Suction head withdrawing device and pipetting system
By introducing a guide shaft and multiple tip ejection areas of different thicknesses into the tip ejection device, the problems of poor resetting effect and increased dead volume of traditional pipettes are solved, achieving more efficient tip removal and lower-cost pipetting operations.
Patent Information
- Application Number
- CN202422563190.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-23
- Publication Date
- 2025-10-10
- Estimated Expiration
- 2034-10-23
AI Technical Summary
The electric tip ejection device of traditional pipettes has problems such as complex installation, poor resetting effect and increased dead volume during the resetting process. In particular, since the deformation direction of the spring is inconsistent with the movement direction, small volumes of liquid cannot be pipetted.
A guide shaft is used to guide the displacement process of the suction head ejection assembly. Combined with a drive assembly including a motor, a lead screw and a lead screw nut, the guide shaft maintains the vertical movement of the suction head ejection assembly. Multiple suction head ejection areas with different thicknesses are used to gradually remove the suction head, reducing the pressure demand on the motor.
The invention improves the reset effect of the tip ejection assembly, reduces the pressure requirement of the motor, reduces the cost and reduces the dead volume of the pipette, so that the pipette can process smaller volumes of liquid samples.
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Figure CN223417293U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of pipetting technology, and in particular to a tip ejection device and a pipetting system comprising the tip ejection device. Background Art
[0002] Pipettes play a vital role in various branches of life sciences, such as biology, pharmaceuticals, and diagnostics. Multichannel pipettes are becoming increasingly popular due to their ability to improve experimental efficiency.
[0003] In experimental operations, pipettes rely on tips to transfer liquid samples. To prevent cross-contamination between samples and reduce errors introduced by washing steps, disposable tips are usually used and removed from the pipette after use.
[0004] The electric tip ejector mechanism of traditional pipettes relies on multiple small springs to reset the tip after removal. Firstly, this complicates the installation process. Secondly, the springs' deformation direction is inconsistent with the movement of the tip ejector assembly, resulting in poor reset performance. Thirdly, the installation of springs increases the dead volume of the pipette, making it impossible to pipette small volumes. Utility Model Content
[0005] According to a first aspect of the present application, there is provided a tip ejection device, comprising: a mounting body, comprising a channel structure, the channel structure comprising a first mounting surface and a second mounting surface arranged opposite to each other, the channel structure further forming a plurality of pipetting channels passing through the first mounting surface and the second mounting surface; an adapter array, comprising a plurality of tip adapters, the plurality of tip adapters being connected to the first mounting surface, the plurality of tip adapters being in one-to-one communication with the plurality of pipetting channels; a tip ejection assembly, movably connected to the mounting body, the tip ejection assembly comprising a guide shaft, the guide shaft being perpendicular to the first mounting surface; and a drive assembly, connecting the mounting body and the tip ejection assembly, for driving the tip ejection assembly to move relative to the mounting body along the guide shaft to remove tips mounted on the plurality of tip adapters.
[0006] In at least one embodiment of the present application, the head ejection assembly includes a head ejection plate; the head ejection assembly includes four guide shafts, and the four guide shafts are fixedly connected to two opposite sides of the head ejection plate in pairs.
[0007] In at least one embodiment of the present application, the channel structure further includes a mounting side surface connected between the first mounting surface and the second mounting surface; the suction head ejection assembly further includes a connecting plate, which is a frame structure and surrounds the mounting side surface of the channel structure; the four guide shafts are fixedly connected between the connecting plate and the suction head ejection plate.
[0008] In at least one embodiment of the present application, the tip retraction assembly further comprises a connecting plate, the tip retraction plate comprises a first surface and a second surface arranged oppositely, the second surface is located between the first surface and the connecting plate; a plurality of through holes are arranged on the tip retraction plate, each through hole penetrates the first surface and the second surface; each tip adapter passes through a through hole.
[0009] In at least one embodiment of the present application, the thickness of the tip retraction plate changes in a stepped manner from the two opposite edges of the first surface to the central area, and each step is provided with a plurality of through holes.
[0010] In at least one embodiment of the present application, the two opposite edges of the first surface are provided with stepped protrusions or grooves towards the central area.
[0011] In at least one embodiment of the present application, the thickness of the tip retraction plate at two steps of the same distance from the central area is the same.
[0012] In at least one embodiment of the present application, the driving assembly comprises a motor, a lead screw and a lead screw nut; one end of the lead screw is connected to the motor, the other end is connected to the tip retraction plate, the lead screw nut is sleeved on the lead screw, and is fixedly connected to the tip retraction assembly; the motor is used to drive the lead screw to rotate, so as to drive the lead screw nut to displace along the lead screw, and synchronously drive the tip retraction plate to displace along the guide shaft.
[0013] In at least one embodiment of the present application, the driving assembly further comprises a linear bearing; one end of the lead screw connected to the tip retraction plate is also connected in the linear bearing.
[0014] The second aspect of the present application provides a pipetting system, comprising: the tip retraction device of any one of the above; and a pipetting device connected to the second mounting surface, used to provide negative pressure to perform pipetting operation through the plurality of pipetting channels.
[0015] The tip retraction device and the pipetting system can avoid the situation that the deformation direction of the spring is inconsistent with the movement direction of the tip retraction assembly, compared with the spring return mode in the comparative example. The guide shaft makes the displacement direction of the tip retraction assembly always keep vertical direction, which can effectively improve the reset effect of the tip retraction assembly. BRIEF DESCRIPTION OF DRAWINGS
[0016] Figure 1 It is a perspective view of the tip retraction device of the embodiment of the present application in the reset state.
[0017] Figure 2 It is an exploded view of the tip retraction device of the embodiment of the present application.
[0018] Figure 3 for Figure 1 Cross-sectional structural diagram of the center-retracting suction head device along line III-III.
[0019] Figure 4 This is a rear view of the suction tip ejection device according to an embodiment of the present application.
[0020] Figure 5 This is a rear view of the suction head ejection device according to an embodiment of the present application in the suction head ejection state.
[0021] Figure 6 2 is a three-dimensional structural diagram of the tip ejection plate in the tip ejection device according to an embodiment of the present application.
[0022] Figure 7 for Figure 6 Enlarged view of part A in .
[0023] Figure 8 This is a three-dimensional structural diagram of the pipetting system according to an embodiment of the present application.
[0024] Description of main component symbols
[0025] Pipetting system: 100
[0026] Tip ejector device: 1
[0027] Installation body: 10
[0028] Channel structure: 11
[0029] First mounting surface: 111
[0030] Second mounting surface: 112
[0031] Mounting side: 113
[0032] Pipetting channels: 114
[0033] Connection: 115
[0034] Front fixing plate: 12
[0035] Front fixed part: 121
[0036] Front mounting: 122
[0037] Front protrusion: 123
[0038] Rear fixing plate: 13
[0039] Rear fixed part: 131
[0040] Rear mounting: 132
[0041] Rear protrusion: 133
[0042] Tip ejector assembly: 20
[0043] Ejector head plate: 21
[0044] First surface: 211
[0045] Second surface: 212
[0046] Through holes: 213
[0047] First suction head withdrawal area: A1
[0048] Second suction head withdrawal area: A2
[0049] The third suction head withdrawal area: A3
[0050] The fourth suction head withdrawal area: A4
[0051] Fifth suction head withdrawal area: A5
[0052] Sixth suction head withdrawal area: A6
[0053] Guide shaft: 22
[0054] Connecting plate: 23
[0055] Bearings: 24
[0056] Drive components: 30
[0057] Motor: 31
[0058] Screw: 32
[0059] Screw nut: 33
[0060] Linear bearings: 34
[0061] Mounting plate: 35
[0062] Adapter array: 40
[0063] Tip adapters: 41
[0064] Row direction: X
[0065] Column direction: Y
[0066] Pipetting device: 2.
[0067] The following specific implementation methods will further illustrate the present application in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION
[0068] The present application provides an automatic tip ejection device for use in a multi-channel pipetting system. The pipetting system is equipped with multiple tips to move liquid samples. After the liquid sample is moved, the pipetting system removes each tip from the pipetting system using the tip ejection device.
[0069] See also Figure 1 The tip ejection device 1 of the embodiment of the present application includes a mounting body 10, a tip ejection assembly 20, a drive assembly 30, and an adapter array 40. The tip ejection assembly 20 is movably connected to the mounting body 10. The drive assembly 30 and the adapter array 40 are fixedly connected to the mounting body 10. The drive assembly 30 is used to drive the tip ejection assembly 20 to move vertically. When a tip (not shown) is mounted on the end of the adapter array 40 away from the mounting body 10, the drive assembly 30 is used to drive the tip ejection assembly 20 downward to remove the tip (i.e., ejection tip) mounted on the adapter array 40, and is used to drive the tip ejection assembly 20 upward to reset the tip ejection assembly 20 after the tip ejection process is completed. Figure 1 The structure shown is the suction head ejection device 1 when the suction head ejection assembly 20 is in the reset state.
[0070] See also Figure 2 The mounting body 10 includes a channel structure 11. The channel structure 11 includes a first mounting surface 111, a second mounting surface 112, and four mounting side surfaces 113. The first mounting surface 111 and the second mounting surface 112 are arranged opposite and parallel to each other. Each mounting side surface 113 is located between the first mounting surface 111 and the second mounting surface 112 and is connected to the edge of the first mounting surface 111 and the second mounting surface 112. The four mounting side surfaces 113 are connected in sequence.
[0071] The channel structure 11 is formed with a plurality of pipetting channels 114. These channels 114 are located within the space enclosed by the four mounting side surfaces 113. The channels 114 are spaced apart and parallel to each other. Each channel 114 is a cylindrical channel extending through the first mounting surface 111 and the second mounting surface 112. That is, each channel 114 forms a circular opening on each of the first mounting surface 111 and the second mounting surface 112. In this embodiment, the first mounting surface 111 is rectangular, and the channels 114 are arranged in a rectangular array comprising multiple rows and columns. In this embodiment, the tip ejection device 1 is a 96-channel device, comprising 96 channels 114 arranged in 12 rows and 8 columns (also referred to as 8 rows and 12 columns). During the operation of the pipetting system (including aspiration and discharge processes), each channel 114 serves as an independent channel for moving liquid samples.
[0072] Please also refer to Figures 2 to 4The mounting body 10 also includes a front fixing plate 12 and a rear fixing plate 13. The front fixing plate 12 and the rear fixing plate 13 are respectively fixed on two oppositely arranged mounting side surfaces 113. The front fixing plate 12 includes a front fixing portion 121 and a front mounting portion 122. The front fixing portion 121 is fixed to a mounting side surface 113 of the channel structure 11 by bolts. The front fixing portion 121 and the front mounting portion 122 are flat plate structures perpendicular to each other, so that the front fixing plate 12 is "L"-shaped as a whole. The rear fixing plate 13 has basically the same structure as the front fixing plate 12, including a rear fixing portion 131 and a rear mounting portion 132. The rear fixing portion 131 is fixed to a mounting side surface 113 of the channel structure 11 by bolts.
[0073] The front fixing plate 12 further includes two front protrusions 123 extending from the front fixing portion 121 toward the connecting plate 23, and the two front protrusions 123 are spaced apart. The rear fixing plate 13 further includes two rear protrusions 133 extending from the rear fixing portion 131 toward the connecting plate 23, and the two rear protrusions 133 are spaced apart.
[0074] The head ejection assembly 20 includes a head ejection plate 21, guide shafts 22, and a connecting plate 23. In this embodiment, the head ejection assembly 20 includes four guide shafts 22 spaced apart and arranged parallel to each other. Each guide shaft 22 is cylindrical and perpendicular to the first mounting surface 111 and the second mounting surface 112. One end of each guide shaft 22 is fixedly connected to the head ejection plate 21, and the other end is fixedly connected to the connecting plate 23. In other words, the four guide shafts 22 are fixedly connected between the head ejection plate 21 and the connecting plate 23. In this embodiment, the head ejection plate 21 and the connecting plate 23 both have a generally rectangular outer profile, and the four guide shafts 22 are connected in pairs to two opposing edges of the head ejection plate 21 and the connecting plate 23.
[0075] The head ejection assembly 20 also includes four bearings 24. A bearing 24 is embedded in each front protrusion 123, and a bearing 24 is embedded in each rear protrusion 133. Two guide shafts 22 are respectively located in a bearing 24 and pass through the front fixing portion 121 to connect to the head ejection plate 21. The other two guide shafts 22 are respectively located in a bearing 24 and pass through the rear fixing portion 131 to connect to the head ejection plate 21.
[0076] The connecting plate 23 is a rectangular frame structure as a whole, and is formed with a rectangular opening 231. The channel structure 11 is located in the opening 231. That is, the connecting plate 23 is surrounded by the periphery of the four mounting side surfaces 113 of the channel structure 11.
[0077] The driving assembly 30 comprises a motor 31, a screw rod 32, a screw nut 33, a linear bearing 34 and a mounting plate 35. The channel structure 11 further comprises two connecting portions 115 protruding from one of the mounting sides 113 and spaced apart from each other. The mounting plate 35 is fixedly connected between the two connecting portions 115. One surface of the mounting plate 35 is fixedly connected with the motor 31, and the other surface is fixedly connected with the connecting plate 23. The linear bearing 34 is embedded in the front mounting portion 122. The screw rod 32 is connected with the motor 31 at one end and connected with the linear bearing 34 and the tip-removal plate 21 after penetrating through the connecting plate 23 at the other end. The screw nut 33 is connected with the screw rod 32 and fixedly connected with the connecting plate 23. The connecting plate 23 is located between the mounting plate 35 and the screw nut 33.
[0078] The adapter array 40 comprises a plurality of pipette tip adapters 41 arranged in an array. The pipette tip adapters 41 are in one-to-one correspondence with the pipetting channels 114. One end of each pipette tip adapter 41 is connected with the first mounting surface 111 and communicates with the opening of the corresponding pipetting channel 114 on the first mounting surface 111; the other end is used for mounting a pipette tip (not shown) during pipetting. In the present embodiment, corresponding to the channel structure 11, the adapter array 40 comprises 96 pipette tip adapters 41 arranged in 12 rows and 8 columns (or 8 rows and 12 columns).
[0079] In the present embodiment, the connecting plate 23, the four guide shafts 22, the tip-removal plate 21 and the screw nut 33 are fixedly connected as one. The motor 31 is used to drive the connecting plate 23, the four guide shafts 22, the tip-removal plate 21 and the screw nut 33 to move synchronously in the vertical direction. When the motor 31 drives the screw rod 32 to rotate, the screw nut 33 moves along the screw rod 32, and the connecting plate 23, the four guide shafts 22 and the tip-removal plate 21 move synchronously with the screw nut 33. During the movement, the linear bearing 34 is used to keep the screw rod 32 stable and not deviate left and right. The four guide shafts 22 are used for guiding in the vertical direction, so that the tip-removal plate 21 is balanced in force at each position, thereby making the displacement of the tip-removal plate 21 consistent in the vertical direction at each position. During the continuous downward movement of the tip-removal plate 21, the pipette tip (not shown) sleeved on each pipette tip adapter 41 falls off from the pipette tip adapter 41 due to the downward extrusion of the tip-removal plate 21 (also referred to as the tip-removal process, see Figure 5 After the tip-removal is completed, the motor 31 drives the screw rod 32 to rotate reversely, the screw nut 33 rotates in along the screw rod 32 upward, thereby driving the connecting plate 23, the four guide shafts 22 and the tip-removal plate 21 to move upward and reset. During the resetting process, the four guide shafts 22 are used for guiding in the vertical direction, so that the tip-removal plate 21 does not deviate in the vertical direction.
[0080] Please refer to Figure 5 and Figure 6The head ejection plate 21 has a first surface 211 and a second surface 212 disposed opposite each other. The first surface 211 is further away from the connecting plate 23 than the second surface 212; that is, the second surface 212 is located between the first surface 211 and the connecting plate 23. Both the first surface 211 and the second surface 212 are rectangular surfaces.
[0081] Please also refer to Figure 6 and Figure 7 The tip ejection plate 21 is provided with a plurality of spaced-apart through-holes 213. Each through-hole 213 corresponds to a tip adapter 41. Each tip adapter 41 passes through a corresponding through-hole 213. Corresponding to the adapter array 40, in this embodiment, the tip ejection plate 21 has 96 through-holes 213 arranged in a rectangular array of 12 rows and 8 columns (or 8 rows and 12 columns). Each through-hole 213 extends through both the first surface 211 and the second surface 212.
[0082] The head ejection plate 21 includes a plurality of head ejection areas 214, at least two of which have different thicknesses. In this embodiment, the head ejection plate 21 includes a first head ejection area A1, two second head ejection areas A2, two third head ejection areas A3, two fourth head ejection areas A4, two fifth head ejection areas A5, and two sixth head ejection areas A6. The first head ejection area A1, the two second head ejection areas A2, the two third head ejection areas A3, the two fourth head ejection areas A4, the two fifth head ejection areas A5, and the two sixth head ejection areas A6 are each rectangular. The thicknesses of the first head ejection area A1, the second head ejection area A2, the third head ejection area A3, the fourth head ejection area A4, the fifth head ejection area A5, and the sixth head ejection area A6 gradually decrease. The two second head ejection areas A2 , the two third head ejection areas A3 , the two fourth head ejection areas A4 , the two fifth head ejection areas A5 , and the two sixth head ejection areas A6 are recessed toward the second surface 212 .
[0083] The row direction of the through-hole array is defined as X, and the column direction is defined as Y. Along the row direction X of the through-hole array, a sixth head-removal area A6, a fifth head-removal area A5, a fourth head-removal area A4, a third head-removal area A3, a second head-removal area A2, a first head-removal area A1, a second head-removal area A2, a third head-removal area A3, a fourth head-removal area A4, a fifth head-removal area A5, and a sixth head-removal area A6 are sequentially arranged and connected. That is, two second head-removal areas A2, two third head-removal areas A3, two fourth head-removal areas A4, two fifth head-removal areas A5, and two sixth head-removal areas A6 are symmetrically distributed on either side of the first head-removal area A1.
[0084] In this embodiment, two central rows of through holes 213 are defined in the first head ejection area A1, and one row of through holes 213 is defined in each second head ejection area A2, each third head ejection area A3, each fourth head ejection area A4, each fifth head ejection area A5, and each sixth head ejection area A6.
[0085] That is, the thickness of the head removal plate 21 gradually decreases in a stepped pattern from opposite sides of the first surface 211 toward the center, with multiple through-holes 213 distributed along each step. In this embodiment, the second surface 212 is generally flat, while the first surface 211 is formed with a stepped recessed groove that is recessed toward the second surface 212 and has multiple regions of varying depths (in other embodiments of the present application, at least two regions of varying depths are formed). The 96 through-holes 213 are distributed within these multiple regions of varying depths. In other embodiments of the present application, the second surface 212 may be generally flat, while the first surface 211 may be formed with a stepped protrusion extending away from the second surface 212 to form multiple regions of varying protrusion heights. Furthermore, in this embodiment, the regions are sequentially connected side by side in a straight line, and the thickness distribution pattern of the head removal plate 21 in each head removal region is such that the thickness gradually decreases from the center toward the sides. In other embodiments of the present application, the thickness may also gradually increase from the center toward the sides.
[0086] In this embodiment, the height difference between each adjacent head ejection area is the same. That is, the thickness difference between each adjacent step on the head ejection plate 21 is the same. For example, the thickness difference between the first head ejection area A1 and the second head ejection area A2 is equal to the thickness difference between the second head ejection area A2 and the third head ejection area A3. In this embodiment, this thickness difference can be set to 0.6 mm.
[0087] In this embodiment, the thickness of two steps on the head ejection plate 21 at the same distance from the center region (i.e., the first head ejection area A1) is the same. For example, if the two second head ejection areas A2 are at the same distance from the center region, the thickness of the head ejection plate 21 at the two second head ejection areas A2 is the same.
[0088] In this embodiment, as the tip ejection plate 21 moves downward, the first surface 211 directly contacts and compresses the tips mounted on the tip adapter 41. By providing multiple tip ejection zones of varying thickness, the first surface 211 is non-flat, forming a stepped groove. Consequently, as the tip ejection plate 21 moves downward, the first surface 211 contacts tips sequentially at different locations within the different tip ejection zones, rather than simultaneously.
[0089] When the motor 31 drives the tip ejection plate 21 to move downward, a certain amount of pressure needs to be applied to remove the tips, and the magnitude of this pressure is positively correlated with the number of tips that need to be removed simultaneously. That is, the more tips that need to be removed simultaneously, the greater the pressure required. In the embodiment of the present application, by setting the first surface 211 to contact the tips in sequence at different positions in different tip ejection zones, the tip ejection plate 21 can successively remove the tips from each tip adapter 41. Compared to removing the tips from all tip adapters 41 at the same time, the number of tips that need to be removed simultaneously by the tip ejection plate 21 is reduced, thereby reducing the pressure applied by the motor 31, allowing the tip ejection device 1 to use a more economical motor 31, which is beneficial to reducing the overall cost of the tip ejection device 1.
[0090] As can be seen from the above description, the thicker head ejection area contacts the tips first, followed by the thinner head ejection area. Therefore, as the head ejection plate 21 moves downward, the first, second, third, fourth, fifth, and sixth head ejection areas A1, A2, A3, A4, A5, and A6 contact the tips in sequence. The head ejection plate 21 sequentially removes the tips from the tip adapters 41 within the through-holes 213 defined by the first, second, third, fourth, fourth, fifth, and sixth head ejection areas A5, A6. In this embodiment, by providing multiple head ejection areas of varying thickness, the pressure applied by the motor 31 simultaneously can be reduced to 2 to 3 N.
[0091] In other embodiments of the present application, the arrangement of the various head removal zones on the head removal plate 21 may vary, for example, an asymmetrical arrangement. In other embodiments of the present application, the arrangement and zoning of the various head removal zones on the head removal plate 21 may also vary, for example, they may not be zoned according to the number of columns of through-holes 213, and the head removal zones may be annular, triangular, or irregularly shaped. In other embodiments of the present application, the thickness of the various head removal zones on the head removal plate 21 may be arranged in a different pattern, for example, the thickness may not increase or decrease sequentially along a certain direction, but may be randomly distributed. In other embodiments of the present application, the difference between the various head removal zones on the head removal plate 21 may also vary. In other embodiments of the present application, the number of head removal zones provided on the head removal plate 21 may also vary, but at least two head removal zones of different thicknesses may be included, for example, a first head removal zone A1 and a second head removal zone A2.
[0092] The present application also provides Figure 8The pipetting system 100 shown in FIG. The pipetting system 100 includes the aforementioned tip ejection device 1 and a pipetting device 2. The pipetting device 2 is connected to the second mounting surface 112 of the channel structure 11. During operation of the pipetting system 100, each tip adapter 41 is mounted with a pipette tip (not shown). The pipetting device 2 communicates with each pipetting channel 114 within the channel structure 11, applying negative pressure to enable the pipette tip to aspirate liquid.
[0093] The tip ejection device 1 and pipetting system 100 of the present embodiment utilize guide shafts 22 within the tip ejection assembly 20 to guide the displacement of the tip ejection assembly 20. Compared to the spring-reset method employed in the comparative embodiment, this method avoids the situation where the spring's deformation direction is inconsistent with the movement direction of the tip ejection assembly 20. The guide shafts 22 ensure that the displacement direction of the tip ejection assembly 20 remains vertical, effectively enhancing the resetting effect of the tip ejection assembly 20. Furthermore, the tip ejection assembly 20 of this embodiment includes four guide shafts 22 spaced apart on either side of the tip ejection plate 21, ensuring uniform force across the tip ejection plate 21 and further preventing deviation in the movement of the tip ejection plate 21.
[0094] Furthermore, in the embodiment of the present application, the head ejection plate 21 includes multiple head ejection areas (a first head ejection area A1, a second head ejection area A2, a third head ejection area A3, a fourth head ejection area A4, a fifth head ejection area A5, and a sixth head ejection area A6) of varying thicknesses. This creates height differences between different locations on the first surface 211. As the head ejection plate 21 moves downward, different locations on the first surface 211 located in different head ejection areas sequentially contact and compress the tips on the tip adapters 41, thereby sequentially removing tips from the different tip adapters 41. Consequently, the number of tips that need to be removed by the head ejection plate 21 in a single operation is reduced, and the pressure required by the motor 31 is reduced. This makes the motor 31 more economical and helps control costs.
[0095] In addition, the tip ejection device 1 in the embodiment of the present application includes a motor 31 to drive the displacement of the tip ejection assembly 20, without the need for a motor (not shown) in the pipetting device 2 to drive the displacement, thereby reducing the dead volume and allowing the pipette to transfer small volumes.
[0096] Those skilled in the art should recognize that the above embodiments are only used to illustrate the present application and are not used to limit the present application. As long as they are within the spirit of the present application, appropriate changes and modifications to the above embodiments are within the scope of protection claimed in the present application.
Claims
1. A suction head ejection device, characterized in that: include: The mounting body includes a channel structure, the channel structure includes a first mounting surface and a second mounting surface arranged opposite to each other, and the channel structure further forms a plurality of pipetting channels passing through the first mounting surface and the second mounting surface; an adapter array, comprising a plurality of pipette tip adapters, the plurality of pipette tip adapters being connected to the first mounting surface, the plurality of pipette tip adapters being in one-to-one communication with the plurality of pipetting channels; a suction head ejection assembly movably connected to the mounting body, the suction head ejection assembly comprising a guide shaft, the guide shaft being perpendicular to the first mounting surface; as well as A driving assembly is connected to the mounting body and the tip ejection assembly, and is used to drive the tip ejection assembly to move relative to the mounting body along the guide axis to remove the tips mounted on the plurality of tip adapters.
2. The suction head ejection device according to claim 1, wherein: The suction head ejection assembly includes a suction head ejection plate; The suction head ejection assembly includes four guide shafts, and the four guide shafts are fixedly connected to two opposite sides of the suction head ejection plate in pairs.
3. The suction head ejection device according to claim 2, wherein: The channel structure further includes a mounting side surface connected between the first mounting surface and the second mounting surface; The suction head ejection assembly further includes a connecting plate, which is a frame structure surrounding the installation side surface of the channel structure; The four guide shafts are fixedly connected between the connecting plate and the suction head ejection plate.
4. The suction head ejection device according to claim 2, wherein: The head ejection assembly further includes a connecting plate, the head ejection plate including a first surface and a second surface disposed opposite to each other, the second surface being located between the first surface and the connecting plate; The suction removal head plate is provided with a plurality of through holes arranged at intervals, and each of the through holes passes through the first surface and the second surface; Each of the suction tip adapters passes through one of the through holes.
5. The suction head ejection device according to claim 4, characterized in that: The thickness of the suction head ejection plate changes in a step-like manner from two opposite sides of the first surface toward the central area, and each step is provided with a plurality of the through holes.
6. The suction head ejection device according to claim 5, characterized in that: Two opposite sides of the first surface are provided with stepped protrusions or grooves toward the central area.
7. The suction head ejection device according to claim 6, wherein: The thickness of the two steps at the same distance from the central area on the suction removal head plate is the same.
8. The suction head ejection device according to claim 2, wherein: The driving assembly includes a motor, a screw and a screw nut; One end of the screw is connected to the motor, and the other end is connected to the suction head ejection plate. The screw nut is sleeved on the screw and fixedly connected to the suction head ejection assembly. The motor is used to drive the screw to rotate, so as to drive the screw nut to move along the screw, and synchronously drive the suction head removal plate to move along the guide shaft.
9. The suction head ejection device according to claim 8, wherein: The drive assembly also includes a linear bearing; One end of the screw rod connected to the suction head removal plate is also connected to the linear bearing.
10. A pipetting system, characterized in that: include: The suction head ejection device according to any one of claims 1 to 9; as well as The pipetting device is connected to the second mounting surface and is used for providing negative pressure to perform a pipetting operation through the plurality of pipetting channels when pipette tips are mounted on the plurality of pipette tip adapters.