Exosome extraction concentrator

Abstract

The utility model discloses an exosome extraction concentrator which comprises a concentrator body, an extraction bin is arranged in the concentrator body, an extraction tank is arranged in the extraction bin, a plurality of sets of supports are fixedly installed on the inner wall of the extraction tank, lantern rings are rotationally connected to the inner side surfaces of the supports, and one end of each lantern ring is fixedly connected with a tank body cover. A rotating seat is hinged to the upper end of the supporting plate, an adjusting screw rod is rotatably connected to the upper surface of the rotating seat, a plurality of groups of sliding grooves are formed in the upper surface of the extraction tank, moving blocks are slidably connected to the interiors of the sliding grooves, and the upper end of the adjusting screw rod penetrates through the moving blocks and is in threaded connection with the moving blocks; and a controller is mounted on one side of the cover plate. The problem that a supporting frame in a traditional concentrator is inconvenient to adjust due to fixed installation is solved, so that the angle of the supporting frame can be flexibly adjusted when exosomes in different liquids are extracted during use, the trouble of workers is reduced, and meanwhile, the use flexibility of the concentrator is improved.

Description

Technical Field

[0001] This utility model relates to the field of concentration instruments, specifically an exosome extraction and concentration instrument. Background Technology

[0002] A concentrator is an instrument used in scientific research experiments, environmental monitoring and evaluation experiments, analytical testing experiments, and material composition analysis research. It is typically used to extract exosomes from bodily fluids such as urine, pleural and peritoneal effusions, breast milk, and saliva.

[0003] Currently, most concentrators are centrifugal concentrators. In use, test tubes containing liquid are mounted on a support frame inside the concentrator, and then the liquid is centrifuged at high speed to extract exosomes. Since the concentration of the extracted liquid varies and the centrifugal force required for centrifugation differs, the test tubes need to be adjusted to different angles; otherwise, the extraction efficiency will be reduced. However, the support frame inside existing concentrators is generally fixed to the motor drive shaft inside the concentrator, so the angle cannot be adjusted during use. Different support frames are required to extract exosomes from different bodily fluids, which is cumbersome and reduces the flexibility of the concentrator. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides an exosome extraction and concentration instrument that solves the problem of inconvenient adjustment of the fixed support frame inside traditional concentrators. This allows for flexible adjustment of the support frame angle when extracting exosomes from different liquids, thus reducing the inconvenience for operators and improving the flexibility of the concentrator.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an exosome extraction and concentration instrument, comprising a concentration instrument body, an extraction chamber inside the concentration instrument body, and an extraction tank inside the extraction chamber. Multiple sets of supports are fixedly installed on the inner wall of the extraction tank, and a collar is rotatably connected to the inner surface of each support. A tank cover is fixedly connected to one end of the collar, and a rotating seat is hinged to the upper end of a support plate. An adjusting screw is rotatably connected to the upper surface of the rotating seat. Multiple sets of sliding grooves are formed on the upper surface of the extraction tank, and a moving block is slidably connected inside each groove. The upper end of the adjusting screw passes through the moving block and is threadedly connected to it. A cover plate is installed on the upper surface of one end of the concentration instrument body, and a controller is installed on one side of the cover plate.

[0006] Preferably, a marker is fixedly connected to the upper surface of the movable block, and a marking line is provided on one side of the slide groove, with the marking line corresponding to the marker.

[0007] Preferably, the upper end of the extraction tank is equipped with a tank cover, and a limit ring is fixedly connected to the upper surface of the tank cover.

[0008] Preferably, a sealing ring is fixedly connected to the inner surface of the cover plate, and a limit rod is slidably connected inside the cover plate. One end of the limit rod is fixedly connected to a spring, and one end of the spring is fixedly connected to the outer surface of the cover plate.

[0009] Preferably, a drive shaft is fixedly connected to the lower surface of the extraction tank, and a drive motor is fixedly connected to the lower end of the drive shaft.

[0010] Preferably, the inner wall of the extraction chamber is fixedly connected to a, and the upper end of the chamber is fixedly connected to a, wherein a wear-resistant ring is provided above, and the wear-resistant ring is fixedly connected to the lower surface of the extraction tank.

[0011] Preferably, the inner surface of the slide groove is symmetrically provided with limiting slide grooves, and the interior of the limiting slide groove is fixedly connected to the moving block by a limiting slider.

[0012] Preferably, the cover plate has symmetrical grooves on one side surface, and a slider is slidably disposed inside the groove, and one side surface of the slider is fixedly connected to the side surface of the limiting rod.

[0013] This invention provides an exosome extraction and concentration apparatus. Compared with the prior art, it has the following advantages:

[0014] 1. The collar rotatably connected to the inner surface of the internal support of the extraction tank and the support plate fixedly connected to one end of the collar, along with the adjusting screw and the moving block inside the slide groove connected to the upper surface of the support plate via a rotating seat, cooperate with each other. This solves the problem of inconvenient adjustment of the fixed installation of the internal support frame of the traditional concentrator. As a result, the angle of the support frame can be flexibly adjusted when extracting exosomes from different liquids, thus reducing the trouble for the staff and improving the flexibility of the concentrator.

[0015] 2. The limiting ring on the upper surface of the extraction tank cover and the limiting rod that is slidably connected inside the cover plate cooperate with the spring that is fixedly connected to one end of the limiting rod. During the rotation of the extraction tank, the extraction tank can be limited and shaken during high-speed rotation, thus preventing the quality of exosomes extracted by the concentrator from being affected. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of this utility model;

[0017] Figure 2 This is a side view of the structure of this utility model;

[0018] Figure 3 This is a schematic diagram of the extraction tank of this utility model;

[0019] Figure 4 for Figure 3 A schematic diagram of the structure viewed from below;

[0020] Figure 5 This is a schematic diagram of the support structure in this utility model;

[0021] Figure 6 for Figure 2 A magnified structural diagram of A in the middle.

[0022] In the diagram: 1. Concentrator body; 101. Extraction chamber; 2. Extraction tank; 201. Tank cover; 202. Limiting ring; 203. Adjusting screw; 204. Slide groove; 205. Marker; 206. Drive shaft; 207. Support; 208. Collar; 209. Moving block; 2091. Marker; 2010. Support plate; 2011. Rotating seat; 3. Cover plate; 301. Limiting rod; 302. Sealing ring; 303. Spring; 304. Groove; 305. Slider; 4. Controller; 5. Hydraulic cylinder; 501. Brake pad. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1-6 This utility model provides a technical solution: an exosome extraction and concentration instrument, including an instrument body 1, an extraction chamber 101 inside the instrument body 1, and an extraction tank 2 inside the extraction chamber 101. Multiple sets of supports 207 are fixedly installed on the inner wall of the extraction tank 2, and a collar 208 is rotatably connected to the inner surface of the support 207. One end of the collar 208 is fixedly connected to a tank cover 201, and a rotating seat 2011 is hinged to the upper end of the support plate 2010. An adjusting screw 203 is rotatably connected to the upper surface of the rotating seat 2011. Multiple sets of sliding grooves 204 are opened on the upper surface of the extraction tank 2, and a moving block 209 is slidably connected inside the sliding groove 204. The upper end of the adjusting screw 203 passes through the moving block 209 and is threadedly connected to the moving block 209. A cover plate 3 is installed on the upper surface of one end of the instrument body 1, and a controller 4 is installed on one side of the cover plate 3.

[0025] As a technical optimization of this utility model, a marker 2091 is fixedly connected to the upper surface of the moving block 209, and a marking line 205 is opened on one side of the slide groove 204, and the marking line 205 corresponds to the marker 2091, so that the staff can easily judge the tilt angle of the collar 208 according to the marking line 205 and the marker 2091.

[0026] As a technical optimization of this utility model, a tank cover 201 is installed on the upper end of the extraction tank 2, and a limit ring 202 is fixedly connected to the upper surface of the tank cover 201.

[0027] As a technical optimization of this utility model, a sealing ring 302 is fixedly connected to the inner surface of the cover plate 3, and a limiting rod 301 is slidably connected inside the cover plate 3. A spring 303 is fixedly connected to one end of the limiting rod 301, and one end of the spring 303 is fixedly connected to the outer surface of the cover plate 3. The sealing ring 302 can seal the extraction chamber 101, and the limiting rod 301 and the limiting ring 202 cooperate with each other to limit the extraction tank 2 and improve the rotational stability of the extraction tank 2, so as to avoid the extraction tank 2 from shaking during rotation.

[0028] As a technical optimization of this utility model, a drive shaft 206 is fixedly connected to the lower surface of the extraction tank 2, and a drive motor is fixedly connected to the lower end of the drive shaft 206.

[0029] As a technical optimization of this utility model, a hydraulic cylinder 5 is fixedly connected to the inner wall of the extraction chamber 101, and a brake pad 501 is fixedly connected to the upper end of the hydraulic cylinder 5. A wear-resistant ring is provided above the brake pad 501, and the wear-resistant ring is fixedly connected to the lower surface of the extraction tank 2. The extraction tank 2 can be stopped by the brake pad 501 at the upper end of the cylinder 5 and the wear-resistant ring on the lower surface of the extraction tank 2, thereby reducing the waiting time of the staff.

[0030] As a technical optimization of this utility model, the inner surface of the slide 204 is symmetrically provided with limiting slide grooves, and the interior of the limiting slide grooves is fixedly connected to the moving block 209 through a limiting slider.

[0031] As a technical optimization of this utility model, a groove 304 is symmetrically provided on one side surface of the cover plate 3, and a slider 305 is slidably provided inside the groove 304. One side surface of the slider 305 is fixedly connected to the side surface of the limiting rod 301.

[0032] As a technical optimization of this utility model, a groove 304 is symmetrically provided on one side surface of the cover plate 3, and a slider 305 is slidably provided inside the groove 304. One side surface of the slider 305 is fixedly connected to the side surface of the limiting rod 301.

[0033] In use, first open the cover plate 3 on the upper surface of the concentrator body 1, then open the tank cover 201 by rotation. Next, place the test tube containing liquid inside the collar 208, and then close the tank cover 201. At this point, the operator rotates the adjusting screw 203, causing the collar 208 inside the support 207 to rotate. As the collar 208 rotates, the moving block 209 inside the slide groove 204 will slide. The operator then observes the marker 2 on the upper surface of the moving block 209. The tilt angle of the collar 208 is determined by marking the line 205 on one side of the slide 204 and the 091. After adjusting the angle of the collar 208, the operator first pulls the limiting rod 301, then covers the extraction chamber 101 with the cover plate 3, and then releases the limiting rod 301. At this time, the limiting rod 301 will be inserted into the limiting ring 202 under the elastic force of the spring 303, thereby limiting the extraction tank 2. Then the operator starts the drive motor to drive the extraction tank 2 to rotate and extract exosomes from the liquid.

[0034] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0035] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, the phrase "comprising an element defined as..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0036] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An exosome extraction and concentration apparatus, characterized in that: include, The concentrator body (1) has an extraction chamber (101) inside, and an extraction tank (2) inside the extraction chamber (101). Multiple sets of brackets (207) are fixedly installed on the inner wall of the extraction tank (2), and a collar (208) is rotatably connected to the inner surface of the bracket (207). One end of the collar (208) is fixedly connected to the tank cover (201), and a rotating seat (2011) is hinged to the upper end of the support plate (2010). An adjusting screw (203) is rotatably connected to the upper surface of the rotating seat (2011). Multiple sets of sliding grooves (204) are opened on the upper surface of the extraction tank (2), and a moving block (209) is slidably connected inside the sliding groove (204).

2. The exosome extraction and concentration apparatus according to claim 1, characterized in that: A marker (2091) is fixedly connected to the upper surface of the movable block (209), and a marking line (205) is provided on one side of the slide groove (204), with the marking line (205) corresponding to the marker (2091).

3. The exosome extraction and concentration apparatus according to claim 1, characterized in that: The extraction tank (2) is equipped with a tank cover (201) at its upper end, and a limit ring (202) is fixedly connected to the upper surface of the tank cover (201).

4. An exosome extraction and concentration apparatus according to claim 1, characterized in that: It also includes a cover plate (3), on the inner surface of which a sealing ring (302) is fixedly connected, and a limit rod (301) is slidably connected inside the cover plate (3). One end of the limit rod (301) is fixedly connected to a spring (303), and one end of the spring (303) is fixedly connected to the outer surface of the cover plate (3).

5. An exosome extraction and concentration apparatus according to claim 1, characterized in that: The lower surface of the extraction tank (2) is fixedly connected to a drive shaft (206), and the lower end of the drive shaft (206) is fixedly connected to a drive motor.

6. An exosome extraction and concentration apparatus according to claim 1, characterized in that: A hydraulic cylinder (5) is fixedly connected to the inner wall of the extraction chamber (101), and a brake pad (501) is fixedly connected to the upper end of the hydraulic cylinder (5). A wear-resistant ring is provided above the brake pad (501), and the wear-resistant ring is fixedly connected to the lower surface of the extraction tank (2).

7. An exosome extraction and concentration apparatus according to claim 1, characterized in that: The inner surface of the slide (204) is symmetrically provided with limiting slide grooves, and the interior of the limiting slide groove is fixedly connected to the moving block (209) through a limiting slider.

8. An exosome extraction and concentration apparatus according to claim 4, characterized in that: The cover plate (3) has symmetrical grooves (304) on one side surface, and a slider (305) is slidably provided inside the groove (304). One side surface of the slider (305) is fixedly connected to the side surface of the limiting rod (301).

9. An exosome extraction and concentration apparatus according to claim 1, characterized in that: A cover plate (3) is installed on the upper surface of one end of the concentrator body (1), and a controller (4) is installed on one side of the cover plate (3).

10. An exosome extraction and concentration apparatus according to claim 1, characterized in that: The upper end of the adjusting screw (203) passes through the moving block (209) and is threadedly connected to the moving block (209).

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