Microbubble generating device used for being connected with injector and foaming experiment injector
By installing a microbubble generator with a variable diameter channel between the syringe and the needle, uniform micro- and nano-bubbles are formed using the Venturi effect and eddy current effect. This solves the problems of uneven microbubble quality and complex operation in existing technologies, and improves the accuracy and safety of detection.
Patent Information
- Application Number
- CN202520272968.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-20
- Publication Date
- 2025-12-12
- Estimated Expiration
- 2035-02-20
AI Technical Summary
In existing foaming experiments, the preparation of microbubbles relies on the personal experience of medical staff, which leads to uneven microbubble quality, affects the accuracy of detection, and the connection of three-way valves is prone to pressure imbalance and the risk of blood spurting.
A microbubble generator is designed to generate uniform micro- and nano-bubbles by installing a variable-diameter channel between the syringe and the needle, utilizing the Venturi effect and eddy current effect. This simplifies the operation process and reduces human interference.
It improves the uniformity and stability of microbubbles, reduces the risk of bleeding, enhances the safety and accuracy of operation, and simplifies the testing process.
Smart Images
Figure CN223654794U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of medical device technology, specifically to a microbubble generator for connecting a syringe and a foaming experimental syringe. Background Technology
[0002] The basic principle of the bubble test is to inject intravenously into physiological saline that generates microbubbles through agitation, and then use ultrasound to observe whether the microbubbles appear in the left atrium, thereby determining whether there is an abnormal passage. Therefore, it can be used to examine PFO (patent foramen ovale). In addition, the bubble test can also be used for angiography of atrial septal defects, pulmonary arteriovenous fistulas, ventricular septal defects, patent ductus arteriosus, other right-to-left shunts in congenital heart diseases, iatrogenic shunts (such as after heart surgery), and shunts related to chronic obstructive pulmonary disease (COPD).
[0003] Currently, PFO (Progressive Follicle Occlusion) examination primarily uses two 10ml syringes. One syringe is injected with 9ml of normal saline + 1ml of air, while the other is empty or contains 1ml of blood drawn from the patient's median cubital vein (to enhance microbubble stability). Connected via a three-way valve, the two syringes are rapidly mixed 20 times by repeatedly pulling them to form a normal saline solution with uniform microbubbles (diameter > 10μm). Next, medical staff use pre-activated agitated normal saline solution (containing air microbubbles) to rapidly inject via the median cubital vein using a bolus injection method at a rate of 1.0-1.5mL / s, ensuring the microbubble size is controlled within the range of 10-50μm. Transcranial Doppler ultrasound (TCD) is then used to monitor the middle cerebral artery (MCA), focusing on detecting any abnormal emboli. If abnormal embolic signals are present, right ventricular echocardiography is required. The right-to-left shunt (RLS) signal on TCD appears within 9-15 seconds after microbubble injection. Right heart echocardiography is a procedure that uses an ultrasound probe to observe whether microbubbles in the right atrium of the four-chamber view have shunted to the left atrium. If the result is positive, the amount of shunted microemboli can be used to determine whether it is small, medium, or large.
[0004] However, current foaming experiments suffer from non-standard operation, relying entirely on the personal experience of medical staff. Specifically, when preparing agitated saline containing air microbubbles, the speed and number of pulls and oscillations of the syringe used to create microbubbles affect the quality of the microbubbles, including their uniform distribution and size within the saline. Furthermore, when using two syringes to prepare the microbubble-containing saline, the nurse preparing the solution must work closely with the examining physician to ensure precise intravenous injection timing. This is because the stability of the microbubbles and their distribution time in the blood affect their imaging efficacy in the heart. Injecting too quickly or too slowly can cause premature rupture or uneven distribution of the microbubbles, making it difficult to accurately detect shunts under ultrasound, potentially leading to false negatives or reduced grading, thus affecting detection sensitivity. Additionally, the current use of three-way valves in foaming experiments is prone to pressure imbalances during injection, posing a risk of blood spurting. Utility Model Content
[0005] (a) Technical problems to be solved
[0006] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a microbubble generator for connecting a syringe. By installing it between the syringe barrel and the needle, the internal structure of the microbubble generator generates a large number of uniformly distributed micro-nano bubbles with a diameter ≤50μm in the injection solution. This eliminates the need to prepare physiological saline containing microbubbles in advance by repeatedly pulling the syringe, which can greatly simplify the pre-operation of tests such as PFO and reduce detection errors caused by human factors.
[0007] (II) Technical Solution
[0008] In a first aspect, this utility model provides a microbubble generator for connecting a syringe, which includes a generator body. The generator body includes a first connecting end and a second connecting end. The first connecting end is used to connect to the liquid outlet of the syringe, and the second connecting end is used to connect to the tail end of the needle.
[0009] The generator body is provided with at least one variable diameter channel, which connects the first connection end and the second connection end. One end of the variable diameter channel is a small hole end and the other end is a large hole end. The small hole end is located at the first connection end and the large hole end is located at the second connection end. The inner diameter of the variable diameter channel gradually increases from the small hole end to the large hole end.
[0010] The diameter of the small end of each of the variable diameter channels is 0.5±0.05mm, and the diameter of the large end is 2.0±0.2mm; the length of each variable diameter channel is 30-35 times the diameter of the small end.
[0011] Preferably, the number of variable diameter channels is 1, 3, 4 or 6.
[0012] Preferably, when there are three or more variable diameter channels, each variable diameter channel is symmetrically distributed relative to the centerline of the generator body.
[0013] Preferably, the first connecting end of the generator body forms a concave surface, and an internal thread is provided on the inner wall of the concave surface; the internal thread can be threadedly connected to the external thread of the syringe outlet tube of the screw-type syringe; or, the first connecting end of the generator body forms a concave surface, and a sealing ring is provided on the inner wall of the concave surface.
[0014] The second connecting end of the generator body forms a concave surface, and an internal thread is provided on the inner wall of the concave surface. This internal thread can be threadedly connected to the external thread of the needle. Alternatively, the second connecting end of the generator body forms a concave surface, and a sealing ring is provided on the inner wall of the concave surface.
[0015] Preferably, the concave opening edge of the first connecting end has a notch or protrusion for aligning with the syringe outlet tube. After alignment with the syringe outlet tube, the syringe outlet tube is inserted into the concave surface, and a half-turn rotation is performed to screw the syringe to the first connecting end of the generator body. Preferably, the internal thread includes at least two parallel thread ribs.
[0016] Preferably, the concave opening edge of the second connecting end has a notch or protrusion for aligning the needle tip. After alignment with the needle tip, the needle tip is inserted into the concave surface, and a half-turn rotation is performed to screw the needle tip to the second connecting end of the generator body. Preferably, the internal thread includes at least two parallel thread ribs.
[0017] Secondly, this utility model also provides a foaming experimental syringe, which includes the microbubble generating device of any of the above embodiments.
[0018] Preferably, the foaming experimental syringe includes a syringe plunger, a syringe barrel, a microbubble generator, and a needle; the syringe barrel has a protruding outlet tube at its bottom, and the needle has a tip and a tail; the first connection end of the microbubble generator is connected to the outlet tube, and the second connection end of the microbubble generator is connected to the tail end of the needle.
[0019] Preferably, the syringe barrel has a volume of 10-50 mL, and the dispensing tube of the syringe barrel has external threads.
[0020] (III) Beneficial Effects
[0021] The technical advantages of this utility model are as follows:
[0022] 1. The microbubble generator provided by this utility model is a foaming experimental consumable used in conjunction with a syringe. It can be used for non-invasive imaging examination of patent foramen ovale (PFO). During use, the operator fills the syringe barrel with physiological saline containing a certain proportion of air. By pushing and squeezing, the physiological saline enters from the small end of the microbubble generator and exits from the large end. The physiological saline flows through a long variable diameter channel. Utilizing the Venturi and eddy current effects of the variable diameter channel, negative pressure and strong shear force are formed. The strong shear force breaks the bubbles in the physiological saline into micro-nano scale and makes these micro-nano scale bubbles evenly distributed in the physiological saline, thereby obtaining a saline containing a large number of uniformly distributed micro-nano bubbles with a diameter ≤50μm. This helps to improve the accuracy of the foaming experiment and reduce the interference of human factors.
[0023] When using this invention to conduct foaming experiments, the fluid control mechanism is simplified compared to the three-way valve structure when injecting bubbly saline solution into the human body. The single-tube injection resistance is directly transmitted to the operator's palm, enhancing the operator's tactile feedback. Furthermore, the structure of the syringe tip is simpler, reducing blind spots and enhancing the operator's visual monitoring, thereby greatly reducing the risk of blood spurting.
[0024] 2. The microbubble generator of this invention does not require electricity or external reagents such as Tween 80, making it safer to perform PFO testing. Compared with existing technologies, this device has the characteristics of simple structure, low preparation cost, easy assembly, and suitability for mass production.
[0025] 3. Among these, the dimensions and proportions of the variable-diameter channel are key elements in achieving this scheme. Changes in the diameters of the small and large orifices of the variable-diameter channel, as well as the length ratio of the variable-diameter channel, directly affect the size, quantity, distribution uniformity, and stabilization time of bubbles in the brine. Experiments have confirmed that when the diameter of the small orifice of the variable-diameter channel is 0.5±0.05mm and the diameter of the large orifice is 2.0±0.2mm, and the length of the variable-diameter channel is 30-35 times the diameter of the small orifice, micro-nano bubble brine that best meets the requirements of foaming experiments can be obtained.
[0026] 4. The foaming test syringe of this utility model is very simple to operate, avoiding the problems of non-standard operation, reliance on the personal experience of medical staff, difficulty in accurately controlling the injection time, and detection errors caused by operation in existing foaming tests.
[0027] 5. The foaming test syringe of this invention can be equipped with a microbubble generating device having one, three, or four variable diameter channels, depending on the testing item. Since the pressure pushing the syringe is generally a fixed value, the pressure distribution of the brine through the variable diameter channels varies with the number of channels, thereby generating shear and eddy current effects of different intensities, resulting in microbubbles of different sizes, distribution densities, and bubble stabilization times. Therefore, this invention has excellent flexibility in use. Attached Figure Description
[0028] Figure 1 This is a schematic diagram of the first connection end of the microbubble generator of this utility model.
[0029] Figure 2 This is a schematic diagram of the second connection end of the microbubble generator of this utility model.
[0030] Figure 3 Perspective view of the generator body of the utility model micro bubble generating device Figure 1 .
[0031] Figure 4 Perspective view of the generator body of the utility model micro bubble generating device Figure 2 .
[0032] Figure 5 This is an exploded view of the foaming experimental syringe of this utility model. Detailed Implementation
[0033] To better explain and facilitate understanding of this utility model, the present utility model will be described in detail below with reference to the accompanying drawings and specific embodiments.
[0034] Example 1
[0035] like Figure 1-4 The diagram shown is a structural schematic of the microbubble generator of this invention. Wherein, Figure 1 This is the first connection end of the microbubble generator. Figure 2 This is a schematic diagram of the second connection end of the microbubble generator. Figure 3-4 This is a perspective view of the generator body of the microbubble generating device 10. The microbubble generating device 10 includes a generator body 11, which includes a first connecting end 111 and a second connecting end 112. The first connecting end 111 is used to connect to the liquid outlet of the syringe, and the second connecting end 112 is used to connect to the needle. Several variable diameter channels 110 are provided inside the generator body 11, such as... Figure 3-4 As shown, in this embodiment, there are four variable diameter channels 110, which are symmetrically distributed with respect to the centerline of the generator body 11. Combined with... Figure 1-2As shown, each variable diameter channel 110 connects the first connecting end 111 and the second connecting end 112. The end of the variable diameter channel 110 passing through the first connecting end 111 is a small hole end 110a, and the end of the variable diameter channel 110 passing through the second connecting end 112 is a large hole end 110b. The inner diameter of each variable diameter channel 110 increases from the small hole end 110a to the large hole end 110b. Specifically, the diameter of the small hole end 110a is 0.5 ± 0.05 mm, and the diameter of the large hole end 110b increases from 2.0 ± 0.2 mm. The length of the variable diameter channel 110 is 30-35 times the diameter of the small hole end, preferably 15 mm-15.75 mm.
[0036] When the generator body 11 is provided with multiple variable diameter channels 110, the aperture sizes of these variable diameter channels 110 on the same cross-section may be the same or different. The figures in this embodiment illustrate a scenario with four variable diameter channels 110. In practical applications, the number of variable diameter channels 110 can be one, three, four, or six. When the number of variable diameter channels 110 is three or more, preferably, these variable diameter channels 110 are symmetrically distributed relative to the centerline of the generator body.
[0037] Combination Figure 3 As shown, the first connecting end 111 of the generator body 11 forms a concave surface (or recessed surface), and an internal thread structure 113 is provided on the inner wall of the concave surface. This internal thread structure 113 can be threadedly connected to the external thread of the liquid outlet tube of a screw-type syringe. Further, as... Figure 3 As shown, the concave opening edge of the first connecting end 111 is also provided with a protrusion 115 for aligning the syringe outlet tube. This guides the operator to quickly align the syringe outlet tube with the concave surface of the first connecting end 111, then insert the syringe outlet tube into the concave surface, and twist to quickly and tightly connect the first connecting end 111 of the generator body 11 with the syringe outlet tube. Preferably, the internal thread of the first connecting end 111 includes at least two parallel thread ribs (preferably 1 / 2 turn thread ribs). When connecting the syringe outlet tube, only a half-turn twist is needed to quickly achieve a tight connection. Figure 4 As shown, an internal thread structure 114 is provided on the inner wall of the concave surface of the second connecting end 112. This internal thread structure 114 can be threadedly connected to the external thread at the tail end of the syringe needle. Further, as... Figure 4As shown, the concave surface of the second connecting end 112 has a protrusion 116 at the edge of the opening for aligning the syringe needle tip. This guides the operator to quickly align the syringe needle tip with the concave surface of the second connecting end 112, then insert the syringe needle tip into the concave surface. By twisting, the second connecting end 112 of the generator body 11 and the syringe needle can be quickly and tightly connected. Preferably, the internal thread of the second connecting end 112 includes at least two parallel thread ribs (preferably 1 / 2 turn thread ribs). When connecting the syringe needle, only a half-turn twist is needed to quickly achieve a tight connection. The generator body 11 can be set to a total length of 21mm-23mm, and the depth of the concave surfaces at both ends is approximately 3-4mm.
[0038] The microbubble generator 10 of this invention can be integrally molded using 3D precision printing technology. It can be a single-piece structure or a combination of multiple components. In a preferred embodiment, the inner diameter of the variable-diameter channel 110 gradually increases proportionally along its length at a linear speed, forming a regular frustum geometry within the channel. Alternatively, in another embodiment, the inner diameter of the variable-diameter channel 110 increases abruptly along its length, forming a multi-section geometry of cylinders or frustums connected together, with stepped surfaces at the joints. Or, in yet another embodiment, the inner diameter of the variable-diameter channel 110 changes in a combination of gradual and abrupt increases along its length, forming a geometry where a frustum connects to a cylinder or frustum with a suddenly increasing diameter, also with stepped surfaces at the joints.
[0039] like Figure 5The diagram shown is an exploded view of a foaming experimental syringe according to this invention. The syringe includes a syringe plunger 20, a syringe barrel 30, a microbubble generator 10, a needle 40, and a needle cap 50. The syringe plunger 20, syringe barrel 30, needle 40, and needle cap 50 can be manufactured according to the standard specifications of intravenous syringes without modification, such as a threaded intravenous syringe with a capacity of 10-50 mL. The syringe barrel 30 has a protruding outlet tube 31 at its lower end, and the needle 40 has a tip and a tail end 42. The outlet tube 31 has external threads, which are threaded into the internal threads of the concave surface of the first connecting end 111 of the microbubble generator 10. The tail end 42 of the needle 40 can be threaded into the internal threads of the concave surface of the second connecting end 112 of the microbubble generator 10. Preferably, the tail end 42 of the needle 40 can be provided with both internal and external threads. When it is necessary to connect with the microbubble generator 10, the external thread of the tail end 42 is connected to the internal thread of the microbubble generator 10. When it is not necessary to use the microbubble generator 10 to generate microbubbles, the internal thread of the tail end 42 of the needle 40 is directly threaded to the external thread of the liquid outlet tube 31 below the syringe 30.
[0040] Example 2
[0041] In this embodiment, the first connecting end 111 of the microbubble generator 10 forms a threadless concave surface, and a sealing ring is provided on the inner wall of the concave surface, thereby enabling a tight fit connection with a non-screw-type syringe. Specifically, the outwardly protruding outlet tube of the syringe barrel is inserted into the concave surface of the first connecting end 111 of the microbubble generator 10, and after being pushed and pressed, the syringe barrel is connected to the microbubble generator 10. Similarly, a sealing ring is provided in the concave surface of the second connecting end 112 of the microbubble generator 10, and the needle tip is fixedly connected to the second connecting end 112 of the microbubble generator 10 in a tight fit manner. In addition, at least one end of the microbubble generator 10 can be provided as a protruding connecting structure, with an injection fluid flow channel provided in the middle of the protruding structure, and an external thread or snap-fit structure provided on the outside of the protruding structure, using the external thread or snap-fit structure to fixally connect to the syringe outlet or the needle tip respectively.
[0042] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features. These modifications or substitutions, or combinations of technical features in the above embodiments that do not conflict with each other, can be made in accordance with the manner described in the embodiments. These modifications, substitutions or combinations do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model.
Claims
1. A microbubble generator for connecting a syringe, characterized in that, Includes a generator body, the generator body including a first connecting end and a second connecting end, the first connecting end being used to connect to the liquid outlet of the syringe, and the second connecting end being used to connect to the tail end of the needle; The generator body is provided with at least one variable diameter channel, which connects the first connection end and the second connection end. One end of the variable diameter channel is a small hole end and the other end is a large hole end. The small hole end is located at the first connection end and the large hole end is located at the second connection end. The inner diameter of the variable diameter channel gradually increases from the small hole end to the large hole end. The diameter of the small end of each of the variable diameter channels is 0.5±0.05mm, and the diameter of the large end is 2.0±0.2mm; the length of each variable diameter channel is 30-35 times the diameter of the small end.
2. The microbubble generator for connecting a syringe according to claim 1, characterized in that, The number of variable diameter channels is 1, 3, 4 or 6.
3. The microbubble generator for connecting a syringe according to claim 1, characterized in that, When there are three or more variable diameter channels, each variable diameter channel is symmetrically distributed relative to the center line of the generator body.
4. The microbubble generator for connecting a syringe according to claim 1, characterized in that, The first connecting end of the generator body forms a concave surface, and an internal thread is provided on the inner wall of the concave surface; or, the first connecting end of the generator body forms a concave surface, and a sealing ring is provided on the inner wall of the concave surface. The second connecting end of the generator body forms a concave surface, and an internal thread is provided on the inner wall of the concave surface; or, the second connecting end of the generator body forms a concave surface, and a sealing ring is provided on the inner wall of the concave surface.
5. The microbubble generator for connecting a syringe according to claim 4, characterized in that, The concave opening edge of the first connecting end is provided with a notch or protrusion for aligning with the liquid outlet tube of the syringe, and the internal thread includes at least two parallel thread ribs.
6. The microbubble generator for connecting a syringe according to claim 4, characterized in that, The concave opening edge of the second connecting end is provided with a notch or protrusion for aligning the tail end of the needle, and the internal thread includes at least two parallel thread ribs.
7. A foaming experimental syringe, characterized in that, It includes the microbubble generating device according to any one of claims 1-6.
8. The foaming experimental syringe according to claim 7, characterized in that, The foaming experimental syringe includes a syringe plunger, a syringe barrel, a microbubble generator, and a needle; the syringe barrel has a protruding outlet tube at its bottom, and the needle has a tip and a tail end; the first connection end of the microbubble generator is connected to the outlet tube, and the second connection end of the microbubble generator is connected to the tail end of the needle.
9. The foaming experimental syringe according to claim 8, characterized in that, The syringe has a syringe volume of 10-50 mL, and the syringe outlet tube has external threads.