Dalteparin sodium production sterilization device

Abstract

The utility model discloses a dalteparin sodium production sterilization device, which belongs to the technical field of dalteparin sodium production and comprises a base, four damping sleeves are fixedly connected to the top of the base, a spring is arranged at the inner bottom of each damping sleeve, and a sliding column is mounted at the top of each spring. According to the dalteparin sodium production sterilization device, a first motor, a cooling box, a cooling pipe and a movable rod between a sliding column and a rotating seat are arranged and can continuously make contact with the bottom of the cooling box, the movable rod drives the cooling box to move upwards along with rotation of the rotating seat, and the cooling box can drive the sliding column to move upwards in a damping sleeve to stretch a spring; and when the movable rod leaves the bottom of the cooling box, the spring drives the cooling box to move downwards through the elastic force, so that the cooling box shakes to drive the raw materials in the cooling box to shake in the cooling box and continuously make contact with the cooling pipe, and therefore the raw materials are rapidly cooled, and the cooling efficiency of the device is improved.

Description

Technical Field

[0001] This utility model belongs to the field of dalteparin sodium production technology, specifically a dalteparin sodium production sterilization device. Background Technology

[0002] Dalteparin sodium is a low molecular weight heparin sodium, a white or off-white powder. It is virtually odorless, tasteless, and hygroscopic. Dalteparin sodium has anticoagulant and antithrombotic effects. Its anticoagulant effect is achieved by promoting the inhibition of coagulation factors and thrombin by antithrombin, primarily strengthening the inhibition of coagulation factors. It can also slightly prolong the activation time of partial thromboplastin, exhibiting strong antithrombotic effects and low bleeding risk. It also promotes fibrinolysis, protecting endothelial cells by binding to them, thus enhancing the antithrombotic effect. Its impact on platelet function and lipid metabolism is also less than that of unfractionated heparin. During the production of dalteparin sodium, sterilization equipment is often used to irradiate the raw material with ultraviolet light to remove N-NO nitrosamine groups. In existing sterilization equipment, after sterilization, the raw material is left to stand in a cooling chamber for a long time to cool naturally. Prolonged standing can easily lead to degradation of the raw material in the cooling chamber, thus affecting its potency. Utility Model Content

[0003] To overcome the above-mentioned defects, this utility model provides a sterilization device for the production of dalteparin sodium, which solves the problem that after the raw material of dalteparin sodium is subjected to ultraviolet irradiation, the raw material is placed in a cooling box and needs to undergo a long period of natural cooling. The long period of standing can easily lead to degradation of the raw material in the cooling box, thereby affecting the potency of the raw material.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a sterilization device for producing dalteparin sodium, comprising a base, four damping sleeves fixedly connected to the top of the base, a spring disposed at the bottom of each damping sleeve, a sliding column mounted on the top of the spring, the sliding column being slidably connected to the damping sleeve, a common cooling box fixedly connected to the four sliding columns, three cooling pipes disposed on the inner wall of the cooling box, one end of each cooling pipe passing through the cooling box and fixedly connected to an inlet pipe, the other end of each cooling pipe away from the inlet pipe passing through the cooling box and disposed of an outlet pipe, a discharge pipe being installed on the inner wall of the cooling box, and two support plates fixedly connected to both sides of the base, the support plates being in groups of two, with an mounting plate disposed between each group of support plates.

[0005] As a further embodiment of this utility model: a rotating seat is provided on one side of the mounting plate, and four movable rods are arranged between the two rotating seats, one of which is equipped with a first motor passing through the mounting plate.

[0006] As a further embodiment of this utility model: a sterilization box is provided on the top of the cooling box, and the sterilization box is fixedly connected to the top of the four support plates, and a feed pipe is installed on the sterilization box.

[0007] As a further embodiment of this utility model: a second motor is fixedly connected to the top of the sterilization box, and the second motor has a rotating rod installed on its output shaft.

[0008] As a further embodiment of this utility model: several stirring rods are fixedly connected to the outside of the rotating rod, an ultraviolet lamp holder is provided inside the sterilization box, and several heating tubes are installed on the inner wall of the sterilization box.

[0009] As a further embodiment of this utility model: a valve is fixedly connected to the bottom of the sterilization box, a flexible hose is provided at the bottom of the valve, and the flexible hose is fixedly connected to the top of the cooling box.

[0010] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0011] 1. This sodium heparin production sterilization device comprises a first motor, a cooling box, cooling pipes, and a sliding column. The first motor drives a rotating base to rotate via its output shaft, allowing a movable rod between the rotating bases to continuously contact the bottom of the cooling box. As the rotating base rotates, the movable rod moves the cooling box upwards, causing the cooling box to move the sliding column upwards within a damping sleeve, stretching a spring. This spring generates a relative elastic force. When the movable rod leaves the bottom of the cooling box, the spring's elastic force causes the cooling box to move downwards, resulting in vibration within the cooling box. This vibration causes the raw material inside the cooling box to sway and continuously contact the cooling pipes, thereby achieving rapid cooling of the raw material and improving the device's cooling efficiency.

[0012] 2. The sodium heparin production sterilization device is equipped with a second motor, a stirring rod, an ultraviolet lamp holder, and a heating tube. When the heating tube is activated, the sterilization chamber is heated, causing the inner wall of the sterilization chamber to gradually heat up. At the same time, the second motor drives the rotating rod to rotate through the output shaft, which allows the stirring rod outside the rotating rod to drive the raw materials inside the sterilization chamber to flow. This ensures that the raw materials can continuously contact the ultraviolet lamp holder and the chamber wall, thereby improving the sterilization effect of the device. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the structure of this utility model;

[0014] Figure 2 This is a cross-sectional structural diagram of the cooling box and damping sleeve of this utility model;

[0015] Figure 3 This is a cross-sectional structural diagram of the sterilization box and heating tube of this utility model;

[0016] In the diagram: 1. Base; 2. Damping sleeve; 3. Spring; 4. Sliding column; 5. Cooling box; 6. Cooling pipe; 7. Liquid outlet pipe; 8. Liquid inlet pipe; 9. Discharge pipe; 10. Support plate; 11. Mounting plate; 12. First motor; 13. Rotating seat; 14. Movable rod; 15. Sterilization box; 16. Feed pipe; 17. Second motor; 18. Rotating rod; 19. Stirring rod; 20. Ultraviolet lamp holder; 21. Valve; 22. Hose; 23. Heating tube. Detailed Implementation

[0017] The technical solution of this patent will be further described in detail below with reference to specific embodiments.

[0018] like Figure 1-3 As shown, this utility model provides a technical solution: a sterilization device for producing sodium dalteparin, including a base 1, four damping sleeves 2 fixedly connected to the top of the base 1, a spring 3 provided at the bottom of each damping sleeve 2, a sliding column 4 installed on the top of the spring 3, the sliding column 4 being slidably connected to the damping sleeve 2, and the same cooling box 5 fixedly connected to the four sliding columns 4. Three cooling pipes 6 are provided on the inner wall of the cooling box 5. By setting the damping sleeves 2, when the cooling box 5 drives the sliding column 4 to slide inside the damping sleeve 2, the damping sleeve 2 can limit the sliding column 4, preventing the sliding column 4 from deviating during the movement, so that the damping sleeve 2 can consume the elastic potential energy generated by the spring 3, and make the swaying of the sliding column 4 gradually become stable.

[0019] One end of the cooling pipe 6 passes through the cooling box 5 and is fixedly connected to the liquid inlet pipe 8. The other end of the cooling pipe 6, away from the liquid inlet pipe 8, passes through the cooling box 5 and is provided with the liquid outlet pipe 7. The inner wall of the cooling box 5 is equipped with the discharge pipe 9. Two support plates 10 are fixedly connected to both sides of the base 1. The top of the cooling box 5 is equipped with a sterilization box 15, and the sterilization box 15 is fixedly connected to the top of the four support plates 10. The sterilization box 15 is equipped with a feed pipe 16. By setting the feed pipe 16, the raw material can be poured into the feed pipe 16 and enter the sterilization box 15 for sterilization treatment.

[0020] A second motor 17 is fixedly connected to the top of the sterilization chamber 15. The second motor 17 has a rotating rod 18 set through its output shaft. Several stirring rods 19 are fixedly connected to the outside of the rotating rod 18. An ultraviolet lamp holder 20 is set inside the sterilization chamber 15. Several heating tubes 23 are installed on the inner wall of the sterilization chamber 15. By setting the rotating rod 18, the rotating rod 18 is connected to the second motor 17 and the stirring rods 19. Thus, when the second motor 17 is operating, the second motor 17 can drive the stirring rods 19 to rotate through the rotating rod 18, so that the stirring rods 19 can drive the raw materials inside the sterilization chamber 15 to flow.

[0021] A valve 21 is fixedly connected to the bottom of the sterilization box 15. A hose 22 is provided at the bottom of the valve 21. The hose 22 is fixedly connected to the top of the cooling box 5. By setting the hose 22, when the cooling box 5 causes the raw materials inside to shake, the hose 22 can ensure the connection between the cooling box 5 and the sterilization box 15, so that the raw materials inside the sterilization box 15 can flow into the cooling box 5 for cooling treatment.

[0022] The support plates 10 are arranged in pairs, and an installation plate 11 is provided between each pair of support plates 10. A rotating seat 13 is provided on one side of the installation plate 11, and four movable rods 14 are provided between the two rotating seats 13. A first motor 12 is provided through the installation plate 11 in one of the rotating seats 13. By providing the first motor 12, the first motor 12 can control the rotating seat 13 to rotate through the output shaft, so that the rotating seat 13 can drive the cooling box 5 to move upward through the movable rods 14, thereby allowing the movable rods 14 to drive the cooling box 5 to vibrate.

[0023] The working principle of this utility model is as follows:

[0024] In use, the raw materials are poured into the sterilization chamber 15 through the feed pipe 16. The second motor 17, the ultraviolet lamp holder 20, and the heating tube 23 are started, so that the heating tube 23 can heat the inner wall of the sterilization chamber 15. At the same time, the second motor 17 drives the rotating rod 18 to rotate through the output shaft, so that the stirring rod 19 outside the rotating rod 18 can drive the raw materials to flow in the sterilization chamber 15, so that the raw materials can continuously contact the chamber wall and the ultraviolet lamp holder 20 to achieve sterilization. After the sterilization of the raw materials is completed, the valve 21 is opened, allowing the raw materials inside the sterilization chamber 15 to flow into the cooling chamber 5 through the hose 22, and coolant is introduced into the liquid inlet pipe 8. 8 enters the cooling pipe 6 of the cooling box 5, and at the same time, the first motor 12 is started. The first motor 12 drives the rotating seat 13 to rotate through the output shaft, so that the rotating seat 13 can drive the movable rod 14 to contact the bottom of the cooling box 5 and drive the cooling box 5 to move upward. When the cooling box 5 moves upward, the sliding column 4 under the cooling box 5 can stretch the spring 3 inside the damping sleeve 2. So when the movable rod 14 moves away from the cooling box 5, the spring 3 drives the sliding column 4 to move downward through the elastic force, thereby causing the cooling box 5 to shake. This allows the raw material inside the cooling box 5 to continuously contact the cooling pipe 6, thereby completing the cooling treatment of the raw material. Afterward, the cooled raw material is discharged from the cooling box 5 through the discharge pipe 9.

[0025] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0026] The preferred embodiments of this patent have been described in detail above. However, this patent is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of this patent.

Claims

1. A sterile device for the production of dalteparin sodium, comprising a base (1), characterised in that: The base (1) top fixedly connected with four damping sleeve (2), each damping sleeve (2) bottom is provided with spring (3), the spring (3) top is installed with sliding column (4), the sliding column (4) and damping sleeve (2) slidingly connected, four sliding column (4) are fixedly connected with the same cooling box (5), the cooling box (5) inner wall is provided with three cooling pipes (6), one end of the cooling pipe (6) passes through the cooling box (5) and is fixedly connected with the liquid inlet pipe (8), the cooling pipe (6) away from the liquid inlet pipe (8) one end passes through the cooling box (5) and is provided with the liquid outlet pipe (7), the cooling box (5) inner wall is installed with the discharge pipe (9), the base (1) both sides are fixedly connected with two support plates (10), the support plate (10) two are a group, and each group of support plate (10) is provided with the mounting plate (11).

2. The device for producing sterilization of dalteparin sodium according to claim 1, characterized in that: The mounting plate (11) one side is equipped with rotating seat (13), four movable rods (14) are arranged between two rotating seats (13), and one rotating seat (13) is provided with the first motor (12) through the mounting plate (11).

3. The device for producing sterilization of dalteparin sodium according to claim 1, characterized in that: The cooling box (5) top is equipped with the sterilization box (15), and the sterilization box (15) is fixedly connected with the top of four support plates (10), and the sterilization box (15) is installed with the feed pipe (16).

4. The device for producing sterilization of dalteparin sodium according to claim 3, characterized in that: The second motor (17) is fixedly connected with the top of the sterilization box (15), and the second motor (17) is provided with the rotating rod (18) through the output shaft.

5. A device for sterilizing dalteparin sodium production according to claim 4, characterized in that: The rotating rod (18) is fixedly connected with a plurality of stirring rods (19) outside, the sterilization box (15) is provided with the ultraviolet lamp holder (20) inside, and a plurality of heating pipes (23) are installed on the inner wall of the sterilization box (15).

6. The device for producing sterilization of dalteparin sodium according to claim 3, characterized in that: The bottom of the sterilization box (15) is fixedly connected with the valve (21), the bottom of the valve (21) is provided with the hose (22), The hose (22) is fixedly connected with the top of the cooling box (5). ​

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