Liquid level height detection device for cell filter

Abstract

The utility model belongs to the technical field of liquid level detection, and provides a liquid level height detection device for a cell filter, which comprises a PCB (printed circuit board), a bracket and a transparent cell filter, the cell filter is vertically arranged on the support, a row of light emitting tubes and a row of light sensitive tubes are vertically arranged on the support, the light emitting tubes and the light sensitive tubes are in one-to-one correspondence, and the light emitting tubes and the light sensitive tubes are electrically connected with the PCB. According to the device, a row of luminescent tubes and a row of photosensitive tubes are arranged on the two sides of a transparent cell filter respectively, when a blood sample exists in the cell filter, light of the luminescent tubes cannot penetrate through blood to be received by the photosensitive tubes, and when the blood in the cell filter is slowly filtered and the liquid level descends below the luminescent tubes and the photosensitive tubes, the light of the luminescent tubes cannot penetrate through the blood to be received by the photosensitive tubes. And light emitted by the light-emitting tube can be received by the light-sensitive tube, so that the liquid level height position of the sample can be judged. And secondly, when the air leakage phenomenon occurs at the interface below the cell filter, the condition that the sample liquid level does not descend or the descending speed is very slow can occur, and at the moment, the change of the liquid level can be detected in time.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of liquid level detection, specifically relates to a cell filter liquid level height detection device. BACKGROUND

[0002] Circulating tumor cells (Circulating Tumor Cells, referred to as CTCs) are tumor cells that are released into peripheral blood circulation from solid tumors or metastatic lesions spontaneously or due to diagnostic and treatment operations, and are an important reason for postoperative recurrence and distant metastasis of malignant tumor patients. In recent years, with the continuous improvement of detection technology, CTC detection as a new type of non-invasive diagnostic tool has become a hot spot in clinical research in the application of early detection of postoperative recurrence and distant metastasis of patients, evaluation of efficacy and prognosis, etc.

[0003] The number of CTCs in peripheral blood is extremely small, and usually only a few tumor cells are found in about 1 billion white blood cells and 500 billion red blood cells, so in order to improve the detection rate of CTCs, CTC enrichment is usually required before detection, that is, CTCs are separated from blood or other samples. The current CTC enrichment method mainly includes enrichment method based on the physical properties of CTCs. The enrichment method based on the physical properties of CTCs mainly includes filtration method.

[0004] The filtration method is a separation method based on the size of tumor cells, which mainly separates tumor cells according to the size difference between tumor cells and normal cells. This physical method separates the cell morphology intact, and the surface of various antigen or molecular markers is not damaged, which does not affect the characteristics of the cells, provides good conditions for subsequent detection, and the equipment technical requirements of the method are not high, and the process is easy to master.

[0005] In the separation method, a cell filter is usually used for separation. However, due to individual differences of samples or differences in sample storage time, etc., the sample may not be smooth or the microporous filter membrane may be blocked during cell separation. In the prior art, whether the cell filter is blocked is judged by a pressure detection system, but the sample liquid level drop height cannot be judged, and thus the sample filtration progress and whether the filtration is completed to stop the filtration cannot be determined.

[0006] Secondly, when the cell filter lower interface leaks, the sample liquid level may not drop or drop very slowly, and the pressure detection system cannot detect it. UTILITY MODEL CONTENTS

[0007] In view of the deficiencies in the prior art, the utility model provides a cell filter liquid level height detection device, which can solve the above problems.

[0008] In order to achieve the above object, the utility model discloses the following technical scheme: a cell filter liquid level height detection device, including PCB, support, transparent cell filter,

[0009] The cell filter is arranged on the support in the vertical direction, a row of light emitting tubes and a row of light sensitive tubes are arranged on the support in the vertical direction, the light emitting tube and the light sensitive tube correspond one by one, the light emitting tube and the corresponding light sensitive tube are arranged oppositely, and the light emitting tube and the corresponding light sensitive tube are located on the two sides of the cell filter respectively, and the light emitting tube and the light sensitive tube are electrically connected with the PCB.

[0010] As preferred, the PCB is arranged on the support.

[0011] As preferred, the PCB is arranged on the support.

[0012] As preferred, the support comprises a first clamping plate and a second clamping plate, the first clamping plate and the second clamping plate jointly form a U-shaped clamping structure, and the cell filter is arranged inside the U-shaped clamping structure.

[0013] As preferred, a row of first mounting holes are arranged on the first clamping plate, the first mounting hole corresponds to the light emitting tube one by one, and the light emitting tube is arranged in the corresponding first mounting hole.

[0014] As preferred, a row of first let -go slots are arranged on the first clamping plate, the first let -go slot corresponds to the first mounting hole one by one, one end of the first let -go slot is communicated with the corresponding first mounting hole, and the other end of the first let -go slot extends to the side wall of the first clamping plate.

[0015] As preferred, a row of second mounting holes are arranged on the second clamping plate, the second mounting hole corresponds to the light sensitive tube one by one, and the light sensitive tube is arranged in the corresponding second mounting hole.

[0016] As preferred, a row of second let -go slots are arranged on the second clamping plate, the second let -go slot corresponds to the second mounting hole one by one, one end of the second let -go slot is communicated with the corresponding second mounting hole, and the other end of the second let -go slot extends to the side wall of the second clamping plate.

[0017] Compared with the prior art, the utility model has the beneficial effects that:

[0018] The utility model provides a kind of cell filter liquid level height detection device, is provided with a row of luminous tube and a row of photosensitive tube respectively on the both sides of transparent cell filter.When there is blood sample in cell filter, the light of luminous tube cannot pass through blood and be received by photosensitive tube, when blood in cell filter is filtered slowly, liquid surface drops to below luminous tube and photosensitive tube, the light emitted by luminous tube can be received by photosensitive tube, so that the sample liquid surface height position is judged out.The detection result is accurate and reliable, avoids the reduction of cell retention rate due to invalid filtration.

[0019] Secondly, when air leakage phenomenon appears in the interface below cell filter, sample liquid surface will not drop or drop very slowly, at this time, whether air leakage phenomenon can be detected in time through liquid surface change. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a kind of cell filter liquid level height detection device's stereoscopic structure schematic diagram provided for the utility model embodiment;

[0021] Figure 2 It is a kind of cell filter liquid level height detection device's explosion structure schematic diagram provided for the utility model embodiment;

[0022] Figure 3 It is a kind of cell filter liquid level height detection device's support stereoscopic structure schematic diagram one provided for the utility model embodiment;

[0023] Figure 4 It is a kind of cell filter liquid level height detection device's support stereoscopic structure schematic diagram two provided for the utility model embodiment.

[0024] In the drawings, the component list represented by each mark is as follows:

[0025] 1, PCB;

[0026] 2, support;201, first clamping plate;202, second clamping plate;203, first mounting hole;204, second mounting hole;205, first let -go slot;206, second let -go slot;

[0027] 3, cell filter;

[0028] 4, luminous tube;

[0029] 5, photosensitive tube. DETAILED DESCRIPTION

[0030] In order to make the technical solutions and advantages of the embodiments of the present application clearer, the exemplary embodiments of the present application are further described in detail below with reference to the drawings. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0031] The present embodiment provides a cell filter liquid level detection device, which comprises a PCB1, a bracket 2, and a transparent cell filter 3.

[0032] The cell filter 3 is arranged vertically on the bracket 2. The bracket 2 is provided with a row of light emitting tubes 4 and a row of light sensitive tubes 5 vertically. The light emitting tubes 4 correspond to the light sensitive tubes 5 one by one. The light emitting tubes 4 are arranged opposite to the corresponding light sensitive tubes 5, and the light emitting tubes 4 and the corresponding light sensitive tubes 5 are respectively located on both sides of the cell filter 3.

[0033] For example, referring to Figures 1-2 , the cell filter 3 is mounted on the bracket 2, and the cell filter 3 is arranged vertically and used for filtering blood samples. The bracket 2 is provided with a plurality of light emitting tubes 4, which are uniformly and vertically spaced. The bracket 2 is also provided with a plurality of light sensitive tubes 5, which are uniformly and vertically spaced. The light emitting tubes 4 correspond to the light sensitive tubes 5 one by one. The emitting end of the light emitting tube 4 is arranged opposite to the receiving end of the corresponding light sensitive tube 5, and the height positions are the same. The central axis of the cell filter 3 is located between the emitting end of the light emitting tube 4 and the receiving end of the corresponding light sensitive tube 5, so that the light emitted by the light emitting tube 4 can pass through the central axis of the cell filter 3 and then be received by the light sensitive tube 5.

[0034] The light emitting tubes 4 and the light sensitive tubes 5 are electrically connected to the PCB1.

[0035] The PCB1 is a printed circuit board, which can be integrated with a controller, a power supply, a ground wire, etc. The light emitting tubes 4 can be respectively electrically connected to the power supply and the ground wire, and the power supply provides power to realize normal light emission of the light emitting tubes 4. The light sensitive tubes 5 can be electrically connected to the controller. The light sensitive tubes 5 can receive the light emitted by the light emitting tubes 4, convert the light signal into an electric signal, and then transmit the electric signal to the controller, so as to determine whether there is a blood sample at the height position of the light emitting tube 4. Specifically, if the light sensitive tube 5 can receive the light signal, it indicates that the liquid level has dropped below the height position. If the light sensitive tube 5 cannot receive the light signal, it indicates that the liquid level has not dropped to the height position.

[0036] In summary, the cell filter liquid level detection device provided by the embodiment provides that the cell filter 3 is a transparent structure, the light of the light emitting tube 4 can pass through the cell filter 3, but cannot pass through the blood sample. Therefore, when the cell filter 3 has the blood sample, the light of the light emitting tube 4 cannot pass through the blood and is received by the photosensitive tube 5, when the blood in the cell filter 3 is slowly filtered, the liquid surface drops below the light emitting tube 4 and the photosensitive tube 5, the light emitted by the light emitting tube 4 can be received by the photosensitive tube 5 opposite, and the information is transmitted to the controller of the PCB 1, so that the sample liquid surface height position is judged. The detection result is accurate and reliable, and the cell retention rate is reduced due to invalid filtration.

[0037] Secondly, when the interface below the cell filter 3 appears air leakage, the sample liquid surface will not drop or drop very slowly, at this time, the liquid surface change can be used to detect whether there is air leakage.

[0038] When the cell filter 3 appears sample wall hanging, whether the sample wall hanging or the sample liquid surface always does not appear change can be judged by combining whether the photosensitive tube 5 below the wall hanging position receives the light signal.

[0039] On the basis of the above technical scheme, in the technical scheme provided by the embodiment, the PCB 1 can be integrated with an alarm, and the controller is electrically connected with the alarm. When the sample liquid surface does not drop or drops very slowly, the controller transmits a signal to the alarm to alarm and warn the staff that there may be air leakage and timely processing.

[0040] In the technical scheme provided by the embodiment, the PCB 1 can be arranged on the support 2.

[0041] Further, the PCB 1 is mounted on the support 2 by bolts.

[0042] For example, referring to Figures 1-2 The support 2 is provided with four mounting seats with screw holes, and the PCB 1 is provided with through holes at four corners, and the four through holes correspond to the four mounting seats one by one. The bolt is screwed and fixed through the through hole and the corresponding mounting seat, so that the PCB 1 is locked and fixed on the support 2.

[0043] The embodiment provides a specific implementation mode of the support 2: the support 2 includes a first clamping plate 201 and a second clamping plate 202, and the first clamping plate 201 and the second clamping plate 202 jointly form a U-shaped clamping structure, and the cell filter 3 is arranged on the inner side of the U-shaped clamping structure.

[0044] For example, referring to Figure 3The first clamping plate 201 and the second clamping plate 202 are vertically arranged, the left end of the first clamping plate 201 is connected with the left end of the second clamping plate 202, and together they form a U-shaped clamping structure. The U-shaped clamping structure is matched with the cell filter 3, and the opening faces right, and the mounting seat with the screw hole is arranged at the left end of the U-shaped clamping structure, that is, the PCB1 is installed on the back of the opening of the U-shaped clamping structure, so that the interference phenomenon between the cell filter 3 and the PCB1 during disassembly and assembly can be avoided.

[0045] The first clamping plate 201 is provided with a row of first mounting holes 203, and the first mounting hole 203 corresponds to the light-emitting tube 4 one by one, and the light-emitting tube 4 is arranged in the corresponding first mounting hole 203.

[0046] Further, the first clamping plate 201 is provided with a row of first let go slots 205, and the first let go slots 205 correspond to the first mounting holes 203 one by one. One end of the first let go slots 205 is in communication with the corresponding first mounting holes 203, and the other end of the first let go slots 205 extends to the side wall of the first clamping plate 201.

[0047] For example, referring to Figure 3 The first clamping plate 201 is provided with a plurality of first mounting holes 203, and the plurality of first mounting holes 203 are uniformly and vertically arranged. The first mounting hole 203 corresponds to the light-emitting tube 4 one by one, and the first mounting hole 203 is matched with the light-emitting tube 4, so that the light-emitting tube 4 can be clamped in the first mounting hole 203. The first mounting hole 203 can play a limiting role to ensure the accurate installation position of the light-emitting tube 4. The side wall of the first clamping plate 201 away from the second clamping plate 202 is provided with a plurality of first let go slots 205, and the plurality of first let go slots 205 are uniformly and vertically arranged. The first let go slots 205 are used to accommodate the pins or pipelines of the light-emitting tube 4, and can also play a certain protection role, preventing the pins or pipelines of the light-emitting tube 4 from being affected by the outside world, causing the light-emitting tube 4 to deviate or loosen, and thus improving the stability of the device.

[0048] The second clamping plate 202 is provided with a row of second mounting holes 204, and the second mounting hole 204 corresponds to the photosensitive tube 5 one by one, and the photosensitive tube 5 is arranged in the corresponding second mounting hole 204.

[0049] Further, the second clamping plate 202 is provided with a row of second let go slots 206, and the second let go slots 206 correspond to the second mounting holes 204 one by one. One end of the second let go slots 206 is in communication with the corresponding second mounting holes 204, and the other end of the second let go slots 206 extends to the side wall of the second clamping plate 202.

[0050] For example, referring to Figure 4A plurality of second mounting holes 204 are provided through the second clamping plate 202, and the plurality of second mounting holes 204 are uniformly and vertically spaced. The second mounting holes 204 correspond to the photosensitive tubes 5 one by one, and the second mounting holes 204 are adapted to the photosensitive tubes 5, so that the photosensitive tubes 5 can be clamped in the second mounting holes 204. The second mounting holes 204 can play a limiting role to ensure the installation position of the photosensitive tubes 5 is accurate, and can also play a shielding role to avoid external light interference. A plurality of second accommodation grooves 206 are provided on the side wall of the side of the second clamping plate 202 away from the first clamping plate 201, and the plurality of second accommodation grooves 206 are uniformly and vertically spaced. The second accommodation grooves 206 are used to accommodate the pins or pipelines of the photosensitive tubes 5, and can also play a certain protection role to prevent the pins or pipelines of the photosensitive tubes 5 from being affected by the outside world, causing the photosensitive tubes 5 to deviate or loosen, thereby improving the stability of the device.

[0051] In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0052] In addition, the terms "first" and "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined as "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is at least two, such as two, three, etc., unless otherwise specifically limited.

[0053] Although the preferred embodiments of the present application have been described, those skilled in the art can make further changes and modifications to the embodiments once they know the basic inventive concept. Therefore, the appended claims are intended to include the preferred embodiments and all changes and modifications falling within the scope of the present application.

[0054] Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application also intends to include these modifications and variations.

Claims

1. A cell filter liquid level detecting device characterized by comprising: The cell filter (3) is arranged on the support (2) in the vertical direction, the support (2) is provided with a row of light emitting tubes (4) and a row of light sensitive tubes (5) in the vertical direction, the light emitting tubes (4) correspond to the light sensitive tubes (5) one by one, the light emitting tubes (4) are arranged opposite to the corresponding light sensitive tubes (5), and the light emitting tubes (4) and the corresponding light sensitive tubes (5) are respectively located on the two sides of the cell filter (3). The PCB (1) is arranged on the support (2).

2. The cell filter liquid level detection device according to claim 1, wherein The PCB (1) is arranged on the support (2) by means of bolts.

3. The cell filter liquid level detection device of claim 2, wherein The support (2) comprises a first clamping plate (201) and a second clamping plate (202), the first clamping plate (201) and the second clamping plate (202) jointly form a U-shaped clamping structure, and the cell filter (3) is arranged inside the U-shaped clamping structure.

4. The cell filter liquid level detection apparatus according to claim 1, wherein The first clamping plate (201) is provided with a row of first mounting holes (203), the first mounting holes (203) correspond to the light emitting tubes (4) one by one, and the light emitting tubes (4) are arranged in the corresponding first mounting holes (203).

5. The cell filter liquid level detection device of claim 4, wherein, The first clamping plate (201) is provided with a row of first accommodating grooves (205), the first accommodating grooves (205) correspond to the first mounting holes (203) one by one, one end of the first accommodating grooves (205) is in communication with the corresponding first mounting holes (203), and the other end of the first accommodating grooves (205) extends to the side wall of the first clamping plate (201).

6. The cell filter liquid level detection device of claim 5, wherein The second clamping plate (202) is provided with a row of second mounting holes (204), the second mounting holes (204) correspond to the light sensitive tubes (5) one by one, and the light sensitive tubes (5) are arranged in the corresponding second mounting holes (204).

7. The cell filter liquid level detection apparatus according to claim 4, wherein The second clamping plate (202) is provided with a row of second accommodating grooves (206), the second accommodating grooves (206) correspond to the second mounting holes (204) one by one, one end of the second accommodating grooves (206) is in communication with the corresponding second mounting holes (204), and the other end of the second accommodating grooves (206) extends to the side wall of the second clamping plate (202).

8. The cell filter liquid level detection apparatus according to claim 7, wherein ​

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