Bottom support for DNA breaking instrument

Abstract

The utility model provides a bottom support for a DNA (Deoxyribose Nucleic Acid) breaking instrument, which belongs to the technical field of DNA breaking instruments, comprises a motor kinetic energy device for driving a test tube for containing a DNA sample to rotate, and is characterized by further comprising a platform plate for supporting and a DNA mounting module for normatively placing the test tube, a central through hole is formed in the middle of the platform plate, and the DNA installation module is placed and installed in the central through hole; the platform plate is further provided with a notch used for containing the motor kinetic energy device. A driving lever for driving the DNA mounting module to rotate is fixedly mounted on an output shaft of the motor kinetic energy device, and contacts are arranged at the two ends of the bottom of the driving lever; the bottom platform of the DNA breaking instrument can solve the problems that when an existing DNA breaking instrument is used, a tray for containing DNA sample test tubes shakes, and the whole tray is difficult to take and place.

Description

Technical Field

[0001] This utility model belongs to the technical field of DNA breaking devices, specifically, it relates to a base for a DNA breaking device. Background Technology

[0002] A fragmentation analyzer is an analytical instrument based on ultrasonic technology, primarily used for high-precision biological sample pretreatment such as next-generation sequencing DNA samples and chromatin immunoprecipitation experiments. This instrument uses an isothermal, non-contact method to fragment, homogenize, and mix samples, breaking chromosomes through centrifuge tubes to avoid cross-contamination, making it suitable for processing high-throughput, valuable samples. Its core technology utilizes focused ultrasound (such as ACUT™ and BoFU technologies) to achieve uniform fragmentation, homogenization, and mixing of nucleic acid, cell, and other samples through non-contact operation, avoiding the cross-contamination problems that can occur with traditional probe ultrasonic fragmenters. As of 2025, domestically produced equipment such as the Xiaomei Ultrasonic XM-26A and the Qingyuan Kaiwu EoSonics® series have broken the foreign technological monopoly, possessing advantages such as high throughput (1-96 samples per batch), adjustable fragment range (100bp-5Kb), and low-temperature isothermal processing.

[0003] In DNA fragmentation devices, a mechanism is needed to transmit the torsion to a tray containing the DNA sample, causing the tray to rotate the DNA sample. However, currently common devices of this type have the following problems:

[0004] 1. When the power source drives the pallet to rotate, a single-shaft drive is usually used, which is not stable enough during the entire power transmission process and is prone to causing the device to shake.

[0005] 2. The tray is not convenient to pick up or put down, and it is easy to tip over when placed. Utility Model Content

[0006] Based on the above problems, this utility model provides a base tray for a DNA fragmentation instrument. This base tray can solve the problems of unstable power transmission, inconvenient tray handling, and inability to place the tray upright when it is removed from conventional DNA fragmentation instruments.

[0007] This invention is implemented as follows: This invention provides a base for a DNA fragmentation device, including a motor kinetic energy unit for driving the rotation of test tubes containing DNA samples, and further including a platform plate for support and a DNA mounting module for properly placing the test tubes; the platform plate has a central through hole in the middle, and the DNA mounting module is placed and installed in the central through hole; the platform plate also has a slot for placing the motor kinetic energy unit; a lever for rotating the DNA mounting module is fixedly installed on the output shaft of the motor kinetic energy unit, and both ends of the lever are provided with contact points.

[0008] The technical advantages of the base for a DNA fragmentation device provided by this utility model are as follows: by setting a motor kinetic energy source, the test tube containing the DNA sample rotates stably, so that the DNA sample inside can be evenly stressed, improving the standardization of sample processing; by setting a platform plate, the motor kinetic energy source is supported, avoiding the weight of the motor kinetic energy source being applied to the DNA mounting module.

[0009] Based on the above technical solution, the base of the DNA breaking device of this utility model can be further improved as follows:

[0010] Furthermore, the DNA mounting module includes a tray, a test tube clamping plate, a test tube mounting plate, and a central connecting shaft. One end of the central connecting shaft is fixedly mounted on the tray with screws, and the other end of the central connecting shaft is fixedly mounted on the test tube mounting plate with screws. The test tube clamping plate is slidably sleeved on the central connecting shaft. The tray has tray holes for placing the contacts. The test tube mounting plate has multiple test tube holes for placing test tubes. The test tube mounting plate also has support foot mounting holes near its edge, and mounting plate support feet are detachably installed in the support foot mounting holes.

[0011] The beneficial effects of adopting the above-mentioned further solution are as follows: by setting a tray, the entire DNA installation module can be supported; by setting a tray hole, it is more convenient to take out and put in the entire DNA installation module, and the staff can use the tray hole to take out or put in the DNA breaking instrument; by setting a mounting plate support foot, the DNA installation module can always be in an upright position and the structure is stable when it is outside the DNA breaking instrument.

[0012] Furthermore, the central through hole is a stepped circular hole, with a minimum hole diameter greater than or equal to the outer diameter of the test tube pressure plate, and smaller than the diameter of the support plate.

[0013] The beneficial effects of adopting the above-mentioned further solution are as follows: by setting the central through hole as a stepped circular hole, the tray can be embedded and installed, making the structure fit better and avoiding the problem of the DNA installation module shaking during the DNA breaking process.

[0014] Furthermore, the diameter of the mounting hole of the test tube pressure plate is 1-4 mm larger than the diameter of the central connecting shaft, and the outer circle diameter of the test tube pressure plate is 1.1 times the outer circle diameter of the test tube mounting plate.

[0015] The beneficial effects of adopting the above-mentioned further solution are as follows: by setting the mounting hole diameter of the test tube pressure plate to be larger than the diameter of the central connecting shaft, the test tube pressure plate can slide smoothly up and down between the support plate and the test tube mounting plate; by setting the outer circle diameter of the test tube pressure plate to be larger than the outer circle diameter of the test tube mounting plate, the test tube pressure plate can perfectly cover the test tubes mounted on the test tube mounting plate, thus preventing the test tubes from shaking during the operation of the device.

[0016] Furthermore, the tray hole is a through hole, and the tray hole is fan-shaped, with the two arcs of the tray hole composed of two circles concentric with the tray. The beneficial effect of adopting the above further solution is that by limiting the shape of the tray hole to a fan shape, it is ensured that the contacts can smoothly drive the entire DNA installation module to rotate during the DNA fragmentation process.

[0017] Furthermore, the pallet is made of polytetrafluoroethylene or polyphenylene sulfide, and the manufacturing process must ensure that the pallet is integrally formed.

[0018] The beneficial effects of adopting the above-mentioned further solution are: by setting the material of the pallet to polytetrafluoroethylene or polyphenylene sulfide, the friction between the pallet and the platform plate is reduced, while ensuring the wear resistance of the pallet structure.

[0019] Furthermore, the test tube clamp is made of SUS304 stainless steel and undergoes surface quantification treatment.

[0020] The beneficial effects of adopting the above-mentioned further solution are as follows: by performing surface quantification treatment on the test tube clamp, the corrosion resistance and pollution resistance of the test tube clamp surface are improved, and damage to the test tube clamp is avoided due to sample spillage and contact with the test tube clamp during use.

[0021] Furthermore, the length of the lever is 3 / 5 to 4 / 5 of the diameter of the concentric circle on the outer side of the tray hole, ensuring that the contact point is located within the tray hole. Furthermore, the lever and the contact point are integrally formed, and the length of the contact point is the same as the thickness of the tray.

[0022] Furthermore, multiple soft rubber pads are also attached to the bottom of the platform plate.

[0023] The beneficial effects of adopting the above-mentioned further solution are: by setting a soft rubber pad, direct contact between the platform plate and the DNA breaking instrument is avoided, providing a buffer between the platform plate and the DNA breaking instrument. Compared with the prior art, the beneficial effects of the base support for the DNA breaking instrument provided by this utility model are:

[0024] By setting up a tray and two tray holes in the middle of the tray, and cooperating with the lever fixed on the output shaft of the motor kinetic energy unit, the entire DNA installation module is driven to rotate; the dual contact structure on the lever has a more stable effect compared with the existing single-axis output of the motor kinetic energy unit, and the power transmission is also more efficient.

[0025] By setting mounting plate support feet at the bottom of the test tube mounting plate, the entire DNA mounting module can be stably placed on the worktable when not in use, such as when the DNA mounting module is removed and left to stand. Attached Figure Description

[0026] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained from these drawings without creative effort.

[0027] Figure 1 This is a schematic diagram of the overall structure;

[0028] Figure 2 This is a sectional view of the overall structure;

[0029] Figure 3 An exploded view of the parts of the overall structure;

[0030] Figure 4 for Figure 2 Enlarged view of point A in the middle;

[0031] Figure 5 This is a top view of the first embodiment of the test tube mounting plate;

[0032] Figure 6 This is a top view of the second embodiment of the test tube mounting plate;

[0033] Figure 7 This is a top view of the third embodiment of the test tube mounting plate;

[0034] Figure 8 This is a top view of the fourth embodiment of the test tube mounting plate;

[0035] Figure 9 This is a top view of the fifth embodiment of the test tube mounting plate.

[0036] The attached diagram lists the components represented by each number as follows:

[0037] 10. Motor power unit; 11. Lever; 111. Contact;

[0038] 20. Platform plate; 21. Center through hole; 22. Soft rubber gasket;

[0039] 30. DNA mounting module; 31. Tray plate; 311. Tray plate hole; 32. Test tube clamping plate; 33. Test tube mounting plate; 331. Test tube hole; 332. Mounting plate support foot; 333. Support foot mounting hole; 34. Central connecting shaft. Detailed Implementation

[0040] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0041] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0042] like Figure 1-5 As shown, this utility model provides a first embodiment of a base for a DNA fragmentation device, including a motor kinetic energy unit 10 for driving the rotation of test tubes containing DNA samples, and further including a platform plate 20 for support and a DNA mounting module 30 for properly placing the test tubes; a central through hole 21 is provided in the middle of the platform plate 20, and the DNA mounting module 30 is placed and installed in the central through hole 21; a slot for placing the motor kinetic energy unit 10 is also provided on the platform plate 20; a lever 11 for rotating the DNA mounting module 30 is fixedly installed on the output shaft of the motor kinetic energy unit 10, and contacts 111 are provided at both ends of the bottom of the lever 11.

[0043] Optionally, in the above technical solution, the DNA mounting module 30 includes a tray 31, a test tube clamping plate 32, a test tube mounting plate 33, and a central connecting shaft 34. One end of the central connecting shaft 34 is fixedly mounted on the tray 31 with screws, and the other end of the central connecting shaft 34 is fixedly mounted on the test tube mounting plate 33 with screws. The test tube clamping plate 32 is slidably mounted on the central connecting shaft 34. The tray 31 has a tray hole 311 for placing the contact 111. The test tube mounting plate 33 has a... Multiple test tube holes 331 are provided for placing test tubes; a support foot mounting hole 333 is also provided near the edge of the test tube mounting plate 33, and a mounting plate support foot 332 can be detachably installed in the support foot mounting hole 333; the mounting plate support foot 332 can be either inserted into the support foot mounting hole 333 or rotated in the support foot mounting hole 333 by means of thread engagement, in which case the support foot mounting hole 333 has an internal thread and the mounting plate support foot 332 has an external thread.

[0044] In this embodiment, the test tube hole 331 on the test tube mounting plate 33 only supports the placement of test tubes with a size of 0.2ml or 0.1ml.

[0045] Optionally, in the above technical solution, the central through hole 21 is a stepped circular hole, with a minimum hole diameter greater than or equal to the outer diameter of the test tube pressure plate 32, and smaller than the diameter of the support plate 31.

[0046] Optionally, in the above technical solution, the mounting hole diameter of the test tube pressure plate 32 is 1-4 mm larger than the diameter of the central connecting shaft 34, and the outer circle diameter of the test tube pressure plate 32 is 1.1 times the outer circle diameter of the test tube mounting plate 33.

[0047] Optionally, in the above technical solution, the tray hole 311 is a through hole and the tray hole 311 is fan-shaped, and the two arcs of the tray hole 311 are composed of two circles concentric with the tray 31.

[0048] Optionally, in the above technical solution, the pallet 31 is made of polytetrafluoroethylene or polyphenylene sulfide, and the manufacturing process must ensure that the pallet 31 is integrally formed.

[0049] Optionally, in the above technical solution, the test tube pressing plate 32 is made of SUS304 stainless steel, and the test tube pressing plate 32 undergoes surface quantification treatment.

[0050] Optionally, in the above technical solution, the length of the lever 11 is 3 / 5 to 4 / 5 of the diameter of the concentric circle outside the tray hole 311, ensuring that the contact 111 is located inside the tray hole 311.

[0051] Optionally, in the above technical solution, the lever 11 and the contact 111 are integrally formed, and the length of the contact 111 is the same as the thickness of the support plate 31.

[0052] Optionally, in the above technical solution, the connection position between the tray 31 and the test tube mounting plate 33 and the central connecting shaft 34 is a countersunk through hole to avoid protrusion at the connection and ensure that the overall structure is flat and aesthetically pleasing.

[0053] Optionally, in the above technical solution, the outer contour of the tray 31 and the contour of the tray hole 311 are both rounded to make the structure smoother and avoid scratching the fingers of the staff when picking it up.

[0054] Optionally, in the above technical solution, multiple soft rubber pads 22 are also attached to the bottom of the platform plate 20. The soft rubber pads 22 are made of rubber.

[0055] like Figure 6 The image shows a second embodiment of the present invention. Unlike the previous embodiment, the test tube mounting plate 33 in this embodiment has a test tube hole 331 that supports the placement of test tubes with a capacity of 2 ml or 1.5 ml.

[0056] like Figure 7 The image shows the third embodiment of the present invention. Unlike the previous embodiments, the test tube mounting plate 33 in this embodiment has a test tube hole 331 that supports the placement of test tubes with a capacity of 2ml, 0.5ml, 0.65ml, 0.2ml, or 0.1ml.

[0057] like Figure 8 As shown, this is the fourth embodiment of the present invention. Unlike the previous embodiments, the test tube hole 331 on the test tube mounting plate 33 in this embodiment only supports the placement of 5.0ml test tubes.

[0058] like Figure 9 The figure shown is the fifth embodiment of the present invention. Unlike the above embodiments, the test tube hole 331 opened on the test tube mounting plate 33 in this embodiment supports the placement of test tubes with specifications of 5.0ml, 2.0ml, 0.2ml, or 0.1ml.

[0059] The above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A base stand for a DNA disruptor, comprising a motor driver (10) for driving a DNA sample test tube to rotate, characterized in that, It also includes a platform plate (20) for support and a DNA mounting module (30) for properly placing test tubes; the platform plate (20) has a central through hole (21) in the middle, and the DNA mounting module (30) is placed and installed in the central through hole (21); the platform plate (20) also has a slot for placing the motor kinetic energy unit (10); a lever (11) is fixedly installed on the output shaft of the motor kinetic energy unit (10), and both ends of the lever (11) are provided with contacts (111).

2. The holder for a DNA disruptor according to claim 1, wherein The DNA mounting module (30) includes a tray (31), a test tube clamping plate (32), a test tube mounting plate (33), and a central connecting shaft (34). One end of the central connecting shaft (34) is fixedly mounted on the tray (31) with screws, and the other end of the central connecting shaft (34) is fixedly mounted on the test tube mounting plate (33) with screws. The test tube clamping plate (32) is slidably mounted on the central connecting shaft (34). The tray (31) has a tray hole (311). The test tube mounting plate (33) has multiple test tube holes (331). The test tube mounting plate (33) also has a support foot mounting hole (333) near the edge, and a mounting plate support foot (332) can be detachably installed in the support foot mounting hole (333).

3. The holder for a DNA disruptor according to claim 2, wherein The central through hole (21) is a stepped circular hole, with a minimum hole diameter greater than or equal to the outer circle diameter of the test tube pressure plate (32) and smaller than the diameter of the support plate (31).

4. The holder for a DNA disruptor according to claim 2, wherein The mounting hole diameter of the test tube pressure plate (32) is 1-4 mm larger than the diameter of the central connecting shaft (34). The outer circle diameter of the test tube pressure plate (32) is larger than the outer circle diameter of the test tube mounting plate (33) and smaller than the diameter of the central through hole (21).

5. The holder for a DNA cutter according to claim 2, wherein The tray hole (311) is a through hole and the tray hole (311) is fan-shaped. The two arcs of the tray hole (311) are composed of two circles concentric with the tray (31).

6. The holder for a DNA cutter according to claim 2, wherein The pallet (31) is made of polytetrafluoroethylene or polyphenylene sulfide, and the manufacturing process must ensure that the pallet (31) is integrally formed.

7. The holder for a DNA cutter according to claim 2, wherein The test tube clamp (32) is made of SUS304 stainless steel and the test tube clamp (32) undergoes surface quantification treatment.

8. The holder for a DNA cutter according to claim 2, wherein The length of the lever (11) is 3 / 5 to 4 / 5 of the diameter of the concentric circle outside the tray hole (311), ensuring that the contact point (111) is located inside the tray hole (311).

9. The holder for a DNA cutter according to claim 2, wherein The lever (11) and the contact (111) are integrally formed, and the length of the contact (111) is the same as the thickness of the tray (31).

10. The holder for a DNA cutter according to claim 1, wherein Multiple soft rubber pads (22) are also attached to the bottom of the platform plate (20), and the soft rubber pads (22) are made of rubber.

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