Optical detection system and optical detection device

Abstract

This application provides an optical detection system and an optical detection device. The optical detection system includes an excitation device, an adjustment device, a capillary separation channel device, a detection device, and a detection channel switching device. The adjustment device is used to adjust the direction of the excitation light. The capillary separation channel device is used to receive the excitation light after the direction is adjusted, and emit fluorescence after a fluorescence reaction. The detection device includes multiple interconnected detection channels and multiple sets of detectors. Fluorescence passes through the multiple detection channels and enters the multiple sets of detectors. The detection channel switching device is rotatably disposed at any position in the optical path formed by the excitation light and fluorescence. The detection channel switching device is provided with multiple light-transmitting parts for the excitation light or fluorescence to pass through. Each detection channel corresponds to one or more light-transmitting parts. The detection channel switching device is used to close the connection between other detection channels and other light-transmitting parts when any detection channel is connected to the corresponding light-transmitting part.

Description

Technical Field

[0001] This utility model relates to the field of optical detection technology, and more specifically, to an optical detection system and optical detection equipment. Background Technology

[0002] The optical detection system employs capillary electrophoresis analysis—a microfluidic method based on gel electrophoresis. It uses multiple channels for multi-channel analysis, and when the analyte is electrophoresed to the capillary detection area, it is stimulated to emit fluorescence. Multiple detectors are used to collect the relevant fluorescence signals, thereby achieving signal detection.

[0003] However, most existing optical inspection systems currently use a one-to-one correspondence between inspection channels and detectors, acquiring signals simultaneously through multiple detectors. This increases the cost and requires higher calibration levels. Alternatively, they use a single detector and multiple excitation sources, acquiring signals by periodically switching the excitation and deactivation of different inspection channels. This frequent switching reduces the effective lifespan of the excitation sources, thereby shortening the lifespan of the system. Another approach is to use various rotating disks with symmetrically arranged through-holes to switch the channels through which the light source passes. Due to the symmetrical arrangement of the through-holes, at least two inspection channels will be connected to their corresponding inspection channels during rotation, leading to mutual interference in signal acquisition.

[0004] Therefore, how to provide an optical detection system that can switch and process signals from different detection channels has become a technical problem that urgently needs to be solved in this field. Utility Model Content

[0005] In view of the shortcomings of the existing technology, the purpose of this utility model is to provide an optical detection system and optical detection equipment that can realize signal switching and processing of different detection channels.

[0006] The above-mentioned technical objective of this utility model is achieved through the following technical solution:

[0007] In a first aspect, embodiments of this application provide an optical detection system, including an excitation device, an adjustment device, a capillary separation channel device, a detection device, and a detection channel switching device. The adjustment device is used to adjust the direction of the excitation light. The capillary separation channel device is used to receive the excitation light after the direction is adjusted, and emit fluorescence after a fluorescence reaction. The detection device includes multiple interconnected detection channels and multiple sets of detectors. Fluorescence passes through the multiple detection channels and enters the multiple sets of detectors. The multiple sets of detectors are used to detect fluorescence and generate fluorescence information. The detection channel switching device is rotatably disposed at any position in the optical path formed by the excitation light and fluorescence. The detection channel switching device is provided with multiple light-transmitting parts for the excitation light or fluorescence to pass through. Each detection channel corresponds to one or more light-transmitting parts. The detection channel switching device is used to close the connection between other detection channels and other light-transmitting parts when any detection channel is connected to the corresponding light-transmitting part.

[0008] Furthermore, the detection channel switching device is a turntable, which can be a circular turntable, a triangular turntable, or a polygonal turntable.

[0009] Furthermore, the turntable is made of an opaque material, and the light-transmitting part is a through hole.

[0010] Furthermore, the light-transmitting part is an arc-shaped hole, and multiple concentric circles corresponding to the detection channel are formed on the rotating disk, with each of the multiple concentric circles having at least one arc-shaped hole.

[0011] Furthermore, the detection channel and its corresponding arc-shaped hole have an angle between them and the center of the turntable. The angle is the angle of rotation when each arc-shaped hole connects to its corresponding detection channel and then switches to an adjacent arc-shaped hole connecting to its corresponding detection channel.

[0012] Furthermore, the turntable includes a first area configured as a light-transmitting part and a second area circumferentially configured in the light-transmitting part, the first area being made of transparent material and the second area being made of opaque material.

[0013] Furthermore, the beginning and end of the light-transmitting part are at an angle β with the center of the turntable, wherein the angle is 0°<β≤30°.

[0014] Furthermore, the line connecting the axes of multiple detection channels is the first line, and the center of the turntable is offset from the first line.

[0015] Furthermore, the detection device also includes an emission component, which is located on the side of the detection channel near the adjustment device, and is used to filter and couple the fluorescence.

[0016] Furthermore, a detection channel switching device is located between the transmitting component and the detection channel.

[0017] Furthermore, the optical detection system also includes a processing device, which is located between the excitation device and the adjustment device, and close to the excitation device, for collimating and shaping the excitation light.

[0018] Furthermore, the detection channel switching device is located between the excitation device and the processing device.

[0019] Furthermore, the detection channel switching device is located between the capillary separation channel device and the adjustment device.

[0020] Secondly, embodiments of this application also provide an optical inspection device, including the optical inspection system described in the above embodiments.

[0021] The beneficial effects of this utility model embodiment are:

[0022] This application embodiment sets up a detection channel switching device in the optical path of excitation light and fluorescence to switch the path through which the excitation light or fluorescence passes. That is, by switching the transmission / blocking state of the excitation light or fluorescence signal of different detection channels, the corresponding switching of the detection channels can be realized. This enables the switching and processing of signals from different detection channels, so that each detection channel can be excited once or multiple times in one detection cycle and the relevant signals can be collected. This can avoid mutual interference between detection channels when collecting signals and improve the acquisition frequency of the detection channels. Attached Figure Description

[0023] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments of this application will be briefly described below.

[0024] Figure 1 This is a cross-sectional view of an optical detection system according to an embodiment of this application;

[0025] Figure 2 This is a schematic diagram of the structure of a detection channel switching device for an optical detection system according to an embodiment of this application;

[0026] Figure 3 This is a schematic diagram of the structure of the turntable of an optical detection system according to an embodiment of this application;

[0027] Figure 4 This is a schematic diagram of the structure of the zero-position sensor connecting the turntable of an optical detection system according to an embodiment of this application.

[0028] Reference numerals: 1. Excitation device; 2. Adjustment device; 3. Capillary separation channel device; 31. Capillary fixing lens; 32. Second collimating lens; 33. Detection device; 4. Detection channel; 41. Emitting fiber; 42. Emitting assembly; 43. Emitting filter; 431. Fiber coupling lens; 432. Detection channel switching device; 5. Turntable; 51. Zero-position baffle; 52. Light-transmitting part; 6. Zero-position sensor; 7. Detection module; 71. Drive motor; 8. Processing device; 9. First collimating lens; 91. Beam shaper; 92. Excitation filter; 93. Mounting bracket; 10. Detailed Implementation

[0029] In the description of this application, it should be noted that the terms "inner" and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing this application and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0030] The technical solutions in the embodiments of this application will now be described with reference to the accompanying drawings.

[0031] See Figure 1 -3. This application provides an optical detection system, including an excitation device 1, an adjustment device 2, a capillary separation channel device 3, a detection device 4, and a detection channel switching device 5.

[0032] Excitation device 1 is used to emit excitation light.

[0033] The adjustment device 2 is provided corresponding to the excitation device 1 and is used to adjust the direction of the excitation light.

[0034] The burr tube separation channel device is located near the adjustment device 2 to receive the excitation light after the direction is adjusted, and emits fluorescence after a fluorescence reaction.

[0035] The detection device 4 is located on the side of the adjustment device 2 away from the capillary separation channel device 3. The detection device 4 includes multiple interconnected detection channels 41 and multiple sets of detectors. Fluorescence passes through the multiple detection channels 41 and enters the multiple sets of detectors. The multiple sets of detectors are used to detect fluorescence and generate fluorescence information.

[0036] The detection channel switching device 5 is rotatably set at any position in the optical path formed by the excitation light and fluorescence. The detection channel switching device 5 is provided with multiple light-transmitting parts 6 for the excitation light or fluorescence to pass through.

[0037] Each detection channel 41 corresponds to one or more light-transmitting parts 6. The detection channel switching device 5 is used to close the connection between other detection channels 41 and other light-transmitting parts 6 when any detection channel 41 is connected to the corresponding light-transmitting part 6.

[0038] In this embodiment, the light-transmitting part 6 of the detection channel switching device 5 enables communication between the excitation light or fluorescence and the detection channel 41. Switching between the transmission or blocking states of the excitation light or fluorescence signals of different channels achieves the switching of the detection channel 41, thus switching the communication between the excitation light and fluorescence and multiple sets of detection channels 41. This allows each detection channel 41 to be excited individually once or multiple times within a detection cycle, and to acquire relevant signals. This avoids mutual interference between detection channels 41 during signal acquisition and increases the acquisition frequency of the detection channels 41. Furthermore, placing the detection channel switching device 5 on the excitation light or fluorescence path enhances the installation flexibility of the detection channel switching device 5.

[0039] In one embodiment, the excitation device 1 is a light source, and the excitation light is emitted by the light source.

[0040] In one embodiment, the detection channel switching device 5 is supported by a mounting bracket 10.

[0041] In one embodiment, the detection channel switching device 5 is a turntable 51, which can be a circular turntable 51, a triangular turntable 51, or a polygonal turntable 51.

[0042] This application sets the detection channel switching device 5 as a turntable 51, and achieves periodic switching of the signal of the detection channel 41 by rotating the turntable to switch the connection between the excitation light or fluorescence and the detection channel 41.

[0043] In one embodiment, the optical detection system further includes a drive motor 8, which is connected to the turntable 51 and the main control system of the optical detection system, and is used to drive the turntable 51 to rotate after receiving control commands from the main control system.

[0044] In one embodiment, the turntable 51 is made of an opaque material, and the light-transmitting part 6 is a through hole, which serves as a transmission channel for excitation light or fluorescence.

[0045] The shape of the through hole can be circular or polygonal.

[0046] In one embodiment, the width of the through hole can be 0.8 mm. The width of the through hole can be greater than or equal to the diameter of the excitation light or fluorescence beam. The width of the through hole is set according to the setting position, but it should not block the emission of excitation light or fluorescence to avoid affecting the detection quality of the signal.

[0047] In another embodiment, the turntable 51 is made of an opaque material, and the light-transmitting part 6 is an arc-shaped hole. When the turntable 51 rotates, multiple concentric circles corresponding to the detection channel 41 are formed (e.g., ...). Figure 3 As shown in the figure (represented by dashed lines), each of the multiple concentric circles has at least one arc-shaped hole.

[0048] Specifically, the rotation paths of the light-transmitting parts 6 that are not on the same concentric circle do not coincide. Each light-transmitting part 6 on the turntable 51 can only coincide with its corresponding detection channel 41. When one of the light-transmitting parts 6 does not coincide with its corresponding detection channel 41, the signal of the detection channel 41 is blocked by the turntable 51, and the detector will not collect the signal of the detection channel 41.

[0049] In other embodiments, the turntable 51 includes a first region configured as a light-transmitting portion 6 and a second region circumferentially disposed in the light-transmitting portion 6, wherein the first region is made of a transparent material and the second region is made of a transparent material.

[0050] In other embodiments, the turntable 51 is made of transparent material. Some areas of the transparent material are coated or blackened so that light cannot pass through the treated areas, while the untreated areas form the light-transmitting parts 6 mentioned above, which can transmit light.

[0051] In one embodiment, the detection channel 41 and its corresponding arc-shaped hole have an included angle α with the center A of the turntable 51. The included angle α is the angle of rotation when each arc-shaped hole is connected to its corresponding detection channel 41 and then switched to an adjacent arc-shaped hole connected to its corresponding detection channel 41.

[0052] In one embodiment, the angle that each detection channel 41 needs to rotate when switching is the included angle α = 360° / the total number of detection channels 41.

[0053] In one embodiment, the angle required for each light-transmitting part 6 to rotate to coincide with or separate from the detection channel 41 is less than or equal to the angle required for switching of the adjacent detection channel 41, so as to ensure that the detection channels 41 do not interfere with each other when detecting signals.

[0054] For example, in one embodiment, there are 8 light-transmitting parts 6 and 8 detection channels 41. The light-transmitting parts 6 include a first light-transmitting part 6 to an eighth light-transmitting part 6, and the detection channels 41 include a first detection channel 41 to an eighth detection channel 41.

[0055] When the included angle α is 45°, and the first light-transmitting part 6 coincides with the first detection channel 41, the second light-transmitting part 6 needs to rotate the turntable 51 counterclockwise by 45° to coincide with the second detection channel 41, the third light-transmitting part 6 needs to rotate the turntable 51 counterclockwise by 90° to coincide with the third detection channel 41, and so on. The eighth light-transmitting part 6 needs to rotate the turntable 51 counterclockwise by 315° to coincide with the eighth detection channel 41. That is, every time the turntable 51 rotates counterclockwise by 45°, the connection sequence of a certain detection channel 41 can be switched to the connection of the next detection channel 41. The turntable 51 can detect the signals of all 8 detection channels 41 by rotating counterclockwise one full circle, which is 360°.

[0056] In one embodiment, the drive motor 8 is connected to the main control system of the optical detection system. The main control system is used to control the number of driving steps of the drive motor 8 to achieve the rotation of the above-mentioned angle. Specifically, in one embodiment, the number of single rotation steps of the drive motor 8 is controlled to be 1.5°, that is, controlling the drive motor 8 to move 30 steps can achieve the rotation of the turntable 51 by 45°.

[0057] In other embodiments, there may be 16 light-transmitting parts 6 and 8 detection channels 41. Two light-transmitting parts 6 are arranged on a concentric circle. Each light-transmitting part 6 needs to rotate 22.5 degrees when switching, that is, the included angle α is 22.5°. Therefore, when the turntable 51 rotates for one detection cycle, each detection channel 41 is sampled twice.

[0058] In one embodiment, the first end and the last end of the light-transmitting part 6 are at an angle β with the center A of the turntable 51, wherein the angle β is 0° < A ≤ 30°.

[0059] When the included angle β is 30°, that is, when the turntable 51 rotates 30°, the light-transmitting part 6 on the turntable 51 can complete the process from the first end of the light-transmitting part 6 just coinciding with the detection channel 41 to the last end of the light-transmitting part 6 just separating from the detection channel 41.

[0060] The aforementioned included angle β and the rotational speed of the turntable 51 can jointly determine the maximum signal acquisition time of each detection channel 41.

[0061] For example, in one embodiment, when there are 8 light-transmitting parts 6 and 8 detection channels 41, the angle β between the head end and tail end of the light-transmitting part 6 and the center A of the turntable 51 is 30°, the rotation speed of the turntable 51 is 30 rpm / s, and it takes 2.778 μs for the turntable 51 to rotate 30° so that the head end of the light-transmitting part 6 just coincides with the detection channel 41 and the tail end of the light-transmitting part 6 just separates from the detection channel 41. Then, the maximum signal acquisition time for each detection channel 41 in each detection cycle is 2.778 μs.

[0062] This embodiment of the application can increase the number of light-transmitting parts 6 and reduce the rotation angle of the turntable 51 when switching between each detection channel 41, thereby increasing the number of acquisition cycles per revolution. By reasonably arranging the position of the light-transmitting parts 6 on the turntable 51, the acquisition frequency of each detection channel 41 can be increased without changing the rotation speed of the turntable 51.

[0063] like Figure 3 As shown, in one embodiment, the line connecting the axes of the plurality of detection channels 41 is a first line L1, and the center A of the turntable 51 is offset from the first line L1.

[0064] In one embodiment, the detection channels 41 of this application are on the same height plane, and the connecting line between the axes of each detection channel 41 is the first line L1 mentioned above.

[0065] In one embodiment, the center line of the line connecting the axes of the plurality of detection channels 41 is the second line L2, and the second line L2 does not coincide with the center A of the turntable 51.

[0066] A third line L3 is formed by drawing a perpendicular line from the center A of turntable 51 to the first line L1, connecting the first line L1 and the center A of turntable 51. The second line L2 and the third line L3 are spaced apart and are arranged in parallel.

[0067] By setting the first line L1, the second line L2, and the third line L3, the center A of the turntable 51 can be offset from the axis of the detection channel 41. In this embodiment, the eccentric setting combined with the asymmetrical setting of the light-transmitting part 6 enables the turntable 51 to collect signals from all channels in a single rotation. Compared with the turntable 51 in the prior art that uses symmetrical through holes, the volume of the turntable 51 can be reduced, saving costs and installation space.

[0068] In one embodiment, such as Figure 1 As shown, the detection device 4 also includes an emission component 43, which is disposed on the side of the detection channel 41 near the adjustment device 2, and is used to filter and couple the fluorescence.

[0069] The emitting component 43 may include an emitting filter 431 and an optical fiber coupling lens 432 arranged sequentially along the optical path of fluorescence formation, for filtering out excitation light and stray light mixed in by reflection or scattering in the fluorescence.

[0070] The detection channel switching device 5 is disposed between the emission component 43 and the detection channel 41. By rotating the detection channel switching device 5, the light-transmitting part 6 is made to overlap or separate from the detection channel 41, so as to switch the light-transmitting part 6 through which the fluorescence passes, thereby switching the transmission of fluorescence signals of different detection channels 41.

[0071] In another embodiment, the optical detection system further includes a processing device 9, which is disposed between the excitation device 1 and the adjustment device 2 and close to the excitation device 1, for collimating and shaping the excitation light.

[0072] The detection channel switching device 5 is located between the excitation device 1 and the processing device 9. When the detection channel switching device 5 rotates, the excitation light is adjusted to pass through the light-transmitting part 6 at different positions, and then processed by the processing device 9 before reaching the adjustment device 2. The light is reflected by the adjustment device 2 and reacted in the capillary separation channel switching device 3 to generate fluorescence. Since the position of the excitation light emission is different, the position of the fluorescence emission is also different, so it can reach different detection channels 41. In this way, the position of the light path formed by the fluorescence is switched after the light-transmitting part 6 through which the excitation light passes is switched, thereby switching the transmission of fluorescence signals of different detection channels 41.

[0073] In one embodiment, the processing device 9 includes a first collimating lens 91, a beam shaper 92, and an excitation filter 93 arranged sequentially along the emission direction of the excitation light. After passing through the first collimating lens 91 and the beam shaper 92, the excitation light reaches the excitation filter 93. Stray light in the excitation light that does not conform to the excitation wavelength cannot pass through the filter. By setting the excitation filter 93, the excitation wavelength of the nucleic acid dye can be accurately matched, avoiding the excitation of other excitation light substances and improving the accuracy of detection.

[0074] The detection channel switching device 5 is used to switch the fluorescence emission path before the adjustment device 2 performs fluorescence transmission, thereby switching the detection channel 41 through which the fluorescence passes.

[0075] In one embodiment, the detection channel switching device 5 is disposed between the capillary separation channel device 3 and the adjustment device 2 to switch the position of the light-transmitting part 6 through which the fluorescence is emitted, thereby switching the transmission of fluorescence signals from different detection channels 41.

[0076] In one embodiment, the capillary separation channel device 3 includes a capillary 31, a capillary fixing lens 32, and a second collimating lens 33 arranged in sequence. When the excitation light is reflected by the adjustment device 2 to the second collimating lens 33, it is focused by the second collimating lens 33. The focused excitation light is focused again when it passes through the capillary fixing lens 32 and is focused in the capillary 31.

[0077] While the excitation device 1 is operating, a high voltage is applied to both ends of the detection area of ​​the capillary 31. The analyte, which has been pre-injected into one end of the capillary 31, begins electrophoretic separation and moves along the interior of the capillary 31 towards the other end. When the analyte moves to the area of ​​the capillary 31 irradiated by the excitation light, it is excited to emit fluorescence. The fluorescence passes through the capillary fixing lens 32 and the collimator diameter and then enters the detection channel 41.

[0078] In one embodiment, the adjustment device 2 is a dichroic mirror used to reflect the excitation light to the aforementioned second collimating mirror 33.

[0079] In one embodiment, the dichroic mirror is set at an angle to the plane of the capillary 31, wherein the dichroic mirror and the plane of the capillary 31 can be set at 45°.

[0080] In one embodiment, the detector is connected to the detection channel 41 to directly receive the fluorescence transmitted by the detection channel 41.

[0081] In another embodiment, such as Figure 2 As shown, the detection device 4 also includes an emitting optical fiber 42, which is connected between the detection channel 41 and the detector, and is set up in a one-to-one correspondence with the detection channel 41 and the detector. Fluorescence can be transmitted to the detector through the emitting optical fiber 42.

[0082] See Figure 4 In one embodiment, the optical detection system further includes a zero-position sensor 7, which is connected to the main control system of the optical detection system. The zero-position sensor 7 is used to detect the situation where the turntable 51 rotates 360° each time, that is, to detect the periodic rotation of the turntable 51, and to transmit the detected rotation situation to the main control system.

[0083] Specifically, a zero-position baffle 52 is provided on the turntable 51, and a detection module 71 is provided on the zero-position sensor. The zero-position baffle 52 starts to rotate when it approaches the initial position of the detection module 71. When the zero-position baffle 52 returns to the position close to the detection module 71 after rotating with the turntable 51, that is, the turntable 51 has rotated one revolution. The zero-position sensor transmits the detected rotation of the turntable 51 for each revolution to the main control system in real time.

[0084] In one embodiment, the zero-position baffle 52 can be integrally formed with the turntable 51.

[0085] In another embodiment, the zero-position baffle 52 can be a separate structure connected to the turntable 51.

[0086] This application also provides an optical inspection device, including the optical inspection system provided in the above embodiments.

[0087] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "setup" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0088] It should be noted that, where there is no conflict, the features in the embodiments of this application can be combined with each other.

[0089] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. An optical detection system, characterized in that, include: Excitation device, used to emit excitation light; An adjustment device, provided corresponding to the excitation device, is used to adjust the direction of the excitation light; A capillary separation channel device is disposed near the adjustment device to receive the excitation light after the direction is adjusted, and emits fluorescence after a fluorescence reaction; A detection device is disposed on the side of the adjustment device away from the capillary separation channel device. The detection device includes multiple interconnected detection channels and multiple sets of detectors. The fluorescence passes through the multiple detection channels and enters the multiple sets of detectors. The multiple sets of detectors are used to detect the fluorescence and generate fluorescence information. The detection channel switching device is rotatably disposed at any position in the optical path formed by the excitation light and the fluorescence. The detection channel switching device is provided with multiple light-transmitting parts for the excitation light or the fluorescence to pass through. Each of the detection channels corresponds to one or more of the light-transmitting parts, and the detection channel switching device is used to close the connection between other detection channels and other light-transmitting parts when any of the detection channels is connected to the corresponding light-transmitting part.

2. The optical detection system according to claim 1, characterized in that, The detection channel switching device is a turntable, which can be a circular turntable or a polygonal turntable.

3. The optical detection system according to claim 2, characterized in that, The turntable is made of an opaque material, and the light-transmitting part is a through hole.

4. The optical detection system according to claim 2, characterized in that, The turntable is made of an opaque material, and the light-transmitting part is an arc-shaped hole. Multiple concentric circles corresponding to the detection channel are formed on the turntable as it rotates, and each of the multiple concentric circles is provided with at least one arc-shaped hole.

5. The optical detection system according to claim 4, characterized in that, The detection channel and its corresponding arc-shaped hole have an angle with the center of the turntable. The angle is the angle of rotation when each arc-shaped hole connects to its corresponding detection channel and then switches to an adjacent arc-shaped hole connecting to its corresponding detection channel.

6. The optical detection system according to claim 2, characterized in that, The turntable includes a first region configured as a light-transmitting part and a second region circumferentially disposed in the light-transmitting part. The first region is made of transparent material, and the second region is made of opaque material.

7. The optical detection system according to claim 2, characterized in that, The first and last ends of the light-transmitting part are at an angle β with the center of the turntable, wherein the angle is 0° < β ≤ 30°.

8. The optical detection system according to claim 2, characterized in that, The line connecting the axes of the multiple detection channels is the first line, and the center of the turntable is offset from the first line.

9. The optical detection system according to claim 1, characterized in that, The detection device further includes an emission component, which is disposed on the side of the detection channel near the adjustment device, for filtering and coupling the fluorescence.

10. The optical detection system according to claim 9, characterized in that, The detection channel switching device is located between the transmitting component and the detection channel.

11. The optical detection system according to claim 1, characterized in that, The optical detection system further includes a processing device, which is disposed between the excitation device and the adjustment device and close to the excitation device, for collimating and shaping the excitation light.

12. The optical detection system according to claim 11, characterized in that, The detection channel switching device is located between the excitation device and the processing device.

13. The optical detection system according to claim 1, characterized in that, The detection channel switching device is located between the capillary separation channel device and the adjustment device.

14. An optical inspection device, characterized in that, Includes the optical inspection system according to any one of claims 1-13.

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