Low-frequency rotating magnetic field equipment for testing performance of magnetic nanoparticles

Abstract

The utility model provides a low frequency rotating magnetic field equipment for magnetic nanoparticle performance test, including magnetic field generation mechanism and sample support mechanism wherein the magnetic field generation mechanism includes motor, turntable and magnet set, motor's output shaft is vertically upward, turntable is connected to motor's output shaft upper end, and the magnet set is connected to the motor's output shaft upper end. The magnet group comprises two magnets arranged on the turntable; the sample supporting mechanism comprises a supporting frame, a mounting block and a sample fixing frame, a rotatable vertical screw rod is arranged on the supporting frame in a penetrating mode, the mounting block is arranged on the vertical screw rod in a sleeving mode, the sample fixing frame is horizontally arranged, one end of the sample fixing frame is connected to the mounting block, and the sample fixing frame is located over the rotating disc; the motor rotates to drive the two magnets on the turntable to rotate, and the screw rotates to drive the sample fixing frame on the mounting block to move up and down. The low-frequency rotating magnetic field equipment has the advantages of being simple in structure, reliable in performance, low in cost, easy to operate and the like, and also has high practicability and universality.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles. Background Technology

[0002] Magnetic nanoparticles are a type of nanoparticle that can be manipulated using magnetic fields. The induction of cell necrosis by magnetic nanoparticles under a rotating magnetic field has attracted widespread attention in recent years. The concept of a "magnetic knife" has also been proposed, in which magnetic spike-like nanoparticles generate a mechanical force with a "rotational stirring" function under the action of a rotating magnetic field. This mechanical force can be used to destroy tumor cells, achieving the same effect as a surgical scalpel.

[0003] In the study of magnetic nanoparticles, rotating magnetic field devices are often used to conduct experiments to test the performance of nanoparticles, such as... Figure 1 The test experiment shown uses mice as experimental subjects. Magnetic nanoparticles are injected into the mice, and then the mice are placed in a rotating magnetic field device. Under the action of the rotating magnetic field, the magnetic nanoparticles move and exert their effect. After the experiment, the mice are removed and the tumor size and tumor cell count are measured to determine the destructive effect of the magnetic nanoparticles on tumor cells.

[0004] Currently, existing experiments testing the performance of magnetic spiked nanoparticles primarily utilize high-frequency rotating magnetic field (HFMM) equipment. HFMM is also a form of magnetic field therapy; however, HFMM equipment is typically complex, making it inconvenient to place on the tumor area of ​​the experimental subject and compromising experimental accuracy. Furthermore, HFMM is usually expensive, resulting in high experimental costs that are generally unaffordable. Low-frequency rotating magnetic fields, as a novel form of magnetic field therapy, are gaining increasing attention and importance in the medical community due to their non-invasiveness, high penetration, and safety. However, there is currently no dedicated low-frequency rotating magnetic field equipment for testing the performance of magnetic nanoparticles, forcing laboratories and research institutions to build their own. Therefore, to facilitate and promote research and exploration of magnetic nanoparticles and magnetic field biology, it is necessary to design a highly reliable, versatile, and practical low-frequency rotating magnetic field device. Utility Model Content

[0005] To better address the aforementioned issues, this invention provides a low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles. This device has advantages such as simple structure, reliable performance, low cost, and easy operation, and also possesses high practicality and versatility.

[0006] To achieve the above objectives, embodiments of this utility model provide a low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles, comprising a magnetic field generating mechanism and a sample support mechanism. The magnetic field generating mechanism includes a motor, a turntable, and a magnet assembly. The motor's output shaft faces vertically upwards, and the turntable is connected to the upper end of the motor's output shaft. The magnet assembly includes two magnets mounted on the turntable. The sample support mechanism includes a support frame, a mounting block, and a sample holder. A rotatable vertical screw is threaded through the support frame, and the mounting block is fitted onto the vertical screw. The sample holder is horizontally positioned with one end connected to the mounting block, and is located directly above the turntable. When the motor rotates, it drives the two magnets on the turntable to rotate; when the screw rotates, it drives the sample holder on the mounting block to move up and down.

[0007] Optionally, two magnets are positioned along a diameter of the turntable, with the two magnets being symmetrical about the center of the turntable and the spacing between them being adjustable.

[0008] Optionally, the turntable is provided with a row of positioning holes along its diameter, and two magnets are detachably mounted at two positioning holes symmetrical to the center of the turntable.

[0009] Optionally, the two magnets have threaded holes at their bottoms and are detachably mounted at two positioning holes by means of mating non-magnetic bolts.

[0010] Optionally, the turntable is also provided with two magnet mounting bases for mounting two magnets. The bottom of the two magnet mounting bases has threaded holes and they are detachably mounted at the two positioning holes by means of mating non-magnetic bolts.

[0011] Optionally, the support frame is also provided with two guide posts, which are located on both sides of the vertical screw and parallel to the vertical screw. The two ends of the mounting block are slidably sleeved on the two guide posts. When the vertical screw rotates, it drives the mounting block to move up and down along the guide posts.

[0012] Optionally, a rotating handle is connected to the top of the vertical screw.

[0013] Optionally, the mounting block is provided with two insertion holes, and one end of the sample holder has two insertion rods. The sample holder is detachably connected to the mounting block by being inserted into the two insertion holes through the two insertion rods respectively.

[0014] Optionally, it also includes a motor speed controller, which is electrically connected to the motor.

[0015] Optionally, it also includes a detachable and assembleable partition frame, which covers the outside of the magnetic field generating mechanism and the sample support mechanism.

[0016] The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to this invention uses a turntable mounted on a motor to house a magnet assembly, and a sample holder mounted above the magnet assembly. When the experimental sample is placed on the sample holder, the motor drives the magnet assembly on the turntable to rotate, generating a low-frequency rotating magnetic field for testing the performance of magnetic nanoparticles. Furthermore, a vertical screw and mounting block are used to support the sample holder on a support frame. The height of the sample holder can be adjusted by rotating the vertical screw, thereby adjusting the magnetic field strength around the sample. This facilitates testing under different magnetic field strengths, enhancing its practicality.

[0017] This low-frequency rotating magnetic field device also features an adjustable spacing between two magnets on a turntable. By adjusting the magnet spacing in conjunction with the sample height, the sample can be placed in different magnetic field intensities, making it easier to adjust different experimental magnetic field strengths. Furthermore, different sized magnets can be selected for different experimental objects, increasing its versatility and practicality. The sample height can also be adjusted by rotating a handle, and the motor operation can be controlled via buttons on the motor speed controller, simplifying operation. Additionally, the magnetic field generating mechanism, sample support mechanism, and partition frame of this low-frequency rotating magnetic field device are primarily detachable, allowing for easy disassembly and assembly, and making it convenient to carry.

[0018] This low-frequency rotating magnetic field device has the advantages of simple structure, reliable performance, low cost and simple operation. It also has high practicality and versatility, which will help promote the research and exploration of magnetic nanoparticles and magnetic field biology. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram illustrating the principle of the magnetic nanoparticle performance testing experiment according to an embodiment of the present invention.

[0021] Figure 2 This is a schematic diagram of the structure of a low-frequency rotating magnetic field device according to an embodiment of the present invention.

[0022] Figure label:

[0023] 1. Motor; 2. Turntable; 3. Magnet; 4. Support frame; 5. Mounting block; 6. Sample holder; 7. Vertical screw; 8. Guide post; 9. Positioning hole; 10. Rotary handle; 11. Motor speed controller; 12. Switch button; 13. Rotary button. Detailed Implementation

[0024] To make the above-mentioned objects, features, and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a full understanding of this utility model. However, this utility model can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this utility model. Therefore, this utility model is not limited to the following embodiments.

[0025] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

[0026] like Figure 2 As shown, the low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to an embodiment of this utility model includes a magnetic field generating mechanism and a sample support mechanism. The magnetic field generating mechanism includes a motor 1, a turntable 2, and a magnet assembly. The output shaft of the motor 1 is vertically upward, and the turntable 2 is connected to the upper end of the output shaft of the motor 1. The magnet assembly includes two magnets 3 disposed on the turntable 2. The sample support mechanism includes a support frame 4, a mounting block 5, and a sample fixing frame 6. A rotatable vertical screw 7 is passed through the support frame 4, the mounting block 5 is sleeved on the vertical screw 7, and the sample fixing frame 6 is horizontally arranged with one end connected to the mounting block 5. The sample fixing frame 6 is located directly above the turntable 2.

[0027] The magnetic field generating mechanism is used to generate a low-frequency rotating magnetic field. Specifically, the motor 1 is located below and extends upwards along its output shaft. The turntable 2 is connected to the top of the output shaft of the motor 1 and can rotate with the output shaft, thereby driving the two magnets 3 mounted on it to rotate. Both magnets 3 have one N pole and one S pole, with the N pole of one magnet 3 facing upwards and the S pole of the other magnet 3 facing upwards. The magnetic field lines of the two magnets 3 run from the N pole to the S pole, generating a low-frequency rotating magnetic field when the motor 1 drives the two magnets 3 to rotate. The sample support mechanism is used to support experimental samples (such as cell samples or mice) and adjust the height of the experimental samples. Specifically, the support frame 4 supports the vertical screw 7 and the mounting block 5. The upper part of the vertical screw 7 is rotatably inserted into a vertical threaded through hole in the support frame 4, and the lower part is rotatably inserted into a vertical threaded through hole in the mounting block 5. By rotating the vertical screw 7, the mounting block 5 is moved up and down, which in turn moves the sample holder 6 connected to the mounting block 5 up and down.

[0028] In this low-frequency rotating magnetic field device, the support frame 4 is positioned above one side of the motor 1. The sample support frame 4 is connected to the mounting block 5 on the side facing the motor 1 and is located above the turntable 2. Placing the experimental sample on the sample holder 6 allows the sample to pass through the magnetic field lines of the two magnets 3. After the sample is fixed, the motor 1 can be started to rotate the two magnets 3, generating a low-frequency rotating magnetic field for testing the performance of magnetic nanoparticles. Furthermore, by rotating the vertical screw 7 to move the sample holder 6, the height of the experimental sample can be adjusted, i.e., the distance between the experimental sample and the two magnets 3 can be adjusted. This allows for adjustment of the magnetic field strength around the experimental sample, facilitating performance testing of magnetic nanoparticles under different magnetic field intensities.

[0029] In one optional embodiment, two magnets 3 are arranged along a diameter of the turntable 2, and are symmetrical about the center of the turntable 2. The distance between the two magnets 3 is adjustable, which, combined with the method of adjusting the sample height via the vertical screw 7, makes it easier to adjust the magnetic field strength of the test experiment. Optionally, a row of positioning holes 9 is provided along a diameter of the turntable 2, the number of positioning holes 9 being even, and multiple sets of symmetrical positioning holes 9 are provided on both sides of the center of the turntable 2. The two magnets 3 are detachably arranged at two positioning holes 9 symmetrical about the center of the turntable 2. The distance between the two magnets 3 can be adjusted by installing the two magnets 3 in different sets of positioning holes 9. For example, the bottom of the two magnets 3 has threaded holes, and they are detachably installed in the two positioning holes 9 by using matching non-magnetic bolts. The installation of the magnets 3 is achieved by passing the non-magnetic bolts through the positioning holes 9 and screwing them into the threaded holes, which facilitates disassembly and adjustment of the installation position of the magnets 3. Of course, in practical applications, the installation method of the two magnets 3 is not limited to this, and other installation methods that can adjust the distance between the two magnets 3 can also be used. For example, the turntable 2 is provided with two magnet mounting bases for mounting two magnets 3. The bottom of the two magnet mounting bases has threaded holes, and they are detachably mounted at two positioning holes 9 by means of mating non-magnetic bolts. By using the non-magnetic bolts to pass through the positioning holes 9 and connect to the threaded bottom of the mounting bases, the two magnets 3 can be detachably mounted. Here, the non-magnetic bolts can be stainless steel bolts or high-strength plastic bolts (such as PEEK screws).

[0030] Optionally, the support frame 4 is further provided with two smooth guide posts, located on both sides of the vertical screw 7 and parallel to the vertical screw 7. The two ends of the mounting block 5 are slidably sleeved on the two guide posts. When the vertical screw 7 rotates, it drives the mounting block 5 to move up and down along the guide posts. Specifically, the support frame 4 can be a vertically arranged shallow U-shaped frame facing the motor 1, with upper and lower protrusions and a middle groove. The vertical screw 7 is threaded through the upper and lower protrusions. The upper and lower ends of the two guide posts are fixedly connected in the upper and lower protrusions. The mounting block 5 is located in the middle groove and spans across the two guide posts and the vertical screw 7. When the vertical screw 7 rotates, it drives the mounting block 5 to move up and down, and the mounting block 5 slides on the two guide posts. The guide posts play a limiting and guiding role. Here, the top and bottom ends of the vertical screw 7 extend out of the upper and lower protrusions of the support frame 4, respectively. The top end is connected to a rotating handle 10, which allows for easy rotation of the vertical screw 7. The bottom end is provided with a limiter to prevent the vertical screw 7 from detaching from the support frame 4 due to excessive rotation.

[0031] Optionally, the mounting block 5 has a insertion hole on the side facing the motor 1, and one end of the sample holder 6 has a plug. By engaging the plug with the insertion hole, the sample holder 6 can be connected to the mounting block 5 and easily disassembled. Here, there are two plugs and two insertion holes, and their positions and sizes are matched to ensure that the sample holder 6 is stably connected to the mounting block 5. In practical applications, the sample support frame 6 is a frame with a hollow center, specifically a square frame, a round frame, or other irregularly shaped frames, to accommodate different shaped petri dishes. Placing the petri dish on the frame allows the edge of the petri dish to be secured to the frame, while the main body of the petri dish protrudes downwards from the hollow center of the frame, placing the petri dish in a magnetic field without any other obstructions, thus making the magnetic nanoparticles react more rapidly in the rotating magnetic field.

[0032] In this embodiment, the magnetic field generating mechanism also includes a motor drive device for controlling the start, stop, forward and reverse rotation, and speed of the motor 1. The user can conveniently control the motor's operation through the motor drive device. This motor drive device can serve as a start / stop and adjustment control device for a low-frequency rotating magnetic field device. For example, the user can adjust the speed of the two magnets 3 by controlling the speed of the motor 1, thereby achieving the purpose of adjusting the speed of the rotating magnetic field. Optionally, the motor drive device includes a motor speed controller 11, which is electrically connected to the motor 1. The motor speed controller 11 has a switch button 12 for controlling the start / stop of the motor 1 and a rotary button 13 for controlling the speed of the motor 1. The user can easily control the motor 1 by performing simple operations using the buttons on the motor speed controller 11.

[0033] The low-frequency rotating magnetic field device also includes a detachable and assembleable partition frame (not shown in the figure). This partition frame includes a base plate and four side plates, each vertically positioned around the base plate. Specifically, the base plate has mounting grooves on its four sides, into which the bottoms of the four side plates can be inserted. The sides of the adjacent side plates are interconnected, for example, via snap-fit ​​components located at the edges of the side plates. This partition frame covers the outside of the magnetic field generating mechanism and the sample support mechanism to isolate external magnetic fields and prevent them from affecting the experimental results. Furthermore, the partition frame is easy to disassemble and assemble. It should be noted that the partition frame may also include a motor 1 support frame 4, placed on the base plate for fixing the motor 1; the support frame 4 is mounted on a side plate and can be detachably connected to the side plate via bolts; here, the side plate is a back plate; a through hole is provided on one side plate to facilitate the passage of the connection wires between the motor 1 and the motor speed controller 11; and the partition frame can be made of acrylic sheet, which is sturdy, durable, and highly transparent.

[0034] According to an exemplary embodiment of this utility model, when using this low-frequency rotating magnetic field device to conduct magnetic nanoparticle performance testing experiments, firstly, in the device assembly stage, the magnetic field generating mechanism, the sample support mechanism, and the partition frame are installed; then, in the experimental preparation stage, the experimental sample is placed (for cell experiments, the cell culture sample can be placed on the sample holder 6; for mouse experiments, the mouse can be placed on the sample holder 6 with the tumor site exposed), and the vertical screw 7 is rotated to adjust the sample height; in the experimental stage, the motor 1 is started and rotated by the motor speed controller 11, and after a certain time, the motor 1 is stopped, and the experimental sample is taken out to observe or test the experimental results.

[0035] In practical applications, the motor 1, motor speed controller 11, and vertical screw 7 in the low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles in this embodiment of the invention can all be devices with corresponding functions and that meet the driving force requirements of the experiment, such as a small DC motor 1 and a DC speed controller. Furthermore, the magnet 3, turntable 2, sample support frame 4, and other components in the low-frequency rotating magnetic field device can have their shapes and sizes determined according to experimental requirements. Here, the magnet 3 can include multiple sets of different sizes, each set of magnet 3 capable of generating magnetic fields of different intensities. The appropriate size of the magnet set can be selected according to the size of the test subject, such as a cell plate or a mouse tumor region. Additionally, other devices or components can be set in the low-frequency rotating magnetic field device, or the actual placement of each device or component can be adjusted to achieve the practical application or other functions of the low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles. For example, a power supply component is also included to supply power to the motor and speed controller.

[0036] It should be noted that, depending on the implementation needs, the various components described in the embodiments of this utility model can be split into more components, or two or more components or parts of components can be combined into new components to achieve the purpose of the embodiments of this utility model.

[0037] The embodiments described above are merely illustrative of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles, characterized in that, Includes a magnetic field generating mechanism and a sample support mechanism, among which, The magnetic field generating mechanism includes a motor, a turntable, and a magnet assembly. The output shaft of the motor faces vertically upward, the turntable is connected to the upper end of the output shaft of the motor, and the magnet assembly includes two magnets disposed on the turntable. The sample support mechanism includes a support frame, a mounting block, and a sample fixing frame. A rotatable vertical screw is threaded through the support frame, the mounting block is sleeved on the vertical screw, and the sample fixing frame is horizontally positioned with one end connected to the mounting block. The sample fixing frame is located directly above the turntable. When the motor rotates, it drives the two magnets on the turntable to rotate, and when the screw rotates, it drives the sample holder on the mounting block to move up and down.

2. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 1, characterized in that, The two magnets are arranged along one diameter of the turntable, and are symmetrical about the center of the turntable with an adjustable spacing.

3. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 2, characterized in that, The turntable has a row of positioning holes along its diameter, and two magnets are detachably mounted at two positioning holes symmetrical to the center of the turntable.

4. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 3, characterized in that, The two magnets have threaded holes at the bottom and are detachably mounted at the two positioning holes by matching non-magnetic bolts.

5. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 3, characterized in that, The turntable is also provided with two magnet mounting bases for mounting two magnets. The bottom of the two magnet mounting bases has threaded holes and they are detachably mounted at the two positioning holes by means of matching non-magnetic bolts.

6. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 1, characterized in that, The support frame is also provided with two guide posts, which are located on both sides of the vertical screw and are parallel to the vertical screw. The two ends of the mounting block are slidably sleeved on the two guide posts. When the vertical screw rotates, it drives the mounting block to move up and down along the guide posts.

7. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 1, characterized in that, A rotating handle is connected to the top of the vertical screw.

8. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 1, characterized in that, The mounting block has two insertion holes, and one end of the sample holder has two insertion rods. The sample holder is detachably connected to the mounting block by being inserted into the two insertion holes through the two insertion rods.

9. The low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to claim 1, characterized in that, It also includes a motor speed controller, which is electrically connected to the motor.

10. A low-frequency rotating magnetic field device for testing the performance of magnetic nanoparticles according to any one of claims 1-9, characterized in that, It also includes a detachable and assembleable partition frame, which covers the outside of the magnetic field generating mechanism and the sample support mechanism.

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