Magnetic frame

By designing the magnetic base and fixed bracket structure of the magnetic stand, the problem of inconvenient magnetic bead separation in batch experiments in the existing technology is solved, and rapid magnetic bead separation and waste liquid discharge of multiple sample reaction tubes are achieved, thereby improving operational efficiency.

CN223409612UActive Publication Date: 2025-10-03WUXI QINGLAN BIOLOGICAL SCI & TECH +1
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Patent Information

Application Number
CN202422521681.8
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-10-17
Publication Date
2025-10-03
Estimated Expiration
2034-10-17

AI Technical Summary

Technical Problem

Existing plate-type magnetic racks are difficult to achieve efficient separation of magnetic beads in batch experiments, and are inconvenient to operate, especially when operated manually, resulting in low efficiency.

Method used

A magnetic rack is designed, including a magnetic base and a fixed bracket. The magnetic base is provided with magnetic parts and adapter holes for plugging in sample reaction tubes. The fixed bracket is detachable and supports simultaneous operation of multiple sample reaction tubes. The magnetic parts are set on the side of the sample reaction tube to facilitate magnetic bead separation and waste liquid discharge.

Benefits of technology

The rapid magnetic bead separation and waste liquid discharge of solutions in multiple sample reaction tubes in batch experiments are realized, which is easy to operate and highly efficient, and improves the efficiency of magnetic bead separation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a magnetic frame which comprises a magnetic frame used for being matched with a sample containing piece, the sample containing piece comprises a plate body part and a plurality of sample reaction tubes, and the magnetic frame comprises a magnetic bottom plate and a fixed support; the magnetic bottom plate is provided with a magnetic part, the magnetic bottom plate is provided with a plurality of adaptive holes around the magnetic part, and the adaptive holes are used for inserting and accommodating sample reaction tubes; the fixing support is detachably connected with the magnetic bottom plate, and the plate body part is limited between the fixing support and the magnetic bottom plate. The magnetic frame disclosed by the utility model is suitable for batch experiments, can quickly realize that magnetic beads of solutions of a plurality of sample reaction tubes are magnetically attracted, can simultaneously pour out waste liquid of the plurality of sample reaction tubes when the waste liquid is poured out, and is convenient to operate and high in efficiency.
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Description

Technical Field

[0001] The utility model relates to the technical field of biomedical instruments, in particular to a magnetic frame. Background Art

[0002] With the development of modern biotechnology and medicine, large-scale purification of trace nucleic acids has become an important method for research in biological fields. Magnetic bead-based nucleic acid extraction is increasingly being used in the biological community and related disciplines due to its high throughput and automation advantages.

[0003] The main problems with existing plate-type magnetic racks are: it is difficult to implement batch experiments to efficiently separate magnetic beads, and the existing magnetic racks are inconvenient and inefficient to use, especially when operated manually. Utility Model Content

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a magnetic stand suitable for batch experiments, which can quickly magnetically attract magnetic beads in solutions in multiple sample reaction tubes and simultaneously pour out waste liquid from multiple sample reaction tubes, thereby achieving convenient and efficient operation.

[0005] According to the magnetic rack of the embodiment of the present invention, the magnetic rack is used to cooperate with the sample holding piece, the sample holding piece includes a plate body and multiple sample reaction tubes, and the magnetic rack includes: a magnetic base plate and a fixed bracket; the magnetic base plate is provided with a magnetic part, and the magnetic base plate is provided with multiple adapter holes around the magnetic part, and the adapter holes are used to plug and accommodate sample reaction tubes; the fixed bracket is detachably connected to the magnetic base plate, and the plate body is located between the fixed bracket and the magnetic base plate.

[0006] The magnetic rack according to the embodiment of the present invention connects the sample holding piece to the magnetic base plate, and a plurality of sample reaction tubes are provided in the sample holding piece. Each sample reaction tube can be filled with a solution, and the magnetic piece of the magnetic base plate magnetically attracts the magnetic beads in the solutions in the plurality of sample reaction tubes, thereby separating the magnetic bead components in the solutions. The magnetic rack is suitable for batch micro-experiments and can quickly achieve magnetic attraction of the magnetic beads in the solutions of the plurality of sample reaction tubes. When pouring out the waste liquid, the waste liquid of the plurality of sample reaction tubes can also be poured out at the same time. The operation is convenient and efficient. In addition, the plurality of sample reaction tubes are arranged around the magnetic piece, so that the magnetic beads in the sample reaction tubes are adsorbed on one side of the reaction tube, which is conducive to separating the waste liquid and further improving the efficiency of separating the magnetic beads.

[0007] According to the magnetic frame of the embodiment of the present invention, the fixed bracket includes a connected handle surface and a limiting surface, the limiting surface is parallel to the magnetic base plate, the handle surface is arranged between the limiting surface and the magnetic base plate and is detachably connected to the magnetic base plate.

[0008] According to the magnetic frame of the embodiment of the present invention, an open opening is provided in the middle of the limiting surface, the area of ​​the plate body is larger than the area of ​​the open opening, and the limiting surface is suitable for limiting the plate body when the magnetic frame is inverted.

[0009] According to the magnetic frame of the embodiment of the present invention, the bottom of the handle surface is provided with a hook facing the magnetic base plate, and one end of the handle surface in the up and down direction is connected to the limiting surface, and the other end can move in the direction away from or close to the magnetic base plate. When the handle surface is connected to the magnetic base plate, the hook is hooked at the bottom of the magnetic base plate to connect the handle surface to the magnetic base plate, and the handle surface is suitable for being pulled in the direction away from the magnetic base plate to separate the hook from the magnetic base plate.

[0010] According to the magnetic frame of the embodiment of the present invention, the handle surface is vertically connected to the magnetic base plate, and the angle between the hook and the handle surface is 80-90°.

[0011] According to the magnetic frame of the embodiment of the present invention, there are two handle surfaces, the two handle surfaces are relatively distributed along the first direction, and the two handle surfaces are both engaged with the bottom surface of the magnetic base along the first direction.

[0012] According to the magnetic frame of the embodiment of the present invention, the magnetic member is constructed in a circular shape, and the distance between each of the adaptation holes and the center of the corresponding magnetic member is equal.

[0013] According to the magnetic frame of the embodiment of the present invention, there are at least four adapter holes around each magnetic part, and the distance between two adjacent adapter holes along the first direction of the four adapter holes is equal, and the distance between two adjacent adapter holes along the second direction is equal.

[0014] According to the magnetic frame of the embodiment of the present invention, the diameter of each of the adapting holes is smaller than the diameter of the magnetic member.

[0015] According to the magnetic rack of the embodiment of the present invention, the number of the adapting holes on the magnetic base plate is 90-100.

[0016] Additional aspects and advantages of the present invention will be given in part in the following description and will become apparent from the following description or learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0018] Figure 1This is a schematic structural diagram of a magnetic frame according to an embodiment of the present invention;

[0019] Figure 2 It is a top view of the magnetic frame of an embodiment of the utility model;

[0020] Figure 3 This is a schematic structural diagram of a sample holder according to an embodiment of the present invention;

[0021] Figure 4 is a side view of a sample holding member according to an embodiment of the present invention;

[0022] Figure 5 It is a structural schematic diagram of a handle surface provided with a hook in an embodiment of the utility model.

[0023] Reference numerals:

[0024] Magnetic stand 100,

[0025] Magnetic base plate 1 , magnetic member 11 , adapting hole 12 , fixing bracket 2 , limiting surface 21 , opening 211 , handle surface 22 , hook 221 , engaging surface 2211 , sample holding member 3 , plate body 31 , sample reaction tube 32 . DETAILED DESCRIPTION

[0026] The following describes embodiments of the present invention in detail. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended only to explain the present invention and are not to be construed as limiting the present invention.

[0027] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, features defined as "first" or "second" may explicitly or implicitly include one or more of such features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0028] In the description of this utility model, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections, electrical connections; direct connections, indirect connections through an intermediate medium, and internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on the specific circumstances.

[0029] Reference below Figure 1-Figure 5 The magnetic rack 100 according to the embodiment of the present invention is described. By connecting the sample holding part 3 to the magnetic base plate 1, a plurality of sample reaction tubes 32 are provided in the sample holding part 3. Each sample reaction tube 32 can be filled with a solution, and the magnetic part 11 of the magnetic base plate 1 magnetically attracts the magnetic beads in the solution of the plurality of sample reaction tubes 32, thereby separating the magnetic bead components in the solution. It is suitable for batch experiments and can quickly achieve magnetic attraction of the magnetic beads in the solution of the plurality of sample reaction tubes 32. When pouring out the waste liquid, the waste liquid of the plurality of sample reaction tubes 32 can also be poured out at the same time. The operation is convenient and efficient. In addition, the plurality of sample reaction tubes 32 are arranged around the magnetic part 11, so that the magnetic beads in the sample reaction tubes 32 are adsorbed on one side of the sample reaction tubes 32, which is conducive to separating the waste liquid and further improving the efficiency of separating the magnetic beads.

[0030] like Figure 1-5 As shown, according to an embodiment of the present invention, a magnetic stand 100 is used to cooperate with a sample holder 3 , the sample holder 3 includes a plate portion 31 and a plurality of sample reaction tubes 32 , and the magnetic stand 100 includes: a magnetic base plate 1 and a fixing bracket 2 .

[0031] Among them, the magnetic base plate 1 is provided with a magnetic part 11, and the magnetic base plate 1 is provided with multiple adapter holes 12 around the magnetic part 11, and the adapter holes 12 are used to insert and accommodate the sample reaction tube 32; the fixed bracket 2 is detachably connected to the magnetic base plate 1, and the plate body 31 is limited between the fixed bracket 2 and the magnetic base plate 1.

[0032] In practice, the plate portion 31 of the sample holder 3 and the multiple sample reaction tubes 32 can be integrally formed, making removal and installation of the sample holder 3 more convenient, eliminating the need to install and remove the multiple sample reaction tubes 32 one by one. Furthermore, the magnetic base 1 of the magnetic stand 100 is provided with a magnetic member 11. The magnetic member 11 can be made of a metal material capable of adsorbing magnetic beads in a solution. The magnetic beads in the solution are nanometer-scale magnetic particles with diameters ranging from a few nanometers to tens of nanometers. These magnetic beads exhibit magnetic properties, a high specific surface area, and good biocompatibility. They have a wide range of applications in biological and biomedical research, such as separation, enrichment, analysis, and detection.

[0033] That is to say, when it is necessary to separate and detect the components containing magnetic beads in the solution, the magnetic part 11 of the magnetic base 1 generates a magnetic field and adsorbs the magnetic beads in the solution in the sample reaction tube 32 in the sample container 3, so that the magnetic beads are adsorbed to the side close to the magnetic part 11, thereby separating the magnetic beads. When pouring out the waste liquid, it is convenient to pour out the waste liquid because the magnetic beads are adsorbed.

[0034] Specifically, during installation, the multiple sample reaction tubes 32 in the sample container 3 are first inserted into the multiple adapter holes 12 of the magnetic base plate 1, and then the fixed bracket 2 and the magnetic base plate 1 are connected, so that the fixed bracket 2, the magnetic base plate 1 and the sample container 3 become one. At this time, the multiple sample reaction tubes 32 in the sample container 3 can be poured with solutions at the same time, and the magnetic member 11 can magnetically attract the solutions in the sample reaction tubes 32 installed in the multiple adapter holes 12, so that the magnetic beads in the solutions in the multiple sample reaction tubes 32 can be effectively separated, and when pouring out the waste liquid, all of them can be poured out at the same time, so the operation is convenient and efficient.

[0035] Moreover, in the prior art, the magnetic field of some magnetic racks 100 is at the bottom or lower middle portion of the sample container 3. When a large amount of magnetic beads is encountered, the magnetic beads may accumulate at the bottom of the sample reaction tube 32 to a certain thickness, and waste liquid may be contained in the magnetic beads, which is not conducive to separation. However, the magnetic field of the magnetic rack 100 in the embodiment of the present invention is at the side of the sample reaction tube 32, so the magnetic beads will not accumulate into a linear shape, which is conducive to the separation of waste liquid.

[0036] In some embodiments, the fixed bracket 2 includes a connected handle surface 22 and a limiting surface 21, the limiting surface 21 is parallel to the magnetic base plate 1, and the handle surface 22 is arranged between the limiting surface 21 and the magnetic base plate 1 and is detachably connected to the magnetic base plate 1.

[0037] In other words, the handle surface 22 is not only detachably connected to the magnetic base 1, thereby allowing the entire fixed bracket 2 and the magnetic base 1 to be detachably connected, facilitating connection of the sample holder 3 to the magnetic base 1; the handle surface 22 also provides primary support for the fixed bracket 2, ensuring more stable placement of the magnetic base 1 and the sample holder 3. In practice, the handle surface 22 can be integrally formed with the limiting surface 21. This allows for easier removal of the magnetic base 1 by simply detachably connecting the handle surface 22 and limiting surface 21 to the magnetic base 1, further facilitating operation.

[0038] Specifically, the detachable connection between the integral body formed by the handle surface 22 and the limiting surface 21 and the magnetic base plate 1 includes a bolt and screw connection, a snap connection, etc. When the detachable connection method is used, it is convenient to disassemble the magnetic base plate 1, thereby facilitating the disassembly of the sample holding part 3 from the magnetic base plate 1, so as to clean the sample holding part 3.

[0039] In some embodiments, an opening 211 is provided in the middle of the limiting surface 21 , and the area of ​​the plate body 31 is larger than the area of ​​the opening 211 . The limiting surface 21 is suitable for limiting the plate body 31 when the magnetic frame 100 is inverted.

[0040] In practice, the setting of the open port 211 facilitates observation of the status of the multiple sample reaction tubes 32 in the sample holding member 3, and when the multiple sample reaction tubes 32 are long, the setting of the open port 211 can avoid the multiple sample reaction tubes 32; and when a magnetic bead solution is set in each sample reaction tube 32, the magnetic bead solution in the multiple sample reaction tubes 32 is magnetically attracted by the magnetic field generated by the magnetic member 11, and the magnetic beads are adsorbed on the side walls of the multiple sample reaction tubes 32 close to the magnetic member 11. Then, when it is necessary to pour out the waste liquid in the multiple sample reaction tubes 32, the magnetic stand 100 can be rotated about 180 degrees, that is, the magnetic stand 100 is inverted, and the waste liquid in the multiple sample reaction tubes 32 is poured out at one time, making the whole operation more efficient and convenient.

[0041] When the magnetic stand 100 is inverted, that is, when the multiple sample reaction tubes 32 are inverted, and the multiple sample reaction tubes 32 in the sample holder 3 become loose from the fitting holes 12 of the magnetic base 1 and the sample holder 3 is about to fall out, the edge of the plate portion 31 of the sample holder 3 contacts the bottom edge of the limiting surface 21, causing the limiting surface 21 to block the sample holder 3 and prevent the sample holder 3 from falling out when the magnetic stand 100 is inverted. Therefore, by setting the area of ​​the plate portion 31 larger than the area of ​​the opening 211, the edge of the plate portion 31 can contact the bottom edge of the limiting surface 21 when the magnetic stand 100 is inverted, so that the limiting surface 21 can limit the sample holder 3.

[0042] In some embodiments, a hook 221 is provided at the bottom of the handle surface 22 facing the magnetic base plate 1, and one end of the handle surface 22 in the up and down direction is connected to the limiting surface 21, and the other end can move in the direction away from or close to the magnetic base plate 1. The hook 221 is clamped on the bottom of the magnetic base plate 1 to connect the handle surface 22 to the magnetic base plate 1, and the handle surface 22 is suitable for being pulled in the direction away from the magnetic base plate 1 to separate the hook 221 from the magnetic base plate 1.

[0043] In practice, the handle surface 22 can be made of plastic or a material that can produce a certain degree of deformation. When the handle surface 22 is connected to the magnetic base plate 1, it is only necessary to clamp the hook 221 of the handle surface 22 toward the magnetic base plate 1 on the bottom of the magnetic base plate 1. Since there is a clamping friction between the hook 221 and the bottom of the magnetic base plate 1, the stability of the clamping between the hook 221 and the magnetic base plate 1 can be guaranteed.

[0044] The upper end of the handle 22 remains connected to the limiting surface 21, while the lower end of the handle 22 is detachably connected to the magnetic base 1 via a hook 221. To remove the magnetic base 1 and sample holder 3, the handle 22 is pulled outward, for example, gently opened horizontally 2-3 mm, to disengage the hook 221 at the bottom of the handle 22 from the magnetic base 1. This disengages the magnetic base 1 and sample holder 3 from the hook 221 of the handle 22, allowing both the magnetic base 1 and sample holder 3 to be removed from the fixed bracket 2. During installation, the hook 221 is positioned below the magnetic base 1, and the handle 22 is slowly moved toward the magnetic base 1 until the hook 221 is fully positioned below the magnetic base 1 and locked into place after a click sound is heard.

[0045] In some embodiments, the handle surface 22 is vertically connected to the magnetic base 1 , and the angle between the hook 221 and the handle surface 22 is 80-90°.

[0046] Combine Figure 5 As shown, the hook 221 connected to the handle surface 22 includes a snap-on surface 2211. In the embodiment of the present invention, when the hook 221 is perpendicular to the handle surface 22, the snap-on surface 2211 is parallel to the magnetic base 1. That is, the snap-on surface 2211 can be quickly snapped onto the bottom of the magnetic base 1 or moved outward along the bottom of the magnetic base 1 for removal. Of course, the hook 221 can also be at an angle of 85° to the bottom surface of the handle surface 22. In this case, the hook 221 and the magnetic base 1 have a slight angle, but it is sufficient for the hook 221 to clamp the magnetic base 1. Since the handle surface 22 and the hook 221 are set to plastic or other deformable materials, the snap-on or removal between the hook 221 and the magnetic base 1 is facilitated.

[0047] In some embodiments, there are two handle surfaces 22 , the two handle surfaces 22 are distributed opposite to each other along the first direction, and both handle surfaces 22 are engaged with the bottom surface of the magnetic base 1 along the first direction.

[0048] In practice, there are two handle surfaces 22 disposed opposite each other. To disassemble, the two opposing handle surfaces 22 can be simultaneously pulled away from the magnetic base 1, moving both handle surfaces 22 away from the magnetic base 1. This allows the hooks 221 corresponding to the two handle surfaces 22 to be detached from the magnetic base 1. Providing two handle surfaces 22 provides support for the mounting bracket 2 and the magnetic base 1 after installation, improving structural stability and force balance. This further stabilizes the limiting surface 21 to which the handle surfaces 22 are attached, and improves the effectiveness of the limiting surface 21 in retaining the sample holder 3 when the magnetic stand 100 is inverted.

[0049] In some embodiments, the magnetic member 11 is circular in shape, and each adapting hole 12 is equidistant from the center of the corresponding magnetic member 11 .

[0050] In practice, the magnetic member 11 is constructed in a circular shape, which can be constructed as a solid circle or as a circle with a through hole in the middle. When multiple adapting holes 12 are provided around the corresponding circular magnetic member 11, the distance between each adapting hole 12 and the center of the magnetic member 11 is equal, that is, the sample reaction tube 32 provided in each adapting hole 12 is at an equal distance from the magnetic member 11, thereby ensuring that the magnetic field strength around each sample reaction tube 32 is the same. At this time, when equal volumes of solution are poured into multiple sample reaction tubes 32, it is convenient to control the time when the magnetic beads in the multiple sample reaction tubes 32 are adsorbed on the side walls of the sample reaction tubes 32, thereby avoiding the difference in adsorption degree caused by some sample reaction tubes 32 being far away from the magnetic member 11 or some being close. In the embodiment of the utility model, the distance between each adapting hole 12 and the center of the corresponding magnetic member 11 is equal, so that the adsorption degree of the magnetic beads in the multiple sample reaction tubes 32 is basically the same, and at this time, it is convenient to control the time of pouring out the waste liquid at one time.

[0051] In some embodiments, there are at least four adapting holes 12 around each magnetic member 11 , and the distance between two adjacent adapting holes 12 along the first direction among the four adapting holes 12 is equal, and the distance between two adjacent adapting holes 12 along the second direction is equal.

[0052] Reference Figure 2 As shown, by setting the number of the adapting holes 12, a plurality of sample reaction tubes 32 can be adapted and arranged, wherein the first direction is along Figure 1 The second direction is along the length of Figure 1 In the width direction, when four adapting holes 12 are located around one magnetic member 11, the distance between two adjacent adapting holes 12 along the length direction of the magnetic base plate 1 is equal, and the distance between two adjacent adapting holes 12 along the width direction of the magnetic base plate 1 is equal, so that the magnetic field force exerted on the solution in the sample reaction tube 32 installed in each adapting hole 12 is uniform, and four adapting holes 12 are arranged around each magnetic member 11. While the layout is reasonable, a larger number of adapting holes 12 can be set, thereby setting a larger number of sample reaction tubes 32.

[0053] In some embodiments, the diameter of each adapting hole 12 is smaller than the diameter of the magnetic member 11 .

[0054] In practice, multiple adapter holes 12 are set around each magnetic part 11, that is, the magnetic field strength generated by the magnetic part 11 needs to be large enough to magnetically attract the magnetic beads in the solution of multiple sample reaction tubes 32 installed with multiple adapter holes 12. Therefore, the diameter of the magnetic part 11 is set larger than the diameter of each adapter hole 12. When the same magnetic material is set, the more magnetic material, the larger the magnetic field generated. That is, a larger diameter can be used to set more magnetic material, so that the magnetic part 11 generates a stronger magnetic field, which facilitates the effective magnetic attraction of the solutions in the multiple sample reaction tubes corresponding to the multiple adapter holes 12.

[0055] In some embodiments, the number of the adapting holes 12 on the magnetic base plate 1 is 90-100.

[0056] In practice, the sample holding member 3 of the present invention is 96 sample reaction tubes 32, and all 96 sample reaction tubes 32 are miniature sample reaction tubes 32. The magnetic base plate 1 can magnetically absorb the solutions in miniature batches of sample reaction tubes 32 at one time, and can process 96 samples at the same time. In addition, the overall volume is small, and the small volume can be used for centrifugation in a desktop centrifuge. For example, when performing nucleic acid testing, after the magnetic member 11 absorbs the magnetic beads in the sample reaction tube 32, the integrity of the DNA adsorbed on the magnetic beads is ensured, the loss of DNA is avoided, and the maximum recovery of nucleic acid is guaranteed. This greatly improves the reliability of using the magnetic stand 100 in purifying trace DNA and improves the efficiency of the entire experimental process.

[0057] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the illustrative use of the above terms does not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0058] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and purpose of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A magnetic frame, characterized in that: The magnetic frame is used to cooperate with a sample holding member, wherein the sample holding member includes a plate body and a plurality of sample reaction tubes, and the magnetic frame includes: A magnetic base plate, wherein the magnetic base plate is provided with a magnetic member, and the magnetic base plate is provided with a plurality of adapting holes around the magnetic member, wherein the adapting holes are used to insert and accommodate sample reaction tubes; A fixing bracket is detachably connected to the magnetic base plate, and the plate body is located between the fixing bracket and the magnetic base plate.

2. The magnetic frame according to claim 1, characterized in that The fixing bracket includes a handle surface and a limiting surface connected to each other, the limiting surface is parallel to the magnetic base plate, and the handle surface is arranged between the limiting surface and the magnetic base plate and is detachably connected to the magnetic base plate.

3. The magnetic frame according to claim 2, characterized in that An opening is provided in the middle of the limiting surface, the area of ​​the plate body is larger than the area of ​​the opening, and the limiting surface is suitable for limiting the plate body when the magnetic frame is inverted.

4. The magnetic frame according to claim 2, characterized in that: The bottom of the handle surface is provided with a hook facing the magnetic base plate, and one end of the handle surface in the up and down direction is connected to the limiting surface, and the other end can move in the direction away from or close to the magnetic base plate. The hook is hooked at the bottom of the magnetic base plate to connect the handle surface to the magnetic base plate, and the handle surface is suitable for being pulled in the direction away from the magnetic base plate to separate the hook from the magnetic base plate.

5. The magnetic frame according to claim 4, characterized in that: The handle surface is vertically connected to the magnetic base plate, and the angle between the hook and the handle surface is 80-90 degrees.

6. The magnetic frame according to claim 4, characterized in that: There are two handle surfaces, the two handle surfaces are distributed opposite to each other along a first direction, and the two handle surfaces are both engaged with the bottom surface of the magnetic base along the first direction.

7. The magnetic frame according to claim 1, characterized in that: The magnetic member is circular in structure, and each of the adapting holes is equidistant from the center of the corresponding magnetic member.

8. The magnetic frame according to claim 7, characterized in that: There are at least four adapting holes around each magnetic member, and the distance between two adjacent adapting holes along the first direction among the four adapting holes is equal, and the distance between two adjacent adapting holes along the second direction is equal.

9. The magnetic frame according to claim 7, characterized in that: The diameter of each of the adapting holes is smaller than the diameter of the magnetic member.

10. The magnetic frame according to claim 1, characterized in that: The number of the adapting holes on the magnetic base plate is 90-100.