Granulation equipment for improving bulk density of beta-nicotinamide mononucleotide

Abstract

The utility model discloses granulation equipment for improving bulk density of beta-nicotinamide mononucleotide, which comprises a mounting plate, a shell is arranged at the top of the mounting plate, a screw driving mechanism inserted into the shell is arranged at one end of the shell, a feeding component is fixedly arranged above the shell, and a discharging component is fixedly arranged above the feeding component. A feeding assembly is arranged in the shell, a sliding type refining assembly is arranged above the feeding assembly, the refining assembly is at least used for uniformly distributing beta-nicotinamide mononucleotide into a medicine matrix in the feeding assembly, and a granulation mechanism is arranged at the tail end of the shell and is at least used for granulating raw materials based on the shell by the screw driving mechanism. The material uniformizing assembly is located above the feeding assembly, a medicine base body can be added into the shell through the feeding assembly, and meanwhile beta-nicotinamide mononucleotide is added into the feeding assembly through the reciprocating linear movement of the material uniformizing assembly, so that the medicine base body can be added into the shell through the feeding assembly. And the bulk density of the beta-nicotinamide mononucleotide in a drug matrix is higher.

Description

Technical Field

[0001] This utility model relates to the field of granulation equipment technology, specifically to a granulation equipment for improving the packing density of β-nicotinamide mononucleotide. Background Technology

[0002] Granulation equipment is mainly used in the pharmaceutical, food, granule, chemical, and solid beverage industries to make the mixed materials into the required granules, and is especially suitable for materials with high viscosity.

[0003] β-Nicotinamide mononucleotide (NMN) is a precursor to NAD+, a cofactor of longevity proteins in the human body. As an intermediate in the NAD+ rescue pathway, β-NMN has antioxidant and oxidative stress-reducing effects, and has also shown good efficacy in the treatment of certain diseases, such as stroke, myocardial ischemia-reperfusion injury, Alzheimer's disease, Parkinson's disease, acute kidney injury, retinopathy, and type II diabetes.

[0004] Since β-nicotinamide mononucleotide (NMN) is an element that the body needs to supplement externally, it needs to be mixed with the drug matrix and granulated to ensure sufficient NMN intake. However, in the preparation of drug particles using NMN, the NMN and drug matrix are directly added into the granulation equipment, resulting in uneven and low NMN density within the drug matrix. Therefore, there is an urgent need to design a granulation device that improves the NMN packing density to solve these problems. Utility Model Content

[0005] The purpose of this invention is to provide a granulation device that improves the packing density of β-nicotinamide mononucleotide, thereby addressing the aforementioned shortcomings in the prior art.

[0006] To achieve the above objectives, this utility model provides the following technical solution:

[0007] A granulation device for improving the bulk density of β-nicotinamide mononucleotide includes a mounting plate, a housing on the top of the mounting plate, a screw drive mechanism inserted into the housing at one end, a feeding assembly fixedly disposed above the housing, a sliding-type leveling assembly above the feeding assembly, the leveling assembly being used at least to uniformly distribute β-nicotinamide mononucleotide into the drug matrix inside the feeding assembly, and a granulation mechanism at the end of the housing, the granulation mechanism being used at least to granulate the raw material from the housing by the screw drive mechanism.

[0008] Preferably, a plurality of support bases are fixedly installed on the top of the mounting plate, and the outer shell is fixed above the support bases.

[0009] Preferably, the screw drive mechanism includes a motor base fixed on the outer wall of one side of the top of the mounting plate, and a motor is mounted above the motor base. A coupling is provided on the output shaft of the motor, and a helical blade inserted into the housing is installed at the end of the coupling away from the motor.

[0010] Preferably, a material tray is fixedly installed at the end of the outer shell by bolts, and the material tray is provided with a discharge hole.

[0011] Preferably, the feeding assembly includes a feeding hopper fixed above the outer shell, two parallel ear seats are provided on both sides of the top of the feeding hopper, and guide rods are provided on the ear seats. Inclined toothed plates are provided on both sides of the top of the feeding hopper, and a sliding sleeve is sleeved on the outside of the guide rods.

[0012] Preferably, the material leveling assembly includes a second motor mounted via a sliding sleeve, with traveling gears on both sides of the second motor, the traveling gears meshing with a toothed plate, a secondary hopper fixedly mounted on one side of the top of the second motor, and a sliding adjustment plate on one side of the secondary hopper.

[0013] Preferably, the granulation mechanism includes a connecting frame fixed to the end of the outer shell, and a bushing is provided at one end of the connecting frame. A drive shaft is inserted into the bushing, and a plurality of blades are fixedly provided at the end of the drive shaft in a ring at equal intervals. A drive module is provided at one end of the drive shaft and fixed on the bushing.

[0014] In the above technical solution, the granulation equipment for improving the packing density of β-nicotinamide mononucleotide provided by this utility model has the following beneficial effects:

[0015] The homogenizing component is located above the feeding component. The drug matrix can be added into the interior of the shell through the feeding component. At the same time, β-nicotinamide mononucleotide is added into the interior of the feeding component by the reciprocating linear movement of the homogenizing component, so that the packing density of β-nicotinamide mononucleotide in the drug matrix is ​​higher. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0017] Figure 1 This is a schematic diagram of the structure of a granulation device for improving the packing density of β-nicotinamide mononucleotide according to an embodiment of the present invention.

[0018] Figure 2 This is a structural cross-sectional view of an embodiment of a granulation device for improving the packing density of β-nicotinamide mononucleotide according to the present invention.

[0019] Figure 3 This is a schematic diagram of the uniform material assembly structure provided in an embodiment of a granulation device for improving the packing density of β-nicotinamide mononucleotide according to the present invention.

[0020] Figure 4 This is a schematic diagram of the granulation mechanism provided in an embodiment of a granulation device for improving the packing density of β-nicotinamide mononucleotide according to the present invention.

[0021] 1. Mounting plate; 11. Support base; 2. Screw drive mechanism; 21. Motor base; 22. Motor 1; 23. Coupling; 24. Spiral blade; 3. Housing; 31. Material tray; 4. Feeding assembly; 41. Feeding hopper; 42. Ear seat; 43. Guide rod; 44. Tooth plate; 45. Sliding sleeve; 5. Material leveling assembly; 51. Motor 2; 52. Travel gear; 53. Secondary hopper; 54. Adjusting plate; 6. Granulation mechanism; 61. Connecting frame; 62. Bushing; 63. Drive shaft; 64. Blade; 65. Drive module. Detailed Implementation

[0022] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings.

[0023] like Figure 1-4 As shown in the figure, the granulation equipment for improving the bulk density of β-nicotinamide mononucleotide provided by this utility model includes a mounting plate 1, a shell 3 is provided on the top of the mounting plate 1, a screw drive mechanism 2 is provided at one end of the shell 3 and inserted into the shell 3, a feeding component 4 is fixedly provided above the shell 3, a sliding uniform component 5 is provided above the feeding component 4, the uniform component 5 is used at least to uniformly distribute β-nicotinamide mononucleotide in the drug matrix inside the feeding component 4, and a granulation mechanism 6 is provided at the end of the shell 3, the granulation mechanism 6 is used at least to granulate the raw material based on the shell 3 by the screw drive mechanism 2.

[0024] In this embodiment, a mounting plate 1 is included; a plurality of support seats 11 are fixedly mounted on the top of the mounting plate 1, and the outer shell 3 is fixed above the support seats 11. The upper part of the support seats 11 has an arc-shaped structure, which is more compatible with the outer surface of the outer shell 3, thereby improving the stability of the outer shell 3 on the mounting plate 1 and ensuring the effect of drug granulation.

[0025] In this embodiment, the top of the mounting plate 1 is provided with a housing 3; the end of the housing 3 is fixedly installed with a material tray 31 by bolts, and the material tray 31 is provided with a discharge hole. The drug is squeezed by the spiral blades 24 inside the housing 3, so that the drug is discharged from the discharge hole on the material tray 31 in a strip shape, which, together with the granulation mechanism 6, realizes the granulation processing of the drug.

[0026] In this embodiment, a screw drive mechanism 2 is provided at one end of the outer shell 3 and inserted into the inner shell 3. The screw drive mechanism 2 includes a motor base 21 fixed on the outer wall of the top side of the mounting plate 1, and a motor 22 is installed above the motor base 21. A coupling 23 is provided on the output shaft of the motor 22. A spiral blade 24 inserted into the inner shell 3 is installed at the end of the coupling 23 away from the motor 22. When granulating the drug, the motor 22 is started, and the spiral blade 24 can be driven to rotate inside the outer shell 3 through the coupling 23, so as to continuously squeeze the drug inside the outer shell 3, so that the drug moves inside the outer shell 3 and is squeezed out from the material tray 31.

[0027] In this embodiment, a feeding assembly 4 is fixedly disposed on the top of the outer shell 3. The feeding assembly 4 includes a feeding hopper 41 fixed on the top of the outer shell 3. Two parallel ear seats 42 are provided on both sides of the top of the feeding hopper 41, and guide rods 43 are provided on the ear seats 42. Inclined toothed plates 44 are provided on both sides of the top of the feeding hopper 41. A sliding sleeve 45 is sleeved on the outside of the guide rods 43. The drug matrix is ​​added into the feeding hopper 41, and the screw drive mechanism 2 is used to realize the delivery of the drug inside the outer shell 3. While delivering the drug matrix, β-nicotinamide mononucleotide is added into the inside of the feeding hopper 41 by the uniform feeding assembly 5.

[0028] In this embodiment, a sliding-type uniform distribution component 5 is provided above the feeding component 4. The uniform distribution component 5 is used to uniformly distribute β-nicotinamide mononucleotide in the drug matrix inside the feeding component 4. The uniform distribution component 5 includes a second motor 51 mounted through a sliding sleeve 45. Both sides of the second motor 51 are provided with traveling gears 52, which are meshed with a toothed plate 44. A secondary hopper 53 is fixedly installed on one side of the top of the second motor 51. When the second motor 51 is started, it can drive the traveling gears 52 on both sides to rotate. The traveling gears 52 and the second motor 51 move linearly on the toothed plate 44 together, driving the secondary hopper 53 to move linearly back and forth above the feeding hopper 41, so as to uniformly distribute β-nicotinamide mononucleotide inside the feeding hopper 41. A sliding adjustment plate 54 is provided on one side of the secondary hopper 53. The size of the bottom opening of the secondary hopper 53 can be adjusted by using the adjustment plate 54, thereby controlling the uniform distribution speed of β-nicotinamide mononucleotide.

[0029] In this embodiment, a granulation mechanism 6 is provided at the end of the outer shell 3. The granulation mechanism 6 is used at least to granulate the raw materials from the outer shell 3 by the screw drive mechanism 2. The granulation mechanism 6 includes a connecting frame 61 fixed to the end of the outer shell 3. The connecting frame 61 is a steel structure, preferably four in number. A bushing 62 is provided at one end of the connecting frame 61. A drive shaft 63 is inserted into the bushing 62. Several blades 64 are fixedly arranged in a ring at equal distances at the end of the drive shaft 63. The number of blades 64 is at least three. A drive module 65 is fixed to the bushing 62 at one end of the drive shaft 63. After the screw drive mechanism 2 extrudes the drug inside the outer shell 3, the drive module 65 is activated. It can be a high-speed motor, which drives the drive shaft 63 to rotate at high speed inside the bushing 62. The drive shaft 63 drives the blades 64 to rotate at high speed. The blades 64 are used to granulate the extruded strip-shaped drug, thereby completing the granulation production of high-density β-nicotinamide mononucleotide drug.

[0030] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide, comprising a mounting plate (1), characterized in that, The top of the mounting plate (1) is provided with a shell (3), one end of the shell (3) is provided with a screw rod driving mechanism (2) inserted in the shell (3), the upper part of the shell (3) is fixedly provided with a feeding assembly (4), the upper part of the feeding assembly (4) is provided with a sliding type uniform material assembly (5), the uniform material assembly (5) is used at least for uniformly spreading β-nicotinamide mononucleotide in the medicine matrix in the feeding assembly (4), the end of the shell (3) is provided with a granulating mechanism (6), the granulating mechanism (6) is used at least for granulating the raw materials from the shell (3) by the screw rod driving mechanism (2).

2. The granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide according to claim 1, characterized by, The top of the mounting plate (1) is fixedly provided with a plurality of support seats (11), and the shell (3) is fixedly arranged above the support seats (11).

3. The granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide according to claim 1, characterized by, The screw rod driving mechanism (2) comprises a motor base (21) fixedly arranged on one side of the outer wall of the top of the mounting plate (1), a motor one (22) is arranged above the motor base (21), a shaft coupling (23) is arranged on the output shaft of the motor one (22), and a spiral blade (24) is inserted in the shell (3) and arranged on the end of the shaft coupling (23) away from the motor one (22).

4. The granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide according to claim 1, characterized by The end of the shell (3) is fixedly provided with a material disc (31) through bolts, and the material disc (31) is provided with a discharging hole.

5. The granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide according to claim 1, characterized by The feeding assembly (4) comprises a feeding hopper (41) fixedly arranged above the shell (3), two ear seats (42) are arranged on the top of the feeding hopper (41) and arranged side by side, a guide rod (43) is arranged on the ear seat (42), and inclined tooth plates (44) are arranged on the two sides of the top of the feeding hopper (41), and a sliding sleeve (45) is arranged outside the guide rod (43).

6. The granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide according to claim 5, wherein The uniform material assembly (5) comprises a motor two (51) arranged through the sliding sleeve (45), walking gears (52) are arranged on the two sides of the motor two (51), the walking gears (52) are in meshing connection with the tooth plates (44), a sub hopper (53) is fixedly arranged on one side of the top of the motor two (51), and a sliding adjusting plate (54) is arranged on one side of the sub hopper (53).

7. The granulating apparatus for improving the bulk density of β-nicotinamide mononucleotide according to claim 1, characterized by The granulating mechanism (6) comprises a connecting frame (61) fixedly arranged on the end of the shell (3), a shaft sleeve (62) is arranged on one end of the connecting frame (61), a transmission shaft (63) is inserted in the shaft sleeve (62), a plurality of equally spaced annularly distributed blades (64) are fixedly arranged on the end of the transmission shaft (63), and a driving module (65) is fixedly arranged on the shaft sleeve (62) on one end of the transmission shaft (63).

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