Editable multiple emulsion droplet preparation device

Abstract

The utility model discloses an editable multiple emulsion droplet preparation device which is characterized in that a feeding shearing part comprises a feeding outer pipe and a feeding inner pipe, the feeding inner pipe is arranged in the feeding outer pipe, a first mixing area is formed between the outlet end of the feeding inner pipe and the outlet end of the feeding outer pipe, and the sectional area of the feeding inner pipe is smaller than that of the feeding outer pipe; the discharging shearing part comprises a connecting pipe, a branch pipe, a discharging pipe and a side pipe, the connecting pipe and the discharging pipe are coaxially arranged, the outlet end of the connecting pipe is arranged in the inlet end of the discharging pipe, the outlet end of the connecting pipe is of a necking structure, and a second mixing area is formed between the outlet end of the connecting pipe and the outlet end of the discharging pipe; the outlet ends of the branch pipes are connected with the inlet end of the connecting pipe, the inlet ends of the branch pipes are connected with the outlet end of the feeding outer pipe, and the side pipe is arranged on the side face of the discharging pipe and located outside the outlet end of the connecting pipe. The device has the advantage of rapid construction, and can realize accurate adjustment of the internal structure of multiple emulsion drops so as to produce multiple emulsion drop products with complex structures.

Description

Technical Field

[0001] This invention belongs to the field of complex emulsion droplet preparation technology, specifically relating to an editable complex emulsion droplet preparation device. Background Technology

[0002] Complex emulsion droplets are formed by multiple emulsions to create complex droplet structures with multi-layer encapsulation characteristics. For example, they are formed by secondary emulsification of ordinary emulsions, with a typical structure of "two films and three phases". For instance, the structure of W / O / W type complex emulsion droplets is that the inner aqueous phase is encapsulated by an oil film to form a primary droplet, which is then dispersed in the outer aqueous phase. Similarly, complex emulsion droplets also include O / W / O type.

[0003] Currently, the fabrication of multilayer droplets is generally achieved using microfluidic chips. However, the fabrication process of microfluidic chips is cumbersome, and their design can only accommodate the fabrication of one or a few types of droplets, making real-time replacement and combination impossible. Therefore, a single microfluidic chip cannot meet the diverse real-time requirements. Based on this, it is necessary to propose a novel device for preparing complex emulsion droplets. Utility Model Content

[0004] To address the aforementioned technical problems, the purpose of this invention is to provide an editable multiemulsion droplet preparation device, which has the advantage of rapid setup and can achieve precise adjustment of the internal structure of multiemulsion droplets to produce multiemulsion droplet products with complex structures.

[0005] To achieve the above-mentioned objectives, the technical solution adopted by this utility model is as follows:

[0006] An editable multiple emulsion droplet preparation device, comprising:

[0007] The feeding shearing unit includes an outer feeding tube and an inner feeding tube. The inner feeding tube is disposed inside the outer feeding tube. A first mixing zone is formed between the outlet end of the inner feeding tube and the outlet end of the outer feeding tube. The cross-sectional area of ​​the inner feeding tube is smaller than that of the outer feeding tube.

[0008] The discharge shearing component includes a connecting pipe, branch pipes, a discharge pipe, and side pipes. The connecting pipe and the discharge pipe are coaxially arranged, and the outlet end of the connecting pipe is located inside the inlet end of the discharge pipe. The outlet end of the connecting pipe has a constricted structure, and a second mixing zone is formed between the outlet end of the connecting pipe and the outlet end of the discharge pipe. The outlet ends of multiple branch pipes are connected to the inlet end of the connecting pipe, and the inlet ends of the branch pipes are connected to the outlet end of the feed outer pipe. The side pipe is located on the side of the discharge pipe, outside the outlet end of the connecting pipe.

[0009] Preferably, the editable multi-emulsion droplet preparation device further includes an adapter, and multiple feed shearing components are connected to or connected to the discharge shearing component via the adapter.

[0010] More preferably, the adapter includes a main adapter and branch adapters, with the outlet ends of multiple branch adapters connected to the inlet end of the main adapter, and the number of adapters is ≥1.

[0011] More preferably, when the number of adapters is less than or equal to the number of branch pipes, the outlet end of the main adapter pipe of each adapter is connected to the inlet end of a branch pipe, the adapter branch pipe of the adapter is connected to the outlet end of the feed pipe, and the remaining branch pipes not connected to the adapter are connected to the feed pipe.

[0012] More preferably, when the number of adapters is greater than the number of branch pipes, multiple adapters are connected in series from bottom to top to form a multi-layer structure. The bottommost adapter is connected to a branch pipe. In two adjacent layers of adapters, the main adapter of the upper adapter is connected to the branch adapter of the lower adapter. The branch adapters in two adjacent layers that are not connected in series are all connected to the feed pipe.

[0013] Preferably, the number of transfer pipes is ≥2 and the number of branch pipes is ≥2.

[0014] Preferably, the inner diameter of the feed tube is 1 to 4 mm.

[0015] Preferably, the inner diameter of the feed tube is 0.2 to 2 mm.

[0016] Preferably, the inner diameter of the adapter pipe of the adapter is 1 to 4 mm.

[0017] Preferably, the inner diameter of the adapter main tube is 1 to 4 mm.

[0018] Beneficial effects:

[0019] This invention allows for the adjustment of the number of adapters and feeding shearing parts according to the design requirements of the composite emulsion droplets. It has the advantage of rapid assembly and can achieve precise adjustment of the internal structure of the composite emulsion droplets to produce composite emulsion droplet products with complex structures. Attached Figure Description

[0020] Figure 1 The diagram shown is a schematic diagram of Embodiment 1 of this utility model.

[0021] Figure 2 The diagram shown is a schematic diagram of embodiment 2 of this utility model.

[0022] Figure 3 The diagram shown is a schematic diagram of embodiment 3 of this utility model.

[0023] Attached reference numerals: 1-feed shearing component, 2-discharge shearing component, 3-transfer component, 11-outer feed pipe, 12-inner feed pipe, 21-connecting pipe, 22-discharge pipe, 23-branch pipe, 24-side pipe, 31-transfer main pipe, 32-transfer branch pipe. Detailed Implementation

[0024] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the specific implementation methods of this utility model will be described below with reference to the accompanying drawings. Obviously, the drawings described below are merely some embodiments of this utility model. For those skilled in the art, other drawings and other implementation methods can be obtained based on these drawings without any creative effort.

[0025] Example 1

[0026] like Figure 1-3 As shown, this utility model proposes an editable multi-emulsion droplet preparation device, including a feeding shearing member 1 and a discharging shearing member 2, with multiple feeding shearing members 1 connected to the discharging shearing member 2.

[0027] Specifically, the feeding shearing unit 1 includes an outer feeding tube 11 and an inner feeding tube 12. The inner feeding tube 12 is disposed inside the outer feeding tube 11. A first mixing zone is formed between the outlet end of the inner feeding tube 12 and the outlet end of the outer feeding tube 11. The cross-sectional area of ​​the inner feeding tube 12 is smaller than that of the outer feeding tube 11. Taking the example that both the inner feeding tube 12 and the outer feeding tube 11 are circular tubes, the inner diameter of the inner feeding tube 12 is smaller than that of the outer feeding tube 11. A first liquid phase flow zone is formed between the outer wall of the inner feeding tube 12 and the inner wall of the outer feeding tube 11.

[0028] Taking the preparation of W / O / W type double emulsion droplets, i.e., water-in-oil-in-water type double emulsion droplets, as an example, water-in-oil droplets are first formed in the feed shearing unit 1. The water phase is introduced into the feed inner tube 12, and the oil phase is introduced into the first liquid phase flow zone between the feed outer tube 11 and the feed inner tube 12. The water phase and the oil phase flow in the same direction. In the first mixing zone, the material at the outlet end of the feed inner tube 12 is focused and stretched, and under the action of shear force and interfacial tension, it undergoes shearing fracture. Thus, the water phase is sheared into droplets by the oil phase, forming water-in-oil droplets. Different feed shearing units 1 can form different water-in-oil droplets, and finally W / O / W type double emulsion droplets are formed in the discharge shearing unit 2.

[0029] Preferably, the inner diameter of the feed outer tube 11 is 1-4 mm, more preferably, the inner diameter of the feed outer tube 11 is 2-4 mm, and more preferably, the inner diameter of the feed outer tube 11 is 2 mm.

[0030] Preferably, the inner diameter of the feed inner tube 12 is 0.2-2 mm, more preferably, the inner diameter of the feed inner tube 12 is 0.5-1 mm, and more preferably, the inner diameter of the feed inner tube 12 is 1 mm.

[0031] It is easy to understand that the outer feed tube 11 and the inner feed tube 12 are preferably coaxially arranged. The outer feed tube 11 and the inner feed tube 12 can be connected and positioned by a connector. This utility model does not impose any restrictions.

[0032] like Figure 1-3 As shown, the discharge shearing component 2 includes a connecting pipe 21, branch pipes 23, a discharge pipe 22, and a side pipe 24. The connecting pipe 21 is coaxially arranged with the discharge pipe 22, and the outlet end of the connecting pipe 21 is located inside the inlet end of the discharge pipe 22. The outlet end of the connecting pipe 21 has a constricted structure. A second mixing zone is formed between the outlet end of the connecting pipe 21 and the outlet end of the discharge pipe 22. The outlet ends of multiple branch pipes 23 are connected to the inlet end of the connecting pipe 21, and the inlet end of the branch pipes 23 is connected to the outlet end of the feed outer pipe 11. A second liquid phase flow zone is formed between the outer wall of the outlet end of the connecting pipe 21 and the inner wall of the discharge pipe 22. The side pipe 24 is arranged on the side of the discharge pipe 22, and one end of the side pipe 24 is connected to the discharge pipe 22 and communicates with the second liquid phase flow zone.

[0033] Taking the preparation of W / O / W type double emulsion droplets as an example, combined with Figure 1 In the feed shearing unit 1, the water-in-oil droplets exist in the oil phase and are fed into the discharge pipe 22 through the branch pipe 23 and the connecting pipe 21. The water phase is introduced through the side pipe 24 of the discharge shearing unit 2. The water phase flows forward along the second liquid phase flow zone, in the same direction as the material flow in the connecting pipe 21. In the second mixing zone, the material at the outlet end of the connecting pipe 21 is focused and stretched, and under the action of shear force and interfacial tension, it undergoes shear fracture to form water-in-oil-in-water droplets. The droplets can contain a variety of different water-in-oil droplets, thereby obtaining W / O / W type double emulsion droplets.

[0034] While keeping the material flow rate constant within the multiple feed shears, increasing the liquid flow rate in the side tube 24 of the discharge shear unit 2 will enhance the shearing frequency, thereby obtaining small-diameter polyemulsion droplets. Conversely, keeping the liquid flow rate constant within the side tube 24 of the discharge shear unit 2, increasing the material flow rate within the multiple feed shears will result in large-diameter polyemulsion droplets.

[0035] It is easy to understand that in the discharge shearing unit 2, the number of branch pipes 23 is ≥2, and each branch pipe 23 can be connected to one feed shearing unit 1. If the number of branch pipes 23 increases and they are connected to more feed shearing units 1, more complex complex emulsion droplets can be prepared. For example, if a discharge shearing unit 2 contains four branch pipes 23, and the four branch pipes 23 are connected to four feed shearing units 1 respectively, then it is possible to produce complex emulsion droplets containing up to four types of water-in-oil droplets.

[0036] Example 2

[0037] like Figure 2-3 As shown, the editable complex emulsion droplet preparation device also includes an adapter 3, and multiple feed shearing parts 1 are connected to or connected to the discharge shearing parts 2 through the adapter 3.

[0038] The adapter 3 includes a main adapter 31 and adapter branches 32. The outlet ends of multiple adapter branches 32 are connected to the inlet end of the main adapter 31. The number of adapters 3 is ≥1.

[0039] When the number of adapters 3 is less than or equal to the number of branch pipes 23, the outlet end of the adapter main pipe 31 of each adapter 3 is connected to the inlet end of a branch pipe 23, the adapter branch pipe 32 of the adapter 3 is connected to the outlet end of the feed pipe 11, and the remaining branch pipes 23 not connected to the adapter 3 are connected to the feed pipe 11.

[0040] When the number of adapters 3 is greater than the number of branch pipes 23, multiple adapters 3 are connected in series from bottom to top to form a multi-layer structure. The bottommost adapter 3 is connected to a branch pipe 23. In two adjacent layers of adapters 3, the main adapter 31 of the upper adapter 3 is connected to the branch adapter 32 of the lower adapter 3. The branch adapters 32 in two adjacent layers of adapters 3 that are not in series are all connected to the feed pipe 11.

[0041] In this invention, for each adapter 3, the number of adapter branches 32 is ≥2, and one or more adapters 3 are connected in series to form a tree-like structure. The function of the adapter 3 is to merge multiple streams of material into a single material input / output shearing component 2. The number of adapters 3 is adjustable, and the connection of multiple adapters 3 resembles a tree-like structure, thereby enabling the production of complex multi-emulsion droplets.

[0042] Preferably, the inner diameter of the adapter branch pipe 32 of the adapter 3 is 1 to 4 mm. More preferably, the inner diameter of the adapter branch pipe 32 is 2 to 4 mm. Even more preferably, the inner diameter of the adapter branch pipe 32 is 2 mm.

[0043] Preferably, the inner diameter of the adapter main pipe 31 of the adapter 3 is 1 to 4 mm; more preferably, the inner diameter of the adapter main pipe 31 is 2 to 4 mm; and even more preferably, the inner diameter of the adapter main pipe 31 is 2 mm.

[0044] This invention allows for the adjustment of the number of adapter 3 and feed shear 1 according to the design requirements of the composite emulsion droplets. It has the advantage of rapid assembly and can achieve precise adjustment of the internal structure of the composite emulsion droplets to produce composite emulsion droplet products with complex structures.

[0045] The technical solution of this utility model will be described in detail below with specific embodiments.

[0046] Preparation of Example 1

[0047] like Figure 1 As shown in this embodiment, the editable complex emulsion droplet preparation device includes a feeding shearing member 1 and a discharging shearing member 2. The discharging shearing member 2 has two branch pipes 23, and the two feeding shearing members 1 are respectively connected to the discharging shearing member 2.

[0048] When preparing water-in-oil-in-water double emulsion droplets, the oil phase is input into the outer feed tube 11, and different water phases are input into the inner shear tubes of the two feed shear members 1. The two feed shear members 1 output two different water-in-oil droplets, and then double emulsion droplets containing the two water-in-oil droplets are formed in the discharge shear member 2.

[0049] Example 2

[0050] like Figure 2 As shown in this embodiment, the editable complex emulsion droplet preparation device includes a feeding shearing component 1, a transfer component 3, and a discharging shearing component 2. The discharging shearing component 2 has two branch pipes 23, the transfer component 3 has two transfer branch pipes 32, and the two transfer components 3 are respectively connected to the two branch pipes 23. The four feeding shearing components 1 are respectively connected to the four transfer branch pipes 32.

[0051] When preparing water-in-oil-in-water double emulsion droplets, the oil phase is input into the outer feed pipe 11, and different water phases are input into the inner shear pipes of the four feed shearing members 1. The four feed shearing members 1 output four different water-in-oil droplets, which are merged through the adapter 3 and the connecting pipe 21 to form a double emulsion droplet containing the four water-in-oil droplets in the discharge pipe 22.

[0052] Example 3

[0053] like Figure 3 As shown in this embodiment, the editable double emulsion droplet preparation device includes a feeding shearing component 1, a transfer component 3, and a discharging shearing component 2. The discharging shearing component 2 has two branch pipes 23, and the transfer component 3 has three. The transfer component 3 is divided into two layers. The lower layer contains two transfer components 3, which are connected to two branch pipes 23 respectively. The upper layer contains one transfer component 3, which is connected to the transfer branch pipe 32 of one of the lower transfer components 3. The transfer branch pipes 32 in the three transfer components 3 are connected to one feeding shearing component 1 respectively, that is, the number of feeding shearing components 1 is five.

[0054] When preparing water-in-oil-in-water double emulsion droplets, the oil phase is input into the outer feed pipe 11, and different water phases are input into the inner shearing pipes of the five feed shearing members 1. The five feed shearing members 1 output five different water-in-oil droplets, which are merged through the adapter 3 and the connecting pipe 21 to form a double emulsion droplet containing the five water-in-oil droplets in the discharge pipe 22.

[0055] The embodiments provided by this utility model have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this utility model. The descriptions of the embodiments above are only for the purpose of helping to understand the core ideas of this utility model. It should be noted that those skilled in the art can make several improvements and modifications to this utility model without departing from the principles of this utility model, and these improvements and modifications also fall within the protection scope of the claims of this utility model.

Claims

1. A programmable multi-emulsion droplet preparation device, characterized in that, include: The feeding shearing component (1) includes an outer feeding tube (11) and an inner feeding tube (12). The inner feeding tube (12) is disposed inside the outer feeding tube (11). A first mixing zone is formed between the outlet end of the inner feeding tube (12) and the outlet end of the outer feeding tube (11). The cross-sectional area of ​​the inner feeding tube (12) is smaller than that of the outer feeding tube (11). The discharge shearing component (2) includes a connecting pipe (21), a branch pipe (23), a discharge pipe (22), and a side pipe (24). The connecting pipe (21) is coaxially arranged with the discharge pipe (22), and the outlet end of the connecting pipe (21) is located inside the inlet end of the discharge pipe (22). The outlet end of the connecting pipe (21) has a constricted structure. A second mixing zone is formed between the outlet end of the connecting pipe (21) and the outlet end of the discharge pipe (22). The outlet ends of multiple branch pipes (23) are connected to the inlet end of the connecting pipe (21), and the inlet end of the branch pipes (23) is connected to the outlet end of the feed pipe (11). The side pipe (24) is located on the side of the discharge pipe (22) and outside the outlet end of the connecting pipe (21).

2. The programmable multi-emulsion droplet preparation device according to claim 1, characterized in that, It also includes an adapter (3), and multiple feed shearing parts (1) are connected to or connected to the discharge shearing parts (2) via the adapter (3).

3. The editable multi-emulsion droplet preparation device according to claim 2, characterized in that, The adapter (3) includes a main adapter (31) and a branch adapter (32). The outlet ends of multiple branch adapters (32) are connected to the inlet end of the main adapter (31). The number of adapters (3) is ≥1.

4. The editable multi-emulsion droplet preparation device according to claim 3, characterized in that, When the number of adapters (3) is less than or equal to the number of branch pipes (23), the outlet end of the adapter main pipe (31) of each adapter (3) is connected to the inlet end of a branch pipe (23), the adapter branch pipe (32) of the adapter (3) is connected to the outlet end of the feed pipe (11), and the remaining branch pipes (23) not connected to the adapter (3) are connected to the feed pipe (11).

5. The editable multi-emulsion droplet preparation device according to claim 3, characterized in that, When the number of adapters (3) is greater than the number of branch pipes (23), multiple adapters (3) are connected in series from bottom to top to form a multi-layer structure. The bottom adapter (3) is connected to a branch pipe (23) respectively. In two adjacent layers of adapters (3), the main adapter (31) of the adapter (3) in the upper layer is connected to the adapter branch pipe (32) in the lower layer. The adapter branch pipes (32) in two adjacent layers of adapters (3) that are not in series are all connected to the feed pipe (11).

6. The editable multi-emulsion droplet preparation apparatus according to any one of claims 3-5, characterized in that, The number of transfer pipes (32) is ≥2, and the number of branch pipes (23) is ≥2.

7. The editable multi-emulsion droplet preparation apparatus according to any one of claims 1-5, characterized in that, The inner diameter of the feed tube (11) is 1-4 mm.

8. The programmable multi-emulsion droplet preparation apparatus according to any one of claims 1-5, characterized in that, The inner diameter of the feed tube (12) is 0.2 to 2 mm.

9. The editable multi-emulsion droplet preparation apparatus according to any one of claims 3-5, characterized in that, The inner diameter of the adapter pipe (32) of the adapter (3) is 1 to 4 mm.

10. The editable multi-emulsion droplet preparation apparatus according to any one of claims 3-5, characterized in that, The inner diameter of the adapter main tube (31) of the adapter (3) is 1-4 mm.

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