Reaction device and reaction system

Abstract

The utility model provides a reaction device and a reaction system, and belongs to the technical field of biochemical engineering and catalytic reaction. The reaction device comprises a catalyst and a reaction sub-tube. The catalyst is configured to be capable of catalyzing raw materials to generate products, every two adjacent reaction sub-pipes are detachably connected in the axial direction and communicate with each other, each reaction sub-pipe comprises a sub-pipe main body and a filtering part, the catalyst is located in the sub-pipe main body, and the filtering part is located in the sub-pipe main body. Filtering pieces are arranged on the two opposite sides, in the axial direction, of the sub-pipe body correspondingly, and the filtering pieces are configured to be capable of filtering a catalyst so that the catalyst can be limited in the sub-pipe body. According to the reaction device, the loading capacity of the catalyst in the reaction device can be conveniently adjusted, the replacement efficiency of the catalyst is improved, and the maintenance period of the reaction device is shortened.

Description

A reaction apparatus and reaction system Technical Field

[0001] This utility model relates to the field of biochemical and catalytic reaction equipment technology, and in particular to a reaction device and reaction system. Background Technology

[0002] Tubular reactors and batch reactors are commonly used fluid reaction equipment in the chemical and pharmaceutical industries. However, batch reactors, when used for heterogeneous reactions involving immobilized enzymes and solid catalysts, often encounter the following problems: 1. Insufficient stirring leads to inadequate contact between the catalyst and the material, resulting in poor reaction conditions; 2. Vigorous stirring causes immobilized enzymes to detach, preventing multiple batches from being recycled; 3. Some may also exhibit significant product inhibition as the reaction progresses.

[0003] In related technologies, tubular immobilized enzyme reactors generally have the following problems: 1. Inefficient replacement of immobilized enzymes, requiring shutdown and disassembly of the reaction column, resulting in long maintenance time; 2. Uneven fluid distribution, with channeling effect leading to immobilized enzyme utilization of less than 50%; 3. Complex equipment structure, making it impossible to flexibly adjust the immobilized enzyme loading; 4. Excessively long pipelines to increase transfer rate result in significant pressure drop and low production efficiency.

[0004] The Chinese utility model patent application CN212882472U, entitled "Continuous Flow Reaction Module, Reaction Device and Packing Block", improves mass transfer efficiency by improving the column structure, but does not solve the problems of catalyst dynamic renewal and multi-step reaction integration. Summary of the Invention

[0005] This invention provides a reaction apparatus and system, the purpose of which is to facilitate the adjustment of the catalyst loading in the reaction apparatus, improve the catalyst replacement efficiency, shorten the maintenance cycle of the reaction apparatus, and improve the uniformity of raw material distribution.

[0006] To achieve the above objectives, this invention provides a reaction apparatus for catalytic reactions in biochemical processes, the reaction apparatus comprising:

[0007] A catalyst is configured to catalyze the production of products from feedstocks.

[0008] There are multiple reaction sub-tubes, and two adjacent reaction sub-tubes are detachably connected along the axial direction and interconnected with each other. Each reaction sub-tube includes a sub-tube body and a filter element. The catalyst is located inside the sub-tube body. The filter element is provided on both opposite sides of the sub-tube body along the axial direction. The filter element is configured to filter the catalyst to confine the catalyst within the sub-tube body.

[0009] In one embodiment, a filter element is disposed between two adjacent sub-tube bodies.

[0010] In one embodiment, two filter elements are disposed between two adjacent sub-tube bodies.

[0011] In one embodiment, when a filter element is provided between two adjacent sub-tube bodies, the opening at one end of the filter element away from itself along the axial direction of each sub-tube body is a feeding port, which is configured as the inlet for the catalyst to enter the reaction sub-tube.

[0012] In one embodiment, when two filters are provided between two adjacent sub-tube bodies, the axial direction of the reaction device is arranged vertically, and each filter located above the sub-tube body has a feed port, which is configured as the inlet for the catalyst to enter the reaction sub-tube.

[0013] In one embodiment, the reaction apparatus has a feed end and a discharge end, which are located at opposite ends of the reaction apparatus along the axial direction. The feed end is configured as the port where the raw material enters the reaction apparatus, and the discharge end is configured as the port where the raw material and / or the product leaves the reaction apparatus. The axial direction of the reaction apparatus is arranged vertically, and the feed end is located below the discharge end.

[0014] In one embodiment, the reaction sub-tube includes a heating element disposed within the sub-tube body, the heating element being configured to regulate the temperature around the catalyst.

[0015] In one embodiment, the reaction sub-tube includes a sight glass configured to be transparent and disposed on the wall of the sub-tube body to allow the catalyst to be observed.

[0016] In one embodiment, the reaction apparatus further includes a silicone gasket and a clamp. The silicone gasket is clamped between the corresponding pipe walls of two adjacent sub-tube bodies. The clamp surrounds the outer periphery of the sub-tube body and spans across the two adjacent sub-tube bodies along the axial direction of the sub-tube body, so that the two adjacent reaction sub-tubes are detachably and sealingly connected along the axial direction.

[0017] Another aspect of this invention provides a reaction system, comprising:

[0018] The reaction unit includes a reaction apparatus, a mixing tank, and a feed pump according to any of the foregoing embodiments, wherein the mixing tank is configured to contain the raw material and is located upstream of the reaction apparatus, and the feed pump is located between the mixing tank and the reaction apparatus and is configured to pump the raw material located in the mixing tank into the reaction apparatus.

[0019] A collection vessel, located downstream of the reaction unit, is configured to collect the products generated by the reaction unit.

[0020] In one embodiment, there are multiple reaction units connected in series, with the downstream reaction unit connected to the collection tank.

[0021] The above-mentioned solution of this utility model has the following beneficial effects:

[0022] In this embodiment, the catalyst is confined within a sub-tube body, with each sub-tube containing a catalyst. This segmented arrangement of the catalyst within the reaction apparatus effectively reduces the channeling effect caused by the excessive axial size of the reaction apparatus, improving the contact between the raw material and the catalyst, and consequently increasing the catalyst utilization rate by over 40%, thereby enhancing the product production efficiency of the reaction apparatus. The detachable connection between adjacent reaction sub-tubes allows the reaction apparatus to dynamically adjust the number of sub-tubes based on the reaction state during the catalyst-catalyzed production process, thereby dynamically increasing or decreasing the catalyst loading and maintaining it at an appropriate level. Furthermore, when the catalyst deactivates, maintenance can be completed simply by disassembling the corresponding reaction sub-tube, replacing the catalyst within it, and then reinstalling the sub-tube. This eliminates the need to disassemble and reassemble the entire reaction apparatus, shortening maintenance time. The reaction apparatus of this application can reduce the time required for catalyst replacement by 70%.

[0023] Other beneficial effects of this invention will be described in detail in the following detailed description section. Attached Figure Description

[0024] Figure 1 is a schematic diagram of the reaction device in one embodiment of the present invention;

[0025] Figure 2 is a schematic diagram of the structure of the reaction tube in one embodiment of the present invention. In Figure 2(a), a filter element is provided on both sides of the main body of the tube along the axial direction. In Figure 2(b), a filter element is provided on one side of the main body of the tube along the axial direction.

[0026] Figure 3 is a schematic diagram of the assembly of two adjacent reaction tubes that can be detachably and sealed in one embodiment of the present invention.

[0027] Figure 4 is a schematic diagram of the reaction system in one embodiment of the present invention.

[0028] [Explanation of Labels in the Attached Image]

[0029] 100. Reaction system; 1. Reaction device; 11. Reaction tube; 111. Tube body; 112. Filter element; 113. Feed port; 114. Heating element; 115. Sight glass; 12. Feed end; 13. Discharge end; 14. Silicone gasket; 15. Clamp; 10. Reaction unit; 2. Batching tank; 3. Feed pump; 20. Collection tank. Detailed Implementation

[0030] To make the technical problems, solutions, and advantages of this utility model clearer, a detailed description will be provided below with reference to the accompanying drawings and specific embodiments. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model. Furthermore, the technical features involved in the different embodiments of this utility model described below can be combined with each other as long as they do not conflict with each other.

[0031] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0032] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a locking connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0033] This application provides a reaction device 1 for catalytic reactions in biochemical processes. Referring to Figure 1, the reaction device 1 can be configured as a tubular structure. Specifically, the reaction device 1 includes a catalyst and reaction sub-tubes 11. The catalyst is configured to catalyze the generation of products from raw materials. The catalyst is in the form of solid particles and can be an immobilized enzyme, such as an immobilized glucose isomerase or β-glucosidase. The number of reaction sub-tubes 11 can be multiple, for example, two, three, four, or five. Adjacent reaction sub-tubes 11 are detachably connected along the axial direction; for example, the connection between adjacent reaction sub-tubes 11 along the axial direction of the reaction device 1 can be a snap-fit ​​detachable connection. Adjacent reaction sub-tubes 11 are interconnected, and the connection between adjacent reaction sub-tubes 11 is sealed, meaning that raw materials can flow from one reaction sub-tube 11 to another, but will not flow out to the external environment from the connection point between adjacent reaction sub-tubes 11. Each reaction sub-tube 11 includes a sub-tube body 111 and a filter element 112. The subtube body 111 can be made of a material with certain strength and hardness, such as fiberglass or stainless steel. The catalyst (not shown) is located within the subtube body 111. The catalyst can be located within the subtube body 111 by covalent bonding or physical adsorption. Filter elements 112 are provided on opposite sides of the subtube body 111 along the axial direction. The filter elements 112 are configured to filter the catalyst, confining it within the subtube body 111, so that the catalyst is segmented along the axial direction of the reaction apparatus 1. For example, both the raw material and the product catalyzed by the catalyst can pass through the filter element 112, while the catalyst cannot pass through it. For example, the filter element 112 can be a filter screen made of stainless steel. The diameter of the mesh of the filter screen is smaller than the diameter of the catalyst particles, preventing the catalyst from passing through and confining it within the subtube body 111. The diameter of the mesh of the filter screen is larger than the diameter of the raw material and the product, allowing both the raw material and the product to pass through the filter screen. For example, the raw material is dissolved in the liquid to form a raw material fluid. The porosity of the filter screen is configured to be 60% to 80%. The flow rate of the raw material fluid is matched with the porosity of the filter screen to improve the contact efficiency between the raw material fluid and the catalyst. The contact efficiency can reach 90%.

[0034] In this embodiment, the catalyst is confined within the sub-tube body 111, with each sub-tube body 111 containing a catalyst. This segmented arrangement of the catalyst within the reaction apparatus 1 effectively reduces the channeling effect caused by the excessive axial size of the reaction apparatus 1, improving the contact between the raw material and the catalyst, thereby increasing the catalyst utilization rate by over 40%, thus enhancing the product production efficiency of the reaction apparatus 1. Adjacent sub-tubes 11 are detachably connected, allowing the reaction apparatus 1 to dynamically increase or decrease the number of sub-tubes 11 based on the reaction state during the catalyst-catalyzed production process, thereby dynamically increasing or decreasing the catalyst loading and maintaining it at a suitable level. Furthermore, when the catalyst deactivates, maintenance of the reaction apparatus 1 can be completed simply by disassembling the sub-tube 11 corresponding to the deactivated catalyst, replacing the catalyst within the sub-tube 11, and then reinstalling the sub-tube 11, eliminating the need to disassemble and reassemble the entire reaction apparatus 1, thus shortening the maintenance time. The reaction apparatus 1 of this application can reduce the time required to replace the catalyst by 70%.

[0035] In one embodiment, referring to Figure 2, a filter element 112 is provided between two adjacent sub-tube bodies 111, meaning that two adjacent sub-tube bodies 111 share a single filter element 112. For example, referring to Figure 2(b), the sub-tube body 111 in the middle position corresponds to only one filter element 112, and the filter element 112 is located axially below the sub-tube body 111. Referring to Figure 2(a), filter elements 112 are provided on both sides of the sub-tube bodies 111 at both ends of the reaction device 1 along the axial direction, so that when multiple reaction sub-tubes 11 are connected sequentially along the axial direction, only one filter element 112 is provided between two adjacent sub-tube bodies 111, thereby reducing the number of filter elements 112 and lowering the material cost of the reaction device 1.

[0036] In one embodiment, referring to FIG2, two filters 112 are provided between two adjacent sub-tube bodies 111, that is, two filters 112 are provided between two adjacent sub-tube bodies 111. For example, referring to FIG2(a), filters 112 are provided on opposite sides of each sub-tube body 111 along the axial direction, such that when multiple reaction sub-tubes 11 are connected sequentially along the axial direction, two filters 112 are provided between two adjacent sub-tube bodies 111. In this embodiment, each sub-tube body 111 corresponds to two filters 112, so that the reaction device 1 of this application has only one type of reaction sub-tube 11, which is beneficial to improving the modularity of the reaction device 1 and improving the convenience of assembling and disassembling the reaction sub-tubes 11.

[0037] In one embodiment, please refer to Figure 2(b), when a filter element 112 is provided between two adjacent sub-tube bodies 111, the opening of one end of each sub-tube body 111 away from its own filter element 112 along the axial direction is a feeding port 113. The feeding port 113 is configured as the inlet for the catalyst to enter the reaction sub-tube 11, so as to facilitate the feeding of the catalyst into the reaction sub-tube 11.

[0038] In one embodiment, referring to FIG2(a), when two filters 112 are arranged between two adjacent sub-tube bodies 111, and the axial direction of the reaction device 1 is arranged vertically, each filter 112 located above the sub-tube body 111 has a feed port 113. The feed port 113 is configured as the inlet for the catalyst to enter the reaction sub-tube 11, so as to facilitate the addition of the catalyst into the reaction sub-tube 11. For example, the feed port 113 of the filter 112 can be opened and closed. Exemplarily, the direction shown by R1 in FIG1 is the vertical direction.

[0039] It is understandable that the feed port 113 can also be located on the filter element 112 below the reaction tube 11.

[0040] In one embodiment, referring to Figure 1, the reaction device 1 has a feed end 12 and a discharge end 13, which are located at opposite ends of the reaction device 1 along its axial direction. The feed end 12 is configured as the port where raw materials enter the reaction device 1, and the discharge end 13 is configured as the port where raw materials and / or products leave the reaction device 1. The axial direction of the reaction device 1 is vertical, with the feed end 12 located below the discharge end 13. That is, the raw material fluid enters the reaction device 1 from the lower feed end 12, flows upward through multiple reaction sub-tubes 11, and generates corresponding products under the catalysis of the catalyst. Unreacted raw materials and generated products flow out of the reaction device 1 from the upper discharge end 13. During this process, the catalyst, driven by the raw material fluid, also tends to flow upward, reducing the possibility of catalyst deposition on the filter element 112 below the corresponding sub-tube body 111, thus clogging the filter element 112 and reducing the possibility of a decrease in the dynamic pressure of the raw material fluid.

[0041] In one embodiment, referring to Figures 1 and 2, the reaction sub-tube 11 includes a heating element 114 disposed within the sub-tube body 111. The heating element 114 is configured to regulate the temperature around the catalyst, ensuring the catalyst operates within a suitable temperature range, thereby improving catalyst activity. For example, the heating element 114 regulates the temperature around the catalyst within a range of 30°C to 80°C. For example, the heating element 114 can be connected to an external power source to generate heat.

[0042] In one embodiment, referring to Figures 1 and 2, the reaction sub-tube 11 includes a sight glass 115, which is configured to be transparent and disposed on the tube wall of the sub-tube body 111 to allow the catalyst to be observed. The activity of the catalyst located within the reaction sub-tube 11 can be observed through the sight glass 115, so that deactivated catalyst can be replaced or replenished more promptly, which is beneficial to ensuring the efficiency of continuous reaction of raw materials to produce products.

[0043] In one embodiment, referring to Figure 3, the reaction device 1 further includes a silicone gasket 14 and a clamp 15. The silicone gasket 14 is clamped between the corresponding pipe walls of two adjacent sub-tube bodies 111. The clamp 15 surrounds the outer periphery of the sub-tube body 111 and spans across the two adjacent sub-tube bodies 111 along the axial direction of the sub-tube body 111, so that the two adjacent reaction sub-tubes 11 are detachably and sealed in the axial direction. Thus, while the two adjacent reaction sub-tubes 11 can be disassembled and assembled relatively quickly, the raw materials will not flow out from the connection position of the two adjacent reaction sub-tubes 11 into the external environment.

[0044] Referring to Figure 4, a second aspect of this application provides a reaction system 100, including a reaction unit 10 and a collection tank 20. The reaction unit 10 includes a reaction apparatus 1, a mixing tank 2, and a feed pump 3 as described in the previous embodiments. The mixing tank 2 is configured to contain raw materials and is located upstream of the reaction apparatus 1. The feed pump 3 is located between the mixing tank 2 and the reaction apparatus 1, and is configured to pump the raw materials located in the mixing tank 2 into the reaction apparatus 1. The flow rate of the feed pump 3 is adjustable in the range of 0.1–0.5 ml / min, and the flow rate control accuracy is ±0.5 ml / min, so that the raw materials react within the reaction apparatus 1 to generate products. This improves the utilization rate of the catalyst, thereby increasing the product production efficiency of the reaction system 100 and shortening the maintenance time of the reaction system 100. The collection tank 20 is located downstream of the reaction unit 10 and is configured to collect the products generated by the reaction unit 10.

[0045] For example, referring to Figure 4, driven by the feed pump 3, the raw material fluid in the mixing tank 2 can be pumped from the feed end 12 located below to the reaction device 1. The raw material fluid generates products under the catalysis of the catalyst in the reaction device 1. The products flow through the discharge end 13 of the reaction device 1 to the collection tank 20 for collection and storage.

[0046] In one embodiment, please refer to FIG4, there are multiple reaction units 10, which are connected in series, and the downstream reaction unit 10 is connected to the collection tank 20.

[0047] For example, please refer to Figure 4. The product generated from the raw materials in the upstream reaction unit 10 can be the raw material for the next reaction unit 10, and then a new product is generated in the next reaction unit 10 to obtain the final desired product. In this process, the materials continuously flow within the reaction system 100. The product generated in the upstream reaction unit 10 is carried to the downstream reaction unit 10. The catalyst in the downstream reaction unit 10 is different from the catalyst in the upstream reaction unit 10, so that the product generated upstream can be used as raw material to continue catalyzing the generation of new products, and so on, until the desired product is finally generated. By integrating the multi-step reaction of initial raw materials being catalyzed by multiple catalysts to generate the final product into the same reaction system 100, the stage products generated in each step can flow to the next reaction unit 10 in a relatively timely manner, reducing the possibility of product accumulation in the reaction device 1 and inhibiting product generation efficiency, that is, reducing the possibility of product inhibition effect, which is beneficial to optimizing the reaction efficiency of the reaction system 100.

[0048] For example, the raw materials do not completely react to form products in the upstream reaction unit 10, so that the products are mixed with the raw materials and flow to the next reaction unit 10 to continue to catalyze the formation of products, and so on, so that the raw materials can be converted into products more completely and collected in the collection tank 20.

[0049] For example, referring to Figures 1 to 4, different types of catalysts can be sequentially arranged along the axial direction of the same reaction apparatus 1. This allows the product generated in the first reaction tube 11 to be used as raw material in the next reaction tube 11, catalyzed by the corresponding catalyst to generate a new product, and so on, until the desired product is finally generated. By integrating the multi-step reaction of initial raw materials being catalyzed by multiple catalysts to generate the final product into the same reaction apparatus 1, the stage products generated in each step can flow to the next reaction tube 11 in a relatively timely manner, reducing the possibility of product accumulation in the reaction tube 11 and causing product inhibition effect, which is beneficial to improving the reaction efficiency of the reaction apparatus 1.

[0050] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and these improvements and modifications should also be considered within the protection scope of this utility model.

Claims

1. A reaction apparatus, characterized in that, A catalytic reaction apparatus for biochemical processes includes: a catalyst configured to catalyze the formation of a product from a feedstock; and multiple reaction subtubes, with adjacent subtubes detachably connected axially and interconnected. Each subtube includes a subtube body and a filter element. The catalyst is located within the subtube body, and the filter element is provided on opposite sides of the subtube body along the axial direction. The filter element is configured to filter the catalyst, thereby confining the catalyst within the subtube body.

2. The reaction apparatus according to claim 1, characterized in that, One filter element is provided between two adjacent sub-tube bodies; or, two filter elements are provided between two adjacent sub-tube bodies.

3. The reaction apparatus according to claim 1, characterized in that, When a filter element is provided between two adjacent sub-tube bodies, the opening at the end of each sub-tube body opposite to its own filter element along the axial direction is a feeding port, which is configured as the inlet for the catalyst to enter the reaction sub-tube; or, when two filter elements are provided between two adjacent sub-tube bodies, the axial direction of the reaction device is arranged vertically, and each filter element located above the sub-tube body has a feeding port, which is configured as the inlet for the catalyst to enter the reaction sub-tube.

4. The reaction apparatus according to claim 1, characterized in that, The reaction device has a feed end and a discharge end, which are located at opposite ends of the reaction device along the axial direction. The feed end is configured as the port where the raw material enters the reaction device, and the discharge end is configured as the port where the raw material and / or the product leaves the reaction device. The axial direction of the reaction device is arranged vertically, and the feed end is located below the discharge end.

5. The reaction apparatus according to any one of claims 1 to 4, characterized in that, The reaction tube includes a heating element disposed within the tube body, and the heating element is configured to regulate the temperature around the catalyst.

6. The reaction apparatus according to any one of claims 1 to 4, characterized in that, The reaction sub-tube includes a sight glass that is configured to be transparent and is disposed on the tube wall of the sub-tube body to allow the catalyst to be observed.

7. The reaction apparatus according to any one of claims 1 to 4, characterized in that, The reaction device also includes a silicone gasket and a clamp. The silicone gasket is clamped between the corresponding pipe walls of two adjacent sub-tube bodies. The clamp is wrapped around the outer periphery of the sub-tube body and spans across the two adjacent sub-tube bodies along the axial direction of the sub-tube body, so that the two adjacent reaction sub-tubes are detachably and sealingly connected along the axial direction.

8. A reaction system, characterized in that, include: A reaction unit includes a reaction apparatus according to any one of claims 1 to 7, a mixing tank, and a feed pump, wherein the mixing tank is configured to contain the raw material and is located upstream of the reaction apparatus, and the feed pump is located between the mixing tank and the reaction apparatus and is configured to pump the raw material located in the mixing tank into the reaction apparatus; and a collection tank is located downstream of the reaction unit and is configured to collect the product generated by the reaction unit.

9. The reaction system according to claim 8, characterized in that, The reaction units are multiple, and the multiple reaction units are connected in series. The reaction unit located at the downstream end is connected to the collection tank.

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