Tumor metastasis experimental device

Abstract

The utility model belongs to the technical field of tumor metastasis experiments, and particularly relates to a tumor metastasis experiment device which comprises a storage box, a partition plate is fixed on the inner side of the storage box, a test plate is arranged on one side of the partition plate, and a first detection groove and a first sample groove are formed in the top face of the test plate. Second detection grooves are symmetrically formed in one side of the first detection groove, second sample grooves are symmetrically formed in one side of the first sample groove, a first limiting ring is fixed to the outer side of the top of the first detection groove, and a second limiting ring is fixed to the outer side of the top of the first sample groove; the outer side of the first limiting ring and the outer side of the second limiting ring are each sleeved with a plugging cover. The test board can be conveniently taken out, subsequent detection operation is facilitated, the situation that other test boards are easily touched by mistake when one test board is detected is avoided, blocking is conducted through the blocking cover, the situation that other undetected grooves are exposed in air and easily interfere with the experiment accuracy during detection is avoided, and the stability and accuracy of experiment operation are improved.

Description

Technical Field

[0001] This utility model belongs to the field of tumor metastasis experimental technology, and specifically relates to a tumor metastasis experimental device. Background Technology

[0002] Tumor metastasis is one of the main characteristics of malignant tumors and a leading cause of death in patients. Tumor metastasis experiments aim to gain a deeper understanding of the mechanisms of tumor metastasis, find effective treatments and prevention strategies, and provide a theoretical basis for clinical treatment. Currently, tumor metastasis experiments often involve comparative studies, administering drugs to multiple groups of identical tumor samples and observing the tumor spread after treatment to determine whether the drug has an inhibitory effect.

[0003] For example, Chinese patent CN218666102U discloses a culture device for organoid proliferation and metastasis, relating to the field of cell culture technology. The device includes a culture box containing a culture zone, which is further divided into an experimental zone and a comparative zone. Both the experimental and comparative zones include culture tanks and detection tanks, which are spaced apart and interconnected via connecting pipes. This application, by setting up a culture zone within a culture box, dividing it into experimental and comparative zones, and providing culture tanks and detection tanks in both zones, allows for indirect reflection of cell activity based on the number of tumor cells in the detection tanks of the experimental and comparative zones within the same timeframe. This enables the inference of whether a drug has an inhibitory effect on tumor cell metastasis.

[0004] However, the above scheme has certain shortcomings. This scheme sets up multiple culture zones inside the culture box for multiple sets of experiments. However, the multiple culture zones are concentrated and fixed inside the culture box and sealed by a lid. When performing sampling or inspection operations on one culture zone, opening the lid will expose other untouched culture zones. This can easily cause external interference to the culture medium and tumor samples inside other culture zones, affecting the accuracy of subsequent test results. In addition, the multiple culture zones are squeezed together in this scheme. When inspecting one culture zone, it is easy to accidentally touch other culture zones, which can also affect subsequent test results. Therefore, it is necessary to propose a tumor metastasis experimental device to solve the above problems. Utility Model Content

[0005] To address the aforementioned problems in the existing technology, this utility model provides a tumor metastasis experimental device, which is characterized by convenient operation and improved experimental stability and accuracy.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a tumor metastasis experimental device, comprising a storage box, a partition fixed to the inner side of the storage box, a test plate provided on one side of the partition, a first detection groove and a first sample groove provided on the top surface of the test plate, a first through hole provided on the inner wall edge of the first detection groove, the first through hole being connected to the first sample groove, a second detection groove symmetrically provided on one side of the first detection groove, a second sample groove symmetrically provided on one side of the first sample groove, a second through hole provided on the inner wall edge of the second detection groove, the second through hole being connected to the second sample groove, a first limiting ring fixed to the top outer side of the first detection groove, a second limiting ring fixed to the top outer side of the first sample groove, a sealing cap sleeved on the outer side of both the first and second limiting rings, a compression washer fixed to the inner wall of the sealing cap, the compression washer being made of elastic material, the sealing cap being made of transparent material, and a box lid provided on the top side of the storage box.

[0007] As a preferred technical solution of the tumor metastasis experimental device of this utility model, an elastic compression plate is fixed on one side of the inner wall of the storage box, and the elastic compression plate is located on one side of the test plate.

[0008] As a preferred technical solution of the tumor metastasis experimental device of this utility model, the partition is provided in multiple ways, the test plate is provided in multiple ways, and the elastic compression plate is provided in multiple ways.

[0009] As a preferred technical solution of the tumor metastasis experimental device of this utility model, the top surface of the partition is provided with a retrieval slot, the retrieval slot penetrates the side wall of the storage box, and the retrieval slot is located on both sides of the test plate.

[0010] As a preferred technical solution of the tumor metastasis experimental device of this utility model, the outer wall of the storage box is fixedly connected with an outer frame, and the top surface of the outer frame is lower than the top surface of the storage box.

[0011] As a preferred technical solution of the tumor metastasis experimental device of this utility model, a plug-in rod is fixed on the top edge of the outer frame. The plug-in rod is made of elastic material. A plug-in hole is provided on the bottom edge of the box cover. The inner dimension of the plug-in hole is adapted to the dimension of the plug-in rod.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] In use, this invention comprises a storage box, test plates, sealing caps, and a box lid. Multiple test plates are inserted and placed inside the storage box, allowing for easy removal of individual test plates for subsequent testing. This avoids the risk of accidentally touching other test plates while testing one. Sealing caps are inserted into the top outer sides of the multiple testing slots and sample slots on the test plates, allowing for targeted testing of specific slots as needed. This prevents other untested slots from being exposed to air, which could interfere with experimental accuracy, thus improving the stability and accuracy of the experimental operation. The box lid seals the entire storage box, preventing the test plates from falling or being impacted. The overall tool structure is simple and easy to operate. Attached Figure Description

[0014] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0016] Figure 2 This is a three-dimensional schematic diagram of the storage box and test plate of this utility model;

[0017] Figure 3 This is a three-dimensional schematic diagram of the storage box and lid of this utility model;

[0018] Figure 4 This is a three-dimensional schematic diagram of the test board of this utility model;

[0019] Figure 5 This is a three-dimensional sectional view of the sealing plate of this utility model.

[0020] In the diagram: 1. Storage box; 11. Divider; 12. Retrieval slot; 13. Elastic compression plate; 14. Outer frame; 15. Insertion rod; 2. Test plate; 21. First detection slot; 211. First limiting ring; 22. First sample slot; 221. Second limiting ring; 23. First through hole; 24. Second detection slot; 25. Second sample slot; 26. Second through hole; 3. Sealing cap; 31. Compression washer; 4. Box lid; 41. Insertion hole. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Example 1

[0023] Please see Figure 1-5 This utility model provides the following technical solution: a tumor metastasis experimental device, including a storage box 1, a partition 11 fixed inside the storage box 1, a test plate 2 provided on one side of the partition 11, and a first detection groove 21 and a first sample groove 22 provided on the top surface of the test plate 2. See attached drawing for details. Figure 4 The inner wall of the first detection groove 21 is provided with a first through hole 23, which is connected to the first sample groove 22. Culture medium is injected into the inner side of both the first detection groove 21 and the first sample groove 22. A tumor sample is placed in the inner side of the first sample groove 22 and an inhibitory drug is added. The cell diffusion inside the first detection groove 21 is observed. A second detection groove 24 is symmetrically provided on one side of the first detection groove 21, and a second sample groove 25 is symmetrically provided on one side of the first sample groove 22. A second through hole 26 is provided on the inner wall of the second detection groove 24, which is connected to the second sample groove 25. Similarly, the same tumor sample is placed in the inner side of the second sample groove 25, but without the inhibitory drug. The tumor cell diffusion is observed through the second detection groove 24. By comparing the two detection results, it is determined whether the inhibitory drug is effective.

[0024] Reference Figure 1 , Figure 2 and Figure 3 As shown, specifically, a lid 4 is provided on the top side of the storage box 1, and an outer frame 14 is fixedly connected to the outer wall of the storage box 1. The top surface of the outer frame 14 is lower than the top surface of the storage box 1. The lid 4 can seal the storage box 1. A plug-in rod 15 is fixed to the top edge of the outer frame 14. The plug-in rod 15 is made of elastic material. A plug-in hole 41 is provided on the bottom edge of the lid 4. The inner dimensions of the plug-in hole 41 are matched with the dimensions of the plug-in rod 15, which improves the stability of the lid 4 after it is closed and facilitates the protection of the inner test plate 2.

[0025] Reference Figure 2 and Figure 3As shown, specifically, an elastic compression plate 13 is fixed to one side of the inner wall of the storage box 1. The elastic compression plate 13 is located on one side of the test plate 2. After the test plate 2 is installed, it can be squeezed and pressed tightly by the elastic compression plate 13. There are multiple partitions 11, multiple test plates 2, and multiple elastic compression plates 13. The top surface of the partition 11 is provided with a retrieval slot 12. The retrieval slot 12 penetrates the side wall of the storage box 1 and is located on both sides of the test plate 2. When the test plate 2 is taken out, it can be held by the retrieval slots 12 on both sides. The installation is stable, easy to take out, and convenient for testing operations. At the same time, it avoids accidentally touching other untested test plates 2 during testing.

[0026] Example 2

[0027] In another embodiment of this solution, refer to Figure 2 and Figure 5 As shown, specifically, a first limiting ring 211 is fixed to the top outer side of the first detection tank 21, and a second limiting ring 221 is fixed to the top outer side of the first sample tank 22. A sealing cap 3 is sleeved on the outer side of both the first limiting ring 211 and the second limiting ring 221. A compression washer 31 is fixed to the inner wall of the sealing cap 3. The compression washer 31 is made of elastic material to improve the stability of the sealing cap 3 after it is sleeved. The sealing cap 3 is made of transparent material to facilitate observation by the tester. By setting multiple sealing caps 3 to seal each culture tank, the tester can test one culture tank while the other culture tanks remain closed, avoiding external interference to other untested tanks and improving the accuracy of subsequent tests.

[0028] The working principle and usage process of this utility model are as follows: When conducting tumor metastasis experiments, the experimenter inserts multiple test plates 2 into one side of the partition 11 inside the storage box 1. The test plates 2 are then positioned by the elastic compression plate 13. Culture medium is then injected into the multiple culture tanks (first detection tank 21, second detection tank 24, first sample tank 22, and second sample tank 25) on the test plates 2. Tumor samples are then placed inside the first sample tank 22 and the second sample tank 25. Inhibitory drugs are added to the inside of the first sample tank 22, but not to the second sample tank 25. Subsequently, multiple sealing caps 3 are used to seal each culture tank separately. After a certain period of time, the operator removes the test plates 2 and checks the spread of tumor cells through the detection tanks. The results are compared to determine whether the inhibitory drugs are effective. By observing multiple sets of test plates 2, the effects of different inhibitory drugs can be compared, facilitating tumor metastasis experiments. The multiple sets of easily removable test plates 2 and the sealing caps 3 that can seal the culture tanks improve the stability and accuracy of the experimental operation.

[0029] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A tumor metastasis experimental device, comprising a storage box (1), characterized in that: A partition (11) is fixed to the inner side of the storage box (1). A test plate (2) is provided on one side of the partition (11). The top surface of the test plate (2) is provided with a first detection groove (21) and a first sample groove (22). A first through hole (23) is provided on the inner wall edge of the first detection groove (21). The first through hole (23) is connected to the first sample groove (22). A second detection groove (24) is symmetrically provided on one side of the first detection groove (21). A second sample groove (25) is symmetrically provided on one side of the first sample groove (22). A second detection groove (25) is provided on the inner wall edge of the second detection groove (24). Through hole (26), the second through hole (26) is connected to the second sample slot (25), the top outer side of the first detection slot (21) is fixed with a first limiting ring (211), the top outer side of the first sample slot (22) is fixed with a second limiting ring (221), the outer sides of the first limiting ring (211) and the second limiting ring (221) are both fitted with a sealing cap (3), the inner wall of the sealing cap (3) is fixed with a compression washer (31), the compression washer (31) is made of elastic material, the sealing cap (3) is made of transparent material, and the top side of the storage box (1) is provided with a box cover (4).

2. The tumor metastasis experimental device according to claim 1, characterized in that: An elastic compression plate (13) is fixed to one side of the inner wall of the storage box (1), and the elastic compression plate (13) is located on one side of the test plate (2).

3. The tumor metastasis experimental device according to claim 2, characterized in that: Multiple partitions (11), multiple test plates (2), and multiple elastic compression plates (13) are provided.

4. The tumor metastasis experimental device according to claim 3, characterized in that: The partition (11) has a retrieval slot (12) in the middle of its top surface. The retrieval slot (12) penetrates the side wall of the storage box (1) and is located on both sides of the test plate (2).

5. The tumor metastasis experimental device according to claim 4, characterized in that: The outer wall of the storage box (1) is fixedly connected to an outer frame (14), and the top surface of the outer frame (14) is lower than the top surface of the storage box (1).

6. The tumor metastasis experimental device according to claim 5, characterized in that: A plug rod (15) is fixed to the top edge of the outer frame (14). The plug rod (15) is made of elastic material. A plug hole (41) is provided on the bottom edge of the box cover (4). The inner dimensions of the plug hole (41) are compatible with the dimensions of the plug rod (15).

Images