A high-throughput screening device for high-yield lycium chinense fermenting strain
By setting up a stirring blade and disc structure in the high-yield wolfberry enzyme strain screening device, the target strain and impurities were efficiently separated, which solved the problem of insufficient separation efficiency in the existing device and improved the screening efficiency and product purity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- NINGXIA ZHONGNING COUNTY GUQI GRASS WOLFBERRY DEV
- Filing Date
- 2025-06-09
- Publication Date
- 2026-05-29
AI Technical Summary
Existing strain screening devices simply perform rotational centrifugation on liquids without considering the efficiency of sample stratification during centrifugation. This results in insufficient separation efficiency between target strains and impurities, making it difficult to meet the modern industry's demand for rapid screening of high-yield and high-quality strains.
A high-throughput screening device for high-yield wolfberry enzyme strains was designed. By setting multiple sets of stirring blades on the outside of the rotating cone seat, the material is evenly distributed between the discs by the centrifugal force of rotation. Large impurities move downward along the disc wall, while light strains move upward along the disc wall. The design of multiple discs increases the material contact area, enabling rapid classification and improving product purity.
It improves the separation efficiency of strains and impurities, shortens the separation time, and enhances product purity and screening throughput, meeting the modern industry's demand for rapid screening of high-yield and high-quality strains.
Smart Images

Figure CN224299204U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the technical field of screening technology, and in particular to a high-throughput screening device for high-yield strains of wolfberry enzyme. Background Technology
[0002] In the field of bioengineering, microbial fermentation engineering is crucial for the production of various bioactive substances. Goji berry enzyme, a bio-fermentation product with multiple benefits such as improving immunity, enhancing antioxidant capacity, protecting the liver, promoting digestion, and lowering blood sugar and lipids, relies heavily on the performance of the bacterial strains during its production. Therefore, a high-throughput screening device for high-yield goji berry enzyme strains is particularly needed to better screen for them.
[0003] Chinese patent CN222250739U, published on December 27, 2024, discloses a screening device for functional probiotic strains. This device uses a drive motor connected to a centrifuge disc via a rotating rod to rotate the strain solution. The rotational centrifugation utilizes gravity to separate impurity particles or microorganisms suspended in the solution, causing them to be thrown and deposited onto the adsorption plate on the inner wall of the centrifuge disc. This facilitates the removal of impurities from the solution, improving the purity and integrity of the strains to meet production or research requirements. However, this screening device simply performs rotational centrifugation on the liquid. The device's structural design does not consider the efficiency of sample stratification during centrifugation, resulting in insufficient separation efficiency between the target strains and impurities. This significantly restricts the screening throughput and efficiency, making it difficult to meet the modern industry's demand for rapid screening of high-yield, high-quality strains. Utility Model Content
[0004] The purpose of this invention is to provide a high-throughput screening device for high-yield wolfberry enzyme strains, in order to solve the problem mentioned in the background art that the existing strain screening devices simply perform rotational centrifugation on the liquid during use. The device structure design does not consider the efficiency of sample stratification during centrifugation, resulting in insufficient separation efficiency between target strains and impurities, which significantly restricts the screening throughput and efficiency, and makes it difficult to meet the needs of modern industry for rapid screening of high-yield and high-quality strains.
[0005] To achieve the above objectives, this utility model provides the following technical solution: a high-throughput screening device for high-yield wolfberry enzyme strains, comprising a support plate, a support frame fixedly connected to the lower surface of the support plate, a drive motor fixedly connected to the upper surface of the support plate, a belt attached to the lower surface of the drive motor, a driven rotating shaft attached to one side surface of the belt, a spring fixedly connected to the upper surface of the driven rotating shaft, a connecting column fixedly connected to the upper surface of the spring, a clamp and teeth fixedly connected to one side surface of the connecting column, and a screening mechanism provided on the upper surface of the clamp and teeth;
[0006] The screening mechanism includes a rotating cone seat mounted on a clamp and teeth. An agitator blade is fixedly connected to the upper surface of the rotating cone seat. An upper ball bearing is slidably connected to one side surface of the rotating cone seat, and a lower ball bearing is slidably connected to one side surface of the rotating cone seat. A clamp and a disc are slidably connected to one side surface of the upper ball bearing. A screening liquid tank is fixedly connected to one side surface of the clamp and disc. A waste liquid outlet is opened on the inner surface of the screening liquid tank. A base groove is movably connected to one side surface of the screening liquid tank. An impurity outlet is opened on one side surface of the base groove. A filtrate storage area is fixedly connected to the upper surface of the screening liquid tank. An inlet pipe is opened on one side surface of the filtrate storage area. A screening liquid pipe is opened on the lower surface of the filtrate storage area. A disc is fixedly connected to one side surface of the screening liquid pipe.
[0007] Preferably, the agitating blades are arranged in six groups symmetrically about the central axis of the rotating cone, and the upper and lower ball bearings are arranged in sixty groups symmetrically about the central axis of the rotating cone.
[0008] Preferably, the rotating cone seat is rotatably connected to the sieve tank through the cooperation of the upper ball bearing, the lower ball bearing, and the locking disc, and sixteen sets of waste liquid outlets are symmetrically arranged around the central axis of the sieve tank.
[0009] Preferably, the base groove is fixedly connected to the support plate, and the radius of the impurity outlet matches the radius of the waste liquid outlet.
[0010] Preferably, the radius of the liquid screening pipe is larger than the radius of the liquid inlet pipe, and the outer surface of the liquid screening pipe is provided with multiple sets of holes.
[0011] Preferably, the lower surface of the liquid screening pipe is provided with an inverted funnel-shaped opening, and the disc is in the shape of a circular disc, with six sets evenly spaced on the outer surface of the liquid inlet pipe.
[0012] Preferably, the overall appearance of the screening tank is spindle-shaped, with its bottom fitting into the base groove, and the inlet pipe passes through the screening outlet and the two are arranged in parallel.
[0013] Compared with the prior art, the beneficial effects of this utility model are as follows: This high-throughput screening device for high-yield wolfberry enzyme strains, through the setting of the screening mechanism, when the motor is started, the motor drives the rotating cone seat to rotate via the belt. At this time, the liquid to be screened is added to the inlet pipe. Due to the presence of multiple sets of stirring blades on the outer surface of the rotating cone seat, the liquid undergoes rotational centrifugation in the screening tank. At this time, the impurity outlet pipe is closed, and the liquid cannot flow out. Due to the action of rotational centrifugation, the material passes through the interval of a set of discs. The heavier impurities will move downward along the disc wall and accumulate at the edge of the waste liquid outlet. The lighter strains move upward along the disc wall and enter the filtrate storage area, and are then output from the screening outlet. The design of multiple sets of discs increases the contact area between the material and the liquid, allowing more material to be quickly classified under the action of the centrifugal force, shortening the separation time and improving the purity of the product. Attached Figure Description
[0014] Figure 1 This is a three-dimensional structural diagram of the present invention;
[0015] Figure 2 This is a schematic diagram of the basic structure of the support plate and support frame of this utility model;
[0016] Figure 3 This is a schematic diagram of the interlocking structure of the spring, connecting post, and clip and teeth of this utility model;
[0017] Figure 4 This is a schematic diagram showing the connection relationship between the rotating cone seat, ball bearings, and locking disc of this utility model;
[0018] Figure 5 This is a schematic diagram showing the distribution of the liquid inlet / outlet pipes and the discs in this utility model;
[0019] Figure 6 This is a schematic diagram of the overall structure of the screening mechanism of this utility model.
[0020] In the diagram: 1. Support plate; 2. Support frame; 3. Drive motor; 4. Belt; 5. Driven shaft; 6. Spring; 7. Connecting column; 8. Clamp and teeth; 9. Screening mechanism; 901. Rotating cone seat; 902. Stirring blade; 903. Upper ball bearing; 904. Lower ball bearing; 905. Clamp and disc; 906. Screening liquid tank; 907. Waste liquid outlet; 908. Base groove; 909. Impurity outlet; 910. Filtrate storage area; 911. Screening liquid outlet; 912. Liquid inlet pipe; 913. Screening liquid pipe; 914. Disc. Detailed Implementation
[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0022] Please see Figure 1-6 This utility model provides a technical solution: a high-throughput screening device for high-yield strains of wolfberry enzyme, including a support plate 1, a support frame 2 fixedly connected to the lower surface of the support plate 1, a drive motor 3 fixedly connected to the upper surface of the support plate 1, a belt 4 attached to the lower surface of the drive motor 3, a driven rotating shaft 5 attached to one side surface of the belt 4, a spring 6 fixedly connected to the upper surface of the driven rotating shaft 5, a connecting column 7 fixedly connected to the upper surface of the spring 6, a clamp and teeth 8 fixedly connected to one side surface of the connecting column 7, and a screening mechanism 9 provided on the upper surface of the clamp and teeth 8;
[0023] The screening mechanism 9 includes a rotating cone seat 901, which is mounted on a clamp and gear 8. An agitator blade 902 is fixedly connected to the upper surface of the rotating cone seat 901. An upper ball bearing 903 is slidably connected to one side surface of the rotating cone seat 901, and a lower ball bearing 904 is slidably connected to one side surface of the rotating cone seat 901. A clamp and disc 905 are slidably connected to one side surface of the upper ball bearing 903. A screening liquid tank 906 is fixedly connected to one side surface of the clamp and disc 905. A waste liquid outlet 907 is opened on the inner surface of the screening liquid tank 906. A side of the screening liquid tank 906... A base groove 908 is movably connected to the surface of the sieve tank 906. An impurity outlet 909 is provided on one side of the base groove 908. A filtrate storage area 910 is fixedly connected to the upper surface of the sieve tank 906. An inlet pipe 912 is provided on one side of the filtrate storage area 910. A sieve pipe 913 is provided on the lower surface of the filtrate storage area 910. A disc 914 is fixedly connected to one side of the sieve pipe 913. The sieve tank 906 is connected by rotating the cone seat 901, stirring blade 902, upper ball bearing 903, lower ball bearing 904, clamping disc 905, and sieve tank 906. The system includes a waste liquid outlet 907, a base tank 908, an impurity outlet 909, a filtrate storage area 910, a screening outlet 911, an inlet pipe 912, a screening pipe 913, and a disc 914. During use, the motor is started, and the motor drives the rotating cone 901 via belt 4. At this time, the liquid to be screened is added to the inlet pipe 912. Due to the presence of multiple sets of agitating blades 902 on the outer surface of the rotating cone 901, the liquid undergoes centrifugal rotation in the screening tank 906. Meanwhile, the impurity outlet 909 is closed. The material cannot flow out. Due to the centrifugal action, the material passes through the intervals of a set of discs 914. The heavier impurities move downward along the disc walls 914 and accumulate at the edge of the waste liquid outlet 907. The lighter strains move upward along the disc walls and enter the filtrate storage area 910, and are then output through the screening outlet 911. The design of multiple discs 914 increases the contact area between the material and the filtrate, allowing more material to be quickly classified under the action of centrifugal force, shortening the separation time and improving the purity of the product.
[0024] Furthermore, six sets of stirring blades 902 are symmetrically arranged around the central axis of the rotating cone 901, and sixty sets of upper and lower balls 903 and 904 are symmetrically arranged around the central axis of the rotating cone 901. Through the arrangement of the stirring blades 902, upper balls 903, and lower balls 904, the six sets of blades 902 are symmetrically distributed during use, which can make the circumferential driving force on the rotating cone uniform during rotation, reduce vibration or eccentric wear caused by uneven force, and improve the stability of equipment operation. Moreover, the symmetrical arrangement of the blades 902 can cover the entire area around the cone 901, avoid stirring blind spots, and make the material subject to uniform shearing and pushing action during rotation, improve mixing efficiency and material uniformity. The rolling friction of the balls 904 is much less than the sliding friction. The symmetrical arrangement can further reduce the friction loss when the cone 901 rotates, improve transmission efficiency, and reduce energy consumption.
[0025] Furthermore, the rotating cone seat 901 is rotatably connected to the sieve tank 906 through the mutual cooperation of the upper ball bearing 903, the lower ball bearing 904, and the clamping disc 905. Sixteen sets of waste liquid outlets 907 are symmetrically arranged around the central axis of the sieve tank 906. Through the arrangement of the waste liquid outlets 907, during use, no matter how the rotating cone seat 901 is placed, the liquid outlets 907 can be easily aligned with the impurity outlets 909, thus speeding up the work efficiency.
[0026] Furthermore, the base groove 908 is fixedly connected to the support plate 1, and the radius of the impurity outlet 909 matches the radius of the waste liquid outlet 907. Through the setting of the waste liquid outlet 907 and the impurity outlet 909, the size matching allows the impurity outlet 909 and the waste liquid outlet 907 to form a seamless connection during use, preventing waste liquid or impurities from accumulating at the interface, reducing the risk of impurity accumulation and blockage, reducing leakage hazards, and improving the equipment's sealing performance.
[0027] Furthermore, the radius of the sieve pipe 913 is larger than that of the inlet pipe 912, and the outer surface of the sieve pipe 913 is provided with multiple sets of holes. With the sieve pipe 913, during use, low-quality liquid can smoothly pass through the multiple sets of holes on the outer surface of the sieve pipe 913 and enter the filtrate storage area 910, thus speeding up the work efficiency.
[0028] Furthermore, the lower surface of the liquid screening pipe 913 is provided with an inverted funnel-shaped opening, and the disc 914 is in the shape of a circular disc. Six sets are equally spaced on the outer surface of the liquid inlet pipe 912. Through the arrangement of the disc 914, the circular disc structure expands the contact area between the disc 914 and the fluid during use. Multi-stage filtration or dispersion paths can be formed by stacking multiple discs 914, which prolongs the residence time of the fluid in the equipment and improves the impurity interception or separation effect.
[0029] Furthermore, the overall appearance of the screening tank 906 is spindle-shaped, with its bottom fitting into the base groove 908. The inlet pipe 912 passes through the screening outlet 911, and the two are arranged in parallel. Through the design of the screening tank 906, the spindle-shaped structure allows the liquid to form a smooth streamlined path when flowing in the tank, reducing turbulence and dead angles, and improving separation efficiency. The bottom fitting into the base groove 908 ensures structural stability and avoids the decrease in separation effect caused by shaking when the screening tank rotates at high speed.
[0030] Working Principle: This high-throughput screening device for high-yield wolfberry enzyme strains utilizes a screening mechanism 9. When in use, the motor is started, and the motor drives the rotating cone 901 via belt 4. At this time, the liquid to be screened is added to the inlet pipe 912. Due to the presence of multiple sets of stirring blades 902 on the outer surface of the rotating cone 901, the liquid undergoes centrifugal treatment in the screening tank 906. Meanwhile, the impurity outlet 909 is closed, preventing liquid outflow. Due to the centrifugal action, the material passes through the intervals of a set of discs 914. Impurities with a higher specific gravity move downwards along the disc walls and accumulate at the edge of the waste liquid outlet 907. Strains with a lower specific gravity move upwards along the disc walls and enter the filtrate storage area 910, before being output from the screening outlet 911. The design of multiple discs 914 increases the contact area between the material and the filtrate, allowing more material to be separated quickly under the action of centrifugal force, shortening the separation time and improving product purity. The drive motor 3 is a Y315S-2 model.
[0031] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.
Claims
1. A high-throughput screening device for high-yield wolfberry enzyme strains, comprising a support plate (1), characterized in that: A support frame (2) is fixedly connected to the lower surface of the support plate (1), a drive motor (3) is fixedly connected to the upper surface of the support plate (1), a belt (4) is attached to the lower surface of the drive motor (3), a driven shaft (5) is attached to one side surface of the belt (4), a spring (6) is fixedly connected to the upper surface of the driven shaft (5), a connecting column (7) is fixedly connected to the upper surface of the spring (6), a clip and a tooth (8) are fixedly connected to one side surface of the connecting column (7), and a screening mechanism (9) is provided on the upper surface of the clip and the tooth (8). The screening mechanism (9) includes a rotating cone seat (901), which is mounted on a clamp and teeth (8). An agitator blade (902) is fixedly connected to the upper surface of the rotating cone seat (901). An upper ball bearing (903) is slidably connected to one side surface of the rotating cone seat (901), and a lower ball bearing (904) is slidably connected to one side surface of the rotating cone seat (901). A clamp and disc (905) are slidably connected to one side surface of the upper ball bearing (903). A screening liquid tank (906) is fixedly connected to one side surface of the clamp and disc (905). The inner surface of the sieve tank (906) is provided with a waste liquid outlet (907). A base groove (908) is movably connected to one side surface of the sieve tank (906). An impurity outlet (909) is provided on one side surface of the base groove (908). A filtrate storage area (910) is fixedly connected to the upper surface of the sieve tank (906). An inlet pipe (912) is provided on one side surface of the filtrate storage area (910). A sieve pipe (913) is provided on the lower surface of the filtrate storage area (910). A disc (914) is fixedly connected to one side surface of the sieve pipe (913).
2. The high-throughput screening device for high-yield wolfberry enzyme strains according to claim 1, characterized in that: The stirring blades (902) are arranged symmetrically in six groups around the central axis of the rotating cone (901), and the upper ball bearings (903) and lower ball bearings (904) are arranged symmetrically in sixty groups around the central axis of the rotating cone (901).
3. The high-throughput screening device for high-yield wolfberry enzyme strains according to claim 1, characterized in that: The rotating cone seat (901) is rotatably connected to the sieve tank (906) through the mutual cooperation of the upper ball bearing (903), the lower ball bearing (904) and the clamping disc (905), and the waste liquid outlet (907) is symmetrically arranged in sixteen groups around the central axis of the sieve tank (906).
4. The high-throughput screening device for high-yield wolfberry enzyme strains according to claim 1, characterized in that: The base groove (908) is fixedly connected to the support plate (1), and the radius of the impurity outlet (909) matches the radius of the waste liquid outlet (907).
5. The high-throughput screening device for high-yield wolfberry enzyme strains according to claim 1, characterized in that: The radius of the liquid screening pipe (913) is larger than that of the liquid inlet pipe (912), and the outer surface of the liquid screening pipe (913) is provided with multiple sets of holes.
6. The high-throughput screening device for high-yield wolfberry enzyme strains according to claim 1, characterized in that: The lower surface of the liquid screening pipe (913) is provided with an inverted funnel-shaped opening, and the disc (914) is a circular disc, with six sets evenly spaced on the outer surface of the liquid inlet pipe (912).
7. The high-throughput screening device for high-yield wolfberry enzyme strains according to claim 1, characterized in that: The overall appearance of the screening tank (906) is spindle-shaped, and its bottom is fitted with the base groove (908). The inlet pipe (912) passes through the screening outlet (911) and the two are arranged in parallel.