Chemiluminescence immunoassay analyzer and integrated magnetic bead cleaning device

Abstract

The utility model discloses a chemiluminescence immunoassay analyzer and an integrated magnetic bead cleaning device, the integrated magnetic bead cleaning device comprises: a support frame, the support frame comprises a base and a vertical plate; the liquid suction mechanism is movably installed on the vertical plate of the supporting frame in the vertical direction, and the liquid suction mechanism is provided with a waste liquid needle; the turntable adsorption mechanism is rotatably mounted on the support frame in the horizontal direction, and a follow-up reaction tube is mounted on the turntable adsorption mechanism; the uniform mixing and needle washing mechanism is movably mounted on the base in the vertical direction and moves in the direction close to or away from the turntable adsorption mechanism; the uniform mixing and needle washing mechanism comprises a uniform mixing head and a needle washing pool, the uniform mixing head is communicated with or separated from the reaction tube, and the waste liquid needle enters or leaves the needle washing pool. Therefore, the probability of pollution is reduced, and the maintenance period is shortened.

Description

TECHNICAL FIELD

[0001] The utility model relates to chemical luminescence detection technical field, concretely relates to a chemical luminescence immunoassay analyzer and integrated formula magnetic bead cleaning device. BACKGROUND

[0002] Chemiluminescence labeled immunoassay is also called chemiluminescence immunoassay, and the chemiluminescence immunoassay analyzer comprises two parts, namely an immune reaction system and a chemiluminescence analysis system. The chemiluminescence analysis system utilizes a chemiluminescent substance to form an excited-state intermediate through the catalysis of a catalyst and the oxidation of an oxidizing agent, and emits photons when the excited-state intermediate returns to a stable ground state. The immune reaction system directly labels the luminescent substance on the antigen or antibody, or the enzyme acts on the luminescent substrate.

[0003] In the prior art, the magnetic bead cleaning device of the analyzer can only complete the cleaning of the magnetic beads, lacks a structure capable of realizing cleaning of the waste liquid needle, and thus the waste liquid needle can only be manually cleaned and wiped by artificial, which is prone to cause pollution and prolongs the maintenance cycle. UTILITY MODEL CONTENT

[0004] Therefore, the utility model embodiment provides a chemiluminescence immunoassay analyzer and integrated formula magnetic bead cleaning device to realize cleaning of the waste liquid needle, so as to reduce the pollution probability and shorten the maintenance cycle.

[0005] In order to achieve the above purpose, the utility model embodiment provides the following technical scheme:

[0006] The utility model provides a kind of integrated formula magnetic bead cleaning device, comprising:

[0007] Support frame, the support frame includes base and vertical plate;

[0008] Liquid suction mechanism, the liquid suction mechanism is vertically movably installed on the vertical plate of the support frame, and the liquid suction mechanism has waste liquid needle;

[0009] Rotary disc adsorption mechanism, the rotary disc adsorption mechanism is horizontally rotatably installed on the support frame, and the rotary disc adsorption mechanism is installed with reaction tube following motion;

[0010] Mixing needle cleaning mechanism, the mixing needle cleaning mechanism is vertically movably installed on the base, and moves to the direction close to or away from the rotary disc adsorption mechanism;The mixing needle cleaning mechanism includes mixing head and needle cleaning pool, the mixing head is communicated or separated with the reaction tube, and the waste liquid needle enters or leaves the needle cleaning pool by height control.

[0011] In some embodiments, the liquid suction mechanism comprises:

[0012] The mounting base is slidably mounted vertically on the vertical plate, and the mounting base has at least one mounting position.

[0013] A liquid suction lifting motor is mounted on the support frame and is connected to the mounting base in a transmission manner.

[0014] Waste liquid needles are installed one-to-one at the mounting positions.

[0015] In some embodiments, the vertical plate is further provided with a vertical guide rail, and the mounting base is slidably mounted on the vertical guide rail.

[0016] In some embodiments, the rotary adsorption mechanism includes:

[0017] A drive assembly, which is mounted on the support frame;

[0018] A turntable, which is connected to the drive assembly for driving horizontal rotation under the drive of the drive assembly;

[0019] The waste liquid needle guide mechanism drives the waste liquid needle to move up and down.

[0020] The reaction tube is moved on the magnetic separation turntable;

[0021] The injection needle is fixed on the magnetic separation plate cover to inject liquid into the reaction tube.

[0022] In some embodiments, the driving component includes:

[0023] Turntable motor;

[0024] The turntable drive wheel is connected to the output shaft of the turntable motor.

[0025] A driven wheel for a turntable, the driven wheel for a turntable being mounted on the turntable;

[0026] A turntable drive belt is wound around the turntable drive wheel and the turntable driven wheel.

[0027] In some embodiments, the mixing and washing needle mechanism includes:

[0028] A mixing and lifting motor, wherein the mixing and lifting motor is mounted on the base;

[0029] A support plate, wherein the support plate is connected to the mixing and lifting motor via a transmission;

[0030] A mixing head, which is mounted on the support plate;

[0031] A needle washing pool is mounted on the support plate.

[0032] In some embodiments, there are multiple mixing heads and needle washing tanks, spaced apart from each other on the support plate; the mixing and needle washing mechanism further includes:

[0033] A mixing motor is connected to the support plate to drive the support plate to rotate in the horizontal direction.

[0034] This invention also provides a chemiluminescence immunoassay analyzer, including the integrated magnetic bead cleaning device described above.

[0035] In one or more specific embodiments, the integrated magnetic bead cleaning device provided by this utility model has the following technical effects:

[0036] The integrated magnetic bead cleaning device provided by this utility model has a waste liquid needle cleaning and guiding structure, which can effectively reduce the occurrence of contamination and shorten the maintenance cycle. The mixing head with an eccentric mixing design where the mixing hole position and the rotation center are not concentric can effectively improve the mixing efficiency and cleaning effect. In this way, the waste liquid needle cleaning structure is integrated into the magnetic bead cleaning device to realize the mechanized cleaning of waste liquid needles, thereby reducing the probability of contamination and shortening the maintenance cycle. Attached Figure Description

[0037] To more clearly illustrate the embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0038] The structures, proportions, sizes, etc. illustrated in this specification are only for the purpose of assisting those skilled in the art in understanding and reading the content disclosed herein, and are not intended to limit the implementation conditions of this utility model. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportions, or adjustments to the size, without affecting the effects and objectives that this utility model can produce, should still fall within the scope of the technical content disclosed in this utility model.

[0039] Figure 1 A schematic diagram of the integrated magnetic bead cleaning device provided by this utility model;

[0040] Figure 2 This is a schematic diagram of the liquid suction mechanism in the integrated magnetic bead cleaning device provided by this utility model;

[0041] Figure 3 This is a schematic diagram of the rotating disk adsorption mechanism in the integrated magnetic bead cleaning device provided by this utility model.

[0042] Figure 4 This is a schematic diagram of the mixing and washing needle mechanism in the chemiluminescence immunoassay analyzer provided by this utility model. Detailed Implementation

[0043] The following specific embodiments illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0044] In one specific implementation, such as Figures 1-4 As shown, this utility model provides an integrated magnetic bead cleaning device for a chemiluminescence immunoassay analyzer. The device includes a support frame 4, a liquid suction mechanism 1, a rotary adsorption mechanism 2, and a mixing and washing needle mechanism 3. The support frame 4 serves as the foundation of the entire device, supporting the remaining working components. In this embodiment, the support frame 4 includes a base and a vertical plate mounted on the base. The liquid suction mechanism 1 is vertically movably mounted on the vertical plate of the support frame 4 and has a waste liquid needle 101. The rotary adsorption mechanism 2 is horizontally rotatably mounted on the support frame 4, and a follow-up reaction tube 202 is mounted on the rotary adsorption mechanism 2. The mixing and washing needle mechanism 3 is vertically movably mounted on the base and moves towards or away from the rotary adsorption mechanism 2. The mixing and washing needle mechanism 3 includes a mixing head 306 and a washing needle pool 305. The mixing head 306 is connected to or separated from the reaction tube 202, and the waste liquid needle 101 enters or leaves the washing needle pool 305.

[0045] In some embodiments, such as Figure 2 As shown, the liquid suction mechanism 1 includes a mounting base 102, a liquid suction lifting motor, and a waste liquid needle 101. The mounting base 102 is slidably mounted on the vertical plate in the vertical direction, and at least one mounting position is provided on the mounting base. The liquid suction lifting motor is mounted on the support frame and is connected to the mounting base 102 in a transmission manner. The waste liquid needles 101 are installed on the mounting positions one by one.

[0046] To improve the guidance of the vertical movement of the liquid suction mechanism, a vertical guide rail is also provided on the vertical plate, and the mounting base is slidably mounted on the vertical guide rail.

[0047] In some embodiments, such as Figure 3As shown, the rotary adsorption mechanism 2 includes a drive assembly, a rotary disk 206, a position sensor 203, a zero-position sensor 205, a waste liquid needle guide mechanism, and an injection needle 204. The drive assembly is mounted on the support frame, and the rotary disk 206 is connected to the drive assembly for horizontal rotation. The waste liquid needle guide mechanism guides the waste liquid needle, preventing it from rubbing against the wall of the reaction tube.

[0048] The driving assembly is a motor-driven belt drive structure, specifically including a turntable motor 201, a turntable drive pulley, a turntable driven pulley, and a turntable drive belt 207. The turntable drive pulley is connected to the output shaft of the turntable motor, the turntable driven pulley is mounted on the turntable, and the turntable drive belt is wound around the turntable drive pulley and the turntable driven pulley. When the turntable motor starts, it drives the turntable drive pulley to rotate, which in turn drives the turntable driven pulley to rotate via the turntable drive belt 207, thereby driving the turntable 206 to rotate.

[0049] In some embodiments, such as Figure 4 As shown, the mixing and washing needle mechanism 3 includes a mixing and lifting motor 303, a support plate 304, a mixing head 306, and a washing needle pool 305. The mixing and lifting motor 303 is mounted on the base, the support plate 304 is connected to the mixing and lifting motor 303, the mixing head 306 is mounted on the support plate 304, and the washing needle pool 305 is mounted on the support plate 304. During the washing process, the mixing and washing needle mechanism 3 moves upward, and the waste liquid needle 101 moves downward, extending the waste liquid needle 101 into the washing needle pool 305. The washing needle pool 305 contains flowing washing liquid, which cleans the outer wall of the waste liquid needle 101.

[0050] In some embodiments, there are multiple mixing heads 306 and needle washing pools 305, which are spaced apart on the support plate 304; the mixing and needle washing mechanism 3 further includes a mixing motor 301, which is connected to the support plate 304 to drive the support plate 304 to rotate in the horizontal direction.

[0051] The mixing head 306 includes an eccentric hole. After the mixing head moves up, the bottom of the reaction cup enters the eccentric hole, and the eccentric rotation of the eccentric hole causes the reaction cup to vibrate and mix.

[0052] In addition to the aforementioned integrated magnetic bead cleaning device, this utility model also provides a chemiluminescence immunoassay analyzer that includes the integrated magnetic bead cleaning device. For the structure of other parts of the chemiluminescence immunoassay analyzer, please refer to the prior art, which will not be described in detail here.

[0053] When the equipment is working normally, such as Figure 1The rotary adsorption mechanism 2 shown has a rotary motor 201 that drives the rotary disk 206 to rotate via a rotary drive belt 207. This causes the reaction tube 202 to move below the injection needle 204. The injection needle 204 then injects liquid into the reaction tube 202. The mixing and lifting motor 303 pushes the mixing and washing mechanism upwards until the mixing head 306 contacts the reaction tube 202. Then, the mixing motor 301 drives the mixing head 306 to rotate and the reaction cup 202 to vibrate via the mixing drive belt 302, using the liquid in the mixing cup for cleaning. The rotary adsorption mechanism moves the reaction tube 202 to the adsorption position. The magnet attracts the magnetic beads inside the reaction tube to the side wall. The liquid suction mechanism 1 moves downwards, and the waste liquid needle 101 draws the liquid out of the reaction tube. The waste liquid needle 101 moves upwards, and the reaction tube moves to the next injection position. The waste liquid needle 101 moves downwards into the washing pool 305 to clean the outer wall of the needle, preventing waste liquid residue.

[0054] In the above specific embodiments, the integrated magnetic bead cleaning device provided by this utility model has a waste liquid needle cleaning and guiding structure, which can effectively reduce the occurrence of contamination and shorten the maintenance cycle. The mixing head with an eccentric mixing design can effectively improve the mixing efficiency and cleaning effect. In this way, the waste liquid needle cleaning structure is integrated into the magnetic bead cleaning device, and a compact structure is adopted to integrate multiple cleanings into a small area, realizing the mechanized cleaning of waste liquid needles, thereby reducing the probability of contamination and shortening the maintenance cycle.

[0055] The above specific embodiments further illustrate the purpose, technical solution, and beneficial effects of this utility model. It should be understood that the above are only specific embodiments of this utility model and are not intended to limit the scope of protection of this utility model. Any modifications, equivalent substitutions, improvements, etc., made on the basis of the technical solution of this utility model should be included within the scope of protection of this utility model.

Claims

1. An integrated magnetic bead cleaning device, characterized in that, include: The support frame includes a base and a vertical plate; A liquid suction mechanism is movably mounted vertically on the vertical plate of the support frame, and the liquid suction mechanism has a waste liquid needle; A rotating adsorption mechanism is rotatably mounted on the support frame in a horizontal direction, and a follow-up reaction tube is mounted on the rotating adsorption mechanism. A mixing and washing needle mechanism is vertically movably mounted on the base and moves toward or away from the turntable adsorption mechanism. The mixing and washing needle mechanism includes a mixing head and a washing needle pool. The mixing head is connected to or separated from the reaction tube, and the waste liquid needle enters or leaves the washing needle pool by continuing to move downward.

2. The integrated magnetic bead cleaning device according to claim 1, characterized in that, The liquid suction mechanism includes: The mounting base is slidably mounted vertically on the vertical plate, and the mounting base has at least one mounting position. A liquid suction lifting motor is mounted on the support frame and is connected to the mounting base in a transmission manner. Waste liquid needles are installed one-to-one at the mounting positions.

3. The integrated magnetic bead cleaning device according to claim 2, characterized in that, The vertical plate is also provided with a vertical guide rail, and the mounting base is slidably mounted on the vertical guide rail.

4. The integrated magnetic bead cleaning device according to claim 1, characterized in that, The rotary adsorption mechanism includes: A drive assembly, which is mounted on the support frame; A turntable, which is connected to the drive assembly for driving horizontal rotation under the drive of the drive assembly; The waste liquid needle guide mechanism is fixed on the magnetic separation disk cover; The reaction tube is located on the magnetic separation turntable; The injection needle is fixed on the magnetic separation disk cover and injects liquid into the reaction tube.

5. The integrated magnetic bead cleaning device according to claim 4, characterized in that, The driving component includes: Turntable motor; The turntable drive wheel is connected to the output shaft of the turntable motor. A driven wheel for a turntable, the driven wheel for a turntable being mounted on the turntable; A turntable drive belt is wound around the turntable drive wheel and the turntable driven wheel.

6. The integrated magnetic bead cleaning device according to claim 1, characterized in that, The mixing and washing needle mechanism includes: A mixing and lifting motor, wherein the mixing and lifting motor is mounted on the base; A support plate, wherein the support plate is connected to the mixing and lifting motor via a transmission; A mixing head, which is mounted on the support plate; A needle washing pool is mounted on the support plate.

7. The integrated magnetic bead cleaning device according to claim 6, characterized in that, There are multiple mixing heads and needle washing tanks, spaced apart on the support plate; the mixing and needle washing mechanism further includes: A mixing motor is connected to the support plate to drive the support plate to rotate in the horizontal direction.

8. A chemiluminescence immunoassay analyzer, characterized in that, Includes the integrated magnetic bead cleaning device as described in any one of claims 1-7.

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