner side of the base of the marking pen tip 2 or the erasing pen tip 6, thereby ensuring the sealing between the pen tip and the pen cap and preventing the volatilization of the film-forming agent and the solvent.

[0033] In another embodiment, in order to improve the recognition performance of the first pen cap 1 and the second pen cap 7, the corresponding first pen cap 1 and the second pen cap 7 can adopt different colors or marks, so that the experimenter can quickly distinguish the marking pen tip and the erasing pen tip, thereby improving the experimental efficiency.

[0034] Furthermore, to further enhance the performance of the immunohistochemistry pen, the cap body 11 and the outer side of the pen holder 4 can be designed with a grip with a non-slip texture to increase grip stability and prevent the cap from falling off due to hand slippage during the experiment. Furthermore, windows can be opened on the pen holder 4 at the positions corresponding to the first volume chamber 41 and the second volume chamber 42 to facilitate observation of the remaining amount of film-forming agent and solvent, allowing the experimenter to replenish or replace them in a timely manner.

[0035] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that these embodiments are intended only to illustrate the present invention and are not intended to limit the scope of protection of the present invention. Furthermore, it should be understood that after reading the technical content of the present invention, those skilled in the art may make various changes, modifications, and / or variations to the present invention, all of which equivalent forms fall within the scope of protection defined by the appended claims.

Claims

1. A modifiable immunohistochemistry pen, characterized in that: The immunohistochemistry pen includes a pen holder, which is a hollow tubular structure. A first volume cavity and a second volume cavity are respectively formed at both ends of the tubular cavity of the pen holder. The first volume cavity encapsulates a film-forming agent, and the second volume cavity encapsulates a solvent that can dissolve and erase the film-forming agent. The immunohistochemistry pen is formed with a marking pen tip at the outer end of the first volume cavity, and the inner side of the marking pen tip is communicated with the first volume cavity; the immunohistochemistry pen is formed with an erasing pen head at the outer end of the first volume cavity, and the inner side of the erasing pen head is communicated with the second volume cavity.

2. The modifiable immunohistochemistry pen according to claim 1, characterized in that: The pen holder is made of aluminum alloy.

3. The modifiable immunohistochemistry pen according to claim 1, characterized in that: The film-forming agent and solvent in the first volume chamber and the second volume chamber are sealed at the outer ends by liquid sealing or piston means, and a through hole is formed on the rod body between the first volume chamber and the second volume chamber to balance the air pressure in the pen tube cavity.

4. The modifiable immunohistochemistry pen according to claim 1, characterized in that: A structural reinforcement liner is also formed in the middle position inside the pen barrel, and the structural reinforcement liner is formed between the first volume cavity and the second volume cavity.

5. The modifiable immunohistochemistry pen according to claim 1, characterized in that: The marking pen tip is a nylon pen tip with a capillary groove, and the capillary groove is connected to the first volume cavity through a capillary guide port on the inner side.

6. The modifiable immunohistochemistry pen according to claim 1, characterized in that: The marking pen tip is a replaceable structure.

7. The modifiable immunohistochemistry pen according to claim 1, characterized in that: The erasing pen tip is made of an absorbent material, and the top surface of the pen tip is beveled.

8. The modifiable immunohistochemistry pen according to claim 1, characterized in that: The pen body is formed with a transition connecting pipe section at the outer end of the first volume cavity and the outer end of the second volume cavity respectively, and the transition connecting pipe section is a cone or a cone-like structure; the marking pen tip and the erasing pen tip are respectively assembled and connected to the pen body through the transition connecting pipe sections at the corresponding ends.

9. The modifiable immunohistochemistry pen according to claim 8, characterized in that: The immunohistochemistry pen also includes a first pen cap and a second pen cap, which can be respectively used to be buckled onto the transition connecting pipe section on the corresponding side to seal and cover the marking pen tip and the erasing pen tip.

10. The modifiable immunohistochemistry pen according to claim 9, characterized in that: An annular sealing ring is formed on the inner side of the first pen cap and / or the second pen cap corresponding to the inner side of the marking pen tip and / or the inner side of the base of the erasing pen tip.

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