Sample loading device

Abstract

The utility model provides a sample loading device which is used for assisting a loading gun head in loading a sample to a chip. The chip is used for gene sequencing. The sample loading device comprises a base and a gland. The base is provided with a positioning bin. The positioning bin is configured to accommodate at least part of the chip. The gland is movably connected to the base. The gland is configured to prevent the chip from separating from the positioning bin. The gland is provided with a positioning opening. The positioning opening communicates with the positioning bin. And the positioning opening is configured to allow the loading gun head to pass through. According to the sample loading device provided by the invention, the assembly position consistency and the assembly efficiency of the chip and the loading gun head are improved.

Description

Technical Field

[0001] This application relates to the field of gene sequencing technology, and more specifically, to a sample loading device. Background Technology

[0002] Gene sequencing samples typically need to be loaded into a chip for detection. Currently, the main methods for loading chip samples are: 1. Manual loading, which does not require any device and is done directly using a loading pipette tip. However, this method requires a high level of operator skill, and the consistency between the loading pipette tip and the chip position cannot be guaranteed; 2. Instrument loading, which provides better consistency between the loading pipette tip and the chip position, but requires specialized instruments and is less efficient. Utility Model Content

[0003] In view of this, this application provides a sample loading device to improve the consistency of chip and loading gun head assembly positions and assembly efficiency.

[0004] One embodiment of this application provides a sample loading device for assisting a loading tip in loading samples onto a microarray. The microarray is used for gene sequencing. The sample loading device includes a base and a cap. The base has a positioning chamber. The positioning chamber is configured to accommodate at least a portion of the microarray. The cap is movably connected to the base. The cap is configured to prevent the microarray from detaching from the positioning chamber. The cap has a positioning opening. The positioning opening communicates with the positioning chamber and is configured to allow the loading tip to pass through.

[0005] After the chip is placed in the positioning chamber of the base, its relative position is fixed by the limiting action of the pressure cap. The loading nozzle can pass through the positioning port to reach the chip in the positioning chamber to load the sample onto the chip. The positioning port can constrain the position of the loading nozzle. Therefore, the sample loading device, through the cooperation of the positioning chamber and the positioning port, positions the relative position of the chip and the loading nozzle, and fixes the chip and the loading nozzle relatively, thereby improving the consistency of the chip and loading nozzle assembly position. Furthermore, the movable pressure cap and base can move closer or further apart to facilitate chip assembly or disassembly; and the loading nozzle can be connected or disconnected from the chip by inserting or removing the positioning port, which is convenient and helps to improve the efficiency of chip and loading nozzle assembly.

[0006] In some embodiments of this application, the gland is provided with a positioning guide. The positioning guide is located at the positioning port. The positioning guide has a guide lumen. The guide lumen communicates with the positioning port and the positioning chamber. And the guide lumen is configured to accommodate at least a portion of the loading nozzle.

[0007] After the loading nozzle passes through the guide tube, it loads the sample onto the chip. The positioning guide tube provides support for the loading nozzle, improving its stability and helping to improve the consistency of the chip and loading nozzle assembly positions.

[0008] In some embodiments of this application, the diameter of the guide tube gradually decreases from the end connected to the positioning port to the end connected to the positioning chamber.

[0009] After the loading gun head extends into the guide tube from the self-positioning port, the guide tube gradually narrows. This not only facilitates the constraint of the insertion depth of the loading gun head and supports and fixes the loading gun head, but also helps to avoid obstructing the insertion or removal of the loading gun head into the positioning guide tube, thereby improving the assembly efficiency of the chip and the loading gun head.

[0010] In some embodiments of this application, the gland is provided with reinforcing ribs. At least a portion of the reinforcing ribs are connected to the positioning guide tube.

[0011] By adding reinforcing ribs, the overall structural strength of the gland is improved, and the shaking of the positioning guide tube is prevented, thereby improving the stability of the loading gun head position and improving the consistency of the chip and loading gun head assembly positions.

[0012] In some embodiments of this application, the pressure cap is configured to stop the chip along a first direction. The base is provided with a positioning portion. The positioning portion is disposed within a positioning compartment. At least one positioning portion is configured to abut the chip along a second direction. At least one positioning portion is configured to abut the chip along a third direction. The first direction, the second direction, and the third direction intersect each other.

[0013] By setting up a positioning part, it is easy to determine the position of the chip in the positioning chamber of the base, and the chip can be pre-fixed; and the positioning part can cooperate with the pressure cover to constrain the position of the chip in the positioning chamber in different directions, thereby improving the consistency of the chip and loading gun head assembly position.

[0014] In some embodiments of this application, the sample loading device is provided with a locking structure. The locking structure connects the base and the pressure cap. The locking structure has a locked state and an unlocked state. When the locking structure is in the locked state, the base and the pressure cap are relatively fixed. When the locking structure is in the unlocked state, the base and the pressure cap can move relative to each other.

[0015] When the locking structure is engaged, the base and the pressure cap are fixed, which not only secures the chip and prevents it from detaching from the sample loading device, but also prevents the pressure cap from moving relative to the base and causing the loading nozzle to move, thus improving the consistency of the chip and loading nozzle assembly positions. When the locking structure is unlocked, the base moves relative to the pressure cap, facilitating chip installation and removal.

[0016] In some embodiments of this application, the base is provided with an observation port. The observation port is connected to the positioning compartment to allow the chip to be exposed through the observation port.

[0017] Users can observe the chip through the observation port, making it easy to observe the loading status of the sample in the chip, thereby effectively and intuitively judging the loading effect of the sample.

[0018] In some embodiments of this application, the gland and the base are rotatably connected.

[0019] By rotating the cap, the relative position of the cap and the base can be easily adjusted to load, unload, or fix the chip; and during the loading, unloading, or fixing of the chip, the cap and the base remain connected at all times, eliminating the need to deliberately search for the cap, which helps to improve the assembly efficiency of the chip and the loading nozzle.

[0020] In some embodiments of this application, the base and / or the gland are provided with clearance grooves. The clearance grooves are located at the junction of the base and the gland.

[0021] By setting a clearance groove, a larger force-bearing position is provided for the user at the junction of the base and the cover when the cover is rotated open, which helps to improve the assembly efficiency of the chip and the loading gun head.

[0022] In some embodiments of this application, the base and / or cover are transparent structures.

[0023] The aforementioned structure allows direct observation of the chip and loading nozzle installation, improving the first-time success rate of sample loading. It also facilitates observation of the sample loading process, allowing users to easily monitor the status of the loading nozzle and the sample loading status. Furthermore, the transparent structure facilitates cleaning and maintenance, reducing maintenance costs. Attached Figure Description

[0024] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation on the scope.

[0025] Figure 1 A schematic diagram of the structure of the sample loading device, chip, and loading nozzle provided in an embodiment of this application;

[0026] Figure 2 for Figure 1 Schematic diagram of the central base;

[0027] Figure 3 for Figure 1 Schematic diagram of the medium pressure cover.

[0028] Explanation of key component symbols:

[0029] 100. Sample loading device; 10. Base; 11. Positioning chamber; 12. Base plate; 13. Protruding edge; 14. Positioning part; 15. Observation port; 16. Alternating groove; 20. Pressure cap; 21. Positioning port; 22. Positioning guide tube; 221. Guide cavity; 23. Reinforcing rib; 24. Cover plate; 25. Side plate; 30. Locking structure; 31. Hook; 32. Slot; 200. Chip; 201. Chip seal; 300. Loading gun head; Z, First direction; Y, Second direction; X, Third direction. Detailed Implementation

[0030] The technical solutions of the embodiments of this application will be described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments.

[0031] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

[0032] The term “and / or” as used herein includes any and all combinations of one or more of the related listed items.

[0033] Embodiments of this application provide a sample loading device for assisting a loading tip in loading samples onto a microarray. The microarray is used for gene sequencing. The sample loading device includes a base and a cap. The base has a positioning chamber. The positioning chamber is configured to accommodate at least a portion of the microarray. The cap is movably connected to the base. The cap is configured to prevent the microarray from detaching from the positioning chamber. The cap has a positioning opening. The positioning opening communicates with the positioning chamber and is configured to allow the loading tip to pass through.

[0034] After the chip is placed in the positioning chamber of the base, its relative position is fixed by the limiting action of the pressure cap. The loading nozzle can pass through the positioning port to reach the chip in the positioning chamber to load the sample onto the chip. The positioning port can constrain the position of the loading nozzle. Therefore, the sample loading device, through the cooperation of the positioning chamber and the positioning port, positions the relative position of the chip and the loading nozzle, and fixes the chip and the loading nozzle relatively, thereby improving the consistency of the chip and loading nozzle assembly position. Furthermore, the movable pressure cap and base can move closer or further apart to facilitate chip assembly or disassembly; and the loading nozzle can be connected or disconnected from the chip by inserting or removing the positioning port, which is convenient and helps to improve the efficiency of chip and loading nozzle assembly.

[0035] The following detailed description of some embodiments of this application is provided in conjunction with the accompanying drawings. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0036] See Figure 1 One embodiment of this application provides a sample loading device 100 for assisting a loading pipette tip 300 in loading samples into a chip 200. The chip 200 is used for gene sequencing. The loading pipette tip 300 can inject samples prepared for gene sequencing into the chip 200, and the chip 200 can hold the samples to carry them into the instrument performing gene sequencing.

[0037] The sample loading device 100 includes a base 10 and a cover 20. The base 10 has a positioning chamber 11. The positioning chamber 11 is configured to accommodate at least a portion of the chip 200. The cover 20 is movably connected to the base 10. The cover 20 is configured to prevent the chip 200 from disengaging from the positioning chamber 11. The cover 20 has a positioning opening 21. The positioning opening 21 communicates with the positioning chamber 11 and is configured to allow the loading nozzle 300 to pass through.

[0038] After the chip 200 is placed in the positioning chamber 11 of the base 10, its relative position is fixed by the limiting action of the pressure cover 20. The loading nozzle 300 can pass through the positioning port 21 to reach the chip 200 located in the positioning chamber 11 to load a sample onto the chip 200. The positioning port 21 constrains the position of the loading nozzle 300. Therefore, the sample loading device 100, through the cooperation of the positioning chamber 11 and the positioning port 21, positions the relative positions of the chip 200 and the loading nozzle 300, and relatively fixes them, thereby improving the consistency of the assembly positions of the chip 200 and the loading nozzle 300. Furthermore, the movable connection of the pressure cover 20 and the base 10 allows them to move closer or further apart to facilitate the assembly or disassembly of the chip 200. The loading nozzle 300 can be connected or separated from the chip 200 by inserting or removing the positioning port 21, making operation convenient and improving the efficiency of the assembly of the chip 200 and the loading nozzle 300. Meanwhile, the sample loading device 100 has a simple structure, which helps to reduce the cost of sample loading.

[0039] The gland 20 and the base 10 are movably connected, which can be maintained when the gland 20 and the base 10 move relative to each other, or the gland 20 and the base 10 can be directly separated when they move relative to each other.

[0040] The sample loading device 100 improves the consistency of the assembly positions of the chip 200 and the loading nozzle 300 and the assembly efficiency, which is conducive to the rapid, accurate and stable insertion of the loading nozzle 300 into the chip 200, so as to assist the loading nozzle 300 in loading samples onto the chip 200.

[0041] In some embodiments, the chip 200 has a chip seal 201. After the loading nozzle 300 passes through the positioning port 21 of the sample loading device 100, the loading nozzle 300 passes through the chip seal 201 to load the sample onto the chip 200.

[0042] In some embodiments, the sample loading device 100 has a positioning seal (not shown). The positioning seal is disposed at the positioning port 21, and when the loading nozzle 300 passes through the positioning port 21, the positioning seal is sealed between the loading nozzle 300 and the positioning port 21.

[0043] In some embodiments, the direction in which the pressure cap 20 is positioned over the base 10 is defined to be parallel to a first direction. The pressure cap 20 is configured to stop the chip 200 along the first direction. It is understood that a positioning opening 21 is located on the side of the pressure cap 20 facing away from the base 10 along the first direction, and the positioning opening 21 allows the loading nozzle 300 to pass through along the first direction to facilitate movement of the loading nozzle 300 to engage with the chip 200. The first direction, the second direction, and the third direction are defined to intersect each other. The first direction is... Figures 1 to 3 As shown, the second direction Y is parallel to the direction indicated by Z. Figures 1 to 3 As shown, parallel to the direction indicated by Y, the third direction X is... Figures 1 to 3 The direction indicated by X is parallel to the direction shown in the diagram. For ease of reference, the first direction will be referred to as "first direction Z", the second direction as "second direction Y", and the third direction as "third direction X" in the following text. The definitions of "first direction Z", "second direction Y", and "third direction X" are for the purpose of describing the relative positional relationships of the related structures, and do not imply that "first direction Z", "second direction Y", and "third direction X" depend on the related structures involved in the above definitions. It is understood that in some embodiments, the first direction Z, the second direction Y, and the third direction X are mutually perpendicular.

[0044] See Figure 1 and Figure 2 In some embodiments, the base 10 has a substrate 12 and a protruding edge 13. The protruding edge 13 is disposed on one side of the substrate 12, and the protruding edge 13 is located on at least two opposite sides of the edge of that side. The positioning chamber 11 is the space enclosed by the protruding edge 13 on the substrate 12. A pressure cap 20 covers the protruding edge 13 of the base 10.

[0045] In some embodiments, the base 10 is provided with a positioning part 14. At least one positioning part 14 is provided. The positioning part 14 is disposed within the positioning chamber 11. At least one positioning part 14 is configured to abut against the chip 200 along the second direction Y. The first direction Z, the second direction Y, and the third direction X intersect each other. One positioning part 14 may abut against the chip 200 along either the second direction Y or the third direction X, or one positioning part 14 may abut against the chip 200 along both the second direction Y and the third direction X. Exemplarily, the positioning part 14 is a block-shaped structure disposed on the protruding edge 13.

[0046] By setting the positioning part 14, it is easy to determine the position of the chip 200 placed in the positioning chamber 11 of the base 10, and the chip 200 can be pre-fixed; and the positioning part 14 can cooperate with the pressure cover 20 to constrain the position of the chip 200 in the positioning chamber 11 in different directions, thereby improving the consistency of the assembly position of the chip 200 and the loading gun head 300.

[0047] Understandably, in some embodiments, the positioning part 14 can abut against the opposing and / or opposing sides of the chip 200 in the second direction Y, so that the chip 200 is fixed relative to the base 10 in the second direction Y; the positioning part 14 can abut against the opposing and / or opposing sides of the chip 200 in the third direction X, so that the chip 200 is fixed relative to the base 10 in the third direction X.

[0048] In some embodiments, the base 10 is provided with an observation port 15. The observation port 15 is connected to the positioning chamber 11 to allow the chip 200 to be exposed through the observation port 15. Users (including operators or machinery) can observe the chip 200 through the observation port 15, which facilitates observation of the loading status of the sample in the chip 200, thereby effectively and intuitively judging the loading effect of the sample.

[0049] It is understood that in some embodiments, the observation port 15 is located on the substrate 12 of the base 10. Along the first direction Z, the observation port 15 and the positioning port 21 are located on opposite sides of the positioning chamber 11.

[0050] In some embodiments, the substrate 12 and the protruding edge 13 are integrally formed, which facilitates the assembly of the base 10 and the cover 20.

[0051] See Figure 1 and Figure 3 In some embodiments, the cap 20 is provided with a positioning guide tube 22. The positioning guide tube 22 is located at the positioning port 21. The positioning guide tube 22 has a guide cavity 221. The guide cavity 221 connects the positioning port 21 and the positioning chamber 11. The guide cavity 221 is configured to accommodate at least a portion of the loading nozzle 300. After the loading nozzle 300 passes through the guide cavity 221, it loads the sample onto the chip 200. The positioning guide tube 22 provides support for the loading nozzle 300, improving the stability of the loading nozzle 300 and facilitating the consistency of the assembly position between the chip 200 and the loading nozzle 300. By providing the positioning guide tube 22, the contact area between the cap 20 and the loading nozzle 300 is increased, making it easier for the loading nozzle 300 to be positioned at a set angle and location relative to the chip 200, facilitating the smooth loading of the sample into the chip 200.

[0052] In some embodiments, when the gland 20 is provided with a positioning guide tube 22, the positioning seal can be omitted. The loading gun head 300 can maintain a stable connection with the chip 200 through the positioning guide tube 22 without the need for the positioning seal to assist in fixation, which helps to reduce the cleaning and replacement of the positioning seal and saves spare parts costs.

[0053] In some embodiments, the diameter of the guide cavity 221 gradually decreases from the end communicating with the positioning port 21 to the end communicating with the positioning chamber 11. After the loading nozzle 300 extends into the guide cavity 221 from the positioning port 21, the guide cavity 221 gradually narrows. This facilitates the constraint of the insertion depth of the loading nozzle 300 and supports and fixes the loading nozzle 300, while also helping to avoid obstructing the insertion or removal of the loading nozzle 300 into or from the positioning guide tube 22, thereby improving the assembly efficiency of the chip 200 and the loading nozzle 300. For example, the positioning guide tube 22 has a tapered structure.

[0054] In some embodiments, the pressure cap 20 is provided with reinforcing ribs 23. At least a portion of the reinforcing ribs 23 are connected to the positioning guide tube 22. By providing reinforcing ribs 23, the overall structural strength of the pressure cap 20 is improved, and it helps to prevent the positioning guide tube 22 from shaking, thereby improving the stability of the loading gun head 300 position and thus improving the consistency of the assembly position of the chip 200 and the loading gun head 300.

[0055] In some embodiments, the pressure cap 20 has a cover plate 24 and a side plate 25. A positioning port 21 is provided on the cover plate 24. The side plate 25 is provided on one side of the cover plate 24 and is disposed around the edge of that side. When the pressure cap 20 is placed on the base 10, the cover plate 24 can cover the base 10 by means of the support of the side plate 25. The positioning guide 22 and the side plate 25 are located on the same side of the cover plate 24. The positioning guide 22 is located in the space enclosed by the side plate 25 and the cover plate 24. On the one hand, the force applied by the loading gun head 300 to the cover plate 24 through the positioning guide 22 can be dispersed by the side plate 25, which is beneficial to improving the stability of the loading gun head 300. On the other hand, the side plate 25 can protect the positioning guide 22, which is beneficial to prevent the positioning guide 22 from being deformed by collision and affecting the consistency of the assembly position of the chip 200 and the loading gun head 300.

[0056] Understandably, in some embodiments, both the cover plate 24 and the side plate 25 are provided with reinforcing ribs 23. The reinforcing ribs 23 are located on the side of the cover plate 24 and the side plate 25 facing the positioning guide tube 22.

[0057] In some embodiments, the cover plate 24, side plate 25, positioning guide tube 22 and reinforcing rib 23 are integrally formed structures, which facilitates the assembly of the pressure cap 20 and the base 10.

[0058] See Figures 1 to 3In some embodiments, the sample loading device 100 is provided with a locking structure 30. The locking structure 30 connects the base 10 and the pressure cap 20. The locking structure 30 has a locked state and an unlocked state.

[0059] When the locking structure 30 is in the locked state, the base 10 and the pressure cap 20 are relatively fixed. When the locking structure 30 is locked, the base 10 and the pressure cap 20 are fixed, which can not only fix the chip 200 and prevent the chip 200 from falling off the sample loading device 100, but also prevent the pressure cap 20 from moving relative to the base 10 and causing the loading gun head 300 to move, thereby improving the consistency of the assembly position of the chip 200 and the loading gun head 300.

[0060] When the locking structure 30 is in the unlocked state, the base 10 and the pressure cover 20 can move relative to each other. When the locking structure 30 is unlocked, the base 10 moves relative to the pressure cover 20, facilitating the installation and removal of the chip 200.

[0061] Understandably, in some embodiments, the locking structure 30 includes a hook 31 and a slot 32. One of the hook 31 and the slot 32 is located on the base 10, and the other is located on the pressure cap 20. When the hook 31 engages with the slot 32, the base 10 and the pressure cap 20 are relatively fixed. The base 10 and the pressure cap 20 are fixed by a snap-fit ​​engagement, which is simple to operate. In other embodiments, the locking structure 30 may also be a bolt and screw hole engagement structure provided on the base 10 and the pressure cap 20, or a clamping member externally connected to the base 10 and the pressure cap 20.

[0062] In some embodiments, the pressure cap 20 and the base 10 are rotatably connected. Rotating the pressure cap 20 facilitates adjusting the relative position of the pressure cap 20 and the base 10 for loading, unloading, or securing the chip 200. Furthermore, during the loading, unloading, or securing of the chip 200, the pressure cap 20 and the base 10 remain connected, eliminating the need to manually locate the pressure cap 20, thus improving the assembly efficiency of the chip 200 and the loading nozzle 300. In other embodiments, the pressure cap 20 and the base 10 may also be slidably connected.

[0063] See Figure 1 and Figure 2 In some embodiments, the base 10 and / or the cover 20 are provided with a relief groove 16. The relief groove 16 is located at the junction of the base 10 and the cover 20. By providing the relief groove 16, a larger force-bearing position is provided for the user at the junction of the base 10 and the cover 20 when the cover 20 is rotated open, which is beneficial to improving the assembly efficiency of the chip 200 and the loading gun head 300.

[0064] Understandably, in some embodiments, when the locking structure 30 adopts a snap-fit ​​form, the clearance groove 16 is provided at the location of the locking structure 30 to reduce the structure of the base 10 and / or the pressure cover 20, making it easier to release the snap-fit ​​connection.

[0065] See Figure 1 In some embodiments, the base 10 and / or the pressure cap 20 are transparent structures. That is, the sample loading device 100 is either fully transparent or partially transparent. This structure allows direct observation of the installation status of the chip 200 and the loading nozzle 300, improving the first-time success rate of sample loading; it also facilitates observation of the sample loading process, allowing users to easily monitor the status of the loading nozzle 300 and the sample loading status. Simultaneously, the transparent structure facilitates cleaning and maintenance, reducing maintenance costs. Figure 1 The sample loading device 100 is shown with dashed lines, revealing the interior of the pressure cap 20 and the structure of the base 10, chip 200, and loading nozzle 300 that are obscured by the pressure cap 20. This allows for a more intuitive understanding of the transparent structure of the sample loading device 100. Figure 2 The base 10 and Figure 3 The cap 20 in the middle is not made transparent in order to show its three-dimensional structure.

[0066] See Figures 1 to 3 In some embodiments, the sample loading device 100 operates as follows:

[0067] Rotate the pressure cap 20 to form an obtuse angle with the base 10, place the chip 200 in the positioning chamber 11 of the base 10, and pre-fix the chip 200 through the positioning part 14; rotate the pressure cap 20 to make it snap into place with the base 10; insert the loading nozzle 300 into the positioning guide tube 22 through the positioning port 21 until the loading nozzle 300 is observed to have entered the chip seal 201 of the chip 200 as required through the transparent pressure cap 20; load the sample into the chip 200 through the loading nozzle 300, observe the sample liquid level of the loading nozzle 300 through the transparent pressure cap 20, and observe the loading status of the sample in the chip 200 through the observation port 15; after the sample loading is completed, pull out the loading nozzle 300, rotate to open the pressure cap 20, and remove the chip 200 for the next loading operation.

[0068] Furthermore, those skilled in the art should recognize that the above embodiments are merely illustrative of this application and are not intended to limit this application. Any appropriate changes and variations made to the above embodiments within the essential spirit and scope of this application fall within the scope of this application's disclosure.

Claims

1. A sample loading device for assisting a loading pipette tip in loading samples onto a chip used for gene sequencing, characterized in that, The sample loading device includes: The base has a positioning compartment configured to accommodate at least a portion of the chip; A pressure cap, movably connected to the base, is configured to prevent the chip from disengaging from the positioning chamber. The pressure cap has a positioning port that communicates with the positioning chamber and is configured to allow the loading nozzle to pass through.

2. The sample loading device according to claim 1, characterized in that, The pressure cap is provided with a positioning guide tube, which is located at the positioning port. The positioning guide tube has a guide cavity that connects the positioning port and the positioning chamber, and the guide cavity is configured to accommodate at least a portion of the loading gun head.

3. The sample loading device according to claim 2, characterized in that, The diameter of the guide tube gradually decreases from the end connected to the positioning port to the end connected to the positioning chamber.

4. The sample loading device according to claim 2, characterized in that, The pressure cap is provided with reinforcing ribs, and at least part of the reinforcing ribs are connected to the positioning guide tube.

5. The sample loading device according to claim 1, characterized in that, The pressure cap is configured to stop the chip along a first direction. The base is provided with a positioning part, which is located in the positioning compartment. At least one positioning part is configured to abut the chip along a second direction, and at least one positioning part is configured to abut the chip along a third direction. The first direction, the second direction, and the third direction intersect each other.

6. The sample loading device according to claim 1, characterized in that, The sample loading device is equipped with a locking structure, which connects the base and the pressure cap. The locking structure has a locked state and an unlocked state. When the locking structure is in the locked state, the base and the pressure cap are relatively fixed; When the locking structure is in the unlocked state, the base and the pressure cover can move relative to each other.

7. The sample loading device according to claim 1, characterized in that, The base is provided with an observation port, which is connected to the positioning chamber to allow the chip to be exposed through the observation port.

8. The sample loading apparatus according to any one of claims 1 to 7, characterized in that, The pressure cap and the base are rotatably connected.

9. The sample loading device according to claim 8, characterized in that, The base and / or the pressure cap are provided with a clearance groove, which is located at the junction of the base and the pressure cap.

10. The sample loading apparatus according to any one of claims 1 to 7, characterized in that, The base and / or the cover are transparent structures.

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