Multi-channel medicine sampling device for sulfur tire compound metabolic kinetic research
By employing a multi-channel drug sampling device with glass material and stainless steel needles, combined with large-area labels and corner plate structures, the problems of sample degradation and cross-contamination of thiochemical compounds in metabolic kinetic studies have been solved, achieving sample purity and label accuracy, and reducing experimental errors.
Patent Information
- Application Number
- CN202520498346.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-20
- Publication Date
- 2026-03-31
- Estimated Expiration
- 2035-03-20
AI Technical Summary
In existing technologies, thiolated compounds are prone to react with metal ions or plastic additives in metabolic kinetic studies, leading to sample degradation or false positive results. Furthermore, multi-channel sampling devices lack effective anti-cross-contamination designs and label identification structures, increasing experimental errors.
The design incorporates a glass first segment and a stainless steel needle, combined with a large-area label and corner plate structure to ensure the use of inert materials for the sample and the reliability of the label, avoiding cross-contamination and human recording errors.
It effectively prevents sample degradation and false positive results, reduces sample residue, ensures sample purity and label accuracy during multi-channel sampling, and reduces experimental errors.
Smart Images
Figure CN224056011U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of drug research technology, and in particular to a multi-channel drug sampling device for the study of the metabolic kinetics of sulfur-containing compounds. Background Technology
[0002] In the study of the metabolic kinetics of thiolated compounds (such as sulfur-containing drugs and metabolic intermediates), accurate and uncontaminated sample collection is crucial to ensuring the reliability of experimental data. These compounds are chemically reactive and readily react with metal ions or additives in plastics, leading to sample degradation or false positive results, which is particularly significant in trace analysis.
[0003] Currently, biological sample collection mostly uses conventional syringes or plastic syringes, whose materials (such as metal pistons and polypropylene syringes) are prone to adsorption or chemical reactions with thiolated compounds, which can damage the integrity of the sample.
[0004] In addition, metabolic kinetic studies often require multi-channel sampling (such as simultaneous collection of blood, bile, tissue fluid, etc.), but traditional devices lack effective cross-contamination prevention designs. Reusing the same syringe or unclear labeling can easily lead to sample confusion and increase experimental errors.
[0005] In existing technologies, the labels on sampling devices are mostly simple stickers that are easy to fall off or misalign, and they lack a quick identification structure, resulting in low efficiency for manual recording.
[0006] Therefore, there is an urgent need to develop sampling devices specifically for the study of the metabolic kinetics of thio compounds to solve the above problems. Utility Model Content
[0007] The purpose of this invention is to at least solve one of the aforementioned technical defects.
[0008] Therefore, one objective of this invention is to provide a multi-channel drug sampling device for the study of the metabolic kinetics of sulfur-containing compounds, in order to solve the problems mentioned in the background art and overcome the shortcomings of the existing technology.
[0009] To achieve the above objectives, one embodiment of the present invention provides a multi-channel drug sampling device for the study of the metabolic kinetics of sulfur-containing compounds, comprising a first segment and a second segment, wherein the tail of the first segment is fixedly connected to the second segment, and the first segment is made of glass.
[0010] The front end of the first segment is detachably connected to a sampling head, and the first segment is provided with a scale.
[0011] An angle plate is fixedly connected to the side of the first segment, and a label is covered on part of the first segment and the angle plate;
[0012] The corner of the label protrudes from a corner plate;
[0013] A handle is fixedly connected to the end of the second segment, and pistons are movably connected inside the first and second segments, with a push rod fixedly connected to one side of the piston.
[0014] Preferably, in any of the above solutions, the first segment and the second segment are bonded together, and the first segment and the second segment are transparent.
[0015] The above technical solution is adopted: the multi-channel drug sampling device for the study of the metabolic kinetics of thiolated compounds, which is a sampling syringe, is different from conventional syringes in that it is specifically designed for the sampling of biological samples of thiolated compounds.
[0016] Thio compounds readily react with metal ions or plastic additives. Most of the syringe is made of inert materials such as glass to prevent sample degradation or false positive results. Since the amount of sample taken at one time is small, it is sufficient to design the first segment to be made of glass.
[0017] The sampling head is made of stainless steel needle, which reduces sample residue and adsorption.
[0018] Preferably, in any of the above schemes, the sampling head is threaded or sleeved to the end of the first segment, and the sampling head is specifically a stainless steel needle.
[0019] The above technical solution employs a multi-channel sampling method (e.g., blood, bile, tissue fluid), requiring each tube to be used individually to avoid cross-contamination. This is achieved by attaching a large, prominent label to the outer surface of each first segment, clearly indicating the channel type, sampling time, and animal number to reduce human error. A long, narrow opening in the center allows for easy observation of the internal fluid level. Furthermore, to prevent incorrect labeling, the first segment features a corner plate structure with raised corners for easy removal and replacement of the correct label.
[0020] Preferably, in any of the above solutions, the corner plate and the first segment are an integral structure, and the label has a sample mark.
[0021] Preferably, in any of the above embodiments, an elongated hole is formed in the middle of the label, and the label is pasted on the surface of the first segment.
[0022] Preferably, in any of the above embodiments, the piston is made of rubber and is bonded to the push rod.
[0023] Compared with the prior art, the advantages and beneficial effects of this utility model are as follows:
[0024] 1. This multi-channel drug sampling device for the study of the metabolic kinetics of thiolated compounds is specifically designed for the sampling of biological samples of thiolated compounds through the coordinated setup of the first segment, corner plate, and label.
[0025] Thio compounds readily react with metal ions or plastic additives. Most of the syringe is made of inert materials such as glass to prevent sample degradation or false positive results. Since the amount of sample taken at one time is small, it is sufficient to design the first segment to be made of glass.
[0026] The sampling head is made of stainless steel needle, which reduces sample residue and adsorption.
[0027] 2. This multi-channel drug sampling device, used for the metabolic kinetics study of sulfur-containing compounds, employs a single-channel sampling method to avoid cross-contamination, as it involves sampling multiple channels (e.g., blood, bile, tissue fluid). To mitigate this, a large, prominent label is affixed to the outer surface of each first segment, clearly indicating the channel type, sampling time, and animal number to reduce human error. A central elongated opening allows for visualization of the internal fluid level. Furthermore, to prevent incorrect labeling, the first segment features a corner plate structure with raised corners for easy removal and replacement of the correct label.
[0028] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description
[0029] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:
[0030] Figure 1 This is a first-view structural schematic diagram of the present invention;
[0031] Figure 2 This is a structural schematic diagram of the present invention from a second perspective;
[0032] Figure 3 This is a cross-sectional structural diagram of the present invention;
[0033] Figure 4 This is a structural schematic diagram of the present invention from a third-view perspective.
[0034] In the diagram: 1-First segment, 2-Second segment, 3-Sampling head, 4-Corner plate, 5-Label, 6-Handle, 7-Piston, 8-Push rod. Detailed Implementation
[0035] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this utility model, and should not be construed as limiting this utility model.
[0036] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.
[0037] like Figure 1-4 As shown, the multi-channel drug sampling device used for the study of the metabolic kinetics of sulfur compounds includes a first segment 1 and a second segment 2. The tail of the first segment 1 is fixedly connected to the second segment 2. The first segment 1 is made of glass.
[0038] The front end of the first segment 1 is detachably connected to a sampling head 3, and the first segment 1 is equipped with a scale.
[0039] Angle plate 4 is fixedly connected to the side of the first segment 1, and a label 5 is covered on part of the first segment 1 and the angle plate 4.
[0040] The corner of label 5 protrudes from corner plate 4;
[0041] A handle 6 is fixedly connected to the end of the second segment 2. A piston 7 is movably connected inside the first segment 1 and the second segment 2. A push rod 8 is fixedly connected to one side of the piston 7.
[0042] Example 1: The first segment 1 and the second segment 2 are bonded together. Both the first segment 1 and the second segment 2 are transparent. This multi-channel drug sampling device, which is essentially a sampling syringe, is used for the metabolic kinetics study of thiolated compounds. Unlike conventional syringes, it is specifically designed for sampling biological samples of thiolated compounds.
[0043] Thio compounds readily react with metal ions or plastic additives. Most syringes are made of inert materials such as glass to prevent sample degradation or false positive results. Since the sample volume is small per sample, it is sufficient to design the first segment 1 to be made of glass.
[0044] Sampling head 3 is a stainless steel needle, which reduces sample residue and adsorption.
[0045] Example 2: The sampling head 3 is threaded or sleeved to the end of the first segment 1. The sampling head 3 is specifically a stainless steel needle. The angle plate 4 is an integral structure with the first segment 1, and the label 5 has a sample mark. An elongated hole is opened in the middle of the label 5, and the label 5 is pasted on the surface of the first segment 1. The piston 7 is made of rubber, and the piston 7 is bonded to the push rod 8.
[0046] The working principle of this utility model is as follows:
[0047] Assign an independent device to each sampling channel (e.g., Ch1-blood, Ch2-bile) according to experimental requirements, and check the matching of label 5 information with the channel;
[0048] If the label needs to be replaced, peel off the old label 5 at corner plate 4, wipe off any remaining adhesive residue with an alcohol swab, and then paste the new label 5.
[0049] After anesthetizing the animal, fix it on a constant temperature operating table (37°C) and expose the target sampling site (such as the jugular vein or bile duct cannulation site);
[0050] The sampling area was disinfected with povidone-iodine and covered with sterile gauze.
[0051] Step 1 (Example of blood sampling):
[0052] a. Hold the device in the anti-slip area and insert the needle (sampling head 3) into the jugular vein at a 30° angle;
[0053] b. Slowly pull back push rod 8 to the target volume (e.g., 50 μL), and observe the liquid level to the graduation mark through the long hole of label 5;
[0054] c. Remove the needle and immediately inject the sample into a cryovial pre-filled with antioxidant, then gently tap the tube wall to mix.
[0055] Step 2 (Example of bile sampling):
[0056] a. Replace with a new device, inserting the needle into the bile duct cannula interface;
[0057] b. Allow the sample to drain naturally into the cylinder (no need to pull the push rod), and remove it after monitoring the sample volume through the elongated hole until it reaches 100 μL;
[0058] c. After sample transfer, seal the cannula opening with sealing film to prevent leakage.
[0059] Compared with the prior art, the present invention has the following advantages:
[0060] 1. This multi-channel drug sampling device for the study of the metabolic kinetics of thiolated compounds is specifically designed for the sampling of biological samples of thiolated compounds through the coordinated arrangement of the first segment 1, the corner plate 4, and the tag 5.
[0061] Thio compounds readily react with metal ions or plastic additives. Most syringes are made of inert materials such as glass to prevent sample degradation or false positive results. Since the sample volume is small per sample, it is sufficient to design the first segment 1 to be made of glass.
[0062] Sampling head 3 is a stainless steel needle, which reduces sample residue and adsorption.
[0063] 2. This multi-channel drug sampling device for the study of the metabolic kinetics of sulfur-containing compounds, due to its multi-channel sampling (e.g., blood, bile, tissue fluid), requires single-channel use to avoid cross-contamination. To achieve this, a label 5 is affixed to the outer surface of each first segment 1. The label 5 is large and prominently displays the channel type, sampling time, and animal number to reduce human error. A long, narrow opening in the center allows for easy observation of the internal fluid level. Furthermore, to prevent incorrect label affixing, the first segment 1 features a corner plate 4 structure; the corners of the label 5 are raised for easy removal and replacement with the correct label 5.
Claims
1. A multi-channel drug sampling device for use in the study of the metabolic kinetics of sulfur-containing compounds, characterized in that, Including first segment (1), second segment (2), the tail of the first segment (1) is fixedly connected with the second segment (2), the first segment (1) is glass material quality; The front end of the first segment (1) is detachably connected with a sampling head (3), and the first segment (1) is provided with a scale; The side of the first segment (1) is fixedly connected with an angle plate (4), and the first segment (1) and the angle plate (4) are covered with a label (5); The corner of the label (5) protrudes the angle plate (4); The end of the second segment (2) is fixedly connected with a handle (6), the inside of the first segment (1) and the second segment (2) is movably connected with a piston (7), one side of the piston (7) is fixedly connected with a push rod (8).
2. A multi-channel drug sampling device for use in the study of the pharmacokinetics of a sulfur-containing compound according to claim 1, wherein: The first segment (1) and the second segment (2) are bonded, and the first segment (1) and the second segment (2) are transparent.
3. A multi-channel drug sampling device for use in the study of the pharmacokinetics of a sulfur-containing compound according to claim 2, wherein: The sampling head (3) is threadedly connected or sleeved with the end of the first segment (1), and the sampling head (3) is a stainless steel needle.
4. A multi-channel drug sampling device for use in the study of the pharmacokinetics of a sulfur-containing compound according to claim 3, wherein: The angle plate (4) is an integral structure with the first segment (1), and the label (5) has a sample mark.
5. A multi-channel drug sampling device for use in the study of the pharmacokinetics of a sulfur-containing compound according to claim 4, wherein: The middle part of the label (5) is provided with a long hole, and the label (5) is pasted on the surface of the first segment (1).
6. A multi-channel drug sampling device for use in the study of the pharmacokinetics of a sulfur-containing compound according to claim 5, wherein: The material of the piston (7) is rubber, and the piston (7) is bonded with the push rod (8).