Cyclodextrin derivative solution concentration device

Abstract

The utility model relates to the technical field of separation equipment, in particular to a cyclodextrin derivative solution concentration device which comprises a biological solution concentration mechanism, and the biological solution concentration mechanism comprises a solution inlet plate, a solution filter screen, a concentration device body, control equipment, a device base, fixing screws and a circulation pipeline. When the equipment is operated, a cyclodextrin derivative solution needing to be concentrated is put into the circulation pipeline through the solution inlet plate, an evaporation concentration method or a freeze drying method is selected to be used for concentration according to the property of the cyclodextrin derivative solution, and when the evaporation concentration method needs to be used, the steam door is pulled open; water resources used for producing steam are put into the steam production bin, the electric heating pipe is started to heat the water resources and generate steam, the steam enters the reaction plate through the steam pipeline to concentrate a cyclodextrin derivative solution, and the steam enters the steam circulating pipeline after concentration is completed for next round of concentration.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of separation equipment, and particularly relates to a cyclodextrin derivative solution concentration device. BACKGROUND

[0002] Cyclodextrin derivatives are mainly divided into two categories: water-soluble cyclodextrin derivatives and hydrophobic cyclodextrin derivatives. Water-soluble cyclodextrin derivatives include glucose derivatives, hydroxypropyl derivatives, methyl derivatives, etc. These derivatives are often used to increase the solubility of poorly soluble drugs, promote drug absorption, reduce hemolytic activity, and serve as inclusion materials for injections. Hydrophobic cyclodextrin derivatives are mainly used to reduce the solubility of water-soluble drugs and achieve sustained-release effects.

[0003] The cyclodextrin derivative solution concentration device disclosed in the authorized announcement CN 222018949 U, although it provides a cyclodextrin derivative solution concentration device, accurately adjusts the temperature of the cyclodextrin derivative solution, and improves the concentration efficiency, does not solve the problem that the biological solution concentration mechanism selects the freeze-drying method for concentration according to the properties of the cyclodextrin derivative solution when facing different cyclodextrin derivative solutions, and the steam circulation of the biological solution concentration mechanism saves resources. SUMMARY

[0004] The utility model aims at providing a cyclodextrin derivative solution concentration device to solve the problems raised in the background.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme:

[0006] A cyclodextrin derivative solution concentration device, comprising a biological solution concentration mechanism, the biological solution concentration mechanism comprising a solution inlet plate, a solution filter screen, a concentration device body, a control device, a device base, a fixing screw, and a flow pipeline, the solution inlet plate being fixedly provided at the bottom end with the solution filter screen, the solution filter screen being fixedly provided at the bottom end with the concentration device body, the concentration device body being fixedly provided at one side with the control device, the control device being fixedly provided at the bottom end with the device base, the device base being threadedly connected at the top end with the fixing screw, and the concentration device body being fixedly provided at the other side with the flow pipeline;

[0007] One side of the flow pipeline is fixedly provided with a reaction plate, the reaction plate being fixedly provided at the bottom end with a steam production device, the steam production device comprising a steam door and a steam pipeline, one side of the steam production device being movably provided with the steam door, the top end of the steam production device being fixedly provided with the steam pipeline, one side of the reaction plate being movably provided with a flow valve, one side of the flow valve being fixedly provided with a solution storage plate, and one side of the solution storage plate being fixedly provided with a solution outlet.

[0008] Preferably, the solution storage plate top end is fixedly provided with a steam circulation pipeline, which can recycle the steam used for biological solution concentration, and the steam circulation pipeline can recycle and utilize the steam multiple times in the system, thereby reducing the steam demand, effectively reducing energy consumption through steam reuse, reducing dependence on energy, and thus reducing the overall system operation cost.

[0009] Preferably, the through pipeline is provided with a temperature detection device on one side, which can detect the temperature of the steam through pipeline in real time and feed back to the control device, so as to timely find out the temperature abnormality, ensure that the conduction temperature of the steam in the through pipeline meets the preset temperature requirement, avoid overheating or insufficient phenomenon, and ensure the concentration effect of the cyclodextrin derivative solution and avoid the concentration of the cyclodextrin derivative solution caused by improper steam temperature from meeting the preset condition.

[0010] Preferably, the reaction plate top end is provided with a cold air emitting device, which is used to make cold air and use the freeze-drying method to concentrate the cyclodextrin derivative solution. The freeze-drying method can effectively preserve the molecular structure and function of the cyclodextrin derivative, and compared with the conventional evaporation concentration method, the freeze-drying method can avoid the degradation or denaturation of the cyclodextrin derivative caused by high temperature, and ensure its drug carrier, packaging and dissolution capacity and other functions.

[0011] Preferably, the steam pipeline top end is fixedly provided with a steam filter screen, which can effectively filter out impurities, solid particles and small pollutants in water vapor in the steam, help reduce the interference of steam impurities on the cyclodextrin derivative solution concentration process, and ensure that the cyclodextrin derivative solution can be concentrated under more effective conditions.

[0012] Preferably, the steam production device comprises an electric heating pipe and a steam production bin, the steam production device bottom end is provided with an electric heating pipe, and the electric heating pipe top end is fixedly provided with a steam production bin. Pull open the steam door, put the water resource used for producing steam into the steam production bin, and start the electric heating pipe to heat the water resource and produce steam.

[0013] Preferably, the fixing screw comprises a nut and a bolt, the fixing screw top end is fixedly provided with a nut, and the nut bottom end is fixedly provided with a bolt. The beneficial effect is that the reliable mechanical connection is realized through the threaded structure, the connection part is ensured not to be loose or fallen off, the threaded structure design makes the installation and disassembly process relatively simple, and the convenience enables the operation to be quickly performed in the case of needing maintenance and replacement, thereby saving time and labor cost.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. The device operates to put the cyclodextrin derivative solution which needs to be concentrated into the flow channel through the solution inlet plate, and according to the properties of the cyclodextrin derivative solution, the evaporation concentration method or the freeze drying method is selected for concentration, when the evaporation concentration method is needed, the steam door is opened, the water resource for producing steam is put into the steam production bin, the electric heating pipe is opened to heat the water resource and produce steam, the steam enters the reaction plate through the steam pipeline to concentrate the cyclodextrin derivative solution, and after the concentration is completed, the steam enters the steam circulation pipeline for the next round of concentration, when the freeze drying method is needed, the cold air emitting device is opened to concentrate the cyclodextrin derivative solution in the reaction plate, and the concentrated cyclodextrin derivative solution is stored in the solution storage plate and taken out through the solution outlet.

[0016] 2. The device has the advantages that the steam circulation pipeline is arranged to recycle the steam used for concentrating the biological solution, the steam circulation pipeline can recycle and use the steam multiple times in the system, the demand for steam is reduced, the energy consumption can be effectively reduced by reusing the steam, the dependence on energy is reduced, the operation cost of the whole system is reduced, the steam filter screen is arranged to effectively filter out impurities, solid particles and small pollutants in water vapor in the steam, the interference of steam impurities on the concentration process of the cyclodextrin derivative solution is reduced, and the cyclodextrin derivative solution can be concentrated under more effective conditions. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0018] Figure 2 It is a schematic diagram of the installation of the concentration device body structure of the utility model;

[0019] Figure 3 It is a schematic diagram of the installation of the reaction plate structure of the utility model;

[0020] Figure 4 It is a schematic diagram of the installation of the steam production equipment structure of the utility model;

[0021] Figure 5 It is a schematic diagram of the installation of the fixed screw structure of the utility model.

[0022] In the drawing: 1, solution inlet plate; 2, solution filter screen; 3, concentration device body; 4, control equipment; 5, device base; 6, fixed screw; 7, flow channel; 8, reaction plate; 9, steam production equipment; 10, steam door; 11, steam pipeline; 12, flow valve; 13, solution storage plate; 14, solution outlet; 15, steam circulation pipeline; 16, temperature detection equipment; 17, cold air emitting equipment; 18, steam filter screen; 19, electric heating pipe; 20, steam production bin; 21, nut; 22, bolt. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application.

[0024] Please refer to Figures 1-4 A technical scheme provided by the present application is shown in the drawings.

[0025] The biological solution concentration mechanism comprises a solution inlet plate 1, a solution filter screen 2, a concentration device body 3, a control device 4, a device base 5, a fixing screw 6 and a flow pipeline 7. The solution filter screen 2 is fixedly arranged at the bottom end of the solution inlet plate 1. The concentration device body 3 is fixedly arranged at the bottom end of the solution filter screen 2. The control device 4 is fixedly arranged at one side of the concentration device body 3. The model of the control device 4 is ABB 800xA. The device base 5 is fixedly arranged at the bottom end of the control device 4. The fixing screw 6 is threadedly connected to the top end of the device base 5. The flow pipeline 7 is fixedly arranged at the other side of the concentration device body 3.

[0026] The flow pipeline 7 is fixedly arranged at one side of the reaction plate 8. The steam production device 9 comprises a steam door 10 and a steam pipeline 11. The steam door 10 is movably arranged at one side of the steam production device 9. The steam pipeline 11 is fixedly arranged at the top end of the steam production device 9. The flow valve 12 is movably arranged at one side of the reaction plate 8. The solution storage plate 13 is fixedly arranged at one side of the flow valve 12. The solution outlet 14 is fixedly arranged at one side of the solution storage plate 13.

[0027] In this embodiment, preferably, the solution storage plate 13 is fixedly arranged at the top end of the steam circulation pipeline 15. The steam circulation pipeline 15 can recycle the steam used for biological solution concentration. The steam circulation pipeline 15 can recycle and utilize the steam in the system for multiple times, thereby reducing the demand for steam. Through the reuse of steam, the energy consumption can be effectively reduced, the dependence on energy can be reduced, and the operation cost of the overall system can be reduced.

[0028] In this embodiment, preferably, the steam circulation pipeline 7 is provided with a temperature detection device 16 on one side. The temperature detection device 16 is a PT100 type. By monitoring the temperature of the steam circulation pipeline 7 in real time and feeding back to the control device 4, the temperature anomaly can be found in time, the conduction temperature of the steam in the circulation pipeline 7 is ensured to meet the preset temperature requirement, the overheat or insufficient phenomenon is avoided, the concentration effect of the cyclodextrin derivative solution is ensured, and the concentration of the cyclodextrin derivative solution caused by improper steam temperature cannot meet the preset conditions.

[0029] In this embodiment, preferably, the reaction plate 8 is provided with a cold air emitting device 17 at the top end. The cold air emitting device 17 is used to manufacture cold air. The freeze-drying method is used to concentrate the cyclodextrin derivative solution. The freeze-drying method can effectively preserve the molecular structure and function of the cyclodextrin derivative. Compared with the conventional evaporation concentration method, the freeze-drying method can avoid the degradation or denaturation of the cyclodextrin derivative caused by high temperature, and ensure its drug carrier, packaging and dissolution capacity and other functions.

[0030] In this embodiment, preferably, the steam pipeline 11 is fixedly provided with a steam filter screen 18 at the top end. The steam filter screen 18 can effectively filter out impurities, solid particles and small pollutants in water vapor in the steam, help to reduce the interference of steam impurities on the concentration process of the cyclodextrin derivative solution, and ensure that the cyclodextrin derivative solution can be concentrated under more effective conditions.

[0031] In this embodiment, preferably, the steam production device 9 includes an electric heating tube 19 and a steam production bin 20. The steam production device 9 is provided with the electric heating tube 19 at the bottom end. The electric heating tube 19 is fixedly provided with the steam production bin 20 at the top end. The steam door 10 is pulled open. The water resource for producing steam is put into the steam production bin 20. The electric heating tube 19 is turned on to heat the water resource and produce steam.

[0032] In this embodiment, preferably, the fixing screw 6 includes a nut 21 and a bolt 22. The fixing screw 6 is fixedly provided with the nut 21 at the top end. The nut 21 is fixedly provided with the bolt 22 at the bottom end. The beneficial effect is that the reliable mechanical connection is realized through the threaded structure, the connected parts are ensured not to be loose or fallen off, the threaded structure design makes the installation and disassembly process relatively simple, and the convenience enables the operation to be quickly performed in the case of needing maintenance and replacement, saving time and labor cost.

[0033] The cyclodextrin derivative solution concentration device of the embodiment has the advantages that when in use, the cyclodextrin derivative solution to be concentrated is put into the flow channel 7 through the solution inlet plate 1, and the evaporation concentration method or the freeze-drying method is selected according to the properties of the cyclodextrin derivative solution, when the evaporation concentration method is needed, the steam door 10 is pulled open, the water resource for producing steam is put into the steam production bin 20, the electric heating tube 19 is turned on to heat the water resource and produce steam, the steam enters the reaction plate 8 through the steam pipeline 11 to concentrate the cyclodextrin derivative solution, and after the concentration is completed, the steam enters the steam circulation pipeline 15 for the next round of concentration, when the freeze-drying method is needed, the cold air emitting device 17 is turned on to concentrate the cyclodextrin derivative solution in the reaction plate 8, the concentrated cyclodextrin derivative solution is stored in the solution storage plate 13 and taken out through the solution outlet 14. The device has the advantages that the steam circulation pipeline 15 is arranged to recycle the steam used for concentrating the biological solution, the steam circulation pipeline 15 can recycle and use the steam multiple times in the system, reduces the demand for steam, the reuse of the steam can effectively reduce energy consumption and reduce the dependence on energy, thereby reducing the operation cost of the whole system, the steam filter screen 18 is arranged to effectively filter out impurities, solid particles and small pollutants in water vapor in the steam, helps to reduce the interference of steam impurities on the concentration process of the cyclodextrin derivative solution, and ensures that the cyclodextrin derivative solution can be concentrated under more effective conditions.

[0034] The basic principle, main features and advantages of the present application are shown and described above. It should be understood by those skilled in the art that the present application is not limited by the above embodiments, and the above embodiments and descriptions in the specification are only preferred examples of the present application and do not limit the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. A cyclodextrin derivative solution concentration device, characterized by: The application discloses a biological solution concentration mechanism, which comprises a solution inlet plate (1), a solution filter screen (2), a concentration device body (3), a control device (4), a device base (5), a fixing screw (6) and a flow pipeline (7), the bottom end of the solution inlet plate (1) is fixedly provided with the solution filter screen (2), the bottom end of the solution filter screen (2) is fixedly provided with the concentration device body (3), one side of the concentration device body (3) is fixedly provided with the control device (4), the bottom end of the control device (4) is fixedly provided with the device base (5), the top end of the device base (5) is threadedly connected with the fixing screw (6), and the other side of the concentration device body (3) is fixedly provided with the flow pipeline (7). One side of the flow pipeline (7) is fixedly provided with a reaction plate (8), the bottom end of the reaction plate (8) is fixedly provided with a steam production device (9), the steam production device (9) comprises a steam door (10) and a steam pipeline (11), one side of the steam production device (9) is movably provided with the steam door (10), the top end of the steam production device (9) is fixedly provided with the steam pipeline (11), one side of the reaction plate (8) is movably provided with a flow valve (12), one side of the flow valve (12) is fixedly provided with a solution storage plate (13), and one side of the solution storage plate (13) is fixedly provided with a solution outlet (14).

2. The cyclodextrin derivative solution concentration device according to claim 1, characterized by: The top end of the solution storage plate (13) is fixedly provided with a steam circulation pipeline (15).

3. The cyclodextrin derivative solution concentration device according to claim 1, characterized by: One side of the flow pipeline (7) is provided with a temperature detection device (16).

4. The cyclodextrin derivative solution concentration device according to claim 1, characterized by: The top end of the reaction plate (8) is provided with a cold air emitting device (17).

5. The cyclodextrin derivative solution concentration device according to claim 1, characterized by: The top end of the steam pipeline (11) is fixedly provided with a steam filter screen (18).

6. The cyclodextrin derivative solution concentration device according to claim 1, characterized by: The steam production device (9) comprises an electric heating pipe (19) and a steam production bin (20), the bottom end of the steam production device (9) is provided with the electric heating pipe (19), and the top end of the electric heating pipe (19) is fixedly provided with the steam production bin (20).

7. The cyclodextrin derivative solution concentration device according to claim 1, characterized by: The fixing screw (6) comprises a nut (21) and a bolt (22), the top end of the fixing screw (6) is fixedly provided with the nut (21), and the bottom end of the nut (21) is fixedly provided with the bolt (22).

Images