Standard tube manufacturing device

Abstract

The utility model discloses a standard tube manufacturing device which comprises a computer, a cable, a first air pipe, a first electromagnetic one-way valve, a high-pressure liquid injection pump, a second electromagnetic one-way valve, a first vacuum pump, a second air pipe, a liquid pipe, a filling liquid tank, a second vacuum pump and a motion control box. When the filling device is used for filling the standard tube, the operations of vacuumizing, liquid pumping and liquid injection can be continuously realized, the automation degree is high, the manufacturing efficiency of the standard tube can be improved, the stability of the filling quality of the standard tube can be ensured by automatic filling, and the standard tube with high quality and stability is obtained.

Description

Technical Field

[0001] This utility model relates to the field of biological detection equipment technology, specifically to a standard tube manufacturing device. Background Technology

[0002] The capillary array consists of multiple regularly arranged elastic fused silica capillaries of equal length, comprising components such as a gel-filling end and a sample inlet end. A highly transparent detection window is located near the gel-filling end of the array, serving as the electrophoresis channel for separating fluorescently labeled DNA fragments. The standard tube, on the other hand, comprises a capillary bundle consisting of multiple regularly arranged elastic fused silica capillaries of equal length, including a gel-filling end and a detection window. By filling each channel of the standard tube with liquid, the Raman peaks generated after laser excitation at the detection window are obtained to evaluate the accuracy of the spatial positioning of each channel, providing a benchmark for adjusting the optical path of the array capillary electrophoresis instrument.

[0003] During the production, research and development, installation, and after-sales maintenance phases of array capillary electrophoresis instruments, optical path debugging and calibration are inevitably required. Existing standard tube filling operations are usually manual, with low automation levels, and it is difficult to guarantee the quality of the standard tubes. Utility Model Content

[0004] In view of the shortcomings of the existing technology, the present invention aims to provide a standard tube manufacturing device.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A standard tube manufacturing device includes a computer, cables, an air tube 1, an electromagnetic check valve 1, a high-pressure injection pump, an electromagnetic check valve 2, a vacuum pump 1, an air tube 2, a liquid tube, a filling liquid tank, a vacuum pump 2, and a motion control box.

[0007] The high-pressure injection pump has an internal plunger, and a drive motor is connected to the plunger to drive its reciprocating movement. The high-pressure injection pump includes at least port one, port two, and port three. Port one, port two, and port three are interconnected internally and all communicate with the plunger's movement channel. Port one is connected to vacuum pump two via air pipe one. Port two is connected to the filling liquid tank via electromagnetic check valve one and a liquid pipe. The filling liquid tank is connected to vacuum pump one via air pipe two. Port three is connected to the glue-filling end of a standard tube via electromagnetic check valve two.

[0008] The computer and the motion control box are connected in communication. The motion control box is connected to the electromagnetic one-way valve, the drive motor, the electromagnetic one-way valve, the vacuum pump, the stirring mechanism, and the vacuum pump via cables.

[0009] Furthermore, the aforementioned standard tube manufacturing apparatus also includes a liquid collection bottle, which is used to collect droplets discharged from the free end of the standard tube.

[0010] Furthermore, the aforementioned standard tube manufacturing apparatus also includes a stirring mechanism, which is located inside the filling liquid tank.

[0011] Furthermore, the aforementioned standard tube manufacturing device also includes a back plate, on which a fixing seat and a support sleeve are provided. The detection window of the standard tube is installed on the fixing seat, and the support sleeve is used to constrain and fix the quartz capillary bundle of the standard tube; the high-pressure injection pump is fixed to the back plate.

[0012] The beneficial effects of this utility model are as follows: by using this utility model for the filling operation of standard tubes, the vacuuming, liquid extraction and liquid injection operations can be continuously realized. Not only is the degree of automation high, which can improve the production efficiency of standard tubes, but the automated filling can also ensure the stability of the filling quality of standard tubes, resulting in high-quality and stable standard tubes. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the standard tube manufacturing device in Embodiment 1 of this utility model;

[0014] Figure 2 This is a schematic diagram of the standard tube after sealing in Embodiment 2 of this utility model. Detailed Implementation

[0015] The present invention will be further described below with reference to the accompanying drawings. It should be noted that this embodiment is based on the present technical solution and provides detailed implementation methods and specific operation processes, but the protection scope of the present invention is not limited to this embodiment.

[0016] Example 1

[0017] This embodiment provides a standard tube manufacturing device for high-pressure liquid filling of each channel of a standard tube, ultimately achieving the encapsulation and molding of the standard tube.

[0018] like Figure 1 As shown, the standard tube includes a quartz capillary bundle 12 composed of multiple fused quartz capillaries arranged in a regular pattern. The quartz capillary bundle 12 has a detection window 10. One end of the quartz capillary bundle 12 is a glue-filled end, and the other end is a free end. The fused quartz capillaries at the corresponding detection windows need to have their coating removed and windows opened to provide a location for laser excitation detection. This embodiment uses a 24-channel standard tube as an example. The standard tube is encapsulated from 24 windowed capillaries. The glue-filled end face is sealed with epoxy resin and then ground, while ensuring that all channels are unobstructed.

[0019] The standard tube manufacturing apparatus in this embodiment is as follows: Figure 1As shown, including computer 1, cable 2, air pipe 3, electromagnetic one-way valve 4, high-pressure liquid injection pump 7, electromagnetic one-way valve 8, fixed seat 11, support sleeve 13, back plate 14, liquid collection bottle 16, vacuum pump 17, air pipe 2 18, stirring mechanism 19, liquid pipe 20, filling liquid tank 21, vacuum pump 22 and motion control box 23.

[0020] The high-pressure liquid injection pump 7 is internally provided with a plunger 5, and the driving motor 6 is drivingly connected to the plunger 5 and used to drive the plunger 5 to reciprocate; the high-pressure liquid injection pump 7 comprises at least port one, port two and port three, the port one, the port two and the port three are communicated with each other in the high-pressure liquid injection pump 7 and are all communicated with the movement channel of the plunger 5; the port one is communicated with the vacuum pump two 22 through the air pipe 3, the port two is communicated with the filling liquid tank 21 through the electromagnetic one-way valve 4 and the liquid pipe 20, the filling liquid tank 21 is communicated with the vacuum pump one 17 through the air pipe 2 18; the port three is communicated with the glue injection end 9 of the standard pipe through the electromagnetic one-way valve 8, and the liquid collection bottle 16 is used to collect the liquid drops 15 discharged from the free end of the standard pipe; the stirring mechanism 19 is arranged in the filling liquid tank 21.

[0021] The computer 1 and the motion control box 23 are in communication connection, and the motion control box 23 is controlled to be connected to the electromagnetic one-way valve 4, the driving motor 6, the electromagnetic one-way valve 8, the vacuum pump one 17, the stirring mechanism 19 and the vacuum pump two 22 through the cable 2.

[0022] The control logic and control parameters of the motion control box are pre-set by the computer, and the motion control box controls the driving motor 6, the vacuum pump two 22, the vacuum pump one 17, the stirring mechanism 19, the electromagnetic one-way valve 4 and the electromagnetic one-way valve 8 according to the control logic and control parameters, so as to realize the motion control such as liquid injection and vacuum pumping, so as to complete Figure 1 The vacuum pumping operation a, the vacuum pumping operation b, the stirring and bubble removing operation c, the liquid sucking operation d, the liquid sucking operation e, the liquid injection operation f, the liquid injection operation g and the like are shown.

[0023] In this embodiment, the standard pipe manufacturing device further comprises a back plate 14, the back plate 14 is provided with a fixed seat 11 and a support sleeve 13, a detection window of the standard pipe is installed on the fixed seat 11, and the support sleeve 13 is used to constrain the quartz capillary bundle 12 for fixing the standard pipe; the high-pressure liquid injection pump 7 is fixed to the back plate 14.

[0024] Embodiment 2

[0025] The embodiment provides a working method of a standard pipe manufacturing device, and the specific process is as follows:

[0026] (1) Inject the filling liquid into the filling liquid tank 21.

[0027] (2) The electromagnetic check valve 4 and the electromagnetic check valve 8 are locked by the motion control box 23.

[0028] (3) The vacuum pump 1 and the vacuum pump 2 are controlled by the motion control box 23 to perform the vacuumizing operation a and the vacuumizing operation b respectively, so as to complete the vacuumizing operation of the inside of the high-pressure liquid injection pump 7 and the inside of the filling liquid tank 21, wherein when the inside of the filling liquid tank 21 is vacuumized, the stirring and bubble-removing operation c is realized by the stirring of the stirring mechanism 19, so as to effectively remove the bubbles in the alcohol polymer.

[0029] (4) The electromagnetic check valve 4 is unlocked by the motion control box 23, and the driving motor 6 is started to drive the plunger 5 to move upward from the original bottom zero position, so as to complete the liquid sucking operation e, and the filling liquid in the filling liquid tank 21 is sucked into the inside of the high-pressure liquid injection pump 7 through the liquid pipe 20 to complete the liquid sucking operation d, and then the electromagnetic check valve 4 is locked again by the motion control box 23.

[0030] (5) The electromagnetic check valve 8 is unlocked by the motion control box 23, and the driving motor 6 is started again to drive the plunger 5 to move downward from the top terminal position of the inside of the high-pressure liquid injection pump 7, so as to complete the liquid injecting operation f, and the filling liquid in the high-pressure liquid injection pump 7 is injected into the quartz capillary bundle of the standard tube through the glue injecting end of the standard tube, so as to complete the liquid injecting operation g. At this time, whether there is liquid drop 15 dripping from each fused quartz capillary can be observed from the free end of the standard tube, and the liquid drop 15 is collected by the liquid collecting bottle 16.

[0031] Thus, the filling operation of the filling liquid (alcohol polymer) in the standard tube is completed.

[0032] (6) After the filling operation is completed, the bundling cylinder 24 is sleeved on the free end of the standard tube, the ceramic blade is used to cut the fused quartz capillary of the free end, so that the length of the free end is consistent with the length of the glue injecting end after the bundling cylinder 24 is sleeved, and finally the free end and the glue injecting end are sealed by the sealing sleeve 25 and the two-component epoxy glue, so as to ensure that the filling liquid in the standard tube does not flow out. As shown in Figure 2

[0033] For those skilled in the art, various corresponding changes and modifications can be given according to the above technical solutions and concepts, and all these changes and modifications should be included in the protection scope of the utility model claim.​

Claims

1. A standard pipe manufacturing apparatus characterized by comprising: The device comprises a computer, a cable, a gas pipe 1, a high-pressure liquid injection pump, an electromagnetic one-way valve 1, a vacuum pump 1, a gas pipe 2, a liquid pipe, a filling liquid tank, a vacuum pump 2 and a motion control box. The high-pressure liquid injection pump is internally provided with a plunger, and a driving motor is transmissionally connected to the plunger and used for driving the plunger to reciprocally move; the high-pressure liquid injection pump comprises at least a port 1, a port 2 and a port 3, the port 1, the port 2 and the port 3 are in communication with each other in the high-pressure liquid injection pump and are all in communication with a movement channel of the plunger; the port 1 is communicated with the vacuum pump 2 through the gas pipe 1, the port 2 is communicated with the filling liquid tank through the electromagnetic one-way valve 1 and the liquid pipe, and the filling liquid tank is communicated with the vacuum pump 1 through the gas pipe 2; the port 3 is communicated with a glue injection end of a standard pipe through the electromagnetic one-way valve 2. The computer and the motion control box are in communication connection, and the motion control box is controlledly connected to the electromagnetic one-way valve 1, the driving motor, the electromagnetic one-way valve 2, the vacuum pump 1, a stirring mechanism and the vacuum pump 2 through the cable.

2. The standard tube making apparatus of claim 1, wherein The device further comprises a liquid collecting bottle, which is used for collecting liquid drops discharged from a free end of the standard pipe.

3. The apparatus of claim 1, wherein The device further comprises the stirring mechanism, which is arranged in the filling liquid tank.

4. The apparatus of claim 1, wherein The device further comprises a back plate, which is provided with a fixing seat and a supporting sleeve; a detection window of the standard pipe is arranged on the fixing seat, the supporting sleeve is used for restricting a quartz capillary bundle of the standard pipe, and the high-pressure liquid injection pump is fixed to the back plate.

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