Solid-phase synthesis carrier with good mechanical property

Abstract

The utility model discloses a solid-phase synthesis carrier with good mechanical property, which comprises a first substrate and a second substrate, the first substrate and the second substrate have the same shape, one side of the first substrate is fixedly connected with two insertion blocks, and the front surface of each insertion block is provided with a fixing hole; the other side of the first base plate is provided with two inserting grooves, and the two inserting grooves correspond to the inserting blocks in position and size. According to the solid-phase synthesis carrier with the good mechanical performance, through the arrangement of the insertion blocks, the fixing holes, the insertion grooves and the positioning holes, in the using process, when a sintered plate of the solid-phase carrier is too large, the insertion blocks of the first substrate can be aligned into the insertion grooves of the second substrate according to the actual size, and complete splicing can be achieved by utilizing the fact that the insertion grooves correspond to the insertion blocks in size; and the two groups of base plates can be quickly spliced by fastening the pins into the positioning holes after being inserted, so that the assembling is convenient, the base plates can be quickly disassembled after being used, and the base plates have the functions of small size and convenience in storage.

Description

Technical Field

[0001] This utility model relates to the field of solid-phase synthesis carrier technology, and in particular to a solid-phase synthesis carrier with good mechanical properties. Background Technology

[0002] Oligonucleotides generally refer to linear polynucleotide fragments consisting of 2 to 10 nucleotide residues linked by phosphodiester bonds. However, there is no strict definition of the number of nucleotide residues when using this term. In many literatures, polynucleotide molecules containing 30 or even more nucleotide residues are also referred to as oligonucleotides. Oligonucleotides can be synthesized automatically by instruments and can be used as primers for DNA synthesis, gene probes, etc., and have a wide range of applications in modern molecular biology research. In the process of preparing oligonucleotides, solid-phase carriers are basically required. In the preparation process of existing solid-phase carriers, they need to be demolded by a substrate. This mainly involves fixing the solid-phase carrier to the mounting holes of the substrate and applying external force to detach the solid-phase carrier from the carrier. However, the area of ​​the existing substrates cannot be adjusted during use, which means that when the sintered plate of the solid-phase carrier is too large, the substrate needs to be replaced, which is very inconvenient.

[0003] A search revealed that Chinese patent application number 202222357420.8 discloses a combined mold base for preparing oligonucleotides based on a solid-phase carrier. This patent allows the combined plates to move by moving sub-sub-bases, thereby enabling the splicing of the combined plates. During the movement of the sub-sub-bases, the position of the sub-sub-bases can be controlled by limiting components, thus facilitating their adjustment. Although the above patent has the function of adjustment, the solid-phase carrier substrate is large in size and does not have the splicing function. Furthermore, the current solid-phase carrier substrate does not have the function of cleaning residual materials. Therefore, it is necessary to design a solid-phase synthesis carrier with good mechanical properties. Utility Model Content

[0004] The main objective of this invention is to provide a solid-phase synthesis carrier with good mechanical properties, which can effectively solve the problems in the background art.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0006] A solid-phase synthesis carrier with good mechanical properties includes a first substrate and a second substrate. The first substrate and the second substrate have the same shape. Two inserts are fixedly connected to one side of the first substrate. The front of each insert has a fixing hole. Two slots are provided on the other side of the first substrate, and the slots correspond to the position and size of the inserts. A pin is threaded to the front of the first substrate near the slot. A positioning hole is provided on the upper surface of the first substrate. A vertical plate is fixedly connected to one side of the lower surface of the first substrate.

[0007] In order to provide a fixed function, as a solid-phase synthesis carrier with good mechanical properties according to this utility model, the inner sidewall of the vertical plate is fixedly connected with two crossbars.

[0008] To enable sliding, as a solid-phase synthesis carrier with good mechanical properties according to this utility model, the outer surface of the crossbar is slidably connected to a slip ring, and a cross plate is fixedly connected to one side of the outer surface of the slip ring.

[0009] In order to achieve a stretching effect, as a solid-phase synthesis carrier with good mechanical properties according to this utility model, a limiting cylinder is fixedly connected to the lower surface of the horizontal plate, and one end of the limiting cylinder penetrates the lower surface of the horizontal plate and extends to the upper surface of the horizontal plate.

[0010] In order to enable the striking effect, as a solid-phase synthesis carrier with good mechanical properties according to this utility model, the limiting cylinder is slidably connected to a sliding rod, and a hammer is fixedly connected to one end of the sliding rod.

[0011] In order to achieve a rebound effect, as a solid-phase synthesis carrier with good mechanical properties according to this utility model, a tension spring is fixedly connected to the lower surface of the horizontal plate, and one end of the tension spring is fixedly connected to the bottom end of the slide rod.

[0012] To facilitate pulling, a pull ring is fixedly connected to the bottom end of the slide rod, which is a solid-phase synthesis carrier with good mechanical properties according to this utility model.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. In this utility model, by setting up inserts, fixing holes, slots and positioning holes, when the sintered plate of the solid carrier is too large during use, the inserts of the first substrate can be aligned with the slots of the second substrate according to the actual size. By utilizing the correspondence between the size of the slots and the inserts, they can be completely spliced. After insertion, the pins are tightened into the positioning holes, and the two sets of substrates can be quickly spliced ​​together. The assembly is convenient, and the substrates can be quickly disassembled after use. It has the function of small size and convenient storage.

[0015] 2. In this utility model, by setting up a crossbar, a sliding bar, a cross plate, and a sliding bar, during use, when there is residual solid carrier material on the surface of the first substrate, the sliding bar can be pulled down by the sliding effect between the sliding bar and the limiting cylinder. At this time, the tension spring is deformed and unfolded by the force. After releasing the sliding bar, the spring rebound effect will drive the sliding bar to push upward quickly. By striking the bottom surface of the first substrate with a hammer, the residual material can be vibrated down, which has the effect of facilitating cleaning. Attached Figure Description

[0016] Figure 1 This is a front view structural diagram of an embodiment of the present utility model;

[0017] Figure 2 This is a schematic diagram of the first substrate structure according to an embodiment of the present utility model;

[0018] Figure 3 This is a schematic diagram of the crossbar structure according to an embodiment of the present utility model;

[0019] Figure 4 This is a schematic diagram of the horizontal plate structure of an embodiment of the present utility model;

[0020] Figure 5 This is a schematic diagram of the first substrate structure according to an embodiment of the present invention.

[0021] In the figure: 1. First substrate; 2. Second substrate; 3. Insert block; 4. Fixing hole; 5. Slot; 6. Pin; 7. Positioning hole; 8. Vertical plate; 9. Horizontal bar; 10. Slip ring; 11. Horizontal plate; 12. Limiting cylinder; 13. Slide rod; 14. Hammer; 15. Tension spring; 16. Pull ring. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Example

[0024] like Figure 1-5 As shown, a solid-phase synthesis carrier with good mechanical properties includes a first substrate 1 and a second substrate 2. The first substrate 1 and the second substrate 2 have the same shape. An insert 3 is fixedly connected to one side of the first substrate 1. There are two inserts 3. A fixing hole 4 is opened on the front side of the insert 3.

[0025] In this embodiment, a slot 5 is provided on the other side of the first substrate 1. There are two slots 5, which correspond to the position and size of the plug 3. A pin 6 is threadedly connected to the side of the front of the first substrate 1 near the slot 5. A positioning hole 7 is provided on the upper surface of the first substrate 1. A vertical plate 8 is fixedly connected to one side of the lower surface of the first substrate 1.

[0026] In practical use, when the sintered plate of the solid carrier is too large, the insert 3 of the first substrate 1 can be aligned with the slot 5 of the second substrate 2 according to the actual size. The slot 5 and the insert 3 correspond in size and can be completely spliced. After insertion, the pin 6 is fastened to the fixing hole 4, and the two sets of substrates can be quickly spliced ​​together. It is easy to assemble and can be quickly disassembled after use. It has the function of small size and convenient storage.

[0027] In this embodiment, two horizontal bars 9 are fixedly connected to the inner sidewall of the vertical plate 8.

[0028] In practical use, the crossbar 9 fixes the two sets of vertical plates 8 together, making the base plate more solid and giving it good mechanical properties.

[0029] In this embodiment, a slip ring 10 is slidably connected to the outer surface of the crossbar 9, and a cross plate 11 is fixedly connected to one side of the outer surface of the slip ring 10.

[0030] In practical use, the slip ring 10 can slide on the surface of the crossbar 9, allowing the cross plate 11 to slide left and right.

[0031] In this embodiment, a limiting cylinder 12 is fixedly connected to the lower surface of the horizontal plate 11, and one end of the limiting cylinder 12 penetrates the lower surface of the horizontal plate 11 and extends to the upper surface of the horizontal plate 11.

[0032] In practical use, the limiting sleeve 12 is fixed to the horizontal plate 11 to facilitate the sliding of the slide rod 13 up and down.

[0033] In this embodiment, a sliding rod 13 is slidably connected inside the limiting cylinder 12, and a hammer 14 is fixedly connected to one end of the sliding rod 13.

[0034] In actual use, when the slide bar 13 rises rapidly, it will drive the hammer 14 to strike the bottom surface of the first substrate 1, generating vibration and shaking off the excess material.

[0035] In this embodiment, a tension spring 15 is fixedly connected to the lower surface of the horizontal plate 11, and one end of the tension spring 15 is fixedly connected to the bottom end of the slide rod 13.

[0036] In actual use, pull down the slide bar 13. At this time, the tension spring 15 is deformed and unfolded under force. After releasing the slide bar 13, the spring 15 will rebound and drive the slide bar 13 to push upward quickly.

[0037] In this embodiment, a pull ring 16 is fixedly connected to the bottom end of the slide bar 13.

[0038] In practical use, the tension spring 15 facilitates pulling down the slide bar 13, making it easy to pull.

[0039] Working principle: When the sintered plate of the solid carrier is too large during use, the insert 3 of the first substrate 1 can be aligned with the slot 5 of the second substrate 2 according to the actual size. The slot 5 and the insert 3 correspond in size and can be completely spliced. After insertion, the pin 6 is tightened into the fixing hole 4, and the two sets of substrates can be quickly spliced ​​together. It is easy to assemble and can be quickly disassembled after use. It has the function of small size and convenient storage. When there is residual solid carrier material on the surface of the first substrate 1, the sliding rod 13 can be pulled down by the sliding effect of the sliding rod 13 and the limiting cylinder 12. At this time, the tension spring 15 is deformed by force and unfolded. After releasing the sliding rod 13, the spring 15 rebounds and drives the sliding rod 13 to push upward quickly. The hammer 14 strikes the bottom surface of the first substrate 1, which can vibrate down the residual material, which has the effect of easy cleaning.

[0040] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A solid-phase synthesis support with good mechanical properties, comprising a first substrate (1) and a second substrate (2), characterized in that: The first substrate (1) and the second substrate (2) are the same shape, one side of the first substrate (1) is fixedly connected with the plug block (3), the number of the plug block (3) is two, the front surface of the plug block (3) is provided with the fixing hole (4); the other side of the first substrate (1) is provided with the insertion slot (5), the number of the insertion slot (5) is two and corresponds to the position and size of the plug block (3), the side of the front surface of the first substrate (1) close to the insertion slot (5) is screwedly connected with the pin (6), the upper surface of the first substrate (1) is provided with the positioning hole (7), one side of the lower surface of the first substrate (1) is fixedly connected with the vertical plate (8).

2. The solid-phase synthesis support with good mechanical properties according to claim 1, characterized in that: The inner side wall of the vertical plate (8) is fixedly connected with the cross rod (9), and the number of the cross rod (9) is two.

3. The solid-phase synthesis support with good mechanical properties according to claim 2, characterized in that: The outer surface of the cross rod (9) is slidably connected with the sliding ring (10), one side of the outer surface of the sliding ring (10) is fixedly connected with the cross plate (11).

4. The solid phase synthesis support of claim 3, wherein: ###0002### The lower surface of the cross plate (11) is fixedly connected with the limiting cylinder (12), one end of the limiting cylinder (12) penetrates through the lower surface of the cross plate (11) and extends to the upper surface of the cross plate (11).

5. The solid phase synthesis support of claim 4, wherein: ###0002### The inside of the limiting cylinder (12) is slidably connected with the sliding rod (13), one end of the sliding rod (13) is fixedly connected with the hammer (14).

6. The solid phase synthesis support of claim 3, wherein: ###0002### The lower surface of the cross plate (11) is fixedly connected with the tension spring (15), one end of the tension spring (15) is fixedly connected with the bottom end of the sliding rod (13).

7. The solid phase synthesis support of claim 5, wherein: ###0001### The bottom end of the sliding rod (13) is fixedly connected with the pull ring (16).

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