Rotary cell culture device

Abstract

The utility model relates to the technical field of biological experiment equipment, in particular to a rotary cell culture device which comprises a driving box, a rotary base and a culture tube, a plurality of rotating bases are rotationally mounted on a front vertical plate of the driving box; a driving mechanism is arranged in the driving box and is used for driving the rotating base to rotate; a first magnetic suction ring is embedded in the front end face of the rotating base. A second magnetic suction ring is embedded in the rear end surface of the culture tube; when the rear end face of the culture tube is in butt joint with the front end face of the rotary base, the first magnetic suction ring and the second magnetic suction ring attract each other. The culture tube can be mounted on the rotary base in a mode that the first magnetic suction ring and the second magnetic suction ring attract each other, operation is simple and rapid, and the problem that in the prior art, operation is tedious when a stud and a threaded hole are adopted for connection is solved.

Description

Technical Field

[0001] This utility model relates to the field of biological experimental equipment technology, and in particular to a rotating cell culture device. Background Technology

[0002] The Synthecon Rotating Cell Culture System (RCCS) is an advanced cell culture device that simulates a microgravity environment and is widely used in basic medicine, drug development, regenerative medicine, and other fields. The RCCS keeps cells suspended in the culture medium by rotating the culture tube. Under the combined effects of rotational tangential force and gravity, the cells form a three-dimensional spherical structure. This culture method avoids the cell flattening phenomenon found in traditional two-dimensional culture and more closely resembles the in vivo cell growth environment. Simultaneously, the system is equipped with a silica gel oxygenation membrane that allows for gas exchange, ensuring that cells receive sufficient oxygen and remove metabolic waste.

[0003] In existing rotating cell culture devices, the connection between the culture tube and the rotating base is achieved via a stud and threaded hole. Specifically, a stud is located at the center of the rotating base, and a threaded hole is located at the center of the end face of the culture tube where it intersects with the rotating base. When installing the culture tube onto the rotating base, the culture tube needs to be rotated multiple times to engage the stud and threaded hole, which is cumbersome. Furthermore, because the rotating base is rotatable, it tends to rotate along with the culture tube during installation, making it difficult to engage the stud and threaded hole properly, thus complicating the installation process.

[0004] In addition, in existing devices, when multiple rotating bases need to be set up, each rotating base is controlled by a separate motor, resulting in a large number of motors required in the entire device, which can easily lead to a large device size. Utility Model Content

[0005] The main objective of this invention is to provide a rotating cell culture device to solve the aforementioned technical problems.

[0006] To achieve the above objectives, this utility model proposes a rotating cell culture device, including a drive box, culture tubes, and multiple rotating bases rotatably mounted on the front upright plate of the drive box; a drive mechanism is provided inside the drive box to drive the rotating bases to rotate; a first magnetic ring is embedded on the front end face of the rotating base; a second magnetic ring is embedded on the rear end face of the culture tube; when the rear end face of the culture tube is in contact with the front end face of the rotating base, the first magnetic ring and the second magnetic ring attract each other.

[0007] Preferably, a positioning countersunk hole is provided at the center of the rear end face of the culture tube; a centering post for interlocking with the positioning countersunk hole is provided at the center of the front end face of the rotating base.

[0008] Preferably, a hemispherical head is provided at the end of the centering column away from the rotating base.

[0009] Preferably, a plurality of slots are evenly distributed in a ring at the edge of the rear end face of the culture tube; and a plurality of blocks for engaging with the slots are evenly distributed in a ring at the edge of the front end face of the rotating base.

[0010] Preferably, the rotating base is mounted on the front plate of the drive box via a rotating shaft; the drive mechanism includes a drive motor, a driving gear, and multiple driven gears; the rotating base is fixedly mounted on the front end of the rotating shaft; a driven gear is fastened to the rear end of each rotating shaft; the driving gear is fixedly mounted on the output shaft of the drive motor; all driven gears mesh with the driving gear.

[0011] Preferably, a support beam is erected between the left and right upright plates of the drive box; the drive motor is mounted on the support beam.

[0012] Preferably, a base plate is provided at the bottom of the drive box, and the front end of the base plate extends forward to form a cantilever end.

[0013] Preferably, the drive box includes a removable top cover and a rear upright.

[0014] Preferably, the number of rotating bases is four.

[0015] Preferably, four slots are provided in each culture tube, and four blocks are provided on each rotating base, with the four blocks integrally formed on the front end surface of the rotating base.

[0016] Due to the adoption of the above technical solution, the beneficial effects of this utility model are as follows:

[0017] (1) In this utility model, by embedding a first magnetic ring on the front end face of the rotating base and a second magnetic ring on the rear end face of the culture tube, when the culture tube needs to be installed on the rotating base, it is only necessary to connect the rear end face of the culture tube with the rotating base, and the culture tube can be installed on the rotating base by using the mutual attraction of the first magnetic ring and the second magnetic ring. The operation is simple and quick, overcoming the cumbersome operation problem that exists when using studs and threaded holes for connection in the prior art.

[0018] (2) In this utility model, by setting a positioning countersunk hole at the center of the rear end face of the culture tube and setting a centering column at the center of the front end face of the rotating base for fitting with the positioning countersunk hole, when the culture tube is installed on the rotating base, the structure of the positioning countersunk hole and the centering column working together helps to ensure that the axis of the culture tube coincides with the axis of the rotating base. When the rotating base drives the culture tube to rotate together, the unbalanced force can be reduced.

[0019] (3) In this utility model, by using the slot on the rear end face of the culture tube to cooperate with the block on the front end face of the rotating base, the rotating base can better drive the culture tube to rotate, and avoid the two from slipping against each other.

[0020] (4) In this utility model, the drive mechanism uses a method of meshing one driving gear with multiple driven gears for transmission. Only one drive motor needs to be connected to the driving gear, which helps to simplify the structure of the drive device, making the drive mechanism more compact and reducing the size of the device. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0022] Figure 1 This is a three-dimensional structural diagram of the rotating cell culture device provided by this utility model.

[0023] Figure 2 This is a schematic diagram of the rotating cell culture device provided by this utility model after removing the top cover plate and the rear upright plate;

[0024] Figure 3 This is a schematic diagram of the drive mechanism inside the drive box in this utility model. Figure 1 ;

[0025] Figure 4 This is a schematic diagram of the drive mechanism inside the drive box in this utility model. Figure 2 ;

[0026] Figure 5 This is a schematic diagram of the drive mechanism inside the drive box in this utility model. Figure 3 .

[0027] Explanation of reference numerals: 1. Base plate; 2. Drive box; 2a. Top cover plate; 2b. Rear upright plate; 3. Rotating base; 3a. Centering column; 3b. Locking block; 3c. Hemispherical head; 4. Culture tube; 4a. Positioning countersunk hole; 4b. Locking slot; 5. First magnetic ring; 6. Second magnetic ring; 7. Rotating shaft; 8. Drive motor; 9. Driving gear; 10. Driven gear; 11. Support beam. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0029] It should be noted that all directional indicators (such as up, down, left, right, front, back, etc.) in this utility model embodiment are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0030] Furthermore, the use of terms such as "first" and "second" in this utility model is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. Additionally, the technical solutions of the various embodiments can be combined with each other, but only on the basis of being achievable by those skilled in the art. When the combination of technical solutions is contradictory or impossible to implement, such a combination of technical solutions should be considered non-existent and not within the scope of protection claimed by this utility model.

[0031] As shown in the accompanying drawings, a rotating cell culture device includes a drive box 2, a culture tube 4, and a plurality of rotating bases 3 rotatably mounted on the front upright plate of the drive box 2. A drive mechanism is provided inside the drive box 2 to drive the rotating bases 3 to rotate. A first magnetic ring 5 is embedded on the front end face of the rotating base 3. A second magnetic ring 6 is embedded on the rear end face of the culture tube 4. When the rear end face of the culture tube 4 is in contact with the front end face of the rotating base 3, the first magnetic ring 5 and the second magnetic ring 6 attract each other.

[0032] By adopting the above structure, when it is necessary to install the culture tube 4 on the rotating base 3, it is only necessary to connect the rear end face of the culture tube 4 with the rotating base 3, and use the first magnetic ring 5 and the second magnetic ring 6 to attract each other to install the culture tube 4 on the rotating base 4. The operation is simple and quick.

[0033] In this embodiment, a positioning countersunk hole 4a is provided at the center of the rear end face of the culture tube 4; a centering post 3a for interlocking with the positioning countersunk hole 4a is provided at the center of the front end face of the rotating base 3. When the culture tube 4 is mounted on the rotating base 3, the interlocking structure of the positioning countersunk hole 4a and the centering post 3a helps to ensure that the axis of the culture tube 4 coincides with the axis of the rotating base 3. When the rotating base 3 drives the culture tube 4 to rotate together, the unbalanced force can be reduced. To facilitate the insertion of the centering post 3a into the positioning countersunk hole 4a, the end of the centering post 3a away from the rotating base 3 is set as a hemispherical head 3c, which serves as a guide.

[0034] In this embodiment, multiple slots 4b are evenly distributed in a ring at the edge of the rear end face of the culture tube 4; multiple locking blocks 3b are evenly distributed in a ring at the edge of the front end face of the rotating base 3 for engaging with the slots 4b. This allows the rotating base 3 to better drive the culture tube 4 to rotate, preventing slippage between them. Specifically, four slots 4b are provided on each culture tube 4, and four locking blocks 3b are provided on each rotating base 3, with the four locking blocks 3b integrally formed on the front end face of the rotating base 3.

[0035] In this embodiment, the rotating base 3 is mounted on the front plate of the drive box 2 via a rotating shaft 7. A bearing (not shown in the figure) is provided between the front plate of the drive box 2 and the rotating shaft 7. Using a bearing to mount the rotating shaft 7 is a conventional technical means, and will not be described in detail here.

[0036] The drive mechanism inside the drive housing 2 includes a drive motor 8, a driving gear 9, and four driven gears 10. Specifically, a rotating base 3 is fixedly mounted on the front end of the rotating shaft 7. In this embodiment, there are four rotating bases 3, each corresponding to one rotating shaft 7, with the rear ends of all four rotating shafts 7 extending into the drive housing 2. A driven gear 10 is fastened to the rear end of each rotating shaft 7, for a total of four driven gears 10. The driving gear 9 is fixedly mounted on the output shaft of the drive motor 8; all four driven gears 10 mesh with the driving gear 9. By employing the above-described drive mechanism, the drive motor 8 drives the driving gear 9 to rotate, thereby synchronously driving the four driven gears 10 to rotate, thus causing the four rotating bases 3 to rotate simultaneously.

[0037] Combination Figure 2As shown, a support beam 11 is erected between the left and right upright plates of the drive box 2; the drive motor 8 is mounted on the support beam 11.

[0038] In this embodiment, a base plate 1 is provided at the bottom of the drive box 2, and the front end of the base plate 1 extends forward to form a cantilever end. By using the base plate 1, the drive box 2 can be prevented from tilting.

[0039] To facilitate the maintenance of the drive mechanism inside the drive box 2, the top cover plate 2a and the rear upright plate 2b of the drive box 2 are designed as detachable structures. Specifically, the top cover plate 2a and the rear upright plate 2b are respectively installed on the main body of the drive box 2 with screws. When disassembly is required, the screws can be loosened for disassembly.

[0040] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. All equivalent structural transformations made under the concept of the present utility model and using the contents of the present utility model specification and drawings, or direct / indirect applications in other related technical fields, are included in the patent protection scope of the present utility model.

Claims

1. A rotating cell culture apparatus, comprising a drive box (2), culture tubes (4), and a plurality of rotating bases (3) rotatably mounted on the front upright plate of the drive box (2); a drive mechanism is provided inside the drive box (2) for driving the rotating bases (3) to rotate; characterized in that, A first magnetic ring (5) is embedded on the front end face of the rotating base (3); A second magnetic ring (6) is embedded on the rear end face of the culture tube (4); When the rear end face of the culture tube (4) is in contact with the front end face of the rotating base (3), the first magnetic ring (5) and the second magnetic ring (6) attract each other.

2. A rotating cell culture device as in claim 1, wherein, A positioning countersunk hole (4a) is provided at the center of the rear end face of the culture tube (4); a centering post (3a) is provided at the center of the front end face of the rotating base (3) for fitting into the positioning countersunk hole (4a).

3. A rotating cell culture device as in claim 2, wherein the cell culture device is a bioreactor. A hemispherical head (3c) is provided at the end of the centering column (3a) away from the rotating base (3).

4. A rotating cell culture device as in claim 1, wherein, Multiple slots (4b) are evenly distributed in a ring at the edge of the rear end face of the culture tube (4); multiple locking blocks (3b) for engaging with the slots (4b) are evenly distributed in a ring at the edge of the front end face of the rotating base (3).

5. A rotating cell culture device as in claim 1, wherein the cell culture device is a bioreactor. The rotating base (3) is mounted on the front upright plate of the drive box (2) via a rotating shaft (7); The drive mechanism includes a drive motor (8), a driving gear (9), and multiple driven gears (10); A rotating base (3) is fixedly installed at the front end of the rotating shaft (7); a driven gear (10) is fastened at the rear end of each rotating shaft (7); The drive gear (9) is fixedly mounted on the output shaft of the drive motor (8); All driven gears (10) mesh with the driving gear (9).

6. A rotating cell culture device as in claim 5, wherein the cell culture device is a bioreactor. A support beam (11) is erected between the left and right upright plates of the drive box (2); the drive motor (8) is mounted on the support beam (11).

7. A rotating cell culture device as in claim 1, wherein the cell culture device is a bioreactor. A base plate (1) is provided at the bottom of the drive box (2), and the front end of the base plate (1) extends forward to form a cantilever end.

8. A rotating cell culture device as in claim 1, wherein, The drive box (2) includes a removable top cover (2a) and a rear upright (2b).

9. A rotating cell culture device as in claim 1, wherein, The number of the rotating bases (3) is four.

10. A rotating cell culture device as in claim 4, wherein the cell culture device is a bioreactor. The number of slots (4b) provided in each culture tube (4) is four, and the number of blocks (3b) provided on each rotating base (3) is four. The four blocks (3b) are integrally formed on the front end surface of the rotating base (3).

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