Multi-flux positive pressure column lifting device

Abstract

The utility model belongs to the technical field of experimental equipment, and particularly relates to a multi-flux positive pressure column lifting device. Comprising a bottom plate, a pump cavity, a stepping motor, a push plate, piston rod assemblies and a driver, the pump cavity is installed at the lower end of the front side face of the bottom plate, the stepping motor is used for being installed at the upper end of the front side face of the bottom plate, the driver is installed on the stepping motor, the lower end of the stepping motor is in transmission connection with the push plate, and the piston rod assemblies are connected to the push plate. A plurality of guide grooves are formed in the pump cavity, the piston rod assemblies are used for being slidably connected to the guide grooves in the vertical direction, and the multiple piston rod assemblies correspond to the multiple guide grooves in a one-to-one mode. The driver and the stepping motor form a closed-loop control system to drive the push plate and the plurality of piston rod assemblies to move, so that a positive pressure filtration extraction experiment can be carried out under the environmental condition without an air source. The multiple piston rod assemblies slide in the multiple guide grooves, and the guide grooves can be used for guiding the piston rod assemblies.

Description

Technical Field

[0001] This utility model belongs to the field of experimental equipment technology, and specifically relates to a multi-throughput positive pressure column lifting device. Background Technology

[0002] Column-based nucleic acid extraction is a method for extracting nucleic acids from various samples. Its principle involves using a silica membrane adsorption column to specifically bind to nucleic acids. Impurities are removed through rinsing, resulting in purified nucleic acids. During column extraction, the sample treated with lysis buffer is passed through a silica membrane extraction column, allowing the fully released nucleic acids to be firmly adsorbed onto the silica membrane surface. Impurities are then removed through rinsing. In the elution state, the electrostatic repulsion between the silanol groups of the silica membrane and the phosphate groups of the nucleic acids releases the nucleic acids. This method offers advantages such as ease of operation, speed, and high automation, making it suitable for various sample types and detection needs.

[0003] Typically, column-based nucleic acid extraction uses centrifugation or negative pressure methods. Both methods are complex, have limited sample size, and low automation, making it difficult to extract multiple samples and significantly restricting the application of column-based nucleic acid extraction. Centrifugation, with its multiple centrifugation operations, not only increases the workload but also poses a risk of cross-contamination. Negative pressure methods, with their pressure differential limitations, result in long column passage times, and some samples may even fail to pass through the silica column due to pressure differential limitations, leading to extraction failure. Therefore, designing a multi-throughput positive pressure column extraction device to address these issues is essential. Utility Model Content

[0004] To address the aforementioned problems, this utility model provides a multi-throughput positive pressure column lifting device to solve the issues raised in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a multi-flow positive pressure column lifting device, comprising a base plate, a pump chamber, a stepper motor, a push plate, piston rod assemblies, and a driver. The pump chamber is installed on the lower end of the front side of the base plate, the stepper motor is installed on the upper end of the front side of the base plate, the driver is installed on the stepper motor, the lower end of the stepper motor is drivenly connected to the push plate, multiple piston rod assemblies are connected to the push plate, multiple guide grooves are opened on the pump chamber, and the piston rod assemblies are slidably connected to the guide grooves in the vertical direction. The multiple piston rod assemblies correspond one-to-one with the multiple guide grooves.

[0006] Furthermore, the multi-throughput positive pressure column lifting device also includes a motor mounting base, which is located at the upper end of the front side of the base plate, and the stepper motor is mounted on the motor mounting base.

[0007] Furthermore, the multi-throughput positive pressure column lifting device also includes a photoelectric sensor and a light-blocking plate. The photoelectric sensor is installed on the stepper motor, and the light-blocking plate is installed on the push plate.

[0008] Furthermore, the multi-throughput positive pressure column lifting device also includes a lead screw nut, and the lower end of the stepper motor is assembled and connected to the push plate through the lead screw nut.

[0009] Furthermore, the multi-throughput positive pressure column lifting device also includes linear guide rails and sliders. The sliders are connected to the push plate. The linear guide rails are installed on both the left and right sides of the upper end of the base plate. Both linear guide rails extend in the vertical direction. The sliders are installed on both the left and right sides of the push plate. The two sliders are slidably connected to the two linear guide rails respectively.

[0010] Furthermore, the multi-flow positive pressure column lifting device also includes a flexible connector, which is installed on the lower left side of the pump chamber. The flexible connector is used to connect a pressure gauge through an air pipe.

[0011] Furthermore, the multi-flow positive pressure column lifting device also includes an eight-hole silicone pad, which is attached to the lower end face of the pump cavity.

[0012] The technical effects and advantages of this utility model are as follows:

[0013] 1. A closed-loop control system consisting of a driver and a stepper motor is used to drive the push plate and multiple piston rod assemblies to move, which can meet the requirements of positive pressure filtration and extraction experiments in environments without a gas source.

[0014] 2. During the sliding process of multiple piston rod assemblies corresponding one-to-one in multiple guide grooves, the guide grooves can be used to guide the piston rod assemblies.

[0015] Other features and advantages of this invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. The objectives and other advantages of this invention can be realized and obtained through the structures pointed out in the description and drawings. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 A schematic diagram of the structure of the multi-throughput positive pressure column lifting device according to an embodiment of the present invention is shown;

[0018] Figure 2 This diagram shows a structural schematic of the multi-throughput positive pressure column lifting device according to another perspective of an embodiment of the present invention;

[0019] Figure 3 This shows a structural schematic diagram of the multi-throughput positive pressure column lifting device according to another perspective of an embodiment of the present invention;

[0020] Figure 4 It shows Figure 3 A cross-sectional view along the AA direction.

[0021] Reference numerals: 1. Base plate; 11. Linear guide rail; 2. Pump chamber; 21. Guide groove; 3. Stepper motor; 31. Motor mounting base; 32. Lead screw nut; 4. Push plate; 41. Slider; 5. Piston rod assembly; 61. Photoelectric sensor; 62. Light blocking plate; 7. Flexible interface; 8. Eight-hole silicone pad; 9. Driver. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0023] like Figures 1 to 4 As shown, a multi-flow positive pressure column lifting device according to an embodiment of the present invention includes a base plate 1, a pump chamber 2, a stepper motor 3, a push plate 4, a piston rod assembly 5, and a driver 9. The pump chamber 2 is installed on the lower end of the front side of the base plate 1. The stepper motor 3 is installed on the upper end of the front side of the base plate 1. The driver 9 is installed on the stepper motor 3. The lower end of the stepper motor 3 is drivenly connected to the push plate 4. Multiple piston rod assemblies 5 are connected to the push plate 4. Multiple guide grooves 21 are opened on the pump chamber 2. The piston rod assembly 5 is slidably connected to the guide groove 21 in the vertical direction. Multiple piston rod assemblies 5 correspond one-to-one with multiple guide grooves 21. The pump chamber 2 can have multiple guide grooves 21 or multiple pump chambers 2, and each pump chamber 2 contains one guide groove 21.

[0024] Specifically, the piston rod assembly 5 includes a piston rod and a piston, with the upper end of the piston rod connected to the push plate 4 and the lower end connected to the piston.

[0025] In this embodiment, a stepper motor 3 is connected to a pusher plate 4, and the pusher plate 4 is connected to multiple piston rod assemblies 5. A closed-loop control system composed of a driver 9 and the stepper motor 3 drives the pusher plate 4 and the multiple piston rod assemblies 5 to move vertically. The multiple piston rod assemblies 5 are slidably connected to multiple guide grooves 21 on the pump chamber 2. When positive pressure is required, the multiple piston rod assemblies 5 move from top to bottom to achieve positive pressure. Therefore, by using the driver 9 and the stepper motor 3 to form a closed-loop control system to drive the pusher plate 4 and the multiple piston rod assemblies 5, positive pressure filtration and extraction experiments can be performed in environments without a gas source.

[0026] Secondly, during the sliding process of multiple piston rod assemblies 5 corresponding to each other in multiple guide grooves 21, the guide grooves 21 can be used to guide the piston rod assemblies 5.

[0027] Optionally, such as Figures 1 to 4 As shown, the multi-throughput positive pressure column lifting device also includes a motor mounting base 31, which is located at the upper end of the front side of the base plate 1, and the stepper motor 3 is mounted on the motor mounting base 31.

[0028] In this embodiment, by installing a motor mounting base 31 on the upper front side of the base plate 1 and then installing the stepper motor 3 on the motor mounting base 31, the motor mounting base 31 can be used to support the stepper motor 3, which helps to ensure the stability of the stepper motor 3.

[0029] Optionally, such as Figure 2 and Figure 4 As shown, the multi-throughput positive pressure column lifting device also includes a photoelectric sensor 61 and a light-blocking plate 62. The photoelectric sensor 61 is installed on the stepper motor 3, and the light-blocking plate 62 is installed on the push plate 4.

[0030] In this embodiment, after positive pressure extraction is completed, the piston rod assembly 5 moves from bottom to top back to its original position. By installing a photoelectric sensor 61 on the stepper motor 3 and a light-blocking plate 62 on the push plate 4, the push plate 4 and the piston rod assembly 5 move upward synchronously, causing the light-blocking plate 62 to approach the photoelectric sensor 61. The photoelectric sensor 61 transmits a signal to the stepper motor 3, thereby controlling the stepper motor 3 to stop, causing the push plate 4 and the piston rod assembly 5 to stop, which facilitates the piston rod assembly 5 returning to its original position.

[0031] Optionally, such as Figures 1 to 4 As shown, the multi-throughput positive pressure column lifting device also includes a lead screw nut 32, and the lower end of the stepper motor 3 is assembled and connected to the push plate 4 through the lead screw nut 32.

[0032] In this embodiment, by connecting a lead screw nut 32 to the movable rod at the lower end of the stepper motor 3, and assembling and connecting the lead screw nut 32 to the push plate 4, it is convenient to connect the stepper motor 3 to the push plate 4.

[0033] Optionally, such as Figures 1 to 4 As shown, the multi-throughput positive pressure column lifting device also includes a linear guide rail 11 and a slider 41. The slider 41 is connected to the push plate 4. The linear guide rail 11 is installed on both the left and right sides of the upper end of the base plate 1. Both linear guide rails 11 extend in the vertical direction. The slider 41 is installed on both the left and right sides of the push plate 4. The two sliders 41 are slidably connected to the two linear guide rails 11 respectively.

[0034] In this embodiment, by installing linear guide rails 11 on the left and right sides of the upper end of the base plate 1 and installing sliders 41 on the left and right ends of the push plate 4, the two sliders 41 are slidably connected to the two linear guide rails 11, and the two linear guide rails 11 extend in the vertical direction, which can guide the two sliders 41 and the push plate 4, which helps to ensure the accuracy and stability of the movement of the push plate 4.

[0035] Optionally, such as Figures 1 to 4 As shown, the multi-flow positive pressure column lifting device also includes a flexible port 7, which is installed on the lower left side of the pump chamber 2. The flexible port 7 is used to connect a pressure gauge through an air pipe.

[0036] In this embodiment, a live port 7 is installed on the lower left side of the pump chamber 2. A pressure gauge is connected to the live port 7 via an air tube to monitor the pressure changes inside the pump chamber 2 and adjust the experimental status in real time.

[0037] Optionally, such as Figure 3 and Figure 4 As shown, the multi-flow positive pressure column lifting device also includes an eight-hole silicone pad 8, which is attached to the lower end face of the pump chamber 2.

[0038] In this embodiment, an eight-hole silicone pad 8 is attached to the lower end face of the pump cavity 2. The eight-hole silicone pad 8 can directly contact the filter consumables, or a protective diaphragm can be added between them to prevent cross-contamination.

[0039] In this embodiment, the power source is a linear motor, which can be replaced by a cylinder. Under the condition of compressed air, a union can be installed on the pump chamber 2. Compressed gas can be directly input into the guide groove 21 of the pump chamber 2 through the connection of the pipeline to the union to achieve positive pressure filtration and extraction experiments. The pump chamber 2 of the device in this embodiment is set with eight flow rates, which is only one example. It can be changed to other flow rate settings, such as single flow rate, two flow rates, three flow rates, twelve flow rates, etc. The number of settings can cover multiple channels. Modifications to the technical solutions or equivalent substitutions of technical features in each embodiment are all included in the scope of protection.

[0040] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A multi-flow positive pressure column lifting device, characterized in that, The device includes a base plate (1), a pump chamber (2), a stepper motor (3), a push plate (4), a piston rod assembly (5), and a driver (9). The pump chamber (2) is installed on the lower end of the front side of the base plate (1). The stepper motor (3) is installed on the upper end of the front side of the base plate (1). The driver (9) is installed on the stepper motor (3). The push plate (4) is connected to the lower end of the stepper motor (3). Multiple piston rod assemblies (5) are connected to the push plate (4). Multiple guide grooves (21) are provided on the pump chamber (2). The piston rod assembly (5) is slidably connected to the guide groove (21) in the vertical direction. The multiple piston rod assemblies (5) correspond one-to-one with the multiple guide grooves (21).

2. The multi-throughput positive pressure column lifting device according to claim 1, characterized in that, It also includes a motor mounting base (31), which is located at the upper front side of the base plate (1), and the stepper motor (3) is mounted on the motor mounting base (31).

3. The multi-throughput positive pressure column lifting device according to claim 1, characterized in that, It also includes a photoelectric sensor (61) and a light-blocking plate (62). The photoelectric sensor (61) is mounted on the stepper motor (3), and the light-blocking plate (62) is mounted on the push plate (4).

4. The multi-throughput positive pressure column lifting device according to claim 1, characterized in that, It also includes a lead screw nut (32), and the lower end of the stepper motor (3) is assembled and connected to the push plate (4) through the lead screw nut (32).

5. The multi-throughput positive pressure column lifting device according to claim 1, characterized in that, It also includes linear guide rails (11) and sliders (41). The sliders (41) are connected to the push plate (4). The linear guide rails (11) are installed on both the left and right sides of the upper end of the base plate (1). Both linear guide rails (11) extend in the vertical direction. The sliders (41) are installed on both the left and right sides of the push plate (4). The two sliders (41) are slidably connected to the two linear guide rails (11) respectively.

6. The multi-throughput positive pressure column lifting device according to claim 1, characterized in that, It also includes a live port (7), which is installed on the lower left side of the pump chamber (2). The live port (7) is used to connect a pressure gauge through an air pipe.

7. The multi-throughput positive pressure column lifting device according to claim 1, characterized in that, It also includes an eight-hole silicone pad (8), which is attached to the lower end face of the pump cavity (2).

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