Betulinic acid extraction device

Abstract

The betulinic acid extraction device comprises a containing box, a stirring frame and a separation barrel, a containing cavity is formed in the containing box, and a containing opening is formed in the upper side of the containing cavity; the stirring frame is arranged in the containing cavity, a vertically-arranged containing cavity is formed in the stirring frame, and the containing cavity corresponds to the containing opening; a plurality of through holes are formed in the surface of the separation barrel and used for separating solid and liquid inside and outside the separation barrel. According to the betulinic acid extraction device, when the stirring frame rotates, liquid on the outer side of the containing cavity is driven to move, so that the liquid in the separation barrel is also driven, solids and the liquid in the separation barrel are fully mixed, and the betulinic acid extraction efficiency is improved; and the other separation barrel filled with the unextracted raw materials is loaded into the accommodating box for next extraction, so that the material changing process is fast, the extracting solution only contains a small amount of fixed powder, the coarse filtering procedure is reduced, and the process difficulty is greatly reduced.

Description

Technical Field

[0001] This application relates to the field of betulinic acid extraction technology, specifically to a betulinic acid extraction device. Background Technology

[0002] Betulinic acid, chemically named 3β-hydroxy-fan-20(29)-en-28-acid, also known as betulinic acid, is a colorless crystal and one of the earliest pentacyclic triterpenoid compounds isolated from birch bark. It is widely distributed in plants of the genera *Betulia*, *Platanus*, Rhamnaceae, Myrtaceae, Araliaceae, and Nelumbo nucifera. Betulinic acid and its derivatives possess various biological activities, including antitumor, anti-HIV, and anti-inflammatory effects, with its anticancer activity being particularly well-known. It has been reported that this class of compounds can induce apoptosis in cancer cells, inhibit tumor growth, and combat angiogenesis. Furthermore, it exhibits selective cytotoxicity between normal and cancer cells, demonstrating its potential in cancer treatment, especially for malignant melanoma. Moreover, it has very low toxicity, making it one of the most promising anticancer drugs. Therefore, researchers are studying the pharmacological activities of betulinic acid and its derivatives through structural modification and developing its medicinal value. There is a large market demand for betulinic acid.

[0003] Betulinic acid extraction typically involves pulverizing a solid containing betulinic acid, placing it in a solvent to dissolve the organic matter, and then separating and purifying impurities. Generally, the pulverized raw material and solvent are mixed and stirred to improve mixing efficiency. After extraction, the mixture needs to be filtered to retain only the liquid, and the container needs to be emptied before the next extraction can be performed. This process involves many steps and has low extraction efficiency. Utility Model Content

[0004] The purpose of this application is to overcome the above-mentioned technical deficiencies and provide a betulinic acid extraction device to solve the problem of low betulinic acid extraction efficiency in the prior art.

[0005] To achieve the above-mentioned technical objectives, the technical solution of this application is as follows: A betulinic acid extraction device includes a receiving box, a stirring rack, and a separating cylinder, wherein: a receiving cavity is formed inside the receiving box, and a receiving opening is opened on the upper side; the stirring rack is disposed in the receiving cavity, and a vertically arranged receiving cavity is formed inside the stirring rack, the receiving cavity corresponding to the receiving opening; the separating cylinder is disposed in the receiving cavity through the receiving opening, and multiple through holes are opened on the surface of the separating cylinder for separating solids and liquids inside and outside the separating cylinder.

[0006] Preferably, the betulinic acid extraction device further includes a drive unit connected to the stirring frame to drive the stirring frame to rotate.

[0007] Preferably, the betulinic acid extraction device further includes two meshing drive gears, one of which is coaxially and fixedly connected to the stirring frame, and the other drive gear is connected to the drive unit so that the drive unit drives the drive gear to rotate.

[0008] Preferably, the stirring rack includes a connecting rod, a connecting plate, and a stirring rod. The plurality of connecting rods are arranged circumferentially along the housing cavity, and the two connecting plates are respectively fixed at both ends of the plurality of connecting rods. The side of the connecting rod away from the housing cavity is connected to the plurality of stirring rods, and the plurality of stirring rods are arranged axially along the connecting rod.

[0009] Preferably, the container includes a container body and a cover plate, the cover plate is fixedly connected to the top of the container body, and the fixed end of the drive unit is fixedly connected to the cover plate.

[0010] Preferably, the cover plate has the receiving opening, and the receiving opening abuts against the outside of the partition cylinder.

[0011] Preferably, an observation window is provided on the side of the container.

[0012] Preferably, the container has an inlet and an outlet communicating with the receiving cavity, the inlet being located on the upper side of the container and the outlet being located on the lower side of the container.

[0013] Preferably, the upper ends of the separator extend outward on both sides to form a gripping portion.

[0014] Preferably, the bottom of the container extends downward to form multiple support legs.

[0015] Compared with the prior art, the beneficial effects of this application include: when the stirring rack rotates, it drives the liquid outside the containment cavity to move, so the liquid in the separator is also driven, which makes the solid and liquid in the separator fully mixed, improving the extraction efficiency of betulinic acid. After the extraction is completed, the separator can be lifted, and another separator containing the raw material that has not been extracted can be put into the containment box for the next extraction. The material replacement process is fast, and the extract contains only a small amount of fixed fragments, reducing the coarse filtration process and greatly reducing the difficulty of the process. Attached Figure Description

[0016] Figure 1 This is a perspective view of the betulinic acid extraction apparatus provided in this application;

[0017] Figure 2 This is a perspective view of a portion of the structure of the betulinic acid extraction apparatus provided in this application;

[0018] Reference numerals: 1-Containing box, 2-Stirring rack, 3-Divider cylinder, 4-Drive unit, 5-Drive gear, 1a-Containing cavity, 1b-Containing port, 1c-Containing box body, 1d-Cover plate, 1e-Observation port, 1f-Liquid inlet, 1g-Liquid outlet, 1h-Support leg, 2a-Loading cavity, 2b-Connecting rod, 2c-Connecting plate, 2d-Stirring rod, 3a-Holding part. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0020] Please see Figure 1 and Figure 2 This embodiment provides a betulinic acid extraction device, including a container 1, a stirring rack 2, and a separator 3. The container 1 is used to contain liquid for extracting betulinic acid. When the stirring rack 2 rotates, it can stir the liquid in the container 1. The separator 3 contains solids containing betulinic acid.

[0021] The receiving box 1 has a receiving cavity 1a, and a receiving opening 1b is provided on the upper side for inserting the separator cylinder 3. Specifically, the receiving box 1 includes a receiving box body 1c and a cover plate 1d. The cover plate 1d is fixedly connected to the top of the receiving box body 1c, and the fixed end of the drive unit 4 is fixedly connected to the cover plate 1d. Furthermore, the cover plate 1d has a receiving opening 1b, which abuts against the outer side of the separator cylinder 3, thereby restricting the movement of the separator cylinder 3. The bottom of the separator cylinder 3 contacts the bottom of the inner side of the receiving box 1, thereby supporting the separator cylinder 3.

[0022] Preferably, an observation window is provided on the side of the container 1 to facilitate the staff to observe the liquid level inside the container 1 and the degree of agitation of the solid-liquid mixture therein.

[0023] Preferably, the container 1 has an inlet 1f and an outlet 1g communicating with the container cavity 1a. The inlet 1f is located on the upper side of the container 1, and the outlet 1g is located on the lower side of the container 1. The inlet 1f is used to input the liquid for extracting betulinic acid into the container cavity 1a, and the outlet 1g allows the extracted liquid to flow out of the container cavity 1a. Generally, a switch can be installed at the outlet 1g to open or close the outlet 1g as needed.

[0024] Preferably, the bottom of the container 1 extends downward to form a plurality of support legs 1h for providing support for the container 1.

[0025] A stirring frame 2 is disposed in a receiving cavity 1a, forming a vertically arranged receiving cavity 2a that corresponds to the receiving opening 1b. Specifically, the stirring frame 2 includes connecting rods 2b, connecting plates 2c, and stirring rods 2d. Multiple connecting rods 2b are arranged circumferentially along the receiving cavity 2a, and two connecting plates 2c are fixed to both ends of the multiple connecting rods 2b. Multiple stirring rods are connected to the side of the connecting rods 2b away from the receiving cavity 2a. The multiple stirring rods are arranged axially along the connecting rods 2b. The upper connecting plate 2c and the cover plate 1d can be rotatably connected by bearings.

[0026] The separator 3 is disposed in the receiving cavity 2a through the receiving port 1b. Multiple through holes are formed on the surface of the separator 3 to separate solids and liquids inside and outside the separator 3, acting as a filter. This keeps the solids within the receiving cavity 2a while allowing the liquid to flow freely on both sides of the separator 3. Preferably, the upper ends of the separator 3 extend outwards to form gripping portions 3a, facilitating gripping and lifting by the operator.

[0027] Preferably, the betulinic acid extraction device further includes a drive unit 4, which is connected to the stirring frame 2 to drive the stirring frame 2 to rotate. The drive unit 4 is generally an electric motor. More preferably, the betulinic acid extraction device further includes two meshing drive gears 5, one drive gear 5 is coaxially arranged and fixedly connected to the stirring frame 2, and the other drive gear 5 is connected to the drive unit 4, so that the drive unit 4 drives the drive gear 5 to rotate. The rotation of the drive unit 4 drives the drive gear 5 to rotate, which in turn drives the stirring frame 2 to rotate, thereby stirring the liquid in the receiving cavity 1a.

[0028] In summary, the betulinic acid extraction device provided in this application, when the stirring frame 2 rotates, drives the liquid outside the receiving cavity 1a to move, thus also driving the liquid in the separator 3, so that the solid and liquid in the separator 3 are fully mixed, improving the extraction efficiency of betulinic acid. After the extraction is completed, the separator 3 can be lifted, and another separator 3 containing unextracted raw material can be put into the receiving box 1 for the next extraction. The material replacement process is fast, and the extract contains only a small amount of fixed fragments, reducing the coarse filtration process and greatly reducing the process difficulty.

[0029] The specific embodiments described above do not constitute a limitation on the scope of protection of this application. Any other corresponding changes and modifications made based on the technical concept of this application should be included within the scope of protection of the claims of this application.

Claims

1. A white birch acid extraction device, characterized by, The device comprises a containing box, a stirring frame and a separation cylinder, wherein: A containing cavity is formed in the containing box, and an accommodating opening is formed in the upper side of the containing box; The stirring frame is arranged in the containing cavity, and a vertically arranged containing cavity is formed in the stirring frame, and the containing cavity corresponds to the accommodating opening; The separation cylinder is arranged in the containing cavity through the accommodating opening, and a plurality of through holes are formed in the surface of the separation cylinder for separating the solid and liquid inside and outside the separation cylinder.

2. The white birch resin extraction device according to claim 1, characterized in that, The device for extracting white birch acid further comprises a driving unit, and the driving unit is connected with the stirring frame to drive the stirring frame to rotate.

3. The white birch resin extraction device according to claim 2, characterized in that The device for extracting white birch acid further comprises two mutually meshing driving gears, one of which is coaxially arranged with the stirring frame and fixedly connected with the stirring frame, and the other is connected with the driving unit, so that the driving unit drives the driving gear to rotate.

4. The white birch resin extraction device according to claim 1, characterized in that, The stirring frame comprises a connecting rod, a connecting plate and a stirring rod, a plurality of connecting rods are arranged circumferentially along the containing cavity, and two connecting plates are fixedly connected at both ends of the connecting rod, respectively, and a plurality of stirring rods are connected to the side of the connecting rod away from the containing cavity, and a plurality of stirring rods are arranged axially along the connecting rod.

5. The white birch resin extraction device according to claim 2, characterized in that, The containing box comprises a containing box body and a cover plate, the top of the containing box body is fixedly connected with the cover plate, and the fixed end of the driving unit is fixedly connected with the cover plate.

6. The white birch resin extraction device according to claim 5, characterized in that The cover plate is provided with the accommodating opening, and the accommodating opening abuts against the outer side of the separation cylinder.

7. The device for extracting betulinic acid according to claim 1, characterized in that An observation window is formed in the side of the containing box.

8. The device for extracting betulinic acid according to claim 1, characterized in that The containing box is provided with a liquid inlet and a liquid outlet which communicate with the containing cavity, the liquid inlet is arranged on the upper side of the containing box, and the liquid outlet is arranged on the lower side of the containing box.

9. The device for extracting betulinic acid according to claim 1, characterized in that The upper end of the separation cylinder extends outward on both sides and forms a holding part.

10. The device for extracting betulinic acid according to claim 1, characterized in that The bottom of the containing box extends downward to form a plurality of supporting legs.

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