Biological medicine preparation spray drying equipment
By introducing a gear ring and scraper structure into the spray drying device for biopharmaceutical formulations, the material falling is slowed down and the material on the inner wall is scraped off, solving the problems of poor drying effect and material adhesion, achieving complete drying and reducing waste.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- LYNK & CO BIOTECHNOLOGY (KUNMING) CO LTD
- Filing Date
- 2025-05-20
- Publication Date
- 2026-04-21
AI Technical Summary
In existing spray drying processes for biopharmaceutical formulations, the drying effect is poor and the dried material tends to adhere to the inner wall of the drying cylinder, resulting in waste.
The drying cylinder employs a gear ring structure and scraper design. The motor drives the gear to rotate the ring, which in turn drives the baffles and scrapers on the convex rod and arc rod to rotate, slowing down the falling speed of the material and scraping the material from the inner wall. Combined with the electric heater heating the air to contact the droplets, the drying process is completed.
It improves drying efficiency, ensures materials are completely dry and prevents them from adhering to the inner wall, thus reducing waste.
Smart Images
Figure CN224141474U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of drying equipment technology, specifically to spray drying equipment for biopharmaceutical preparations. Background Technology
[0002] Biopharmaceutical preparations refer to drugs or treatments produced using biotechnology for the treatment, prevention, or diagnosis of diseases. During the production and processing of biopharmaceutical preparations, spray drying is required. However, existing methods for drying biopharmaceutical preparations often utilize atomizers to disperse the liquid material into fine droplets. These droplets mix with a hot drying medium, causing the moisture in the droplets to evaporate and form a dry powder. In actual drying operations, the material falls too quickly, and the descent speed cannot be slowed down, thus limiting the drying time and preventing complete drying. Furthermore, the dried material may adhere to the inner wall of the drying cylinder, resulting in waste. To address these issues, the inventors have proposed a spray drying equipment for biopharmaceutical preparations. Utility Model Content
[0003] To address the issues of poor drying efficiency and waste caused by dried material adhering to the inner wall of the drying cylinder during the use of existing spray drying methods for biopharmaceutical formulations, this invention aims to provide spray drying equipment for biopharmaceutical formulations.
[0004] To solve the above-mentioned technical problems, this utility model adopts the following technical solution: a spray drying equipment for biopharmaceutical preparations, including a drying cylinder, an inlet pipe fixedly connected to the center of the top surface of the drying cylinder, a liquid supply connector fixedly connected to one end of the inlet pipe, and an atomizing nozzle fixedly connected to the other end of the inlet pipe, a toothed ring provided in the upper inner part of the drying cylinder, a motor provided on one side of the drying cylinder, a gear fixedly connected to the output shaft end of the motor, the gear corresponding to and meshing with the toothed ring, a protruding rod fixedly connected to the bottom surface of the toothed ring, an arc-shaped rod fixedly connected to the bottom end of the protruding rod, a baffle fixedly connected to the side wall of the arc-shaped rod, and a scraper fixedly connected to the bottom end of the arc-shaped rod, the drying cylinder including a conical cavity, the scraper located inside the conical cavity and cooperating with the conical cavity, and an electric heater inserted through the side wall of the drying cylinder.
[0005] Preferably, the liquid supply connector is located outside the drying cylinder, and the atomizing nozzle is located inside the drying cylinder. The liquid supply connector is used to connect to an external liquid supply pipe. The raw material liquid enters the inlet pipe through the liquid supply connector and is then atomized and sprayed out through the atomizing nozzle to form droplets. The air inside the drying cylinder can be heated by an electric heater. By directly contacting the heated air with the droplets, a powder-shaped product can be obtained to complete the spray drying of biological agents. A base is provided on the side wall of the motor. The bottom surface of the base is fixedly connected to the top surface of the drying cylinder. The motor is installed through the base. When the motor is started, the gear rotates under the action of the motor output shaft. Through the meshing of the gear and the gear ring, and the cooperation of the convex ring, the gear ring can drive the convex rod to rotate. In turn, the baffle and scraper can be rotated by the arc rod. The baffle is used to block the material undergoing preliminary drying to slow down the falling speed of the material, so as to prolong the drying time and ensure that the material is completely dried.
[0006] Preferably, a convex ring is fixedly connected to the top surface of the gear ring, and the side of the convex ring facing away from the gear ring extends into the drying cylinder. The convex ring is rotatably connected to the drying cylinder. When the gear and the gear ring mesh, the gear ring can drive the convex rod to rotate under the cooperation of the convex ring. The atomizing nozzle is located inside the ring opening of the gear ring. The axis of the gear ring coincides with the axis of the drying cylinder. The baffles are inclined, and each arc-shaped rod has three baffles, which are staggered. The atomizing nozzle is used to... The agent is atomized and sprayed to form droplets. The baffle is inclined so that the dried material can slide down. A discharge pipe is fixedly connected to the bottom center of the conical cavity. A solenoid valve is provided on the side wall of the discharge pipe. Activating the solenoid valve makes the discharge pipe unobstructed so that the dried material can be discharged. Four support legs are fixedly connected to the outer side wall of the drying cylinder. The four support legs are arranged in an array around the axis of the drying cylinder. The support legs are used to support and fix the drying cylinder.
[0007] Compared with the prior art, the beneficial effects of this utility model are as follows: the drying effect is good. When drying, the motor is started, and the gear and the toothed ring mesh with each other, and with the cooperation of the convex ring, the toothed ring can drive the convex rod to rotate, which in turn can make the baffle and scraper rotate. The baffle can block the material being dried in the initial stage, so as to slow down the falling speed of the material and extend the drying time, so that the material can be completely dried. The scraper can scrape the inner wall of the conical cavity to prevent the dried material from adhering to the inner wall of the conical cavity and avoid waste. Attached Figure Description
[0008] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0009] Figure 1 This is a schematic diagram of the overall structure of this utility model.
[0010] Figure 2 This is a schematic diagram of the internal structure of the drying cylinder of this utility model.
[0011] Figure 3 This is a schematic diagram showing the cooperation between the arc-shaped rod, the baffle, and the scraper of this utility model.
[0012] Figure 4 This is an enlarged view of section A of this utility model.
[0013] In the diagram: 1. Drying cylinder; 2. Support leg; 3. Liquid inlet pipe; 4. Liquid supply connector; 5. Atomizing nozzle; 6. Convex ring; 7. Gear ring; 8. Convex rod; 9. Arc rod; 10. Baffle; 11. Scraper; 12. Motor; 13. Base; 14. Gear; 15. Conical cavity; 16. Discharge pipe; 17. Solenoid valve; 18. Electric heater. Detailed Implementation
[0014] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0015] Example: Figure 1-4 As shown, this utility model provides a spray drying equipment for biopharmaceutical preparations, including a drying cylinder 1. A liquid inlet pipe 3 is fixedly connected to the middle of the top surface of the drying cylinder 1. One end of the liquid inlet pipe 3 is fixedly connected to a liquid supply connector 4, and the other end of the liquid inlet pipe 3 is fixedly connected to an atomizing nozzle 5. A toothed ring 7 is provided in the upper inner part of the drying cylinder 1. A motor 12 is provided on one side of the drying cylinder 1. A gear 14 is fixedly connected to the output shaft end of the motor 12. The gear 14 corresponds to and meshes with the toothed ring 7. A protruding rod 8 is fixedly connected to the bottom surface of the toothed ring 7. An arc-shaped rod 9 is fixedly connected to the bottom end of the protruding rod 8. A baffle 10 is fixedly connected to the side wall of the arc-shaped rod 9. A scraper 11 is fixedly connected to the bottom end of the arc-shaped rod 9. The drying cylinder 1 includes a conical cavity 15. The scraper 11 is located in the conical cavity 15 and cooperates with the conical cavity 15. An electric heater 18 is provided through the side wall of the drying cylinder 1.
[0016] The liquid supply connector 4 is located outside the drying cylinder 1, and the atomizing nozzle 5 is located inside the drying cylinder 1.
[0017] By adopting the above technical solution, the liquid supply connector 4 is used to connect with the external liquid supply pipe. The raw material liquid enters the liquid inlet pipe 3 through the liquid supply connector 4, and then is atomized and sprayed out through the atomizing nozzle 5 to form droplets. The air inside the drying cylinder 1 can be heated by the electric heater 18. By directly contacting the heated air with the droplets, a powder-shaped product can be obtained to complete the spray drying of biological agents.
[0018] A base 13 is provided on the side wall of the motor 12, and the bottom surface of the base 13 is fixedly connected to the top surface of the drying cylinder 1.
[0019] By adopting the above technical solution, the top surface of the drying cylinder 1 is provided with air holes. The motor 12 is installed through the base 13. When the motor 12 is started, the gear 14 rotates under the action of the output shaft of the motor 12. Through the meshing of the gear 14 and the gear ring 7, and with the cooperation of the convex ring 6, the gear ring 7 can drive the convex rod 8 to rotate. Then, the baffle 10 and the scraper 11 can be rotated through the arc rod 9. The baffle 10 is used to block the material undergoing preliminary drying, so as to slow down the falling speed of the material, so as to extend the drying time and allow the material to be completely dried.
[0020] A protruding ring 6 is fixedly connected to the top surface of the toothed ring 7. The side of the protruding ring 6 facing away from the toothed ring 7 extends into the drying cylinder 1, and the protruding ring 6 is rotatably connected to the drying cylinder 1.
[0021] By adopting the above technical solution, when gear 14 meshes with gear ring 7, under the cooperation of convex ring 6, gear ring 7 can drive convex rod 8 to rotate.
[0022] The atomizing nozzle 5 is located inside the annulus of the toothed ring 7. The axis of the toothed ring 7 coincides with the axis of the drying cylinder 1. The baffles 10 are set at an angle, and there are three baffles 10 on each arc rod 9, and the three baffles 10 are staggered with each other.
[0023] By adopting the above technical solution, the atomizing nozzle 5 is used to atomize and spray the agent to form droplets, and the baffle 10 is inclined so that the dried material can slide down.
[0024] A discharge pipe 16 is fixedly connected to the middle of the bottom surface of the conical cavity 15, and a solenoid valve 17 is provided on the side wall of the discharge pipe 16.
[0025] By adopting the above technical solution, the solenoid valve 17 is activated to make the discharge pipe 16 unobstructed, so that the dried material can be discharged.
[0026] The outer wall of the drying cylinder 1 is fixedly connected with four support legs 2, which are arranged in an array with the axis of the drying cylinder 1 as the center.
[0027] By adopting the above technical solution, the support leg 2 is used to support and fix the drying cylinder 1.
[0028] Working principle: When using this utility model, the liquid supply connector 4 is connected to the external liquid supply pipe. The biological agent enters the liquid inlet pipe 3 through the liquid supply connector 4, and then is atomized and sprayed out through the atomizing nozzle 5 to form droplets. The air inside the drying cylinder 1 is heated by the electric heater 18. The heated air comes into direct contact with the droplets to obtain a powder-shaped product, thereby completing the spray drying of the biological agent.
[0029] At the same time, the motor 12 is started, and the gear 14 rotates under the action of the output shaft of the motor 12. Through the meshing of the gear 14 and the gear ring 7, and the cooperation of the convex ring 6, the gear ring 7 drives the convex rod 8 to rotate, and the arc rod 9 causes the baffle 10 and the scraper 11 to rotate.
[0030] The baffle 10 can block the material undergoing preliminary drying to slow down the falling speed of the material, thereby extending the drying time and ensuring that the material is completely dried. The scraper 11 can scrape the inner wall of the conical cavity 15 to prevent the dried material from adhering to the inner wall of the conical cavity 15. At the same time, the solenoid valve 17 is activated to unblock the discharge pipe 16, allowing the dried material to be discharged.
[0031] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.
Claims
1. Spray drying apparatus for biopharmaceutical preparations, comprising a drying cylinder (1), characterized in that: A liquid inlet pipe (3) is fixedly connected to the middle of the top surface of the drying cylinder (1). One end of the liquid inlet pipe (3) is fixedly connected to a liquid supply connector (4), and the other end of the liquid inlet pipe (3) is fixedly connected to an atomizing nozzle (5). A gear ring (7) is provided in the upper inner part of the drying cylinder (1). A motor (12) is provided on one side of the drying cylinder (1). A gear (14) is fixedly connected to the output shaft end of the motor (12). The gear (14) corresponds to and meshes with the gear ring (7). A protruding rod (8) is fixedly connected to the bottom surface of the ring (7), and an arc-shaped rod (9) is fixedly connected to the bottom end of the protruding rod (8). A baffle (10) is fixedly connected to the side wall of the arc-shaped rod (9), and a scraper (11) is fixedly connected to the bottom end of the arc-shaped rod (9). The drying cylinder (1) includes a conical cavity (15), and the scraper (11) is located inside the conical cavity (15) and the scraper (11) cooperates with the conical cavity (15). An electric heater (18) is interspersed on the side wall of the drying cylinder (1).
2. The biopharmaceutical formulation spray drying apparatus of claim 1, wherein, The liquid supply connector (4) is located outside the drying cylinder (1), and the atomizing nozzle (5) is located inside the drying cylinder (1).
3. The biopharmaceutical formulation spray-drying apparatus of claim 1, wherein the biopharmaceutical formulation spray-drying apparatus is configured to produce a biopharmaceutical formulation having a bulk density of at least 0.1 g / mL. The motor (12) has a base (13) on its side wall, and the bottom surface of the base (13) is fixedly connected to the top surface of the drying cylinder (1).
4. The spray drying equipment for biopharmaceutical formulations as described in claim 1, characterized in that, The top surface of the toothed ring (7) is fixedly connected to a convex ring (6), the side of the convex ring (6) facing away from the toothed ring (7) extends into the drying cylinder (1), and the convex ring (6) is rotatably connected to the drying cylinder (1).
5. The biopharmaceutical formulation spray drying apparatus of claim 1, wherein the biopharmaceutical formulation spray drying apparatus is configured to produce a biopharmaceutical formulation having a bulk density of at least 0.3 g / mL. The atomizing nozzle (5) is located inside the annulus of the toothed ring (7), and the axis of the toothed ring (7) coincides with the axis of the drying cylinder (1).
6. The biopharmaceutical formulation spray drying apparatus of claim 1, wherein the biopharmaceutical formulation spray drying apparatus is configured to produce a biopharmaceutical formulation having a bulk density of at least 0.3 g / mL. The baffle (10) is inclined, and there are three baffles (10) on each of the arc rods (9), and the three baffles (10) are staggered with each other.
7. The biopharmaceutical formulation spray drying apparatus of claim 1, wherein the biopharmaceutical formulation spray drying apparatus is configured to produce a biopharmaceutical formulation having a bulk density of at least 0.3 g / mL. A discharge pipe (16) is inserted and fixedly connected to the middle of the bottom surface of the conical cavity (15), and a solenoid valve (17) is provided on the side wall of the discharge pipe (16).
8. The biopharmaceutical formulation spray drying apparatus of claim 1, wherein, The outer wall of the drying cylinder (1) is fixedly connected with four support legs (2), and the four support legs (2) are arranged in an array with the axis of the drying cylinder (1) as the center.