Turnover type filtering, washing and drying machine for particle preparation

Abstract

The utility model relates to a turnover type filtering, washing and drying machine for particle preparation, which solves the problems that materials are filtered, accumulated and hardened, the filtering rate is reduced, the materials are not fully mixed and the drying yield of solid materials is low in the using process of the existing filtering, washing and drying equipment. An upper sealing head is arranged at the top of a charging barrel, a stirring motor is arranged on the upper portion of the upper sealing head and connected with a stirring shaft extending downwards into the charging barrel, a filter basket is arranged in the charging barrel, a base plate is arranged at the bottom of the charging barrel, and an upper sealing piece is arranged between the circumference of the upper end face of the filter basket and the upper sealing head. An upper sealing element is arranged between the circumference of the lower end surface of the filter basket and the chassis, a lower sealing element is arranged between the circumference of the lower end surface of the filter basket and the chassis, the upper sealing element and the lower sealing element are flexible sealing elements, a plurality of vibrators are uniformly arranged on the chassis around the central point, and vibration heads of the vibrators are fixed with the bottom surface of the filter basket from bottom to top. The vibration performance of the overturning type filtering, washing and drying machine is improved, the problem of blockage of the filter basket is solved, and the material uniformity is improved.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical equipment and relates to a filtration, washing and drying device for particulate pharmaceutical preparations, and particularly to a rotary filtration, washing and drying machine for particulate preparation. Background Technology

[0002] The preparation of particulate pharmaceutical formulations often involves one or more steps in the process of solid-liquid separation, solid-liquid suspension, solid-solid mixing, and solid drying. The rotary filter washing and drying machine can complete the above process flow of particulate pharmaceutical formulations in a closed container. This equipment can not only reduce the transfer of materials between equipment, simplify the process flow, improve production efficiency, and prevent cross-contamination of materials, but also clean and sterilize online, realize mechatronics, effectively reduce the cleanroom area used in the entire production process, and reduce the basic investment cost of pharmaceutical production. However, the following problems have been found in the use of the rotary filter washing and drying machine currently on the market: (1) During the solid-liquid separation filtration process, a thick filter cake is generated, which affects the filtration rate and throughput. The bottom layer of the filter cake has the longest solid content due to the accumulation of particles and the longest pressure time, and is most prone to particle adhesion and caking due to compression. Under the worst conditions, the thick filter cake generated by the accumulation of particles at the bottom layer may even block the filter screen, and the filtrate cannot be filtered smoothly. (2) Some pharmaceutical microparticle formulations require the addition of desiccant during the drying process to prevent microparticles from sticking together, adhering to the inner surface of the equipment, and being degraded or inactivated by high temperatures. There are generally differences in particle size, bulk density, and other powder properties between microparticles and desiccant, which can lead to inconsistent mixing uniformity when they are directly mixed. In some cases, insufficient desiccant may cause clumping of the microparticle formulation, affecting sieving. (3) Microparticle formulations tend to adhere to the screen or sidewalls. There are dead zones in the equipment. If the microparticles adhering to the equipment cannot be detached from the equipment in a short time, the material may stick and clump in the dead zone, affecting the final product yield.

[0003] For example, Chinese patent CN 117482887 A discloses a microsphere drying and curing molding device, which includes a pressure control unit, a gas collection hood, a vibration generating unit, etc. This device has several drawbacks: (1) During the filtration process, the filtrate is filtered from both the side and bottom of the filter basket at the same time, and it is not possible to filter separately from the side or bottom of the filter basket. Once the material is highly viscous, it will clog the filter basket in the material contact area, resulting in dense material near the filter basket and a lot of solvent residue in the center of the filter basket, which cannot be effectively filtered. At this time, if the filtration pressure is slightly increased, the pressure will leak from the space above the material layer on the side of the filter basket, which cannot effectively increase the filtration pressure. (2) The filter basket is fixed to the cylinder by a rigid connection through a positioning plate and a gasket. This rigid connection structure determines that it is not possible to use high-frequency and high-intensity vibration, and the vibration can only be limited to a small area. The vibration of the vibration generating unit is located on the side, and the low vibration frequency and small vibration range cannot effectively shake off the material at the bottom of the filter basket. (3) The air hammer striking head extends into the interior of the reactor. During the oscillation process, potential metal chips may be generated. This structure cannot effectively prevent metal chips from entering the product and is not actually suitable for the pharmaceutical equipment field.

[0004] For example, Chinese patent CN 216677166 U discloses a filter chassis with backflushing function, including a base, a filter element and a perforated plate supported below the filter element at the upper end of the chassis, and multiple purge pipes fixedly installed on the base. One end of the purge pipe serves as the purge end and extends to the bottom of the filter element, while the other end serves as the air inlet end and extends downward to the outside of the base. This device is used to provide a filter chassis with backflushing function to improve drying, filtration effect and efficiency. Its disadvantages are: (1) One end of the purge pipe opens into the filter element, and the other end is connected to the air pipe connector. During the filtration stage, filtrate will inevitably be retained inside the purge pipe. This residual filtrate is blown back into the material during the gas backflushing process, which is not conducive to the drying of the material and increases the risk of residual solvent and moisture; (2) Once the gas backflushing penetrates the material during the backflushing drying process, the material forms a gas channel above the air hole, and the gas is quickly discharged, which cannot effectively achieve the purpose of backflushing the material to remove it from the screen. The material still adheres to the screen. Microparticles and microspheres have small particle sizes, which can easily cause gas to blow through the material during the backflushing process, forming a "honeycomb"-like gas channel.

[0005] For example, Chinese patent CN 110813899 A discloses a tilting filter washing and drying machine. To address the technical problem of traditional tilting filter washing and drying machines where material is filtered from a single direction (below the material), resulting in limited filtration area and thus affecting filtration efficiency, the tank device increases the filtration area by replacing the traditional planar filter element with a barrel-shaped filter element. A stirring paddle, driven by a rotating mechanism, provides fluid guiding force to direct the material towards the sides and bottom of the barrel-shaped filter element, thereby improving filtration efficiency. This tank device is not suitable for sticky materials, as it easily causes the sticky material to adhere and accumulate in the filter basket, and the maximum dead volume is likely to exist at the right angle of the filter basket. The tank device also discloses the addition of a vibrator with a discharge port at the top of the tank. Before or during the tilting process, the vibrator vibrates the filter screen, shaking off material adhering to the filter element or the inner wall of the tank, ensuring complete discharge when the tank is in the discharge position and accelerating the discharge process. Therefore, the addition of the vibrator only causes vibration before discharge or during tumbling, which cannot effectively solve the problem of filter element adhesion and blockage at any step of the operation. Furthermore, the barrel-shaped filter element is rigidly connected between the upper and lower tanks by the mounting edge of the upper periphery, so even with the addition of the vibrator, the vibration effect on the filter element is extremely limited. Utility Model Content

[0006] This invention addresses the problems of material caking, reduced filtration rate, insufficient material mixing, and low yield of solid materials in existing filtration, washing, and drying equipment by providing a microparticle preparation rotary filtration, washing, and drying machine.

[0007] The technical solution adopted by this utility model to solve its technical problem is: a microparticle preparation rotary filter washing and drying machine, including a rotary support, a material cylinder is mounted on the rotary support, a rotary motor is arranged on the side of the rotary support to drive the material cylinder to rotate, an upper end cap is arranged on the top of the material cylinder, a stirring motor is arranged on the upper part of the upper end cap, the stirring motor is connected to a stirring shaft extending downward into the material cylinder, a filter basket is arranged inside the material cylinder, a base plate is arranged at the bottom of the material cylinder, an upper sealing element is arranged between the circumference of the upper end face of the filter basket and the upper end cap, and a lower sealing element is arranged between the circumference of the lower end face of the filter basket and the base plate. Both the upper and lower sealing elements are flexible sealing elements. Several vibrators are evenly arranged around the center point on the base plate. The vibrators are flexibly inserted into the base plate, and the vibrating heads of the vibrators are rigidly fixed to the bottom surface of the filter basket from bottom to top.

[0008] In this device, the stirring motor drives the stirring shaft to rotate, stirring the material in the filter basket. The lower end of the stirring shaft is equipped with stirring blades. The tilting motor drives the material cylinder to tilt and swing at an angle of +150° to -150°, increasing material flow and drying efficiency, and achieving material tilting and discharge. Several evenly distributed vibrators can vibrate simultaneously or in pairs intermittently, providing multiple vibration mode adjustment functions. They not only directly affect the vibration of the filter basket but also promote changes in the flow direction of the material within the basket. Whether the stirring is activated or not, they have an enhanced effect on quickly resolving screen clogging problems. For example, the appropriate vibration mode can be adjusted according to the material properties, including intermittent vibration of some or all vibrators. When using intermittent vibration of some vibrators, it also includes intermittent pair vibration in a forward or reverse sequence, or intermittent pair vibration in a forward-then-reverse sequence. For example, intermittent pair vibration in a specific sequence causes easily adhering materials to move in the same direction under the vibration of the filter basket. After a period of time, the vibration sequence is changed, causing the material to move in the opposite direction. Further optimization is that, in the intermittent vibration operation mode, the local vibration force of the vibration unit can be adjusted so that it does not exceed the acceptable vibration shear stress tolerance value of the filter basket, and the filter basket will not deform during the vibration process.

[0009] Preferably, there are four or more vibrators, which are evenly and symmetrically distributed at a distance from the center of the chassis.

[0010] Preferably, the vibrator can be a pneumatic vibrator, an electric vibrator, an ultrasonic vibrator, etc.

[0011] Preferably, both the side and bottom filter screens of the filter basket are composed of 3 to 8 layers of woven mesh, and both the side and bottom filter screens are provided with several filter screen support frames. These filter screen support frames typically have the function of resisting deformation stress.

[0012] The filter basket is flexibly connected to the tank body via upper and lower seals. This, combined with the rigid connection between several evenly distributed vibrators and the filter basket, as well as the flexible connection between the vibrators and the chassis, effectively enhances the vibrator's effect on the filter basket during larger vibrations while ensuring the stability of the filter basket within the tank along its vibration trajectory. The material cylinder and chassis are connected by a detachable sealed connection.

[0013] Preferably, the rigid connection between the vibrator and the filter basket is detachable; for example, the top of the vibrator and the support frame at the bottom of the filter basket are rigidly and detachably connected via threaded connections. This detachable connection allows for replacement of the vibrator or adjustment of the number of vibrators.

[0014] Preferably, the outer sides of the side filter screen, upper seal, and lower seal of the filter basket form a side filtration cavity with the material cylinder; the lower side of the bottom filter screen, the inner side of the lower seal, and the upper side of the chassis form a bottom filtration cavity; a bottom filtrate outlet communicating with the bottom filtration cavity is provided in the middle of the chassis, and a side filtrate outlet communicating with the side filtration cavity is provided on the side of the chassis.

[0015] Under normal conditions of adjusting the stirring speed and direction or without starting the stirring, this device can simultaneously adjust or switch between multiple filtration and vibration modes to promptly resolve the problem of material adhesion and deposition on the filter screen during operation. For example, when adhesion and deposition occur on the side filter screen of a single filter basket, the side filtrate outlet is closed and the bottom filtrate outlet is opened, adjusting to bottom filtration of the single filter basket. At this time, the material in the filter basket forms a screening force at the bottom of the basket, which, combined with the vibration adjustment of the vibrator (including simultaneous vibration or intermittent vibration between pairs), creates a tangential flow velocity on the side filter screen of the basket. Adjusting the filter surface and strengthening the flushing of the material adhering or deposited on the side filter screen under different vibration actions, solves the problem of easy clogging. When there is a lot of material adhering and depositing on the bottom filter screen of a single filter basket, the device is adjusted to side filter screen filtration of the single filter basket again. At this time, the screening force of the material in the side filter screen of the basket creates a tangential flow velocity on the bottom filter screen of the basket, effectively reducing the material's screening and deposition on the bottom filter screen of the basket. Combined with the various vibration modes of the vibrator, it effectively solves the clogging caused by material adhesion or deposition on the bottom filter screen of the basket.

[0016] Preferably, the side filter chamber and the bottom filter chamber are sealed and separated. The side filter chamber and the bottom filter chamber are sealed and separated, and the side filtrate outlet or the bottom filtrate outlet on the chassis is opened separately or simultaneously to discharge the filtrate separately or simultaneously, thereby completing the methods of separate side filtration, separate bottom filtration, or simultaneous side and bottom filtration.

[0017] Preferably, the upper and lower ends of the upper seal are fixed parts and the middle section is a flexible section, and the upper and lower ends of the lower seal are fixed parts and the middle section is a flexible section.

[0018] Preferably, the flexible segment is a stretchable corrugated segment. More preferably, the fixing part is made of stainless steel or rubber, and the flexible segment is made of any one of stainless steel, rubber, plastic, or fiber. The rubber, plastic, or fiber may be covered with a suitable inert material, such as polytetrafluoroethylene.

[0019] Preferably, the fixing part is made of stainless steel, and the lower fixing part of the upper sealing member is detachably or non-detachably sealed to the upper end face of the filter basket, and the upper fixing part and the upper end cap are sealed by a detachable contact seal; the upper fixing part of the lower sealing member is detachably or non-detachably sealed to the lower end face of the filter basket, and the lower end is detachably sealed to the chassis by a chuck, and the chassis and the lower sealing member are respectively provided with fixing holes. The upper sealing member's lower fixing part is sealed to the upper end face of the filter basket, and the lower sealing member's upper fixing part is sealed to the lower end face of the filter basket. The connection is non-removable, such as by welding, or detachable, such as by bolts and washers. More preferably, the upper fixing part and the upper end cap are sealed by a compression contact seal. The upper end face of the upper fixing part has a groove that fits a washer, and the washer and the upper end cap are sealed by compression. Even more preferably, the upper fixing part has two grooves that fit two washers, so that the circumferentially arranged upper sealing member and the upper end cap form a circumferential compression contact seal.

[0020] Preferably, the chassis and vibrator are provided with vibration holes corresponding to each other. A vibration sleeve extending into the vibration hole is provided on the bottom surface of the filter basket. A vibration head is inserted through the inner side of the vibration sleeve. The vibration head and the vibration sleeve are fitted with a clearance. The upper end of the vibration head is detachably fixed to the bottom surface of the filter basket. A flexible chuck is provided between the lower end of the vibration head and the lower end of the vibration hole. A vibration connector is provided at the lower end of the flexible chuck. The flexible chuck is detachable. More preferably, the flexible chuck is a telescopic corrugated pipe chuck. Even more preferably, a telescopic corrugated pipe is provided in the middle of the flexible chuck, and the two ends are chucks.

[0021] Preferably, a sealing bellows is fitted around the outside of the vibrating sleeve. The vibrator is located inside the vibrating sleeve of the filter basket, and the vibrating sleeve has a sealing assembly containing a bellows to isolate the inner and outer cavities of the vibrating sleeve. Isolating the vibrator within the vibrating sleeve further prevents potentially insoluble particles caused by vibration from entering the material cavity. More preferably, the vibrating sleeve is made of stainless steel. The potentially insoluble particles include, but are not limited to, metal shavings that may be generated by the vibrating device.

[0022] Preferably, the side wall of the material cylinder or chassis is provided with a fixing pin, and the outer wall of the filter basket's side screen is correspondingly provided with a fixing pin positioning plate. The fixing pin is pneumatically opened and closed. One or more sets of fixing pins and fixing pin positioning plates can be provided to further stabilize the filter basket during operation and prevent the side of the filter basket from colliding with the side of the material cylinder during the flipping process. The fixing pin positioning plate is set on the support frame of the side screen. More preferably, the side support frame of the filter basket's screen is provided with a fixing pin positioning plate and a sealing gasket that contacts the fixing pin when it pops out. The part of the material cylinder or chassis side wall corresponding to the fixing pin positioning plate of the filter basket is a fixing pin hole, and a fixing pin is set in the fixing pin hole. Preferably, this fixing pin is a pneumatically opened and closed structure. When a certain pressure is reached or exceeded, it extends and fits into the concave positioning groove. When the pressure is below a certain pressure, it retracts and disengages from the concave positioning groove. When the air source provides pressure from the air inlet of the fixing pin valve, the fixing pin and the annular washer can pop out in time. After the air source pressure is removed, the fixing pin and the annular washer retract back into the fixing pin hole. Further preferably, when the fixing pin pops out, the fixing pin and its annular washer seal the recessed part of the fixing pin positioning plate and the fixing pin hole, preventing possible contamination by insoluble particles. Even further, the annular washer is an expansion-filled sealing washer, such as an inflatable sealing washer, which can expand or shrink within a certain range. When the cavity needs to be flipped, this fixing pin pops out into the cavity, engaging with the concave positioning groove of the side wall filter support frame. When the cavity is flipped, this structure further supports the filter basket, improving its stability. Even more preferably, the pop-out signal control of the fixing pin and the vibration signal control of the vibrator are mutually exclusive; if one is activated, the other can automatically check and deactivate the corresponding signal. For example, when the vibrator is activated, if it is confirmed that the fixing pin is in a retracted state and disengaged from the fixing pin positioning plate, and if the fixing pin is in a popped-out state, it can be automatically controlled to retract back into the fixing pin hole.

[0023] Preferably, a lifting motor is also provided between the upper end cap and the stirring motor, and a telescopic corrugated pipe is sleeved on the section of the stirring shaft corresponding to the bottom surface of the upper end cap.

[0024] The beneficial effects of this utility model are:

[0025] (1) In the later stages of material filtration, the particulate solid content in wet materials is relatively high, which increases the adhesion to the filter basket contact surface and makes it easy to deposit. At this time, the stirring effect of the stirring device in the tank has a very limited effect on promoting the filtration rate and throughput of solid content. The device of this utility model realizes the side filtration and bottom filtration functions of the filter basket through the upper and lower sealing parts of the filter basket, combined with the side filtrate outlet and bottom filtrate outlet of the chassis. By controlling the switching of multiple filtration modes of the side and bottom of the filter basket, either individually or simultaneously, it effectively avoids the compaction of the material liquid on the filter screen surface, alleviates the screen clogging problem, increases the filtration rate and filtration throughput. Combined with the multiple vibration modes of the several vibrators distributed on the chassis, it is beneficial to adjust in time according to the filtration conditions, enhance the vibration loosening and shedding of the material, promote the displacement of the material in the filter basket, further improve the filtration efficiency and throughput of solid-liquid separation, increase the uniformity of material mixing, and thus effectively improve the yield and content uniformity of the product.

[0026] (2) In the prior art devices, the rigid connection of the filter basket within the tank restricts the vibration effect of the vibrator on the filter basket. In the tank device of this utility model, the filter basket is flexibly connected to the tank through an upper and lower sealing member. Combining the rigid connection between the vibrator and the filter basket with the flexible connection between the vibrator and the chassis, it not only effectively enhances the vibration effect of the vibrator on the filter basket at a larger amplitude, but also effectively ensures the stability of the filter basket within the tank under the vibration trajectory. Through the detachable connection between several vibrators fixedly distributed on the chassis and the bottom of the filter basket, the filter basket moves back and forth according to the vibration trajectory of the vibrator, without shaking in other directions, effectively avoiding collisions of the filter basket within the tank.

[0027] (3) Through the sealing connection between the upper and lower seals of the filter basket and the chassis via the positioning element in the device of this application, the independent sealing of the side filter chamber and the bottom filter chamber of the filter basket is effectively guaranteed even under the trajectory of vibration and reciprocating motion.

[0028] (4) Through this utility model, the metal chips that may be generated by the vibrator are isolated outside the cylinder that the material can access, eliminating potential insoluble particles.

[0029] (5) With the device of this utility model, multiple filtration and vibration modes can be controlled repeatedly according to the properties of the material, effectively solving the clogging problem online and improving the processing efficiency of the liquid without interrupting the process to clean the equipment. Attached Figure Description

[0030] The present invention will be further described below with reference to the accompanying drawings.

[0031] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0032] Figure 2 This is a schematic diagram of a material cylinder and filter basket structure according to this utility model.

[0033] Figure 3 This is a schematic diagram of a filter basket structure according to the present invention.

[0034] Figure 4 This is the utility model Figure 1 Schematic diagram of the structure at point A in the middle.

[0035] Figure 5 This is the utility model Figure 1 Schematic diagram of the structure at point B.

[0036] Figure 6 This is the utility model Figure 1 Schematic diagram of the structure at point C.

[0037] Figure 7 This is the utility model Figure 1 Schematic diagram of the structure at point D.

[0038] Figure 8 This is a schematic diagram of the chassis structure of this utility model.

[0039] In the diagram: 1. Tilting bracket, 2. Tilting motor, 3. Upper end cap, 4. Stirring motor, 5. Lifting motor, 6. Stirring shaft, 7. Telescopic bellows, 8. Cylinder, 9. Chassis, 10. Bottom filtrate outlet, 11. Side filtrate outlet, 12. Cylinder media inlet, 13. Cylinder media outlet, 14. Chassis media outlet, 15. Chassis media inlet, 16. Filter basket, 161. Side filter screen, 162. Bottom filter screen, 17. Side filter chamber, 18. Bottom filter chamber, 19. Vibrator, 20. Lower seal, 21. Upper seal, 22. Vibration sleeve, 23. Sealing bellows, 24. Fixing pin positioning plate, 25. Fixing pin, 26. Chuck, 27. Flexible chuck, 28. Vibration head, 29. Vibration connector, 30. Fixing hole, 31. Vibration hole. Detailed Implementation

[0040] The present invention will be further described below with reference to specific embodiments and accompanying drawings.

[0041] Example: A microparticle preparation rotary filter washing and drying machine, such as Figure 1 As shown. This device includes a tilting bracket 1, on which a material cylinder 8 is mounted. A tilting motor 2 is mounted on the side of the tilting bracket to drive the material cylinder to tilt. An upper end cap 3 is mounted on the top of the material cylinder. A stirring motor 4 is mounted on the upper part of the upper end cap. The stirring motor is connected to a stirring shaft 6 that extends downward into the material cylinder. A lifting motor 5 is also mounted between the upper end cap 3 and the stirring motor 4. A telescopic corrugated pipe 7 is fitted onto a section of the stirring shaft 6 and the lower part of the bottom surface of the upper end cap 3.

[0042] like Figure 1 , 2 As shown in Figure 3, a filter basket 16 is provided inside the material cylinder 8, and a base plate 9 is provided at the bottom of the material cylinder 8. The material cylinder and the base plate 9 are connected in a detachable sealed manner. Figure 1 Point A in the middle and Figure 4 As shown, an upper sealing element 21 is provided between the circumference of the upper end face of the filter basket 16 and the upper end cap. Figure 1 Point B in the middle and Figure 5 As shown, a lower seal 20 is provided between the lower end face of the filter basket 16 and the chassis 9. Both the upper seal 21 and the lower seal 20 are flexible seals. The upper and lower ends of the upper seal are fixed portions, and the middle section is a flexible section. Similarly, the upper and lower ends of the lower seal are fixed portions, and the middle section is a flexible section. In this example, the fixed portion is made of stainless steel, and the flexible section is a stretchable corrugated section of PTFE-coated rubber. The lower fixed portion of the upper seal 21 is fixedly sealed to the upper end face of the filter basket 16, and the upper fixed portion is also sealed by a compression contact with the upper end cap. The upper fixed portion of the lower seal 20 is fixedly sealed to the lower end face of the filter basket 16, and the lower end is detachably sealed to the chassis using a chuck 26. Figure 8 Therefore, the chassis 9 and the lower sealing element are respectively provided with fixing holes 30.

[0043] Both the barrel 8 and the chassis 9 are equipped with hollow jackets. The barrel media inlet 12 and the barrel media outlet 13 are respectively arranged on the side wall of the barrel. The chassis media outlet 14 is arranged on one side, and the chassis media inlet 15 is arranged on the bottom surface of the other side.

[0044] A side filtration chamber 17 is formed between the outer sides of the side filter screen 161, the upper seal 21, and the lower seal 20 of the filter basket and the material cylinder 8; a bottom filtration chamber 18 is formed between the lower side of the bottom filter screen 162, the inner side of the lower seal 20, and the upper side of the chassis; a bottom filtrate outlet 10 communicating with the bottom filtration chamber 18 is provided in the middle of the chassis 9, and a side filtrate outlet 11 communicating with the side filtration chamber 17 is provided on the side of the chassis. The side filtration chamber and the bottom filtration chamber are sealed and separated.

[0045] Eight vibration holes 31 are evenly distributed around the center point on the chassis 9. A vibrator 19 is arranged at each vibration hole 31, flexibly inserted into the chassis, with its vibration head rigidly fixed to the bottom surface of the filter basket from bottom to top. Specifically... Figure 1 C and Figure 6As shown, a vibrating sleeve 22 extending into a vibration hole is provided on the bottom surface of the filter screen 162 at the bottom of the filter basket, and a sealing bellows 23 is fitted on the outside of the vibrating sleeve 22. A vibrating head 28 is inserted through the inner side of the vibrating sleeve, and there is a clearance fit between the vibrating head and the vibrating sleeve. The upper end of the vibrating head 28 is detachably fixed to the bottom surface of the filter basket, and a flexible chuck 27 is provided between the lower end of the vibrating head and the lower end of the vibration hole. A vibration connector 29 is provided at the lower end of the flexible chuck.

[0046] One or more fixing pins 25 are provided on the side wall of the material cylinder 8 or the chassis 9, and a fixing pin positioning plate 24 is correspondingly provided on the side support frame of the filter screen. The fixing pins are pneumatically opened and closed. The pop-out signal control of the fixing pin and the vibration signal control of the vibrator are mutually exclusive. When one is started, the other can automatically check and shut down the corresponding signal. If the vibrator is started, it is confirmed that the fixing pin is in the retracted state and disengaged from the fixing pin positioning plate. If the fixing pin is in the pop-out state, it can be automatically controlled to retract it back into the fixing pin hole.

[0047] In this example, the vibration connector 29 can be connected to an air source to achieve vibration, or to a power source to achieve electric vibration, or to an ultrasonic vibrator.

[0048] The vibration connection 29 connects to the air source and operates as follows: The hardened microparticle suspension is fed into the equipment through the inlet under pressure. The bottom filtrate drain valve is closed, and the filtrate is discharged from the side filtrate outlet to the waste liquid pipeline. When the liquid level drops below a certain point, both the bottom and side filtrate outlets are opened simultaneously for drainage. When the liquid level decreases further, the side filtrate outlet is closed, and the filtrate is discharged from the bottom filtrate outlet to the waste liquid pipeline. The vibrator is turned on and vibrates for 3-8 minutes to loosen the filter residue. Cleaning liquid is then introduced through the inlet for further washing and stirring of the filter residue for 10-20 minutes. The valves are opened and closed as described above to filter the filtrate and loosen the filter residue. An external vacuum pump is connected to the side or bottom filtrate outlet, and a heat transfer medium is introduced into the material cylinder jacket to vacuum dry the microparticles in the cylinder. During the drying process, the equipment is rotated, and the stirring paddles are turned on to agitate the material, causing it to tumble and dry in the filter basket. During the drying process, periodically rotate the equipment back to a vertical angle, turn off the agitator, and turn on the vibrator for 5-10 minutes to fully vibrate and disperse the material in the dead corners of the agitator. Then, rotate the equipment again to stir and dry. Continue drying until the microparticle formulation is completely dried. Return to normal pressure, rotate the equipment to 150°C, and discharge the material from the outlet of the upper end cap. The resulting material has low discharge loss, high solid drying yield, significantly reduced drying time, and thorough and homogeneous mixing. Observe the filter basket surface for any particle adhesion, blockage, or caking.

[0049] The ultrasonic vibration operation connected to the vibration connector 29 is as follows: The hardened microparticle suspension is fed into the equipment through the inlet under pressure. The bottom filtrate outlet is closed, and the side filtrate outlet is opened, allowing the filtrate to be discharged into the waste liquid pipeline. When the liquid level drops below a certain point, both the side and bottom filtrate outlets are opened simultaneously. The ultrasonic vibrator is continuously activated during filtration to accelerate filtration and loosen the filter residue. Further washing is performed by introducing cleaning solution through the inlet, stirring and cleaning the filter residue for 5-10 minutes, while the ultrasonic vibrator is continuously activated to clean any unencapsulated drug adhering to the surface of the microparticles. After cleaning, the side or bottom filtrate outlet is opened and closed as described above for filtration. An external vacuum pump is connected to the side or bottom filtrate outlet, and a heat transfer medium is introduced into the cylinder jacket to vacuum dry the microparticles inside the cylinder. The pneumatic positioning pin in the middle of the cylinder / chassis connection chuck is opened. After confirming the position signal is correct, the equipment is rotated for drying until drying is complete. The resulting solid dried material has a discharge loss of less than 5%, a high solid drying yield, a drying time of no more than 12 hours, good uniformity of discharge content, and no particle adhesion, blockage, or caking on the surface of the filter basket.

Claims

1. A microparticle preparation rotary filter washing and drying machine, comprising a rotary support, a material cylinder supported on the rotary support, a rotary motor for rotating the material cylinder is arranged on the side of the rotary support, an upper end cap is arranged on the top of the material cylinder, a stirring motor is arranged on the upper part of the upper end cap, and the stirring motor is connected to a stirring shaft extending downward into the material cylinder, characterized in that: The filter basket is installed inside the material cylinder, and a base plate is installed at the bottom of the material cylinder. An upper sealing element is installed between the upper end face of the filter basket and the upper end cap, and a lower sealing element is installed between the lower end face of the filter basket and the base plate. Both the upper and lower sealing elements are flexible sealing elements. Several vibrators are evenly arranged around the center point on the base plate. The vibrators are flexibly inserted into the base plate, and the vibrating heads of the vibrators are rigidly fixed to the bottom surface of the filter basket from bottom to top.

2. The microparticle preparation rotary filter washing and drying machine according to claim 1, characterized in that: The side filter screen, upper seal, and lower seal of the filter basket form a side filter cavity with the outer side of the material cylinder; the bottom filter screen of the filter basket forms a bottom filter cavity with the lower side of the bottom seal and the upper side of the chassis; the middle of the chassis is provided with a bottom filtrate outlet communicating with the bottom filter cavity, and the side of the chassis is provided with a side filtrate outlet communicating with the side filter cavity.

3. The microparticle preparation rotary filter washing and drying machine according to claim 2, characterized in that: A sealed partition is established between the side filter chamber and the bottom filter chamber.

4. The microparticle preparation rotary filter washing and drying machine according to claim 1, characterized in that: The upper and lower ends of the upper seal are fixed parts, and the middle section is a flexible section; the upper and lower ends of the lower seal are fixed parts, and the middle section is a flexible section.

5. The microparticle preparation rotary filter washing and drying machine according to claim 4, characterized in that: The flexible section is a stretchable corrugated section.

6. A microparticle preparation rotary filter washing and drying machine according to claim 4 or 5, characterized in that: The fixing part is made of stainless steel. The lower fixing part of the upper sealing member is detachably or non-detachably sealed to the upper end face of the filter basket, and the upper fixing part and the upper end cap are sealed by a detachable contact seal. The upper fixing part of the lower sealing member is detachably or non-detachably sealed to the lower end face of the filter basket, and the lower end is detachably sealed to the chassis by a chuck. The chassis and the lower sealing member are respectively provided with fixing holes.

7. The microparticle preparation rotary filter washing and drying machine according to claim 1, characterized in that: The chassis and vibrator are provided with vibration holes corresponding to each other. The bottom surface of the filter basket is provided with a vibration sleeve that extends into the vibration hole. The vibration head is inserted through the inner side of the vibration sleeve. The vibration head and the vibration sleeve are fitted with a clearance. The upper end of the vibration head is detachably fixed to the bottom surface of the filter basket. A flexible chuck is provided between the lower end of the vibration head and the lower end of the vibration hole. A vibration connector is provided at the lower end of the flexible chuck.

8. The microparticle preparation rotary filter washing and drying machine according to claim 7, characterized in that: A sealing bellows is fitted on the outside of the vibration sleeve.

9. A microparticle preparation rotary filter washing and drying machine according to claim 1, characterized in that: One or more fixing pins are provided on the side wall of the material cylinder or chassis, and a fixing pin positioning plate is provided on the outer wall of the filter screen on the side of the filter basket. The fixing pins are pneumatically opened and closed.

10. A microparticle preparation rotary filter washing and drying machine according to claim 1, characterized in that: A lifting motor is also provided between the upper end cap and the stirring motor, and a telescopic corrugated pipe is sleeved on the section of the stirring shaft corresponding to the bottom surface of the upper end cap.

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