Prostate cancer multi-gene diagnostic kit based on exosome

Abstract

The utility model relates to the technical field of kits, and discloses a prostate cancer polygene diagnostic kit based on exosomes, a material pushing mechanism is arranged on a polygene diagnostic kit body, fixing mechanisms are arranged on the polygene diagnostic kit body and a kit cover, the material pushing mechanism comprises a moving assembly and a rotating assembly, the moving assembly comprises a sliding groove, and the rotating assembly comprises a rotating shaft. Placing grooves are densely formed in the top of the placing plate, springs are fixedly connected to the bottom of the placing plate and the bottom of the inner wall of the multi-gene diagnostic kit body, and a long plate is fixedly connected to the back of the placing plate. According to the prostate cancer multi-gene diagnostic kit based on the exosome, the pushing mechanism and the fixing plate are moved out of the square groove, limitation on the position of the connecting plate can be cancelled, a limiting plate is conveniently pulled to move out of the top end of a long plate in the later period, and when the limiting plate moves out of the top of the long plate, under the rebound acting force of a spring, the limiting plate can move out of the long plate. The reagent tube placed in the placing groove can be pushed upwards, so that the reagent tube can be directly taken conveniently.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of reagent kit, concretely is a kind of prostate cancer multi-gene diagnostic kit based on exosome. BACKGROUND

[0002] Prostate cancer refers to the epithelial malignant tumor occurring in prostate, and the occurrence of prostate cancer is related to genetic factors, in addition, the incidence of prostate cancer is related to sexual activity and eating habits. The risk of prostate cancer increases in people with more sexual activity. High-fat diet is also related to the incidence.

[0003] In the process of prostate cancer multi-gene diagnosis of exosome, gene reagent needs to be stored, and then reagent kit will be used. In the process of using the existing reagent kit, the reagent tube is directly inserted into the slot in the reagent kit, and the simple insertion and placement setting has the problems of poor storage stability and difficult to take material, therefore, a new type of prostate cancer multi-gene diagnostic kit based on exosome is needed to solve the above problems. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a kind of prostate cancer multi-gene diagnostic kit based on exosome to solve the problems raised in the above background.

[0005] To achieve the above object, the utility model provides the following technical scheme: a kind of prostate cancer multi-gene diagnostic kit based on exosome, including multi-gene diagnostic kit body, the hinge articulation of the multi-gene diagnostic kit body top is covered, the fixed connection of the inner wall of the multi-gene diagnostic kit body is isolated board, the push material mechanism is arranged on the multi-gene diagnostic kit body, the fixed mechanism is arranged on the multi-gene diagnostic kit body and cover;

[0006] The push material mechanism includes moving assembly and rotating assembly, and the rotating assembly is arranged on the moving assembly.

[0007] The moving assembly comprises a sliding groove densely arranged on the left and right inner walls of the multi-gene diagnostic kit body, sliding blocks are movably connected inside the left and right sliding grooves, a placing plate is fixedly connected between the left and right sliding blocks, placing grooves are densely arranged on the top of the placing plate, springs are fixedly connected between the bottom of the placing plate and the inner wall bottom of the multi-gene diagnostic kit body, a long plate is fixedly connected to the back of the placing plate, a rectangular groove is densely arranged on the right side of the multi-gene diagnostic kit body, long sliding grooves are arranged on the front and back inner walls of the rectangular groove, a limiting plate is inserted into the rectangular groove, sliding plates are fixedly connected to the front and back sides of the limiting plate, the sliding plates are movably connected with the long sliding grooves, the limiting plate is arranged on the top of the long plate, a connecting plate is fixedly connected to the right side of the limiting plate, and the connecting plate is arranged on the right side of the multi-gene diagnostic kit body.

[0008] Preferably, the limiting plate is fixedly connected to the right side of the long plate, the connecting plate is arranged on the right side of the multi-gene diagnostic kit body, the reagent tube placed in the placing groove is pushed upward, the reagent tube can be directly taken, and the reagent tube is prevented from being removed from the multi-gene diagnostic kit body, so that the excess reagent tube is protected from being affected or damaged.

[0009] Preferably, the rotating assembly comprises a rotating shaft, the rotating shaft is rotatably connected to the right side, a handle is fixedly connected to the right side of the rotating shaft, a first gear is fixedly connected to the surface of the rotating shaft, a second gear is meshingly connected to the top and bottom of the first gear, respectively, a rotating rod is fixedly connected to the shaft center of the second gear, the rotating rod is rotatably connected to the right side of the multi-gene diagnostic kit body, a fixed plate is fixedly connected to the surface of the rotating rod, square grooves are arranged on the top and bottom of the connecting plate, and the second gear is arranged between the multi-gene diagnostic kit body and the fixed plate.

[0010] Preferably, the front and back sides and the outer side of the square groove are open, the fixed plate is inserted into the square groove, and the first screw is threadedly connected in the fixed plate and the connecting plate.

[0011] Preferably, the fixing mechanism includes a square plate, which is fixedly connected to the front of the multi-gene diagnostic reagent kit. Insert plates are fixedly connected to both ends of the front of the box cover. A slot is formed inside the square plate, with openings at the top and bottom. The surface of the insert plate is inserted into the slot. A long groove is formed inside the insert plate on the side away from the box cover, with an opening on the side away from the box cover. A long block is inserted into the long groove. A square plate is fixedly connected to the front of the two long blocks on the left and right sides. A long rod is fixedly connected to the center of the front of the square plate. A sleeve is fixedly connected to the center of the front of the square plate, and the sleeve is disposed on the surface of the long rod. A mounting plate is fixedly connected to the front of the sleeve. A second bolt is threadedly connected to the mounting plate and the square plate.

[0012] Preferably, an elongated slot is formed at the center of the square plate, and the surface of the long rod is inserted through the elongated slot formed at the center of the square plate.

[0013] Preferably, the square plate has through slots at both ends of its front side, and the long block is inserted through the through slots at both ends of the square plate's front side.

[0014] Compared with the prior art, this invention provides a prostate cancer multi-gene diagnostic kit based on exosomes, which has the following beneficial effects:

[0015] 1. This exosome-based prostate cancer multi-gene diagnostic kit, through a pushing mechanism, involves the first gear driving the second gears at the top and bottom to mesh and connect. The rotation of the two second gears drives the rotating rod to rotate, which in turn moves the fixing plate out of the square groove. This removes the restriction on the position of the connecting plate, making it easier to pull the limiting plate out of the top of the long plate later. Pulling the connecting plate moves the limiting plate. When the limiting plate moves out of the top of the long plate, the spring's rebound force causes the placement plate to slide the slider in the groove, pushing the reagent tubes placed in the groove upwards for easy retrieval. This also prevents the entire reagent tube from being removed from the multi-gene diagnostic kit, protecting excess reagent tubes from being affected or damaged.

[0016] 2. This exosome-based prostate cancer multi-gene diagnostic kit, through a fixing mechanism, when the insert plate is inserted into the slot, the square plate drives the long block to be inserted into the long slot. At the same time, the sleeve is set on the surface of the long rod. The mounting plate and the square plate are fixed by thread using the second bolt. The box cover can be fixed on the top of the multi-gene diagnostic kit body to prevent the reagent tubes inside the box from falling off when the whole kit is carried. Attached Figure Description

[0017] In order to more clearly illustrate the technical scheme in the embodiments of the present application, the drawings needed to be used in the embodiment description will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without any creative effort on the basis of these drawings.

[0018] Figure 1 It is a whole structure perspective view of the present application.

[0019] Figure 2 It is a structure section schematic view of the moving assembly.

[0020] Figure 3 It is a structure schematic view of the moving assembly. Figure 2 It is a structure schematic view of the moving assembly.

[0021] Figure 4 It is a structure schematic view of the moving assembly.

[0022] Figure 5 It is a structure schematic view of the rotating assembly.

[0023] Figure 6 It is a structure schematic view of the rotating assembly. Figure 5 It is an enlarged structure schematic view of A in the rotating assembly.

[0024] Figure 7 It is a structure schematic view of the fixing mechanism.

[0025] Figure 8 It is a structure schematic view of the fixing mechanism. Figure 7 It is a structure schematic view of the fixing mechanism.

[0026] In the figure: 1, multi-gene diagnosis kit body; 2, partition; 3, box cover; 4, pushing mechanism; 41, moving assembly; 411, sliding groove; 412, sliding block; 413, long sliding groove; 414, connecting plate; 415, limiting plate; 416, rectangular groove; 417, sliding plate; 418, placing groove; 419, placing plate; 4101, spring; 4102, long plate; 42, rotating assembly; 421, square groove; 422, first gear; 423, second gear; 424, rotating shaft; 425, handle; 426, rotating rod; 427, first bolt; 428, fixed plate; 5, fixing mechanism; 51, insertion plate; 52, square plate; 53, long rod; 54, sleeve; 55, second bolt; 56, mounting plate; 57, square plate; 58, long block; 59, insertion groove; 501, long groove. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of the present application.

[0028] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting", "fixing" and the like should be understood in a broad sense. For example, it can be fixed connection, or detachable connection, or integrated; it can be mechanical connection, or electrical connection; it can be direct connection, or indirect connection through an intermediate medium; it can be the communication inside two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0029] The present application provides the following technical solutions: Embodiment 1

[0030] In combination Figures 1 to 6 A prostate cancer multi-gene diagnostic kit based on exosomes comprises a multi-gene diagnostic kit body 1, a box cover 3 is hingedly connected to the top of the multi-gene diagnostic kit body 1, a partition plate 2 is fixedly connected to the inner wall of the multi-gene diagnostic kit body 1, a pushing mechanism 4 is arranged on the multi-gene diagnostic kit body 1, and a fixing mechanism 5 is arranged on the multi-gene diagnostic kit body 1 and the box cover 3;

[0031] The pushing mechanism 4 comprises a moving assembly 41 and a rotating assembly 42, and the rotating assembly 42 is arranged on the moving assembly 41;

[0032] The moving assembly 41 comprises a sliding groove 411 densely arranged on the left and right inner walls of the multi-gene diagnostic kit body 1, and a sliding block 412 is slidably connected inside the left and right sliding grooves 411. The left and right sliding blocks 412 are fixedly connected with a placing plate 419, the top of the placing plate 419 is densely provided with a placing groove 418, the bottom of the placing plate 419 and the bottom of the inner wall of the multi-gene diagnostic kit body 1 are fixedly connected with a spring 4101, the back of the placing plate 419 is fixedly connected with a long plate 4102, a rectangular groove 416 is densely arranged on the right side of the multi-gene diagnostic kit body 1, long sliding grooves 413 are arranged on the front and back inner walls of the rectangular groove 416, a limiting plate 415 is inserted into the rectangular groove 416, and the limiting plate 415 is fixedly connected with a sliding plate 417 on the front and back sides. The surface of the sliding plate 417 is slidably connected with the inside of the long sliding groove 413, the limiting plate 415 is arranged on the top of the long plate 4102, the right side of the limiting plate 415 is fixedly connected with a connecting plate 414, the connecting plate 414 is arranged on the right side of the multi-gene diagnostic kit body 1, and the inside of the partition plate 2 is densely provided with a through hole groove. The placing groove 418 is arranged at the bottom of the through hole groove densely arranged in the inside of the partition plate 2, and the diameter of the placing groove 418 is smaller than that of the through hole groove densely arranged in the inside of the partition plate 2.

[0033] The rotating assembly 42 comprises a rotating shaft 424 rotatably connected to the right side, a handle 425 fixedly connected to the right side of the rotating shaft 424, a first gear 422 fixedly connected to the surface of the rotating shaft 424, a second gear 423 meshingly connected to the top and bottom of the first gear 422, a rotating rod 426 fixedly connected to the shaft center of the second gear 423, the surface of the rotating rod 426 rotatably connected to the right side of the multi-gene diagnostic kit body 1, a fixed plate 428 fixedly connected to the surface of the rotating rod 426, a square groove 421 arranged on the top and bottom of the connecting plate 414, the second gear 423 arranged between the multi-gene diagnostic kit body 1 and the fixed plate 428, the front and back sides and the outer side of the square groove 421 on the top and bottom sides are arranged as openings, the surface of the fixed plate 428 is inserted into the inside of the square groove 421, and the first screw 427 is threadedly connected in the inside of the fixed plate 428 and the connecting plate 414.

[0034] Further, the rotating rod 426 drives the fixed plate 428 to move out of the square groove 421, the position of the connecting plate 414 can be cancelled, the limiting plate 415 is pulled out of the top end of the long plate 4102, the connecting plate 414 drives the limiting plate 415 to move, when the limiting plate 415 moves out of the top of the long plate 4102, under the rebounding force of the spring 4101, the placing plate 419 drives the sliding block 412 to slide in the sliding groove 411, the reagent tube placed in the placing groove 418 can be pushed upward, the reagent tube can be directly taken, and meanwhile, the reagent tube is prevented from being pulled out of the multi-gene diagnostic kit body 1, and the excess reagent tube is protected from being affected or damaged. Example 2

[0035] ReferenceFigures 1-8 And on the basis of example one, further get the fixed mechanism 5 includes the square plate 52, the square plate 52 is fixedly connected to the front of the multi-gene diagnostic kit body 1, the plug-in plate 51 is fixedly connected to the front of the box cover 3, the two ends of the square plate 52 is provided with the insertion slot 59, the top and bottom of the insertion slot 59 is set as an opening, the surface of the plug-in plate 51 and the inside of the insertion slot 59 are inserted, the inside of the plug-in plate 51 away from the box cover 3 is provided with a long slot 501, the long slot 501 away from the box cover 3 is set as an opening, the long block 58 is inserted into the inside of the long slot 501, the front of the left and right two long blocks 58 is fixedly connected with the square plate 57, the front of the square plate 57 is fixedly connected with the long rod 53, the front of the square plate 57 is fixedly connected with the sleeve 54, the sleeve 54 is arranged on the surface of the long rod 53, the front of the sleeve 54 is fixedly connected with the mounting plate 56, the mounting plate 56 and the square plate 52 are internally threadedly connected with the second bolt 55;

[0036] The inside of the square plate 57 is provided with a long hole slot, the surface of the long rod 53 is inserted through the long hole slot in the inside of the square plate 57, the front of the square plate 52 is provided with a through slot, the surface of the long block 58 is inserted through the through slot in the front of the square plate 52.

[0037] Further, when the plug-in plate 51 is inserted into the insertion slot 59, the square plate 57 drives the long block 58 to be inserted into the long slot 501, and the sleeve 54 is arranged on the surface of the long rod 53, and the mounting plate 56 and the square plate 52 are threadedly fixed by the second bolt 55, so that the box cover 3 can be fixed and arranged on the top of the multi-gene diagnostic kit body 1, and the reagent tube in the box will not fall off when the whole reagent kit is carried.

[0038] In the actual operation process, when the device is used, the test tube loaded with prostate cancer multi-gene diagnostic reagent of exosome is placed in the placement slot 418 through the through hole slot densely arranged in the inside of the partition plate 2, when the upper placed reagent tube in the one-way horizontal row needs to be taken, first, the first bolt 427 is threadedly removed, then the rotating shaft 424 is driven to rotate by the handle 425, the rotating shaft 424 drives the first gear 422, and when the first gear 422 drives the second gear 423 at the top and the bottom to meshing connection respectively, at this time, the upper and lower second gears 423 drive the rotating rod 426 to rotate, and the fixed plate 428 is moved out of the square slot 421 driven by the rotating rod 426, so that the position of the connecting plate 414 can be cancelled, and the limiting plate 415 is conveniently pulled out of the top end of the long plate 4102;

[0039] When the connecting plate 414 is pulled to move the limiting plate 415, the limiting plate 415 drives the sliding plate 417 to slide in the rectangular groove 416, and when the limiting plate 415 is moved away from the top of the long plate 4102, under the rebounding force of the spring 4101, the placing plate 419 drives the sliding block 412 to slide in the sliding groove 411, so as to push the reagent tube placed in the placing groove 418 upward, which is convenient for directly taking the reagent tube and avoids the reagent tube from being taken out of the multi-gene diagnostic reagent box body 1, thereby protecting the excess reagent tube from being affected or damaged;

[0040] When the box cover 3 drives the plug plate 51 to be plugged in the plug groove 59, the square plate 57 drives the long block 58 to be plugged in the long groove 501, and the sleeve 54 is arranged on the surface of the long rod 53, the mounting plate 56 and the square plate 52 are threadedly fixed by the second bolt 55, so that the box cover 3 can be fixed and arranged on the top of the multi-gene diagnostic reagent box body 1, thereby avoiding that the reagent tube in the box falls off when the reagent box is carried.

[0041] It should be noted that, in the present text, the relationship terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between the entities or operations. Moreover, the terms "include", "contain" or any other variants thereof are intended to cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements not only includes those elements, but also includes other elements not explicitly listed or inherent to such process, method, article or equipment. Without more limitations, the element defined by the statement "including a" does not exclude the existence of other identical elements in the process, method, article or equipment including the element.

Claims

1. An exosome-based multi-gene diagnostic kit for prostate cancer, comprising a multi-gene diagnostic kit body (1), characterized in that: The multi-gene diagnostic reagent kit (1) has a lid (3) hinged to the top, a partition (2) is fixedly connected to the inner wall of the multi-gene diagnostic reagent kit (1), a pusher mechanism (4) is provided on the multi-gene diagnostic reagent kit (1), and a fixing mechanism (5) is provided on the multi-gene diagnostic reagent kit (1) and the lid (3). The feeding mechanism (4) includes a moving component (41) and a rotating component (42), wherein the rotating component (42) is disposed on the moving component (41); The moving component (41) includes a slide groove (411), which is densely arranged on the left and right sides of the inner wall of the multi-gene diagnostic reagent kit (1). A slider (412) is slidably connected inside the two slide grooves (411). A placement plate (419) is fixedly connected between the sliders (412) on the left and right sides. Placement slots (418) are densely arranged on the top of the placement plate (419). A spring (4101) is fixedly connected to the bottom of the placement plate (419) and the bottom of the inner wall of the multi-gene diagnostic reagent kit (1). A long plate (4102) is fixedly connected to the back of the placement plate (419). The multi-gene... The diagnostic reagent kit (1) has a densely packed rectangular groove (416) on the right side. The inner walls of the rectangular groove (416) have long sliding grooves (413) on both the front and back sides. A limiting plate (415) is inserted into the rectangular groove (416). Slide plates (417) are fixedly connected to the front and back sides of the limiting plate (415). The surface of the slide plate (417) and the inside of the long sliding groove (413) are slidably connected. The limiting plate (415) is located on the top of the long plate (4102). A connecting plate (414) is fixedly connected to the right side of the limiting plate (415). The connecting plate (414) is located on the right side of the multi-gene diagnostic reagent kit (1).

2. The exosome-based multi-gene diagnostic kit for prostate cancer according to claim 1, characterized by: The partition (2) has densely arranged through-hole slots inside, and the placement slot (418) is located at the bottom of the densely arranged through-hole slots inside the partition (2). The diameter of the placement slot (418) is smaller than the diameter of the densely arranged through-hole slots inside the partition (2).

3. The exosome-based multi-gene diagnostic kit for prostate cancer according to claim 1, characterized by: The rotating assembly (42) includes a rotating shaft (424), which is rotatably connected to the right side. A handle (425) is fixedly connected to the right side of the rotating shaft (424). A first gear (422) is fixedly connected to the surface of the rotating shaft (424). A second gear (423) is meshed with the top and bottom of the first gear (422). A rotating rod (426) is fixedly connected to the axis of the second gear (423). The surface of the rotating rod (426) is rotatably connected to the right side of the multi-gene diagnostic kit body (1). A fixing plate (428) is fixedly connected to the surface of the rotating rod (426). A square groove (421) is opened at the top and bottom of the connecting plate (414). The second gear (423) is disposed between the multi-gene diagnostic kit body (1) and the fixing plate (428).

4. The exosome-based multi-gene diagnostic kit for prostate cancer according to claim 3, characterized by: The square groove (421) is provided with openings on the front and rear sides and the outer side, the fixing plate (428) is inserted into the square groove (421), and the first bolt (427) is threadedly connected to the inside of the fixing plate (428) and the connecting plate (414).

5. The exosome-based multi-gene diagnostic kit for prostate cancer according to claim 1, characterized by: The fixing mechanism (5) comprises a square plate (52) fixedly connected to the front of the multi-gene diagnostic kit body (1), the two ends of the cover (3) are fixedly connected with an insertion plate (51), the inside of the square plate (52) is provided with an insertion slot (59), the top and bottom of the insertion slot (59) are provided with openings, the surface of the insertion plate (51) is inserted into the inside of the insertion slot (59), the inside of the side, away from the cover (3), of the insertion plate (51) is provided with a long slot (501), the side, away from the cover (3), of the long slot (501) is provided with an opening, the inside of the long slot (501) is inserted with a long block (58), the front of the left and right two long blocks (58) is fixedly connected with a square plate (57), the front center of the square plate (57) is fixedly connected with a sleeve (54), the front of the sleeve (54) is fixedly connected with a mounting plate (56), and the inside of the mounting plate (56) and the square plate (52) is threadedly connected with a second bolt (55).

6. The exosome-based multi-gene diagnostic kit for prostate cancer according to claim 5, characterized in that: The inside of the square plate (57) is provided with a long hole slot at the center, and the surface of the long rod (53) is inserted into the long hole slot at the center of the inside of the square plate (57).

7. The exosome-based multi-gene diagnostic kit for prostate cancer according to claim 5, characterized by: The front of the square plate (52) is provided with a through slot at the two ends, and the surface of the long block (58) is inserted into the through slot at the two ends of the square plate (52). The front of the square plate (52) is provided with a through slot at the two ends, and the surface of the long block (58) is inserted into the through slot at the two ends of the square plate (52).

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