Heparin sodium enzymolysis device

Abstract

The utility model discloses a heparin sodium enzymolysis device which comprises an enzymolysis reaction barrel, and is characterized in that a heating interlayer is arranged in the enzymolysis reaction barrel, a pH value monitoring meter is arranged at the upper end of the enzymolysis reaction barrel, a stirring turning plate is arranged in the enzymolysis reaction barrel, a stirring rod is arranged on the stirring turning plate, and the stirring rod is connected with the heating interlayer. The upper end of the enzymolysis reaction barrel is connected with a flow pump through a liquid inlet pipeline, and a flow control valve is mounted on the liquid inlet pipeline. The stirring turning plate and the stirring rod are driven and controlled by the motor to synchronously rotate, a heparin sodium enzymolysis solution can be deeply mixed and stirred, meanwhile, the temperature control mechanism is arranged, the enzymolysis reaction temperature can be conveniently and accurately controlled and adjusted, meanwhile, the pH value of the solution in the barrel body can be monitored in real time through the pH value monitoring meter, and the stirring efficiency is improved. The optimal pH value of the enzymolysis reaction can be conveniently maintained, and the concentration of the enzymolysis liquid can be accurately controlled by adopting the flow control device, so that the enzymolysis efficiency is further improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to heparin sodium zymolysis technical field, concretely is a kind of heparin sodium zymolysis device. BACKGROUND

[0002] Heparin sodium is a mucopolysaccharide sulfate anticoagulant, which is a sodium salt of sulfated amino dextran extracted from the intestinal mucosa of pigs or cattle, and belongs to mucopolysaccharide substances. In recent years, research has shown that heparin sodium also has a blood lipid-lowering effect, with very high medicinal value. During production, heparin sodium generally undergoes processes such as scraping intestines, enzymatic hydrolysis, adsorption, desorption, and precipitation. The enzymatic hydrolysis process involves adding an enzymatic hydrolysis agent to the pig small intestine mucosa solution obtained from the scraping step to decompose the medicinal components in the mucosa solution from biological matter, so that they can be adsorbed by resin. Enzymatic hydrolysis is usually carried out in an enzymatic hydrolysis tank.

[0003] Chinese patent document with authorization announcement number CN221344583U discloses an enzymatic hydrolysis device for heparin sodium, relating to the technical field of organic chemical processing equipment, solves the technical problem of existing technology that cannot uniformly stir and reliably regulate temperature, and includes a main base, an inner support fixedly installed on the main base, a processing tank rotatably installed in the inner support, a main shaft rotatably installed in the processing tank, a stirring rod fixedly installed on the main shaft, a heating structure installed in the main shaft, a tank body overturning structure installed on the main base, and a stirring driving structure installed on the main base. The utility model can uniformly stir and reliably regulate temperature, improve the efficiency and quality of heparin sodium enzymatic hydrolysis, better control the temperature and stirring speed during enzymatic hydrolysis, make the device more stable and reliable, reduce the failure rate during operation, make the processing tank more stably installed on the main base, and reduce shaking and tilting during operation.

[0004] The above-mentioned prior art cannot perform deep mixing and stirring on heparin sodium enzymatic hydrolysis solution, cannot accurately control and adjust the flow of enzymatic hydrolysis solution, and results in low enzymatic hydrolysis reaction efficiency, so a new type of heparin sodium enzymatic hydrolysis device needs to be developed. UTILITY MODEL CONTENTS

[0005] The utility model aims to provide a heparin sodium enzymatic hydrolysis device to solve the problem of low enzymatic hydrolysis reaction efficiency caused by the inability of the prior art to perform deep mixing and stirring on heparin sodium enzymatic hydrolysis solution and the inability to accurately control and adjust the flow of enzymatic hydrolysis solution.

[0006] To achieve the above object, the utility model provides the following technical scheme: a heparin sodium enzymatic hydrolysis device, including enzymatic hydrolysis reaction bucket, its characterized in being that the inside installation of enzymatic hydrolysis reaction bucket has heating sandwich, the inside installation of heating sandwich has heating pipe, the upper end of enzymatic hydrolysis reaction bucket is equipped with acid-base degree monitoring table, the inside installation of enzymatic hydrolysis reaction bucket has stirring paddle, the stirring paddle is installed on the stirring rod, the upper end of enzymatic hydrolysis reaction bucket is connected with flow pump through liquid inlet pipeline, and flow control valve is installed on the liquid inlet pipeline.

[0007] Preferably, the upper end of the enzymatic hydrolysis reaction bucket is provided with a working machine box, and the inside of the working machine box is provided with a driving motor.

[0008] Preferably, the output end of the driving motor is connected with the stirring paddle through a rotating shaft, and the stirring rods are distributed in parallel on the surface of the stirring paddle.

[0009] Preferably, one end of the flow pump is sealingly connected with an enzymatic hydrolysis liquid storage tank through a liquid pumping pipeline.

[0010] Preferably, the bottom of the enzymatic hydrolysis reaction bucket is provided with a control cabinet, the front surface of the control cabinet is respectively provided with a temperature display screen, a temperature adjusting knob and a power switch, and the bottom of the control cabinet is welded and fixed with a support rack.

[0011] Preferably, the side surface of the enzymatic hydrolysis reaction bucket is provided with a liquid outlet pipeline, and a liquid outlet control valve is installed on the liquid outlet pipeline.

[0012] Preferably, a temperature sensor is installed on the inner surface wall of the enzymatic hydrolysis reaction bucket, and the temperature sensor is electrically connected with the temperature display screen.

[0013] Compared with the prior art, the utility model has the beneficial effects that:

[0014] The utility model discloses a motor-driven stirring paddle and stirring rod are used to carry out synchronous rotation operation, can carry out depth mixing and stirring to heparin sodium enzymatic hydrolysis solution, is provided with temperature control mechanism simultaneously, is convenient for accurate control and adjustment to enzymatic hydrolysis reaction temperature, simultaneously utilizes acid-base degree monitoring table and can carry out real time monitoring to the solution PH value in the barrel body, is convenient for maintaining the optimum PH value of enzymatic hydrolysis reaction, can accurately control enzymatic hydrolysis liquid concentration by adopting flow control device, further improves enzymatic hydrolysis efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0015] Fig. 1 It is the inside installation structure schematic view of the utility model;

[0016] Fig. 2 It is the front view of the utility model;

[0017] Fig. 3The utility model discloses an enzymolysis reaction bucket external structure schematic diagram.

[0018] In the drawing: 1, operation machine box, 2, drive motor, 3, enzymolysis reaction bucket, 4, heating pipe, 5, heating sandwich, 6, stirring rod, 7, stirring paddle, 8, liquid outlet control valve, 9, liquid outlet pipeline, 10, support frame, 11, temperature display screen, 12, control cabinet, 13, temperature adjusting knob, 14, power switch, 15, rotating shaft, 16, liquid inlet pipeline, 17, flow control valve, 18, flow pump, 19, liquid suction pipeline, 20, enzymolysis solution storage tank, 21, temperature sensor, 22, pH monitoring table. DETAILED DESCRIPTION

[0019] The technical scheme in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments.

[0020] Please refer to Figs. 1-3 The utility model provides an embodiment: a heparin sodium enzymolysis device, the inside installation of enzymolysis reaction bucket 3 has heating sandwich 5, the inside installation of heating sandwich 5 has heating pipe 4, the upper end of enzymolysis reaction bucket 3 is installed with pH monitoring table 22, the inside installation of enzymolysis reaction bucket 3 has stirring paddle 7, is installed with stirring rod 6 on stirring paddle 7, the upper end of enzymolysis reaction bucket 3 is connected with flow pump 18 through liquid inlet pipeline 16, is installed with flow control valve 17 on liquid inlet pipeline 16.

[0021] Further, the upper portion of enzymolysis reaction bucket 3 is installed with operation machine box 1, the inside installation of operation machine box 1 has drive motor 2, the output of drive motor 2 is connected with stirring paddle 7 through rotating shaft 15, stirring rod 6 is parallelly distributed on the surface of stirring paddle 7, by opening drive motor 2 for driving control rotating shaft 15 rotation, to further drive stirring paddle 7 and stirring rod 6 to the heparin sodium enzymolysis solution carries out depth sufficient mixing stirring operation, improves enzymolysis reaction efficiency.

[0022] Further, one end of flow pump 18 is sealingly connected with enzymolysis solution storage tank 20 through liquid suction pipeline 19, by opening flow pump 18, the enzymolysis solution inside enzymolysis solution storage tank 20 can be quantitatively extracted through liquid suction pipeline 19, cooperate flow control valve 17, and the enzymolysis solution is quantitatively delivered to the inside of enzymolysis reaction bucket 3 through liquid inlet pipeline 16, to reach the accurate control adjustment of enzymolysis solution amount, improve enzymolysis reaction efficiency.

[0023] Further, the bottom of the enzymolysis reaction barrel 3 is provided with a control cabinet 12, and the front surface of the control cabinet 12 is provided with a temperature display screen 11, a temperature adjusting knob 13 and a power switch 14, respectively. The bottom of the control cabinet 12 is welded and fixed with a support rack 10 for supporting and stabilizing the bottom of the control cabinet 12.

[0024] Further, the side surface of the enzymolysis reaction barrel 3 is provided with a liquid outlet pipeline 9, and the liquid outlet pipeline 9 is provided with a liquid outlet control valve 8. After the liquid outlet control valve 8 is opened, the fully reacted heparin sodium enzymolysis solution can be discharged through the liquid outlet pipeline 9.

[0025] Further, the inner surface wall of the enzymolysis reaction barrel 3 is provided with a temperature sensor 21, and the temperature sensor 21 is electrically connected with the temperature display screen 11. The temperature sensor 21 can be used for real-time monitoring of the reaction temperature in the enzymolysis reaction barrel 3, and the temperature display screen 11 can be used for real-time display of the temperature value, so as to facilitate the observation, control and adjustment of the operator.

[0026] Working principle: when in use, the upper end of the enzymolysis reaction barrel 3 is connected with a flow pump 18 through a liquid inlet pipeline 16, and the liquid inlet pipeline 16 is provided with a flow control valve 17. One end of the flow pump 18 is sealingly connected with an enzymolysis liquid storage tank 20 through a liquid pumping pipeline 19. By opening the flow pump 18, the enzymolysis liquid in the enzymolysis liquid storage tank 20 can be quantitatively pumped out through the liquid pumping pipeline 19. The enzymolysis liquid is quantitatively delivered into the enzymolysis reaction barrel 3 through the liquid inlet pipeline 16 by cooperating with the flow control valve 17, so as to achieve precise control and adjustment of the amount of enzymolysis liquid, improve the enzymolysis reaction efficiency, and drive the control rotating shaft 15 to rotate by opening the driving motor 2, so as to further drive the stirring paddle 7 and the stirring rod 6 to perform deep and sufficient mixing and stirring operation on the heparin sodium enzymolysis solution, thereby improving the enzymolysis reaction efficiency. The inside of the enzymolysis reaction barrel 3 is provided with a heating sandwich 5, and the inside of the heating sandwich 5 is provided with a heating pipe 4. The heating pipe 4 can be used for heating control of the inside of the enzymolysis reaction barrel 3. The temperature sensor 21 can be used for real-time monitoring of the reaction temperature in the enzymolysis reaction barrel 3, and the temperature display screen 11 can be used for real-time display of the temperature value, so as to facilitate the observation, control and adjustment of the operator. The upper end of the enzymolysis reaction barrel 3 is provided with a pH value monitoring table 22 for real-time monitoring of the PH value in the enzymolysis reaction barrel 3.

[0027] It is to be noted that, in the present document, relational terms such as first and second and the like can be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus.

[0028] The standard parts used in the present application can be purchased from the market, the specific connection mode of each part is connected by using the conventional means such as bolt, rivet and welding in the prior art, and the mechanical, part and equipment adopt the conventional type in the prior art, and the circuit connection adopts the conventional connection mode in the prior art, which will not be described in detail here.

[0029] Although the embodiments of the present application have been shown and described, it is to be understood that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A heparin sodium enzymatic hydrolysis device comprising an enzymatic hydrolysis reaction barrel (3), characterized in that, The inside of the enzymolysis reaction bucket (3) is internally provided with a heating sandwich (5), the inside of the heating sandwich (5) is internally provided with a heating pipe (4), the upper end of the enzymolysis reaction bucket (3) is provided with a pH monitoring table (22), the inside of the enzymolysis reaction bucket (3) is internally provided with a stirring paddle (7), the stirring paddle (7) is provided with a stirring rod (6), the upper end of the enzymolysis reaction bucket (3) is connected with a flow pump (18) through a liquid inlet pipeline (16), and the liquid inlet pipeline (16) is provided with a flow control valve (17).

2. The heparin sodium enzymatic device according to claim 1, wherein: The upper end of the enzymolysis reaction bucket (3) is provided with a working machine box (1), and the inside of the working machine box (1) is internally provided with a driving motor (2).

3. A heparin sodium enzymatic device according to claim 2, characterized in that: The output end of the driving motor (2) is connected with the stirring paddle (7) through a rotating shaft (15), and the stirring rod (6) is parallelly distributed on the surface of the stirring paddle (7).

4. The heparin sodium enzymatic device of claim 1, wherein: One end of the flow pump (18) is sealingly connected with an enzymolysis liquid storage tank (20) through a liquid pumping pipeline (19).

5. The heparin sodium enzymatic device of claim 1, wherein: The bottom of the enzymolysis reaction bucket (3) is provided with a control cabinet (12), the front surface of the control cabinet (12) is respectively provided with a temperature display screen (11), a temperature adjusting knob (13) and a power switch (14), and the bottom of the control cabinet (12) is welded and fixed with a support rack (10).

6. The heparin sodium enzymatic device of claim 1, wherein: The side surface of the enzymolysis reaction bucket (3) is provided with a liquid outlet pipeline (9), and the liquid outlet pipeline (9) is provided with a liquid outlet control valve (8).

7. The heparin sodium enzymatic device of claim 5, wherein: The inner surface wall of the enzymolysis reaction bucket (3) is provided with a temperature sensor (21), and the temperature sensor (21) and the temperature display screen (11) are electrically connected.

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