Rodent nasal mucosa tissue sampling device
By designing a device for obtaining nasal mucosal tissue from rodents, and utilizing structures such as a fixation plate, a head container, and a ruler, the problems of tissue integrity and cutting stability were solved, thus achieving both accurate tissue collection and ease of pathological diagnosis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI QIANYA JINGZHI BIOTECHNOLOGY CO LTD
- Filing Date
- 2024-12-31
- Publication Date
- 2026-06-09
AI Technical Summary
Existing rodent nasal mucosa tissue sampling devices suffer from problems such as low sample integrity, low cutting stability, and high device complexity, which affect the accuracy of pathological diagnosis.
A device for obtaining nasal mucosal tissue from rodents was designed, including a fixing plate, a head receiver, a slot insertion port, and a ruler. The animal's head is fixed by the fixing slot, a cutting blade is used to cut through the slot, and the cutting distance is measured using the ruler, ensuring the accuracy of the tissue collection and simplifying the operation process.
It improves the integrity and accuracy of sample collection, simplifies the operation process, avoids problems of non-standard operation due to insufficient training or limited technical level, and ensures the accuracy of pathological diagnosis.
Smart Images
Figure CN224330970U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the technical field of nasal tissue pathological specimen collection in rodents, and in particular to a device for collecting nasal mucosal tissue from rodents. Background Technology
[0002] Laboratory animal pathological sampling is a crucial step in the pathological diagnosis process. It involves obtaining diseased tissue or cell samples from dissected animals for subsequent pathological examination and analysis. Specifically, pathological sampling requires technicians to cut representative tissue blocks or cell samples from the animal according to the protocol and the characteristics of the lesion. These samples will be used to prepare pathological sections, perform staining, and conduct other pathological tests to clarify the diagnosis, determine the nature of the lesion, ascertain the success of the animal model, and assess the toxicity of the test substance or the mechanism of action of the drug in the animal.
[0003] Nasal mucosal tissue sampling devices for rodents (such as mice and rats) are commonly used to study the physiological and pathological changes of the nasal mucosa or for drug delivery research. To obtain nasal mucosal tissue, the device needs specific design features to ensure accurate and efficient tissue collection with minimal harm to the animal. Rodent nasal mucosal tissue sampling devices need to be designed with a compact size to fit the animal's nasal cavity structure without causing excessive trauma. The device should possess good operational stability and controllability to ensure precise positioning of the target area of the nasal mucosa for sampling, without deviation or excessive intrusion.
[0004] Existing rodent nasal mucosal tissue sampling devices have the following technical problems: 1. Integrity of the sample: The nose mainly contains nasal mucosa tissue, which is relatively fragile and easily damaged during sampling. This requires operators to have a high degree of skill and patience to ensure the integrity and representativeness of the sampled tissue. 2. Stability of cutting: During the cutting process, if a cutting knife is used directly by hand, a stable cut cannot be guaranteed. In addition, the skull is hard and may collide with the cutting knife, posing a danger to personnel. 3. Complexity of the sampling device: Due to insufficient personnel training or limited technical level, if the sampling device is too complex, it may lead to problems of non-standard and imprecise operation during pathological sampling, affecting the quality of the sample and thus the accuracy of pathological diagnosis. Utility Model Content
[0005] (a) Technical problems to be solved
[0006] To address the aforementioned problems, this utility model provides a device for collecting nasal mucosa tissue from rodents, particularly a device for collecting nasal mucosa tissue from rodents. The purpose is to solve the problems of low tissue integrity, low cutting stability, and complex collection devices in current rodent nasal mucosa tissue collection devices.
[0007] (II) Technical Solution
[0008] To solve the aforementioned technical problem, this utility model provides a rodent nasal mucosa tissue sampling device, including a fixing plate. A first fixing slot and a second fixing slot are respectively provided on one side of the fixing plate. A head receiver is provided on the fixing plate. The head receiver is respectively provided with a first slot insertion port, a second slot insertion port and a cutting blade slot. A scale is provided on one side of the head receiver.
[0009] Furthermore, the cutting blade slots are provided in multiple ways, and the multiple cutting blade slots are arranged in parallel.
[0010] Furthermore, the first card slot insertion port and the second card slot insertion port are located on both sides of the plurality of cutting blade card slots.
[0011] Furthermore, the scale is located on one side of the plurality of cutting blade slots.
[0012] Furthermore, the second card slot insertion port is located between the second fixed card slot and the scale.
[0013] Furthermore, the head receiver is located between the first fixing slot and the scale.
[0014] Furthermore, an irregular arc groove is provided in the first fixing slot.
[0015] Furthermore, the first card slot insertion port is located between the first fixed card slot and the scale.
[0016] Beneficial effects
[0017] 1. The rodent nasal mucosa tissue sampling device provided by this utility model includes a fixing plate, a first fixing slot and a second fixing slot respectively provided on one side of the fixing plate, a head receiver provided on the fixing plate, and a first slot insertion port, a second slot insertion port and a cutting blade slot respectively provided on the head receiver, and a scale provided on one side of the head receiver; the rodent nasal mucosa tissue sampling device has a simple overall structure, is easy to install and use, and facilitates the sampling of rodent nasal mucosa tissue by workers.
[0018] 2. The rodent nasal mucosa tissue sampling device provided by this utility model fixes the head of the rodent to be sampled in a head container, and uses the cutting blade slot on the head container to cut the rodent's head tissue. Since the head container is provided with a first slot insertion port and a second slot insertion port, the position between the first slot insertion port and the second slot insertion port can be adjusted according to the size of the rodent's head to be cut, and the cutting distance between the cutting blade slots can be adjusted as needed.
[0019] 3. The rodent nasal mucosa tissue sampling device provided by this utility model has a scale for measuring distance on the base plate. The scale has multiple graduation grooves, which allows for accurate cutting of the rodent's head tissue by measuring its position, thus improving the accuracy of nasal mucosa tissue sampling. Furthermore, the device's simple and reasonable design avoids the problems of non-standard and imprecise operation during pathological sampling caused by insufficient personnel training or limited technical skills, or by complex sampling devices. This prevents affecting the quality of the required samples and helps ensure the accuracy of pathological diagnoses. Attached Figure Description
[0020] Fig. 1 This is a simplified structural diagram of the rodent nasal mucosa tissue sampling device of this utility model;
[0021] Fig. 2 This is a scale structure diagram of the rodent nasal mucosa tissue sampling device of this utility model.
[0022] The component names corresponding to the various attached figures are: 1. Fixing plate; 2. Head receiver; 3. First slot insertion port; 4. Cutting blade slot; 5. First fixing slot; 6. Second fixing slot; 7. Ruler; 8. Second slot insertion port. Detailed Implementation
[0023] The present application will now be described in detail with reference to the accompanying drawings and specific embodiments.
[0024] The following specific examples illustrate the implementation of this application. Those skilled in the art can easily understand other advantages and effects of this application from the content disclosed in this specification. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. This application can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of this application. It should be noted that, in the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0025] It should be noted that various aspects of embodiments within the scope of the appended claims are described below. It will be apparent that the aspects described herein can be embodied in a wide variety of forms, and any particular structure and / or function described herein is merely illustrative. Based on this application, those skilled in the art will understand that one aspect described herein can be implemented independently of any other aspect, and two or more of these aspects can be combined in various ways. For example, any number and aspects set forth herein can be used to implement the device and / or practice the method. Additionally, this device and / or method can be implemented using structures and / or functionalities other than one or more of the aspects set forth herein.
[0026] It should also be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of this application. The drawings only show the components related to this application and are not drawn according to the actual number, shape and size of the components in the actual implementation. In the actual implementation, the form, quantity and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex.
[0027] Additionally, specific details are provided in the following description to facilitate a thorough understanding of the examples. However, those skilled in the art will understand that practice can be carried out without these specific details.
[0028] The technical solutions provided by the various embodiments of this application are described below with reference to the accompanying drawings.
[0029] See Figs. 1-2 This utility model provides a device for obtaining nasal mucosal tissue from rodents. To make the practical purpose, technical solution and advantages of this utility model clearer, the specific operation process of this utility model will be described in detail below with reference to the accompanying drawings and the working process of this device.
[0030] This utility model provides a device for obtaining nasal mucosal tissue from rodents, including a fixing plate 1. A first fixing slot 5 and a second fixing slot 6 are respectively provided on one side of the fixing plate 1. A head container 2 is provided on the fixing plate 1. A first slot insertion port 3, a second slot insertion port 8 and a cutting blade slot 4 are respectively provided on the head container 2. A scale 7 is provided on one side of the head container 2.
[0031] See Figs. 1-2 Multiple cutting blade slots 4 are provided, and the multiple cutting blade slots 4 are arranged in parallel. The first slot insertion port 3 and the second slot insertion port 8 are located on both sides of the multiple cutting blade slots 4. The scale 7 is located on one side of the multiple cutting blade slots 4. The second slot insertion port 8 is located between the second fixed slot 6 and the scale 7. The head receiver 2 is located between the first fixed slot 5 and the scale 7. The first fixed slot 5 is provided with an irregular arc groove. The first slot insertion port 3 is located between the first fixed slot 5 and the scale 7.
[0032] The working principle and specific workflow of the rodent nasal mucosa tissue sampling device are as follows:
[0033] According to the overall structural design of the rodent nasal mucosa tissue sampling device, the first fixing slot 5 and the second fixing slot 6 are placed on both sides of the fixing plate 1 respectively, and the distance between the first fixing slot 5 and the second fixing slot 6 is adjusted according to actual needs. The first slot insertion port 3 and the second slot insertion port 8 are installed at the head receiver 2 on the fixing plate 1. Then, the cutting blade slot 4 is installed between the first slot insertion port 3 and the second slot insertion port 8 in sequence. The ruler 7 is placed horizontally on one side of the cutting blade slot 4. After installation is completed;
[0034] The head of the rodent from which nasal mucosa tissue needs to be extracted is placed on the head container 2 of the sampling device and fixed with the first slot insertion port 3 and the second slot insertion port 8. The rodent head tissue is cut with the cutting blade slot 4 according to the sampling needs.
[0035] Because a ruler 7 for measuring distance is provided on the fixed plate 1, and the ruler 7 has multiple graduated grooves, the position of the rodent's head tissue can be measured by the ruler 7, which facilitates accurate cutting and thus helps improve the accuracy of nasal mucosal tissue sampling from rodents. In addition, because the rodent nasal mucosal tissue sampling device is simple and reasonable in design, it avoids the problems of non-standard and imprecise operation during pathological sampling caused by insufficient personnel training or limited technical level and complex sampling devices, thus avoiding affecting the quality of the required samples and helping to ensure the accuracy of pathological diagnosis by staff.
[0036] After cutting, the nasal mucosa tissue of the rodent is sampled and processed. After sampling, the nasal mucosa tissue sampling device of the rodent is cleaned.
[0037] The same or similar parts between the various embodiments in this specification can be referred to mutually. Each embodiment focuses on describing the differences from other embodiments.
[0038] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.
Claims
1. A device for obtaining nasal mucosal tissue from rodents, characterized in that: Includes a fixing plate (1), on one side of the fixing plate (1) are respectively provided a first fixing slot (5) and a second fixing slot (6), on the fixing plate (1) are provided a head receiver (2), on the head receiver (2) are respectively provided a first slot insertion port (3), a second slot insertion port (8) and a cutting blade slot (4), and on one side of the head receiver (2) are provided a scale (7).
2. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The cutting blade slots (4) are provided in multiple ways, and the multiple cutting blade slots (4) are arranged in parallel.
3. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The first slot insertion port (3) and the second slot insertion port (8) are located on both sides of the plurality of cutting blade slots (4).
4. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The scale (7) is located on one side of the plurality of cutting blade slots (4).
5. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The second card slot insertion port (8) is located between the second fixed card slot (6) and the scale (7).
6. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The head receiver (2) is located between the first fixing slot (5) and the scale (7).
7. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The first fixing slot (5) is provided with an arc groove.
8. The rodent nasal mucosa tissue sampling device according to claim 1, characterized in that: The first card slot insertion port (3) is located between the first fixed card slot (5) and the scale (7).