Sterile biological reaction bag with position-adjustable stirring paddle

Abstract

The utility model discloses a sterile biological reaction bag with position-adjustable stirring paddles, which comprises an accommodating bag and a stirring shaft, the stirring shaft is provided with a plurality of stirring paddles, one end of the stirring shaft penetrates through the accommodating bag and is connected with a driving mechanism, the stirring shaft positioned between the driving mechanism and the accommodating bag is an adjusting section of the stirring shaft, and the adjusting section is provided with a telescopic device. The telescopic device is hermetically connected with the stirring shaft and is used for controlling the lifting of the stirring shaft. According to the sterile biological reaction bag with the position-adjustable stirring paddle, the purpose of adjusting the position of the stirring paddle outside the containing bag is achieved through the structure that the adjusting section is sleeved with the telescopic device, meanwhile, due to the fact that the telescopic device is connected with the stirring shaft in a sealed mode and has a certain telescopic range, the stirring paddle is not prone to falling off, and the stirring paddle is not prone to falling off. And the stirring shaft in the telescopic range can be isolated from the external environment, so that the purpose of keeping the internal environment of the accommodating bag not polluted even if the position of the stirring paddle is repeatedly adjusted is achieved.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceuticals, and in particular to a sterile bioreactor bag with an adjustable stirring paddle position. Background Technology

[0002] Due to its many advantages such as easy disassembly and assembly and practicality, bioreactor bags are widely used in bioreactors. However, in most existing bioreactor bags, the position of the agitator is fixed and cannot be reasonably adjusted according to the actual capacity of the reaction bag.

[0003] Among the existing technologies, there is also an adjustable blade height stirring paddle and a reaction vessel using the stirring paddle disclosed in Chinese Patent Publication No. CN204074085U, which includes a paddle rod and a blade. The paddle rod is fitted with an axially sliding and circumferentially positioning sleeve. The blade is fixed to the bottom of the sleeve. The top of the paddle rod is threaded with an adjusting sleeve. The top of the sleeve engages with the adjusting sleeve and is axially positioned.

[0004] Although the adjustable blade height stirring paddle provided by the above patent achieves the function of adjustable blade height, during the adjustment process, there will be a situation where the paddle rod is exposed to the sterile environment and then re-enters the vessel, which will destroy the sterile environment inside the entire vessel and affect the culture. Utility Model Content

[0005] To address the problems existing in the prior art, this utility model discloses a sterile bioreactor bag with an adjustable stirring paddle position.

[0006] An adjustable-position sterile bioreactor bag includes a containment bag and a stirring shaft. The stirring shaft is provided with a plurality of stirring blades. One end of the stirring shaft passes through the containment bag and is connected to a drive mechanism. The stirring shaft located between the drive mechanism and the containment bag is an adjustable section of the stirring shaft. The adjustable section is provided with a telescopic device. The telescopic device is sealed to the stirring shaft and is used to control the raising and lowering of the stirring shaft.

[0007] Specifically, the lifting and lowering of the stirring shaft is controlled by a telescopic device, and the stirring paddle is set on the stirring shaft. Therefore, the lifting and lowering of the stirring shaft will move the position of the stirring paddle, thus realizing the adjustment of the stirring paddle position. At the same time, since the telescopic device is set on the adjustment section outside the containment bag, the containment bag can maintain the isolation between the internal environment and the external environment during the adjustment process.

[0008] Preferably, the stirring shaft includes a main shaft and a sleeve movably fitted outside the main shaft, the stirring paddle is fixed on the sleeve, the axial length of the main shaft is greater than the axial length of the sleeve, and the driving mechanism is connected to the main shaft;

[0009] The telescopic device includes a flexible telescopic component sleeved on the outside of the sleeve, and sealing connectors at both ends of the flexible telescopic component, each of which is fixed to the flexible telescopic component;

[0010] The sealing connector includes a first sealing bushing that is sleeved on the outside of the sealing sleeve, with one end sealed and fixed to the flexible telescopic member and the other end sealed and fixed to the receiving bag. The first sealing bushing is movably connected to the sleeve through a first bearing assembly.

[0011] The sealing connector further includes a second sealing bushing that is sealed and fixed to the flexible telescopic member and sealed to the sleeve. The second sealing bushing does not move axially with the sleeve, and the second sealing bushing is movably connected to the sleeve through a second bearing assembly.

[0012] Specifically, the main shaft of the stirring shaft is connected to the drive mechanism, the stirring paddle is set on the sleeve, and the telescopic device is sleeved on the sleeve. That is, the position of the stirring paddle can be changed by raising and lowering the sleeve, while the position of the stirring paddle remains stable.

[0013] In practical use, pushing / pulling the second sealing sleeve will cause the sleeve to move axially along the main shaft because the second sealing sleeve and the sleeve are axially fixed (i.e., there is no relative axial movement between them). At this time, the position of the stirring paddle will change accordingly, and the flexible telescopic component will be compressed / stretched. Meanwhile, since the first sealing sleeve is sealed to the container bag and the flexible telescopic component, and the second sealing sleeve is sealed to the flexible telescopic component and the sleeve, the stirring shaft of the telescopic device sleeve section is always isolated from the external environment. That is, adjusting the position of the stirring paddle within the telescopic range of the telescopic device will not damage the internal environment of the container bag.

[0014] Preferably, the flexible expansion member is a corrugated pipe.

[0015] Specifically, corrugated pipes have good sealing and expansion properties, making them suitable as flexible expansion components.

[0016] Preferably, the stirring shaft includes a main shaft and a sleeve movably fitted outside the main shaft, wherein the axial length of the main shaft is greater than the axial length of the sleeve;

[0017] The telescopic device includes a sliding bushing and a sealing connector. The sealing connector includes a first sealing bushing and a second sealing bushing. The first sealing bushing is sealed and fixed to the receiving bag and is sealed and sleeved with the sleeve. The sleeve can slide and rotate relative to the first sealing bushing. The second sealing bushing is sleeved with the sleeve, and the stirring shaft can rotate along the second sealing bushing. There is no axial movement between the second sealing bushing and the stirring shaft.

[0018] The sliding bushing is sealed and slidably connected with the first sealing bushing and the second sealing bushing; the sliding bushing can slide along the axial direction of the first sealing bushing and the second sealing bushing.

[0019] Specifically, due to the sealed connection of the first sealing bushing and the second sealing bushing, and the structure that the second sealing bushing and the sleeve do not move axially, combined with the structure that the sliding bushing can slide along the first sealing bushing and the second sealing bushing, the stirring shaft of the telescopic device sleeve section is always isolated from the external environment during the adjustment of the stirring paddle position. That is, the adjustment of the stirring paddle position within the telescopic range of the telescopic device will not damage the internal environment of the container bag.

[0020] Preferably, a first limiting structure is provided between the first sealing bushing and the sliding bushing, and a second limiting structure is provided between the second sealing bushing and the sliding bushing.

[0021] Specifically, in this structure, when the two ends of the sliding bushing are restricted from moving by the first limiting structure and the second limiting structure respectively, the position of the stirring paddle is at its highest adjustable position.

[0022] Preferably, the first sealing bushing is movably connected to the stirring shaft via a first bearing assembly, and the second sealing bushing is movably connected to the stirring shaft via a second bearing assembly.

[0023] Specifically, the first bearing assembly is typically a rolling bearing and a seal or other structure that can achieve the same function, and the second bearing assembly is typically a ball bearing and a thrust bearing or other structure that can achieve the same function.

[0024] Preferably, an elastic fixing device is provided between the sleeve and the main shaft, the elastic fixing device being used to fix the relative position between the sleeve and the main shaft and to transmit power.

[0025] Specifically, an elastic fixing device is used to fix the relative position of the sleeve and the main shaft, so that there is no relative movement between the sleeve and the main shaft during the rotation of the stirring shaft, thus ensuring the stability of the stirring shaft rotation. At the same time, with this structure, applying a certain tension / thrust to the sleeve can make the sleeve move along the axial direction of the main shaft, thereby realizing the adjustment of the position of the stirring paddle; that is, this structure can achieve the function of adjustable stirring paddle position while ensuring the stable rotation of the stirring shaft.

[0026] Preferably, the elastic fixing device includes an elastic fixing element and a sliding fixing groove.

[0027] Specifically, when the elastic fastener is engaged in the sliding fixing groove, the relative position between the spindle and the sleeve can remain stable.

[0028] Preferably, the elastic fixing member is a ball-head plunger, and the sliding fixing groove is an arc-shaped groove.

[0029] Specifically, the ball-head plunger and the arc-shaped groove are stably engaged, and the ball-head plunger can slide out of the arc-shaped groove without applying excessive thrust / pull force, thereby adjusting the position of the agitator.

[0030] Compared with the prior art, the advantages of this utility model are:

[0031] By using a telescopic device attached to the adjustment section, the position of the stirring paddle can be adjusted outside the containment bag. At the same time, since the telescopic device is sealed to the stirring shaft and has a certain range of extension, the stirring shaft within the extension range can be isolated from the external environment. This achieves the goal of keeping the internal environment of the containment bag uncontaminated even if the position of the stirring paddle is repeatedly adjusted. Attached Figure Description

[0032] Figure 1 This is a schematic diagram of the first embodiment of the aseptic bioreactor bag with adjustable stirring paddle position disclosed in this utility model.

[0033] Figure 2 for Figure 1 Enlarged view of point A in the middle;

[0034] Figure 3 This is a schematic diagram of the second embodiment of the aseptic bioreactor bag with adjustable stirring paddle position disclosed in this utility model (initial state of the sleeve);

[0035] Figure 4 This is a schematic diagram of the second embodiment of the aseptic bioreactor bag with adjustable stirring paddle position disclosed in this utility model (the sleeve is at its highest point).

[0036] Figure 5 This is a schematic diagram of the second embodiment of the aseptic bioreactor bag with adjustable stirring paddle position disclosed in this utility model (the sleeve is in the lowest point state). Detailed Implementation

[0037] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0038] like Figure 1 , 3As shown in Figure 5, the sterile bioreactor bag with adjustable stirring paddle position disclosed in this utility model includes a container bag 10 and a stirring shaft. The stirring shaft is provided with a plurality of stirring paddles 30. One end of the stirring shaft passes through the container bag 10 and is connected to a drive mechanism. The stirring shaft located between the drive mechanism and the container bag 10 is an adjustment section of the stirring shaft. The adjustment section is provided with a telescopic device. The telescopic device is sealed to the stirring shaft and is used to control the lifting and lowering of the stirring shaft.

[0039] The lifting and lowering of the stirring shaft is controlled by the telescopic device, and the stirring paddle 30 is set on the stirring shaft. Therefore, the lifting and lowering of the stirring shaft will move the position of the stirring paddle 30, thus realizing the adjustment of the position of the stirring paddle 30. At the same time, since the telescopic device is set on the adjustment section outside the container bag 10, the internal environment of the container bag 10 can be kept isolated from the external environment during the adjustment process.

[0040] The stirring shaft includes a main shaft 21 and a sleeve 22 movably sleeved on the outside of the main shaft 21. The stirring paddle 30 is fixed on the sleeve 22. The axial length of the main shaft 21 is greater than the axial length of the sleeve 22. The drive mechanism is connected to the main shaft 21.

[0041] like Figure 1 As shown, the telescopic device includes a flexible telescopic member 41 sleeved on the outside of the sleeve 22, and sealing connectors at both ends of the flexible telescopic member 41. Each sealing connector is fixed to the flexible telescopic member 41.

[0042] The sealing connector includes a first sealing bushing 42 that is sealed and fixed to the outside of the sleeve 22, with one end sealed and fixed to the flexible telescopic member 41 and the other end sealed and fixed to the receiving bag 10. The first sealing bushing 42 is movably connected to the sleeve 22 through a first bearing assembly.

[0043] The sealing connector also includes a second sealing bushing 43 that is sealed and fixed to the flexible telescopic member 41 and sealed and connected to the sleeve 22. The second sealing bushing 43 and the sleeve 22 do not move axially. The second sealing bushing 43 is movably connected to the sleeve 22 through a second bearing assembly.

[0044] The main shaft 21 of the stirring shaft is connected to the drive mechanism. The stirring paddle 30 is mounted on the sleeve 22. At the same time, the telescopic device is sleeved on the sleeve 22. That is, the position of the stirring paddle 30 can be changed by raising and lowering the sleeve 22. While changing the position of the stirring paddle 30, the positions of the main shaft 21 and the drive mechanism remain stable.

[0045] The flexible expansion joint 41 is a corrugated pipe.

[0046] Corrugated pipes have good sealing and expansion properties, making them suitable as flexible expansion components 41.

[0047] like Figure 3-5As shown, the stirring shaft includes a main shaft 21 and a sleeve 22 that is movably sleeved on the outside of the main shaft 21. The axial length of the main shaft 21 is greater than the axial length of the sleeve 22.

[0048] The telescopic device includes a sliding bushing 44 and a sealing connector. The sealing connector includes a first sealing bushing 42 and a second sealing bushing 43. The first sealing bushing 42 is sealed and fixed to the receiving bag 10 and is sealed and sleeved with the sleeve 22. The sleeve 22 can slide and rotate relative to the first sealing bushing 42. The second sealing bushing 43 is sleeved with the sleeve 22, and the stirring shaft can rotate along the second sealing bushing 43. There is no axial movement between the second sealing bushing 43 and the stirring shaft.

[0049] The sliding bushing 44 is sealed and slidably connected with the first sealing bushing 42 and the second sealing bushing 43; the sliding bushing 44 can slide along the axial direction of the first sealing bushing 42 and the second sealing bushing 43.

[0050] Due to the sealed connection of the first sealing sleeve 42 and the second sealing sleeve 43, and the structure that prevents axial movement between the second sealing sleeve 43 and the sleeve 22, combined with the structure that allows the sliding sleeve 44 to slide along the first sealing sleeve 42 and the second sealing sleeve 43, the stirring shaft of the telescopic device sleeve section is always isolated from the external environment during the adjustment of the position of the stirring paddle 30. That is, the adjustment of the position of the stirring paddle 30 within the telescopic range of the telescopic device will not damage the internal environment of the container bag 10.

[0051] A first limiting structure is provided between the first sealing bushing 42 and the sliding bushing 44, and a second limiting structure is provided between the second sealing bushing 43 and the sliding bushing 44.

[0052] In this structure, when the two ends of the sliding bushing 44 are restricted from moving by the first limiting structure and the second limiting structure respectively, the position of the stirring paddle 30 is at its highest adjustable position.

[0053] The first sealing bushing 42 is movably connected to the stirring shaft via the first bearing assembly, and the second sealing bushing 43 is movably connected to the stirring shaft via the second bearing assembly.

[0054] The first bearing assembly is typically a rolling bearing and a seal or other structure that can achieve the same function, while the second bearing assembly is typically a ball bearing and a thrust bearing or other structure that can achieve the same function.

[0055] like Figure 2 As shown, an elastic fixing device is provided between the sleeve 22 and the main shaft 21. The elastic fixing device is used to fix the relative position between the sleeve 22 and the main shaft 21 and to transmit power.

[0056] The relative positions of the sleeve 22 and the main shaft 21 are fixed by an elastic fixing device, so that there is no relative movement between the sleeve 22 and the main shaft 21 during the rotation of the stirring shaft, thus ensuring the stability of the stirring shaft rotation. At the same time, with this structure, applying a certain tension / thrust to the sleeve 22 can make the sleeve 22 move along the axial direction of the main shaft 21, thereby realizing the adjustment of the position of the stirring paddle 30. That is, this structure can achieve the function of adjustable position of stirring paddle 30 while ensuring stable rotation of the stirring shaft.

[0057] The elastic fixing device includes an elastic fixing element 51 and a sliding fixing groove 52.

[0058] When the elastic fastener 51 is engaged in the sliding fixing groove 52, the relative position between the main shaft 21 and the sleeve 22 can remain stable.

[0059] The elastic fastener 51 is a ball-head plunger, and the sliding fixing groove 52 is an arc-shaped groove.

[0060] The ball-head plunger and the arc-shaped groove are stably engaged, and the ball-head plunger can slide out of the arc-shaped groove without applying excessive thrust / pull force, thereby adjusting the position of the agitator 30.

[0061] In practical use, pushing / pulling the second sealing sleeve 43 will cause the sleeve 22 to move axially along the main shaft 21, since the second sealing sleeve 43 and the sleeve 22 are axially fixed (i.e., there is no relative axial movement between them). At this time, the position of the stirring paddle 30 will change accordingly, and the flexible telescopic member 41 will be compressed / stretched (or the sliding sleeve 44 will slide along the axis of the first sealing sleeve 42 and the second sealing sleeve 43). At the same time, since the first sealing sleeve 42 is sealed to the container bag 10 and the flexible telescopic member 41 (or the sliding sleeve 44), and the second sealing sleeve 43 is sealed to the flexible telescopic member 41 (or the sliding sleeve 44) and the sleeve 22, the stirring shaft of the telescopic device sleeve section is always isolated from the external environment. That is, the adjustment of the position of the stirring paddle 30 within the telescopic range of the telescopic device will not damage the internal environment of the container bag 10.

Claims

1. A sterile bioreactor bag with adjustable impeller position, comprising a receiving bag and an agitator shaft, wherein the agitator shaft is provided with a plurality of impellers, characterized in that, One end of the stirring shaft passes through the container bag and is connected to the drive mechanism. The stirring shaft located between the drive mechanism and the container bag is the adjustment section of the stirring shaft. The adjustment section is equipped with a telescopic device, which is sealed to the stirring shaft. The telescopic device is used to control the lifting and lowering of the stirring shaft.

2. The aseptic bioreactor bag with adjustable agitator position according to claim 1, characterized in that, The stirring shaft includes a main shaft and a sleeve that is movably fitted onto the outside of the main shaft. The stirring paddle is fixed on the sleeve. The axial length of the main shaft is greater than the axial length of the sleeve. The driving mechanism is connected to the main shaft. The telescopic device includes a flexible telescopic component sleeved on the outside of the sleeve, and sealing connectors are provided at both ends of the flexible telescopic component, with each sealing connector being fixed to the flexible telescopic component.

3. The aseptic bioreactor bag with adjustable stirring paddle position according to claim 2, characterized in that, The sealing connector includes a first sealing bushing that is sealed and fixed to the outside of the sleeve, with one end sealed and fixed to the flexible telescopic member and the other end sealed and fixed to the receiving bag. The first sealing bushing is movably connected to the sleeve through a first bearing assembly.

4. The aseptic bioreactor bag with adjustable agitator position according to claim 3, characterized in that, The sealing connector further includes a second sealing bushing that is sealed and fixed to the flexible telescopic member and sealed to the sleeve. The second sealing bushing does not move axially with the sleeve, and the second sealing bushing is movably connected to the sleeve through a second bearing assembly.

5. The aseptic bioreactor bag with adjustable impeller position according to claim 2, characterized in that, The flexible expansion joint is a corrugated pipe.

6. The aseptic bioreactor bag with adjustable agitator position according to claim 1, characterized in that, The stirring shaft includes a main shaft and a sleeve that is movably fitted onto the outside of the main shaft. The axial length of the main shaft is greater than the axial length of the sleeve. The telescopic device includes a sliding bushing and a sealing connector. The sealing connector includes a first sealing bushing and a second sealing bushing. The first sealing bushing is sealed and fixed to the receiving bag and is sealed and sleeved with the sleeve. The sleeve can slide and rotate relative to the first sealing bushing. The second sealing bushing is sealed and sleeved with the sleeve, and the stirring shaft can rotate along the second sealing bushing. There is no axial movement between the second sealing bushing and the stirring shaft. The sliding bushing is sealed and slidably connected with the first sealing bushing and the second sealing bushing; the sliding bushing can slide along the axial direction of the first sealing bushing and the second sealing bushing.

7. The aseptic bioreactor bag with adjustable agitator position according to claim 6, characterized in that, A first limiting structure is provided between the first sealing bushing and the sliding bushing, and a second limiting structure is provided between the second sealing bushing and the sliding bushing.

8. The aseptic bioreactor bag with adjustable agitator position according to claim 6, characterized in that, The first sealing bushing is movably connected to the stirring shaft via a first bearing assembly, and the second sealing bushing is movably connected to the stirring shaft via a second bearing assembly.

9. The aseptic bioreactor bag with adjustable agitator position according to claim 2 or 6, characterized in that, An elastic fixing device is provided between the sleeve and the main shaft. The elastic fixing device is used to fix the relative position between the sleeve and the main shaft and to transmit power.

10. The aseptic bioreactor bag with adjustable impeller position according to claim 9, characterized in that, The elastic fixing device includes an elastic fixing element and a sliding fixing groove.

Images