Multi-channel nerve stimulation device

Abstract

The embodiment of the utility model provides a multichannel nerve stimulation device which is used for medical animal experiments and belongs to the technical field of nerve stimulation. The multichannel nerve stimulation device comprises a stimulation unit which comprises at least two stimulation parts, and the at least two stimulation parts are connected with a driving system used for providing stimulation energy; the fixing part is provided with at least two fixing positions according to a preset arrangement rule, and the stimulation parts are fixed on the fixing positions; the sample placing unit comprises at least two sample placing parts which are arranged corresponding to the at least two stimulation parts and are used for placing experimental animal samples; one end of the adjusting unit is connected with the fixing part, and the other end of the adjusting unit is connected with the sample placing unit. According to the multichannel nerve stimulation device, true nerve stimulation and / or pseudo nerve stimulation can be carried out on a plurality of experimental animal samples at the same time, and the experimental efficiency is improved.

Description

Technical Field

[0001] This invention belongs to the field of nerve stimulation technology, and specifically relates to a multi-channel nerve stimulation device. Background Technology

[0002] Neurostimulation technology is an important technique in modern neuroscience. Taking transcranial magnetic stimulation (TMS) as an example, common TMS devices are widely used in clinical treatment. They output a changing magnetic field through specific coils, which then induces currents in corresponding areas of the patient's head, thereby modulating brain nerves or functional networks. Additionally, nerve stimulation can be applied to the spinal region to monitor or regulate the function of the central nervous system.

[0003] To more accurately monitor or regulate the nervous system and its functions in the brain or spine, further in-depth research into the mechanisms of neural stimulation regulation is needed through relevant animal experiments. Taking rodents as an example, behavioral tests such as mazes are commonly used to assess the efficacy of neural stimulation. Therefore, a large sample size (dozens or even hundreds) is required to obtain high-reliability results. Because rodents grow extremely rapidly, stimulation of a large number of animal samples must be completed within a very short time (within a few hours). Therefore, improving experimental efficiency through advanced equipment is crucial.

[0004] Therefore, there is a need for a novel multichannel neurostimulation device for medical animal experiments to solve all or part of the above problems. Utility Model Content

[0005] To address at least one of the aforementioned problems and deficiencies in the existing technology, embodiments of this utility model provide a multi-channel neurostimulation device. This device arranges multiple stimulation units within a stimulation unit, and, according to the neurostimulation requirements of animal experiments, configures these units to include both true and spurious stimulation units. This allows for simultaneous stimulation of the brains or spines of multiple animal samples, achieving simultaneous true and spurious stimulation of multiple animal samples in a single operation. This significantly improves the efficiency of animal experiments and reduces their costs. The technical solution is as follows:

[0006] According to one aspect of the present invention, a multi-channel nerve stimulation device is provided for use in medical animal experiments. The multi-channel nerve stimulation device includes:

[0007] The stimulation unit includes at least two stimulation parts connected to a drive system for providing stimulation energy;

[0008] The fixing part is set with at least two fixing positions according to a preset arrangement rule, and at least two stimulation parts are fixed on at least two fixing positions.

[0009] A sample placement unit includes at least two sample placement sections for placing experimental animal samples, which are provided corresponding to at least two stimulation sections;

[0010] An adjustment unit is used to adjust the relative position between the fixing part and the sample placement unit. One end of the adjustment unit is connected to the fixing part, and the other end is connected to the sample placement unit.

[0011] In some embodiments, alternatively, each of at least two stimulation portions is configured as a true stimulation portion, and each true stimulation portion is connected to the drive system.

[0012] In some embodiments, alternatively, at least one of the at least two stimulation parts includes at least one spurious stimulation part, and the remaining stimulation parts, except for the at least one spurious stimulation part, are configured as true stimulation parts, wherein the true stimulation parts are connected to the drive system, and the spurious stimulation parts are not connected to the drive system.

[0013] In some embodiments, specifically, when at least two stimulation parts include a true stimulation part and a spurious stimulation part, each true stimulation part and each spurious stimulation part have the same housing structure; each true stimulation part has the same stimulation coil disposed inside the housing structure, and each true stimulation part is connected to the drive system through the stimulation coil; each spurious stimulation part does not have a stimulation coil inside the housing structure.

[0014] In some embodiments, specifically, the fixing part has a fixing plane, and at least two fixing positions are disposed on the fixing plane.

[0015] In some embodiments, the sample placement unit further includes a placement plane on which at least two placement positions are provided corresponding to at least two fixed positions, and each of the at least two sample placement parts is placed on each of the at least two placement positions.

[0016] In some embodiments, the adjustment unit specifically includes a position adjustment section and a control section connected in cooperation with the position adjustment section. The control section controls the fixed plane and the placement plane to move closer to each other or further apart by adjusting the position adjustment section.

[0017] In some embodiments, alternatively, the fixing plane is parallel to the placement plane and is positioned directly above the placement plane in a vertical direction; the adjustment unit is positioned at the center of the fixing plane and the placement plane; at least two stimulation parts are arranged in a ring around the adjustment unit; at least two sample placement parts and at least two stimulation parts are arranged in a ring around the adjustment unit, corresponding one-to-one.

[0018] In some embodiments, alternatively, the fixing plane is parallel to the placement plane and is positioned directly above the placement plane in a vertical direction; at least two stimulation parts are arranged in a straight line; at least two sample placement parts are arranged in a straight line in a one-to-one correspondence with at least two stimulation parts.

[0019] In some embodiments, alternatively, the fixing plane and the placement plane are disposed on the same plane; the placement plane is disposed around the outside of the fixing plane; at least two stimulation parts are arranged radially around the center of the fixing plane; at least two sample placement parts and at least two stimulation parts are arranged radially around the center of the fixing plane in a one-to-one correspondence.

[0020] In some embodiments, alternatively, the fixing plane and the placement plane are arranged parallel to each other on the same plane; at least two stimulation parts are arranged in a straight line; at least two sample placement parts are arranged in a straight line in a one-to-one correspondence with at least two stimulation parts.

[0021] The multi-channel nerve stimulation device provided by the embodiments of this utility model has at least one or a portion of the following advantages:

[0022] (1) The multi-channel nerve stimulation device provided in the embodiments of this utility model can simultaneously stimulate multiple experimental animal samples according to the specific experimental requirements by arranging multiple true stimulation parts or multiple true stimulation parts and multiple pseudo stimulation parts in the same stimulation unit, thereby achieving synchronous stimulation or true and pseudo synchronous stimulation of multiple experimental animal samples at one time, which greatly improves the efficiency of animal experiments and reduces the cost of animal experiments.

[0023] (2) The multi-channel nerve stimulation device provided in the embodiments of this utility model provides stimulation energy simultaneously through multiple channels by connecting identical stimulation coils in parallel or series in the same stimulation unit and using the same drive system. This ensures that each true stimulation part has the same magnetic field distribution and capacitance-inductance characteristics, thereby ensuring the consistency of electromagnetic output intensity and stimulation cycle, and thus ensuring the consistency and reliability of animal experimental results.

[0024] (3) The multi-channel nerve stimulation device provided in the embodiments of this utility model provides a pseudo-stimulus that is the same as or similar to the real stimulation scenario for the control experimental animal sample by simultaneously setting a real stimulation part and a pseudo-stimulus part in the same stimulation unit, thus ensuring the objectivity of the animal experimental results.

[0025] (4) The multi-channel nerve stimulation device provided in the embodiments of this utility model can simultaneously stimulate multiple experimental animal samples under the same conditions by arranging multiple identical true stimulation parts in one stimulation unit, which greatly reduces the cost of experimental equipment, reduces personnel consumption, reduces experimental space, and shortens experimental time, thereby greatly reducing the overall cost of animal nerve stimulation experiments.

[0026] (5) The multi-channel nerve stimulation device provided in the embodiments of this utility model can ensure that the experimental animal sample is placed in the accurate position by setting the placement plane and placement position in the sample placement unit, so that it can obtain accurate true stimulation or false stimulation, improve the efficiency of obtaining experimental data and ensure the reliability of experimental data.

[0027] (6) The multi-channel nerve stimulation device provided in the embodiments of this utility model designs the shape and relative position of the fixing plane of the fixing part and the placement plane of the sample placement unit, so that the preset arrangement rules of the stimulation part have multiple forms, which helps to flexibly adjust the overall shape of the multi-channel nerve stimulation device according to the experimental site and experimental conditions, effectively reducing the volume of the multi-channel electromagnetic stimulation device, reducing the space occupied by the equipment, and saving experimental site.

[0028] (7) The multi-channel nerve stimulation device provided in the embodiments of this utility model is equipped with an adjustment unit, and a telescopic structure and a control unit are provided on the adjustment unit to realize the control and adjustment of the relative position of the fixing part and the sample placement unit, so that the multi-channel nerve stimulation device is suitable for various experimental requirements, experimental animal samples and experimental scenarios. Attached Figure Description

[0029] These and / or other aspects and advantages of this invention will become apparent and readily understood from the following description of preferred embodiments taken in conjunction with the accompanying drawings, in which:

[0030] Figure 1 This is a schematic diagram of the structure of the multichannel nerve stimulation device according to Embodiment 1 of the present invention;

[0031] Figure 2 for Figure 1 A schematic diagram showing the structure of the stimulation coils in the true stimulation section of the multichannel neural stimulation device and the connections between adjacent stimulation coils;

[0032] Figure 3 for Figure 2 The diagram shows the simulated magnetic field distribution curve of the stimulation coil when it generates a magnetic field after being powered.

[0033] Figure 4 This is a schematic diagram of the structure of the multi-channel nerve stimulation device according to Embodiment 2 of the present invention;

[0034] Figure 5 This is a schematic diagram of the structure of the multichannel nerve stimulation device according to Embodiment 3 of the present invention;

[0035] Figure 6 This is a schematic diagram of the structure of the multichannel nerve stimulation device according to Embodiment 4 of the present invention. Detailed Implementation

[0036] The technical solution of this utility model will be further described in detail below through embodiments and in conjunction with the accompanying drawings. In this specification, the same or similar reference numerals indicate the same or similar components. The following description of the embodiments of this utility model with reference to the accompanying drawings is intended to explain the overall concept of this utility model and should not be construed as a limitation thereof.

[0037] Existing neurostimulation devices for animal experiments typically require one device, one animal, and one operator. However, animal experiments often require a very large number of animal samples, both to ensure sample validity and the reproducibility of results. Clearly, existing equipment cannot meet these requirements. Using existing equipment and manually stimulating each animal individually is inefficient, inefficient, costly, and requires significant manpower, resources, and space. Furthermore, manual operation may introduce uncontrollable factors. Therefore, this invention proposes a novel multi-channel neurostimulation device. By arranging multiple stimulation units according to a preset rule within the stimulation unit, it enables simultaneous neurostimulation of multiple animal samples on a single device, meeting experimental requirements. This avoids the unavoidable errors associated with manual operation and significantly improves overall experimental efficiency.

[0038] See Figure 1 The image illustrates an embodiment of a multichannel neural stimulation device 100. This multichannel neural stimulation device 100 mainly consists of four parts: a stimulation unit 10, a fixing part 20, a sample placement unit 30, and an adjustment unit 40. Specifically, the stimulation unit 10 is used to provide neural stimulation to experimental animal samples, and the stimulation unit 10 includes at least two stimulation parts (e.g., ...). Figure 1 The diagram shows several true stimulation parts 11 or several pseudo stimulation parts 12, with at least two stimulation parts connected to a drive system (not shown) for providing stimulation energy; the fixing parts 20 are arranged according to a preset rule (e.g., Figure 1 The ring-shaped arrangement shown has at least two fixed positions 211, and a number of true stimulation parts 11 and / or a number of spurious stimulation parts 12 are fixed one by one on each fixed position 211; the sample placement unit 30 includes at least two sample placement parts 32 for placing experimental animal samples, which are arranged corresponding to the at least two stimulation parts (a number of true stimulation parts 11 and / or a number of spurious stimulation parts 12); the adjustment unit 40 is used to adjust the relative position of the fixed part 20 and the sample placement unit 30, one end of the adjustment unit 40 is connected to the fixed part 20, and the other end is connected to the sample placement unit 30.

[0039] In one example, alternatively, at least two stimulation sites (e.g.) Figure 1Each of the plurality of true stimulation portions 11 and / or plurality of pseudo stimulation portions 12 shown is configured as a true stimulation portion 11, and each true stimulation portion 11 is connected to and conducts through the drive system.

[0040] In one example, the driving system is used to provide stimulation energy. Theoretically, the driving system can be electromagnetic, optical, acoustic, etc. For different types of driving systems, the structure of the true stimulation unit 11 only needs to be designed to receive the energy source conducted by the corresponding type of driving system and convert it into a stimulation signal. For example, if the driving system is electromagnetic, then simply placing a metal coil, for example, in the true stimulation unit 11 can create a stimulation magnetic field to complete the neural stimulation of the experimental animal sample. This example is merely illustrative and should not be construed as a limitation of the present invention. All embodiments of the present invention use an electromagnetically driven driving system to provide stimulation energy to the multi-channel neural stimulation device 100.

[0041] In one example, alternatively, at least two stimulation sites (e.g.) Figure 1 The plurality of true stimulation parts 11 and / or plurality of pseudo stimulation parts 12 shown include at least one pseudo stimulation part 12, and the remaining stimulation parts except for at least one pseudo stimulation part 12 are set as true stimulation parts 11, wherein the true stimulation parts 11 are connected to and conduct through the drive system, and the pseudo stimulation parts 12 are connected to but not conduct through the drive system.

[0042] The main purpose of including both a true stimulation unit 11 and a spurious stimulation unit 12 within the same multi-channel neurostimulation device 100 is to provide control samples (those not subjected to neurostimulation) for experimental samples undergoing neurostimulation. In animal experiments, it is usually necessary to set up experimental and control groups to determine the effectiveness of the experiment. Therefore, by simultaneously setting up several experimental and control samples within the same multi-channel neurostimulation device 100 and allowing them to complete the experiment under the same conditions, the overall efficiency of animal experiments can be further improved.

[0043] Furthermore, the specific number of true stimuli 11 and spurious stimuli 12 can be set according to specific experimental requirements. For example, in one set of experiments, the number of true stimuli 11 is equal to the number of spurious stimuli 12, or in another set of experiments, only a small number of spurious stimuli 12 are set (only 1 or 2 spurious stimuli 12 are set, or the number of spurious stimuli 12 is 1 / 10 of the number of true stimuli 11, etc.).

[0044] The structure of the multi-channel neurostimulation device 100 is described in detail below through specific embodiments 1-4. In embodiments 1-4, it is preferred that the stimulation unit 10 includes both a true stimulation section 11 and a spurious stimulation section 12. If it is necessary for the stimulation unit 10 to consist entirely of true stimulation sections 11, simply replace the spurious stimulation sections 12 with true stimulation sections 11.

[0045] Example 1

[0046] like Figure 1 As shown, the multi-channel neurostimulation device 100 of Embodiment 1 arranges the true stimulation unit 11 and the spurious stimulation unit 12 alternately in a ring-shaped arrangement by setting a fixing part 20 with a circular cross-section and a sample placement unit 30. At the same time, several sample placement units 32 are arranged in a ring, corresponding one-to-one with the true stimulation unit 11 and the spurious stimulation unit 12. Each sample placement unit 32 holds one experimental animal sample. The driving system that provides stimulation energy is preferably an electromagnetic drive.

[0047] In one example, specifically, each true stimulation part 11 and each spurious stimulation part 12 have the same outer shell structure 111. Each true stimulation part 11 has the same stimulation coil 112 disposed inside the outer shell structure 111 (e.g., Figure 2 As shown, each true stimulation part 11 is connected to the drive system through the stimulation coil 112; each pseudo stimulation part 12 does not have a stimulation coil 112 inside the housing structure 111, and therefore is not connected to the drive system.

[0048] In one example, combined Figure 1 and Figure 2 Furthermore, with Figure 2 Taking the two stimulation coils 112 connected in series as an example, firstly, these two stimulation coils 112 are located in Figure 1 The stimulation unit 10 shown contains two adjacent true stimulation sections 11. To ensure that the stimulation effects produced by several true stimulation sections 11 are identical under each experimental condition on the same multichannel neurostimulation device 100, each stimulation coil 112 in each true stimulation section 11 must be identical. This arrangement ensures that each stimulation coil 112 generates the exact same magnetic field distribution and capacitance-inductance characteristics after the drive system is activated, thereby producing the exact same stimulation environment or stimulation signal.

[0049] In one example, alternatively, the structural parameters of the stimulation coil 112 may include, but are not limited to, for example, the metal wire material, the metal wire diameter, the cross-sectional shape of the stimulation coil 112 formed by winding the metal wire, the number of turns, etc.

[0050] In one example, specifically, the metal wires used to wind and form the stimulation coil 112 are made of the same material, such as copper wire; the diameter of the metal wires also needs to be the same. Further, the stimulation coil 112 is formed by winding and stacking the metal wires. During the formation of the stimulation coil 112, it is required to wind and stack to the same number of turns with exactly the same cross-sectional shape. Alternatively, the exactly the same cross-sectional shape can be circular, elliptical, or a parallel figure-eight shape. Preferably, as shown... Figure 2 As shown, stimulation coils 112 are formed by winding and stacking the same number of turns with a circular cross section.

[0051] In one example, alternatively, each stimulation coil 112 can be connected and energized to the drive system in series or in parallel. Regardless of whether they are connected in series or in parallel, since the parameters of each stimulation coil 112 are exactly the same, the energy obtained by each stimulation coil 112 after the drive system is started is also the same, and consequently, the magnetic field distribution and capacitance-inductance characteristics generated by each stimulation coil 112 are also the same.

[0052] In one example Figure 3 Further demonstration Figure 2 The example shown is two adjacent stimulation coils 112 connected in series. Their magnetic field distributions are exactly the same, and the stimulation magnetic field or stimulation signal generated under such the same magnetic field distribution can also be completely consistent.

[0053] In one example, such as Figure 1 As shown, when the stimulation unit 10 contains both true stimulation parts 11 and spurious stimulation parts 12, the specific arrangement of the true stimulation parts 11 and spurious stimulation parts 12 will also affect the experimental results. Theoretically, the true stimulation parts 11 and spurious stimulation parts 12 should be arranged alternately, and the number of spurious stimulation parts 12 placed between every two true stimulation parts 11 should be as uniform as possible. This arrangement can make the layout of all true stimulation parts 11 and spurious stimulation parts 12 more uniform, which is conducive to the similarity or consistency of the spurious stimulation environment formed by each spurious stimulation part 12.

[0054] In one example, alternatively, the true stimulation portion 11 and the spurious stimulation portion 12 can be arranged as follows: Figure 1The diagram shows a dummy stimulation part 12 arranged next to a true stimulation part 11, and so on, in a circular arrangement. That is, there must be a dummy stimulation part 12 between every two true stimulation parts 11. Alternatively, the number of dummy stimulation parts 12 between two true stimulation parts 11 can be increased, for example to two or three, meaning two or three dummy stimulation parts 12 are arranged between every two true stimulation parts 11. Alternatively, the number of dummy stimulation parts 12 between every two true stimulation parts 11 does not have to be a fixed value; for example, one dummy stimulation part 12 can be arranged between the first and second true stimulation parts 11, and two dummy stimulation parts 12 can be arranged between the second and third true stimulation parts 11, etc. This example is merely illustrative and should not be construed as a limitation of the present invention by those skilled in the art.

[0055] In one example, alternatively, such as Figure 1 As shown, the specific structures of the fixing part 20 and the sample placement unit 30 are also provided. Because... Figure 1 The stimulation units 10 of the multi-channel nerve stimulation device 100 shown are arranged in a ring pattern, with the true stimulation part 11 and the spurious stimulation part 12 arranged in a ring pattern. Therefore, the fixing part 20 is presented as a cylindrical structure, and the stimulation unit 10 is disposed inside the cylindrical structure. At the same time, the sample placement unit 30 presents as a disc structure and faces the bottom of the fixing part 20.

[0056] In one example, specifically, the fixing part 20 includes a fixing plane 21, and fixing positions 211 are disposed on the fixing plane 21. Once the total number of true stimulation parts 11 and / or spurious stimulation parts 12 is determined, alternatively, a corresponding number of fixing positions 211 can be disposed on the fixing plane 21 to match the shell structure 111 of the true stimulation parts 11 (spurious stimulation parts 12). For example... Figure 1 As shown, the upper end of the outer shell structure 111 of the true stimulation part 11 (pseudo-stimulation part 12) has a flange structure, while the main body of the stimulation coil 112 is located at the bottom end inside the outer shell structure 111. Therefore, flange holes matching the flange structure at the upper end of the outer shell structure 111 are opened on the fixing plane 21. Several true stimulation parts 11 and several pseudo-stimulation parts 12 are first mounted on the fixing plane 21 of the fixing part 20 through the flange holes according to a preset arrangement order (for example, one pseudo-stimulation part 12 is placed between every two true stimulation parts 11), and the bottom end of the outer shell structure 111 extends out of the fixing plane 21. Finally, it is locked and fixed by the flange.

[0057] In one example, furthermore, once the stimulation unit 10 is fixed, the structure of the sample placement unit can be set accordingly. For example... Figure 1 As shown, a sample placement part 32 needs to be provided directly opposite the bottom of the shell structure 111 of each true stimulation part 11 (pseudo stimulation part 12).

[0058] In one example, specifically, the sample placement unit 30 has a placement plane 31, on which the same number of placement positions 311 are provided corresponding to the fixing positions 211 of the fixing part 20, and each of the same number of sample placement parts 32 is placed on each placement position 311. Further, as... Figure 1 As shown, the placement position 311 is formed by slotting a groove in the placement plane 31, and the groove surface should at least cover the bottom area of ​​the outer shell structure 111 of the true stimulation part 11 (pseudo-stimulation part 12). The sample placement part 32 is designed as a box shape, and the box size should ensure that it can be placed in the slot-shaped placement position 311. During the experiment, the experimental animal sample is placed in this box-shaped sample placement part 32 to receive the experimental stimulus.

[0059] Furthermore, after the multi-channel neurostimulation device 100 is connected to the drive system and a stimulation magnetic field is formed, since a certain number of true stimulation parts 11 are arranged around the spurious stimulation part 12, the magnetic field effect generated by the stimulation magnetic field of the surrounding true stimulation parts 11 will partially diffuse into the range of the spurious stimulation part 12. The experimental animal samples corresponding to the spurious stimulation part 12 will feel a part of the magnetic field effect, but in reality, the stimulation magnetic field does not actually stimulate the experimental animal samples corresponding to the spurious stimulation part 12, thus achieving the purpose of having a control group experiment within the same group of experiments in the same multi-channel neurostimulation device 100. The magnetic field effect can be vibration, noise or sound, temperature changes, etc., that the experimental animal samples can perceive due to the magnetic field.

[0060] In one example, to achieve controllable and adjustable experimental conditions, an adjustment unit 40 is also provided in the multi-channel neurostimulation device 100. The main function of the adjustment unit 40 is to adjust the relative position between the fixed part 20 and the sample placement unit 30. For example, the sample placement unit 30 can be fixed, and the distance between the fixed part 20 and the sample placement unit 30 can be adjusted by adjusting the distance between the real stimulation part 11 and the sham stimulation part 12 and the sample placement unit 30 (especially the experimental animal sample in the sample placement part 32). Conversely, the sample placement unit 30 can be moved while keeping the fixed part 20 and the real stimulation part 11 and the sham stimulation part 12 stationary. Alternatively, both the fixed part 20 and the sample placement unit 30 can be movable. The various embodiments of this utility model are merely illustrative examples and should not be construed as a limitation of this utility model by those skilled in the art.

[0061] In one example, since there is always a certain distance between the stimulation unit 10 and the sample placement unit 30 in the initial state, regardless of how they are arranged, it is considered to provide a position adjustment unit 41 in the adjustment unit 40, so that the relative position between the stimulation unit 10 and the sample placement unit 30 can be adjusted in a controlled manner by the position adjustment unit 41.

[0062] In one example, specifically, such as Figure 1 As shown, the adjustment unit 40 includes a position adjustment part 41, a support part 42, and a control part 43. The position adjustment part 41 and the support part 42 form a frame that holds the stimulation unit 10 and the sample placement unit 30 at their vertical ends. One end of the position adjustment part 41 is connected to the fixing plane 21 of the fixing part 20, and the other end is connected to the placement plane 31 of the sample placement unit 30. The control part 43 works in conjunction with the position adjustment part 41 to control the fixing plane 21 and the placement plane 31 to move closer together or further apart, thereby achieving the movement of the stimulation unit 10 and the sample placement unit 32 (and the experimental animal samples placed inside it) towards or away from each other.

[0063] In one example, alternatively, the position adjustment unit 41 includes a main rod 411 with a telescopic structure, which passes through the center of the placement plane 31 of the sample placement unit 30 and the center of the fixing plane 21 of the fixing unit 20. A control unit 43, which is a hand crank, is provided at the uppermost end of the main rod 411. When it is necessary to adjust the relative position of the fixing plane 21 and the placement plane 31, the telescopic structure in the main rod 411 is extended or shortened by gripping the control unit 43 and rotating it in a preset direction (e.g., clockwise, counterclockwise, etc.). For example, if the placement plane 31 is fixed and the telescopic structure is located near the fixed plane 21, rotating the control unit 43 clockwise can extend the telescopic structure, causing the fixed plane 21 to move downwards closer to the placement plane 31.

[0064] In one example, alternatively, two telescopic structures can be provided on the main rod 411, one telescopic structure being positioned close to the fixed plane 21 and the other telescopic structure being positioned close to the placement plane 31. This allows the positions of both the fixed plane 21 and the placement plane 31 to be adjustable.

[0065] In one example, alternatively, the main rod 411 may also be equipped with a sliding buckle structure, a threaded structure, etc., to adjust the relative position between the fixed plane 21 and the placement plane 31.

[0066] In one example, alternatively, the control unit 43 can also use an electric control method, such as using a small stepper motor instead of a hand crank. The small stepper motor can be configured according to the specific settings of the position adjustment unit 41 (e.g., whether a telescopic structure, a sliding structure, or a threaded structure is used), and can also be configured according to the number of telescopic structures, sliding structures, or threaded structures.

[0067] Those skilled in the art will understand that the specific structure of the adjustment unit 40, the adjustment method it employs, and the specific structures of its internal components such as the position adjustment part 41, the support part 42, and the control part 43 can be designed in various ways according to the design requirements of the multi-channel nerve stimulation device 100 (related to specific animal experiment requirements). The various embodiments of this utility model are merely illustrative examples and should not be construed as limiting the utility model by those skilled in the art.

[0068] In one example, with the above configuration, the fixed plane 21 of the multi-channel nerve stimulation device 100 of Embodiment 1 is parallel to the placement plane 31 and the fixed plane 21 is positioned directly above the placement plane 31 in a vertical direction; the adjustment unit 40 (especially the position adjustment part 41) is positioned at the center of the fixed plane 21 and the placement plane 31; the true stimulation part 11 and the pseudo stimulation part 12 in the stimulation unit 10 are arranged in a ring around the position adjustment part 41, and a pseudo stimulation part 12 is provided between every two true stimulation parts 11; the sample placement parts 32, which are the same number as the total number of true stimulation parts 11 and pseudo stimulation parts 12, are arranged in a ring around the position adjustment part 41 in a one-to-one correspondence.

[0069] Example 2

[0070] Based on Example 1, and taking into account actual experimental conditions, experimental site and specific experimental requirements, the arrangement of several true stimulation parts 11 and several pseudo stimulation parts 12 in the stimulation unit 10 and the relative position of the stimulation unit 10 and the sample placement unit 30 were appropriately adjusted.

[0071] See Figure 4 The diagram shows a schematic of the structure of the multi-channel neurostimulation device 100' of Embodiment 2. In Embodiment 2, similar to Embodiment 1, the stimulation unit 10 is positioned vertically above, and the sample placement unit 30' is directly below the stimulation unit 10. The difference from Embodiment 1 is that the circular arrangement of Embodiment 1 is unfolded into a linear arrangement.

[0072] In one example, such as Figure 4 As shown, the fixed plane 21' is parallel to the placement plane 31' and the fixed plane 21' is set directly above the placement plane 31' in the vertical direction; each stimulation part (true stimulation part 11 and spurious stimulation part 12) in the stimulation unit 10 is arranged in a line; the sample placement part 32 is arranged in a line corresponding to each stimulation part (true stimulation part 11 and spurious stimulation part 12).

[0073] The arrangement of the true stimulation part 11 and the pseudo stimulation part 12, the specific setting of the adjustment unit 40', etc. can be referred to the description in Embodiment 1 or an equivalent design can be used, and will not be repeated here.

[0074] Example 3

[0075] In Embodiments 1 and 2 described above, the stimulation unit 10 and sample placement unit 30 are arranged vertically. The stimulation magnetic field generated by the true stimulation part 11 in the stimulation unit 10 is conducted downwards to the experimental animal sample placed in the sample placement part 32 on the sample placement unit 30. Theoretically, by designing the specific structure of the true stimulation part 11 in the stimulation unit 10, especially the structure of the stimulation coil 112 inside the true stimulation part 11, the stimulation signal generated by the stimulation magnetic field can also be conducted horizontally on the same horizontal plane.

[0076] See Figure 5 The multi-channel nerve stimulation device 100 of Embodiment 3 is shown. The fixed plane 21 and the placement plane 31 are disposed on the same plane (e.g., on the same horizontal plane). The placement plane 31 is disposed around the outside of the fixed plane 21. The true stimulation part 11 and the pseudo stimulation part 12 in the stimulation unit 10 are arranged radially around the center of the fixed plane 21. The sample placement part 32 is arranged radially around the center of the fixed plane 21 (which is also the placement plane 31) in a one-to-one correspondence with each stimulation part (true stimulation part 11 and pseudo stimulation part 12).

[0077] The arrangement of the true stimulation part 11 and the pseudo stimulation part 12, the specific setting of the adjustment unit 40”, etc. can be referred to the description in Embodiment 1 or used with an equivalent design, and will not be repeated here.

[0078] Example 4

[0079] Based on Example 3, the circular arrangement can be expanded into a straight line. This is similar to Example 2, which expands the circular arrangement of Example 1 into a straight line.

[0080] See Figure 6 The multi-channel neural stimulation device 100'” of Embodiment 4 is shown, wherein the fixed plane 21'” and the placement plane 31'” are arranged parallel to each other on the same plane (e.g., on the same horizontal plane); each stimulation part (true stimulation part 11 and spurious stimulation part 12) of the stimulation unit 10 is arranged in a line; the sample placement part 32 is arranged in a line corresponding to each stimulation part (true stimulation part 11 and spurious stimulation part 12).

[0081] The arrangement of the true stimulation part 11 and the pseudo stimulation part 12, the specific setting of the adjustment unit 40'”, etc. can be referred to the description in Embodiment 1 or the use of an equivalent design, and will not be repeated here.

[0082] The multi-channel nerve stimulation device provided by the embodiments of this utility model has at least one or a portion of the following advantages:

[0083] (1) The multi-channel nerve stimulation device provided in the embodiments of this utility model can simultaneously stimulate multiple experimental animal samples according to the specific experimental requirements by arranging multiple true stimulation parts or multiple true stimulation parts and multiple pseudo stimulation parts in the same stimulation unit, thereby achieving synchronous stimulation or true and pseudo synchronous stimulation of multiple experimental animal samples at one time, which greatly improves the efficiency of animal experiments and reduces the cost of animal experiments.

[0084] (2) The multi-channel nerve stimulation device provided in the embodiments of this utility model provides stimulation energy simultaneously through multiple channels by connecting identical stimulation coils in parallel or series in the same stimulation unit and using the same drive system. This ensures that each true stimulation part has the same magnetic field distribution and capacitance-inductance characteristics, thereby ensuring the consistency of electromagnetic output intensity and stimulation cycle, and thus ensuring the consistency and reliability of animal experimental results.

[0085] (3) The multi-channel nerve stimulation device provided in the embodiments of this utility model provides a pseudo-stimulus that is the same as or similar to the real stimulation scenario for the control experimental animal sample by simultaneously setting a real stimulation part and a pseudo-stimulus part in the same stimulation unit, thus ensuring the objectivity of the animal experimental results.

[0086] (4) The multi-channel nerve stimulation device provided in the embodiments of this utility model can simultaneously stimulate multiple experimental animal samples under the same conditions by arranging multiple identical true stimulation parts in one stimulation unit, which greatly reduces the cost of experimental equipment, reduces personnel consumption, reduces experimental space, and shortens experimental time, thereby greatly reducing the overall cost of animal nerve stimulation experiments.

[0087] (5) The multi-channel nerve stimulation device provided in the embodiments of this utility model can ensure that the experimental animal sample is placed in the accurate position by setting the placement plane and placement position in the sample placement unit, so that it can obtain accurate true stimulation or false stimulation, improve the efficiency of obtaining experimental data and ensure the reliability of experimental data.

[0088] (6) The multi-channel nerve stimulation device provided in the embodiments of this utility model designs the shape and relative position of the fixing plane of the fixing part and the placement plane of the sample placement unit, so that the preset arrangement rules of the stimulation part have multiple forms, which helps to flexibly adjust the overall shape of the multi-channel nerve stimulation device according to the experimental site and experimental conditions, effectively reducing the volume of the multi-channel electromagnetic stimulation device, reducing the space occupied by the equipment, and saving experimental site.

[0089] (7) The multi-channel nerve stimulation device provided in the embodiments of this utility model is equipped with an adjustment unit, and a telescopic structure and a control unit are provided on the adjustment unit to realize the control and adjustment of the relative position of the fixing part and the sample placement unit, so that the multi-channel nerve stimulation device is suitable for various experimental requirements, experimental animal samples and experimental scenarios.

[0090] While some embodiments of the general concept of this utility model have been shown and described, those skilled in the art will understand that changes may be made to these embodiments without departing from the principles and spirit of the general concept of this utility model, the scope of which is defined by the claims and their equivalents.

Claims

1. A multi-channel nerve stimulation device for medical animal experiments, characterized in that, The multichannel nerve stimulation device includes: A stimulation unit, comprising at least two stimulation parts connected to a drive system for providing stimulation energy; The fixing part is provided with at least two fixing positions according to a preset arrangement rule, and each of the at least two stimulation parts is fixed on each of the at least two fixing positions. A sample placement unit, the sample placement unit comprising at least two sample placement portions for placing experimental animal samples, which are disposed corresponding to the at least two stimulation portions; An adjustment unit for adjusting the relative position of the fixing part and the sample placement unit, wherein one end of the adjustment unit is connected to the fixing part and the other end is connected to the sample placement unit.

2. The multi-channel nerve stimulation device according to claim 1, characterized in that, Each of the at least two stimulation parts is configured as a true stimulation part, and each of the true stimulation parts is connected to the driving system; or The at least two stimulation parts include at least one spurious stimulation part, and the remaining stimulation parts are configured as true stimulation parts, wherein the true stimulation parts are connected to the driving system, and the spurious stimulation parts are not connected to the driving system.

3. The multi-channel nerve stimulation device according to claim 2, characterized in that, When the at least two stimulation portions include a true stimulation portion and a spurious stimulation portion. Each of the true stimulation parts and each of the spurious stimulation parts have the same shell structure; Each of the true stimulation parts is provided with the same stimulation coil inside the housing structure, and each true stimulation part is connected to the driving system through the stimulation coil; Each of the pseudo-stimulation parts has no stimulation coil inside the housing structure.

4. The multi-channel nerve stimulation device according to claim 2, characterized in that, The fixing part has a fixing plane, and the at least two fixing positions are disposed on the fixing plane.

5. The multi-channel nerve stimulation device according to claim 4, characterized in that, The sample placement unit has a placement plane, on which at least two placement positions are provided corresponding to the at least two fixed positions, and each of the at least two sample placement parts is placed on each of the at least two placement positions.

6. The multi-channel nerve stimulation device according to claim 5, characterized in that, The adjustment unit includes a position adjustment section and a control section connected in cooperation with the position adjustment section. The control section controls the fixed plane and the placement plane to move closer to each other or further apart by adjusting the position adjustment section.

7. The multi-channel nerve stimulation device according to claim 6, characterized in that, The fixing plane is parallel to the placement plane and is positioned directly above the placement plane in a vertical direction; The adjustment unit is positioned at the center of the fixed plane and the placement plane; The at least two stimulation portions are arranged in a ring around the adjustment unit; The at least two sample placement portions and the at least two stimulation portions are arranged in a ring around the adjustment unit, each corresponding to the other.

8. The multi-channel nerve stimulation device according to claim 6, characterized in that, The fixing plane is parallel to the placement plane and is positioned directly above the placement plane in a vertical direction; The at least two stimulation sites are arranged in a straight line; The at least two sample placement portions and the at least two stimulation portions are arranged in a line, corresponding one-to-one.

9. The multi-channel nerve stimulation device according to claim 6, characterized in that, The fixing plane and the placement plane are located on the same plane; The placement plane is arranged around the outside of the fixed plane; The at least two stimulation portions are arranged radially around the center of the fixed plane; The at least two sample placement portions and the at least two stimulation portions are arranged radially around the center of the fixed plane, corresponding one-to-one.

10. The multi-channel nerve stimulation device according to claim 6, characterized in that, The fixing plane and the placement plane are arranged parallel to each other on the same plane; The at least two stimulation sites are arranged in a straight line; The at least two sample placement portions and the at least two stimulation portions are arranged in a line, corresponding one-to-one.

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