Liquid chromatography separation column

Abstract

The utility model relates to a liquid chromatography separation column, which comprises a cover body, a column casing, a shunting baffle plate, an upper filter disc, a lower filter disc and a buckle, the lower filter disc is arranged at the bottom of an inner cavity of the column casing, the shunting baffle plate and the upper filter disc are arranged at the top of the inner cavity of the column casing, the outer wall of the top of the column casing is provided with a ridge part protruding radially, and an annular groove is formed at the bottom of the cover body. A groove part matched with the ridge part is further arranged on the outer edge of the cover body, when the cover body and the column casing are in a sealing state, the top edge of the top of the column casing can stretch into the groove and extrude the sealing ring, meanwhile, the buckle can be clamped between the groove part of the cover body and the ridge part of the column casing, and therefore the cover body and the column casing are locked. According to the utility model, the cover body and the column casing can be easily separated even if a material is deformed, the service life of the separation column is prolonged, and the buckle is locked and matched with the top edge of the column casing to tightly press the sealing ring in the annular groove of the cover body, so that the tight sealing of the sealing cover of the liquid chromatography separation column is ensured.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography separation technology, specifically to a liquid chromatography separation column. Background Technology

[0002] Liquid chromatography (LC) columns are used to separate the stationary and mobile phases from a mixture. To ensure the column's sealing and ease of operation, current technology uses a threaded connection between the cap and column barrel, coupled with a pressure-locking internal sealing ring. Both the cap and column barrel are typically made of PP material. Prolonged immersion in organic solvents in the mixture causes the PP material to swell, making it difficult to manually unscrew the cap, increasing operational difficulty, and affecting the column's lifespan. Utility Model Content

[0003] This invention provides a liquid chromatography separation column.

[0004] Specifically, this utility model is achieved through the following technical solution:

[0005] In a first aspect, this utility model provides a liquid chromatography separation column, including a cap, a column, a split baffle, an upper filter, a lower filter, and a snap fastener. The lower filter is disposed at the bottom of the inner cavity of the column, and the split baffle and the upper filter are disposed at the top of the inner cavity of the column. The outer wall of the top of the column is provided with a radially protruding ridge. The bottom of the cap is formed with an annular groove, and a sealing ring is embedded in the annular groove. The outer edge of the cap is also provided with a groove that matches the ridge. When the cap and the column are in a sealed state, the top edge of the top of the column can extend into the groove and squeeze the sealing ring tightly. At the same time, the snap fastener can be locked between the groove of the cap and the ridge of the column, thereby locking the cap and the column.

[0006] In some embodiments, the ridge extends continuously along the circumference of the column.

[0007] In some embodiments, the buckle is provided with an upper locking part and a lower locking part. The upper locking part is pivotally connected to the cover body in the groove. When the cover body and the column are in a sealed state, the upper locking part and the lower locking part are respectively locked between the groove of the cover body and the ridge of the column.

[0008] In some embodiments, protruding posts are provided on both sides of the upper card portion, and recessed holes are provided on both sides of the groove portion. The protruding posts and recessed holes match, thereby allowing the upper card portion to pivotally connect with the cover body within the groove portion.

[0009] In some embodiments, the buckle is further provided with a handle extending below the lower latch portion.

[0010] In some embodiments, a protrusion is provided at the bottom of the ridge and a hook is provided at the top of the lower locking part. The protrusion and the hook match each other, and when the lower locking part is locked on the ridge of the cylinder, the protrusion and the hook lock together.

[0011] In some embodiments, the number of slots is set to correspond one-to-one with the buckle, the width of each slot is equal to that of the buckle, and the multiple slots are evenly spaced along the circumference of the cover.

[0012] In some embodiments, the cover is provided with a liquid inlet hole, which is connected to the liquid inlet pipe via a Luer male connector.

[0013] In some embodiments, a liquid outlet hole is provided at the bottom of the column, and the liquid outlet hole is connected to the liquid outlet pipe through a Luer female connector.

[0014] According to this utility model, by locking the cap and column cylinder cap together in the groove on the outer edge of the cap and the ridge on the top outer wall of the column, the cap can be opened by simply removing the buckle from the groove and ridge. Even if the material is deformed, the cap and column can be easily separated, which increases the service life of the separation column. The buckle locks in place with the top edge of the column, pressing the sealing ring in the annular groove of the cap to ensure that the liquid chromatography separation column cap is tightly sealed.

[0015] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0016] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with this application and, together with the description, serve to explain the principles of this application.

[0017] Figure 1 This is a schematic diagram of a liquid chromatography separation column in one embodiment of the present invention;

[0018] Figure 2 This is a cross-sectional view of a liquid chromatography separation column in one embodiment of the present invention;

[0019] Figure 3 This is a schematic diagram of the disassembled state of the cover and the column in one embodiment of the present invention.

[0020] Figure label:

[0021] 1: Inlet pipe; 2: Luer male connector; 3: Cover body; 31: Annular groove; 32: Groove; 4: Buckle; 41: Upper locking part; 42: Lower locking part; 421: Hook part; 43: Handle part; 5: Column; 51: Ridge; 511: Protrusion; 52: Top edge; 6: Luer female connector; 7: Outlet pipe; 8: Sealing ring; 9: Diverter baffle; 10: Upper filter plate; 11: Sample; 12: Lower filter plate. Detailed Implementation

[0022] This disclosure will now be discussed with reference to several embodiments. It should be understood that these embodiments are discussed only to enable those skilled in the art to better understand and thus implement this disclosure, and are not intended to imply any limitation on the scope of this disclosure.

[0023] As used herein, the term "comprising" and its variations are to be interpreted as open-ended terms meaning "including but not limited to"; the terms "embodiment" and "one embodiment" are to be interpreted as "at least one embodiment"; the term "another embodiment" is to be interpreted as "at least one other embodiment"; the terms "first," "second," etc., may refer to different or the same objects; the term "setup" is not limited to direct or indirect connections, nor to specific connection methods. Other explicit and implicit definitions may also be included below.

[0024] Specific numerical values ​​or ranges may be referred to in the following description. It should be understood that these values ​​and ranges are merely exemplary and may be helpful in putting the ideas of this disclosure into practice. However, the description of these examples is not intended to limit the scope of this disclosure in any way. These values ​​or ranges may be set differently depending on the specific application scenario and requirements.

[0025] As mentioned above, in existing technologies, prolonged immersion of PP material in organic solvents in the mixture causes the material to swell, making it difficult to manually unscrew the cap from the column due to deformation. This increases operational difficulty and also affects the lifespan of the liquid chromatography column. The liquid chromatography column proposed in the embodiments of this invention at least partially solves the above-mentioned problems. Figures 1-3 As shown, the liquid chromatography separation column of this utility model embodiment generally includes a cover 3, a column cylinder 5, a split baffle 9, an upper filter 10, a lower filter 12, a snap fastener 4, a Luer male connector 2, a Luer female connector 6, an inlet pipe 1, and an outlet pipe 7. The cover 3 is provided with an inlet hole, which is connected to the inlet pipe 1 through the Luer male connector 2. The bottom of the column cylinder 5 is provided with an outlet hole, which is connected to the outlet pipe 7 through the Luer female connector 6.

[0026] To enable quick sealing and disassembly between the cover 3 and the cylinder 5, this embodiment of the invention provides a buckle 4 to fasten the cover 3 and the cylinder 5 together. The cylinder 5 has a ridge 51 on the outer wall of the top region. The ridge 51 protrudes radially outward from the outer wall, forming a top and a bottom. The bottom of the ridge 51 is used for the lower locking part of the buckle 4 to lock upward.

[0027] In one embodiment, a protrusion 511 may be provided at the bottom of the ridge 51, and correspondingly, a hook 421 may be provided at the top of the lower locking part. When the lower locking part is locked with the ridge 51, the protrusion and the hook 421 may also cooperate to prevent the lower locking part from disengaging from the ridge 51.

[0028] In one embodiment, the ridge 51 may extend continuously along the circumference of the cylinder 5, allowing the buckle 4 to be engaged with the ridge 51 at any position within 360 degrees, greatly improving the convenience of the capping operation. In another embodiment, the ridge 51 may also be arranged intermittently along the circumference of the cylinder 5. When engaging the buckle 4 with the ridge 51, the buckle 4 needs to be aligned with the ridge 51 in the circumference of the cylinder 5.

[0029] The outer edge of the cover 3 is provided with a groove for the upper locking part 41 of the buckle 4 to extend into and lock downward. If the ridge 51 is designed to extend continuously along the circumference of the cylindrical tube 5, the buckle 4 extending into the groove can lock with the lower ridge 51. If the ridge 51 is designed to extend discontinuously along the circumference of the cylindrical tube 5, the cover 3 needs to be rotated to align the groove with the lower ridge 51 in order for the buckle 4 extending into the groove to lock with the lower ridge 51.

[0030] In one embodiment, the buckle 4 is not connected to the cover 3. When the cover 3 covers the top opening of the column cylinder 5, the upper locking part 41 of the buckle 4 is inserted into the groove and the lower locking part of the buckle 4 is inserted under the ridge 51, so that the buckle 4 can lock the cover 3 and the column cylinder 5.

[0031] In another embodiment, the upper locking part 41 of the buckle 4 is pivotally connected to the cover 3 in the groove to prevent the buckle 4 from being lost. When in use, simply press the buckle 4 so that the lower locking part is inserted under the ridge 51 to lock the cover 3 and the cylinder 5. When it is necessary to remove the cover 3 from the cylinder 5, continue to pull the lower locking part out from under the ridge 51. The whole operation is convenient and is not affected by the deformation of the cover 3 and the cylinder 5.

[0032] In one embodiment, to achieve a pivotal connection between the buckle 4 and the cover 3, protrusions are provided on both sides of the upper buckle 41 and recesses are provided on both sides of the groove. The upper buckle 41 is inserted into the groove 32 and the protrusions are embedded in the recesses, thereby achieving a pivotal connection. It also allows for easy installation between the upper buckle 41 and the cover 3, as well as easy removal of the upper buckle 41 from the cover 3.

[0033] In one embodiment, a handle 43 may also be provided at the lower part of the buckle 4. The handle 43 extends below the lower latch. The operator can press the handle 43 to lock the lower latch and the spine 51, or pull the handle 43 to lock the lower latch and the spine 51.

[0034] In one embodiment, the number of slots is the same as the number of buckles 4, that is, each buckle 4 is embedded in a slot, and the width of each slot is equal to that of the buckle 4. With this arrangement, the sidewall of the slot provides a limiting effect on the buckle 4 in the circumferential direction of the cover 3, so as to prevent the cover 3 and the column cylinder 5 from loosening in the circumferential direction due to the buckle 4 shaking.

[0035] In one embodiment, multiple grooves are evenly spaced along the circumference of the cover 3, thereby ensuring that the corresponding multiple buckles 4 are evenly distributed along the circumference at the clamping force points of the cover 3 and the column cylinder 5, thus ensuring a balanced seal between the cover 3 and the column cylinder 5.

[0036] To improve the sealing performance of the cover, an annular groove 31 is formed at the bottom of the cover body 3, and a sealing ring 8 is embedded in the annular groove 31. When the cover body 3 covers the opening at the top of the column cylinder 5, the top edge 52 of the column cylinder 5 can extend into the groove 32 and squeeze the sealing ring 8 tightly.

[0037] When using the liquid chromatography separation column of this invention, such as Figure 3 As shown, the lower filter 12 is placed at the bottom of the column 5, the sample 11 is injected into the column 5, and then the upper filter 10 and the split baffle 9 are placed near the top opening of the column 5 in sequence. Finally, the cover 3 is put on and the buckle 4 is operated to lock it. The liquid chromatography separation column deforms after long-term use and immersion, which makes the cover 3 and the column 5 more separated in the axial position. This only increases the locking force between the buckle 4 and the groove and ridge 51. Since the operation of the buckle 4 to unlock only requires overcoming the friction between the upper locking part 41 and the groove 32, and the friction between the lower locking part and the ridge 51, the force required to overcome is not large. Therefore, it can be easily operated to unlock without being affected by material deformation.

[0038] The description of the embodiments herein, including any references to directions and orientations, is for ease of description only and should not be construed as limiting the scope of protection of this utility model. The description of preferred embodiments involves combinations of features, which may exist independently or in combination; this utility model is not particularly limited to the preferred embodiments. The scope of this utility model is defined by the claims.

[0039] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A liquid chromatography separation column, characterized by, The cover, the cylinder, the flow distribution baffle, the upper filter, the lower filter and the buckle are included, the lower filter is arranged at the bottom of the inner cavity of the cylinder, the flow distribution baffle and the upper filter are arranged at the top of the inner cavity of the cylinder, the outer wall of the top of the cylinder is provided with a radially protruding ridge, the bottom of the cover is formed with a ring groove, the ring groove is embedded with a sealing ring, the outer edge of the cover is further provided with a groove part matched with the ridge, when the cover and the cylinder are in the capped state, the top edge of the top of the cylinder can extend into the groove and extrude the sealing ring, at the same time, the buckle can be clamped between the groove part of the cover and the ridge of the cylinder, so as to lock the cover and the cylinder.

2. The liquid chromatography separation column of claim 1, wherein, The ridge continuously extends along the circumference of the cylinder.

3. The liquid chromatography separation column of claim 1, wherein, The buckle is provided with an upper clamping part and a lower clamping part, the upper clamping part is pivotally connected with the cover in the groove part, when the cover and the cylinder are in the capped state, the upper clamping part and the lower clamping part are clamped between the groove part of the cover and the ridge of the cylinder respectively.

4. The liquid chromatography separation column of claim 3, wherein, The upper clamping part is provided with a convex column on both sides, the groove part is provided with a concave hole on both sides, the convex column is matched with the concave hole, so that the upper clamping part is pivotally connected with the cover in the groove part.

5. The liquid chromatography separation column of claim 3, wherein, The buckle is further provided with a handle part extending below the lower clamping part.

6. The liquid chromatography separation column of claim 3, wherein, The bottom of the ridge is provided with a protrusion, the top of the lower clamping part is provided with a hook part, the protrusion is matched with the hook part, when the lower clamping part is clamped on the ridge of the cylinder, the protrusion and the hook part are locked with each other.

7. The liquid chromatography separation column of claim 1, wherein, The number of groove parts is one-to-one corresponding to the buckle, the width size of each groove part is equal to the buckle, and the plurality of groove parts are uniformly and interval distributed along the circumference of the cover.

8. The liquid chromatography separation column of claim 1, wherein, The cover is provided with a liquid inlet hole, the liquid inlet hole is connected with a liquid inlet pipe through a luer male joint.

9. The liquid chromatography separation column of claim 1, wherein, The bottom of the cylinder is provided with a liquid outlet hole, the liquid outlet hole is connected with a liquid outlet pipe through a luer female joint.

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