An aerosol actuator having a drying function

Abstract

The utility model discloses an aerosol driver with drying function relates to the method for isolating and / or drying medicine delivery channel in medicine delivery instrument, including shell, drier and protective cover, the shell has the sealing structure in, and sealing structure divides the shell inside portion and is used for installing aerosol jar's containing cavity and is used for delivering medicine's delivery cavity, and the shell still is equipped with the nozzle that is connected with the discharge port of aerosol jar on ration valve stem, and the spray hole of nozzle communicates with delivery cavity, and sealing structure has the installation port that is sealed with nozzle cooperation on, still have the suction nozzle that communicates with delivery cavity on the shell, the drier is used for drying delivery cavity, nozzle, aerosol jar on ration valve stem, the protective cover is used for opening or closing delivery cavity, and drier is installed in protective cover or delivery cavity. The utility model can solve the moisture problem from the root, ensure that medicine delivery channel and suction nozzle inhale inner cavity always keep dry state.

Description

Technical Field

[0001] This invention relates to a method for isolating and / or drying a drug delivery channel in a drug delivery instrument, and more specifically, to an aerosol driver with a drying function. Background Technology

[0002] Metered-dose inhaled nebulizers (MDIs) are formulations that deliver medication to the lungs via the respiratory tract by atomizing the liquid into uniform droplets through a delivery device. During administration, the patient's exhaled breath and the moisture in the air wet the residual aerosol powder inside the nozzle and valve stem, causing it to adhere to the inner walls of the valve stem and nozzle orifice. With repeated use and prolonged contact with humid air, this can narrow the drug delivery channel, and in severe cases, even cause blockage. To address this technical problem, utility model patent application number 201880079337.2 discloses a drug delivery system and related methods with drying and sealing functions. However, after detailed research, this invention found that its structural design is still imperfect. The provided drug delivery system still faces the problem of significant changes in spray pattern after prolonged use, thus affecting the uniformity of the delivered dose and effective lung deposition, reducing clinical treatment efficacy.

[0003] In view of this, it is indeed necessary to improve the nebulizers of existing metered-dose inhaled nebulizers (MDI) to solve the aforementioned problems. Utility Model Content

[0004] The purpose of this invention is to provide an aerosol driver with a drying function, which can solve the moisture problem at its source, ensuring that the drug delivery channel and the inhalation cavity of the mouthpiece are always kept dry. This eliminates the problems caused by moisture in the air and moisture caused by the patient's exhalation during use, effectively reducing the water vapor content in the drug delivery channel and the inhalation cavity of the mouthpiece, thereby reducing the potential risks caused by the growth of impurities and bacteria due to water vapor accumulation, and providing patients with a safer and more efficient treatment experience.

[0005] To achieve the objective of this utility model, the technical solution adopted is: an aerosol driver with a drying function, comprising:

[0006] The outer casing has a sealing structure that divides the interior of the casing into a receiving cavity for mounting the aerosol can and a delivery cavity for delivering the drug. The casing also houses a nozzle connected to the outlet of the metering valve stem on the aerosol can. The nozzle's nozzle orifice communicates with the delivery cavity. The sealing structure has an installation port that seals with the nozzle. The casing also has a suction nozzle that communicates with the delivery cavity.

[0007] Desiccant, the desiccant being used to dry the delivery chamber, nozzle, and metering valve stem on the aerosol can;

[0008] A protective cover is provided for opening or closing the delivery chamber, and a desiccant is installed inside the protective cover or the delivery chamber.

[0009] Furthermore, the protective cover is also provided with limiting ribs for compressing the desiccant.

[0010] Furthermore, the protective cover has a cavity inside, a desiccant is installed inside the cavity, and a limiting rib is installed inside the opening end of the cavity.

[0011] Furthermore, an annular channel is formed between the periphery of the desiccant and the inner wall of the cavity.

[0012] Furthermore, a drying shell is installed inside the delivery cavity, and a desiccant is installed inside the drying shell, with a through hole on the side of the drying shell for the desiccant to be released.

[0013] Furthermore, the desiccant is in granular, powdery, or block form.

[0014] Furthermore, the desiccant is installed inside the delivery chamber.

[0015] Furthermore, the sealing structure includes a fixed plate fixed inside the housing and a sealing plate that can be close to or away from the fixed plate. When the protective cover is on, the sealing plate and the fixed plate are sealed and fitted together, and the mounting port on the sealing plate is slidably sealed and fitted with the nozzle.

[0016] Furthermore, the sealing plate also has a fixing frame that extends through the fixing plate into the delivery cavity. The protective cover and the fixing frame are both provided with a plug-in structure, which allows the sealing plate to be pulled into contact with the fixing plate while the protective cover is being closed.

[0017] Furthermore, the plug-in structure includes a push hole disposed on the fixed frame and a push arm disposed on the sealing plate, wherein the wall of the push hole has a wedge-shaped surface that mates with the push arm.

[0018] Furthermore, the extended end of the fixed frame also has a limiting buckle A, and the delivery cavity also has a limiting buckle B that engages with the limiting buckle A, and the limiting buckle A can slide on the limiting buckle B along the movement direction of the sealing plate.

[0019] Furthermore, the limiting buckle A consists of two locking hooks arranged opposite each other, and the limiting buckle B is T-shaped, with the two locking hooks in the limiting buckle A respectively hooked on both sides of the limiting buckle B.

[0020] Furthermore, a spring is also installed between the fixing plate and the sealing plate.

[0021] Furthermore, the fixing plate or / and sealing plate is also provided with a spring mounting hole, and the end of the spring is installed in the spring hole.

[0022] Furthermore, the fixing plate is also provided with a positioning post, and the sealing plate is also provided with a sliding hole that slides with the positioning post.

[0023] Furthermore, a sealing ring is also provided on the mating surface of the sealing plate or the mating surface of the fixing plate.

[0024] The beneficial effects of this utility model are:

[0025] 1. In this invention, a sealing structure is provided inside the outer shell to separate the delivery chamber from the receiving chamber. When the protective cap is placed on the nozzle, the delivery chamber is sealed, and the desiccant is installed inside the protective cap or the delivery chamber. When not in use by the patient, the desiccant in either the delivery chamber or the protective cap can dry the entire delivery chamber. Since the valve stem and nozzle on the aerosol can are located within the delivery chamber, the desiccant in either the protective cap or the delivery chamber can dry the valve stem and nozzle, thus solving the moisture problem at its source. This ensures that the drug delivery channel and the suction cavity of the nozzle remain dry at all times, preventing the aforementioned problems caused by air humidity and patient exhalation. The actuator provided by this invention, after 30 days of use with three API drugs, showed a median particle size change of less than 0.2 μm in MMAD, and the spray area decreased to 0.5 cm from 3 cm at the nozzle outlet. 2 The spray angle of the actuator drops by less than 3° at 5.3cm and 8.3cm from the nozzle outlet, which significantly improves the stability of the actuator provided by the present invention in terms of atomization effect, spray area and spray angle.

[0026] 2. Effectively reduces the water vapor content in the channel, thereby reducing the potential risks caused by the accumulation of water vapor and the growth of impurities and bacteria, providing patients with a safer and more efficient treatment experience.

[0027] 3. The driver provided by this utility model has a simpler structural component design. While meeting the requirements for preventing scaling of the nozzle and spray hole caused by moisture in the driver, it has fewer parts and lower cost during mass production, which can significantly reduce the production cost of the product. At the same time, because the driver provided by this utility model has simpler components, it is easier to assemble, thus greatly improving the assembly efficiency. Attached Figure Description

[0028] The accompanying drawings illustrate exemplary embodiments of the present invention and, together with the description thereof, serve to explain the principles of the present invention. These drawings are included to provide a further understanding of the present invention and are incorporated in and constitute a part of this specification.

[0029] Figure 1 This is an exploded view of the aerosol driver with drying function in Example 1;

[0030] Figure 2 This is a structural diagram of the protective cover in Example 1;

[0031] Figure 3 This is a schematic diagram of the desiccant installation in Example 1;

[0032] Figure 4 This is a diagram showing the arrangement of the nozzles in Example 1;

[0033] Figure 5 This is a diagram showing the arrangement of the fixing plate in Example 1;

[0034] Figure 6 This is a diagram showing the arrangement of the sealing plates in Example 1;

[0035] Figure 7 This is a structural diagram of the sealing plate in Example 1;

[0036] Figure 8 This is a diagram showing the engagement of limit buckle A and limit buckle B in Example 1;

[0037] Figure 9 This is a structural diagram of the desiccant installed inside the protective cover in Example 1;

[0038] Figure 10 This is a schematic diagram of the aerosol driver with drying function in Example 1 when the protective cover is not in place;

[0039] Figure 11 This is a schematic diagram of the protective cover being installed in the aerosol driver with drying function in Example 1;

[0040] Figure 12 This is a CT image of the control driver before spraying, provided in Example 1;

[0041] Figure 13 This is a CT scan of the control driver 20 days after spraying, as provided in Example 1;

[0042] Figure 14 This is a CT image of the aerosol driver with drying function before spraying in Example 1;

[0043] Figure 15 This is a CT scan of the aerosol driver with drying function in Example 1 20 days after spraying;

[0044] Figure 16 This is an exploded view of the aerosol driver with drying function in Example 2;

[0045] Figure 17This is a structural diagram of the protective cover in Example 2;

[0046] Figure 18 This is a schematic diagram of the desiccant installation in Example 2;

[0047] Figure 19 This is a diagram showing the nozzle arrangement in Example 2;

[0048] Figure 20 This is a diagram showing the arrangement of the fixing plate in Example 2;

[0049] Figure 21 This is a diagram showing the arrangement of the sealing plates in Example 2;

[0050] Figure 22 This is a structural diagram of the sealing plate in Example 2;

[0051] Figure 23 This is a diagram showing the engagement of limit buckle A and limit buckle B in Example 2;

[0052] Figure 24 This is a schematic diagram of the aerosol driver with drying function in Example 2 when the protective cover is not in place;

[0053] Figure 25 This is a schematic diagram of the protective cover being installed in the aerosol driver with drying function in Example 2;

[0054] Figure 26 This is a CT image of the aerosol driver with drying function before spraying in Example 2;

[0055] Figure 27 This is a CT scan of the aerosol driver with drying function in Example 2 after 20 days of spraying;

[0056] Figure 28 This is an exploded view of the control driver provided in Example 2;

[0057] Figure 29 This is a structural diagram of the protective cover in Example 2;

[0058] Figure 30 This is a structural diagram of the cylindrical shell in Example 2;

[0059] Figure 31 This is a diagram showing the arrangement of the positioning ribs in the cylindrical shell in Example 2;

[0060] Figure 32 This is a structural diagram of the nozzle in Example 2;

[0061] Figure 33 This is a schematic diagram of the desiccant installation in Comparative Example 2;

[0062] Figure 34This is a schematic diagram of the structure in Comparative Example 2 where the desiccant is installed inside the protective cover;

[0063] Figure 35 This is a schematic diagram of the protective cover being installed in the control driver provided in Comparative Example 2;

[0064] Figure 36 This is a CT image of the control driver before spraying, provided in Comparative Example 2;

[0065] Figure 37 The image shown is a CT scan of the control driver 20 days after spraying, as provided in Example 2.

[0066] The attached diagram shows the markings and corresponding component names:

[0067] 1. Outer shell; 2. Protective cover; 3. Desiccant; 4. Cylindrical structure; 5. Drying outer shell; 6. Annular channel;

[0068] 100. Receiving cavity; 101. Delivery cavity; 102. Fixing plate; 103. Sealing plate; 104. Mounting port; 106. Fixing frame; 107. Pushing hole; 108. Wedge-shaped surface; 109. Limiting buckle A; 120. Limiting buckle B; 121. Spring; 122. Spring mounting hole; 123. Positioning pin; 124. Sliding hole; 125. Sealing ring; 126. Nozzle; 127. Suction nozzle; 128. Clearance port; 129. Opening.

[0069] 200. Cavity; 201. Push arm;

[0070] 400, limiting reinforcement;

[0071] 500, through hole;

[0072] 100', Circular boss;

[0073] 200' Semi-circular buckle, 201' Insertion interface, 202' Cylindrical shell, 204' Positioning rib, 205' Circular stepped surface, 206' Raised ridge, 207' Cross rib, 208' Annular soft rubber pad, 209' Circular boss. Detailed Implementation

[0074] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be noted that, for ease of description, only the parts relevant to the present invention are shown in the accompanying drawings.

[0075] It should be noted that, where there is no conflict, the embodiments and features described in these embodiments can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0076] Example 1

[0077] like Figures 1 to 11 As shown, this utility model provides an aerosol driver with a drying function, including a housing 1 and a protective cover 2. The housing 1 is generally L-shaped and has a sealing structure inside. The sealing structure is located at the corner inside the housing 1 and divides the interior of the housing 1 into a receiving cavity 100 and a delivery cavity 101. The receiving cavity 100 is used to install the aerosol can, and the delivery cavity 101 is used to deliver the sprayed medication into the patient's mouth. In this embodiment, the aerosol can itself has a metering valve, and the delivery cavity 101 has a nozzle 126. The nozzle 126 is inserted and engaged with the outlet of the metering valve stem on the aerosol can, and the nozzle orifice of the nozzle 126 communicates with the delivery cavity 101. Since the aerosol can is installed in the receiving cavity 100 and the nozzle 126 is installed in the delivery cavity 101, in order to ensure that the valve stem of the metering valve on the aerosol can can be inserted into the nozzle 126, the sealing structure also has an installation port 104 that seals with the nozzle 126. This ensures both the normal pressing of the aerosol can and the airtight isolation between the receiving cavity 100 and the delivery cavity 101.

[0078] In this embodiment, the installation height of the sealing structure within the housing 1 is lower than the upper end face of the nozzle 126. That is, the end of the nozzle 126 near the receiving cavity 100 extends into the receiving cavity 100 through the mounting port 104 on the sealing structure. Of course, in this embodiment, the installation height of the sealing structure within the housing 1 can also be higher than the nozzle 126. In this case, the mounting port 104 on the sealing structure needs to be sealed and fitted with the valve stem of the metering valve on the aerosol can.

[0079] The outer shell 1 also has a suction nozzle 127, which is an integral structure with the outer shell 1. The inside of the suction nozzle 127 is connected to the inside of the delivery chamber 101, which ensures that the patient's mouth can be placed on the suction nozzle 127 when the aerosol driver is in use, and also ensures that the drug sprayed through the nozzle 126 can enter the patient's oral cavity through the suction nozzle 127.

[0080] The aerosol driver also includes a protective cover 2 that is placed on the nozzle 127. After the protective cover 2 is placed on the nozzle 127, the delivery chamber 101 is closed, thus isolating the delivery chamber 101 from the outside world.

[0081] To ensure the dryness of the delivery cavity 101, such as Figure 3As shown, the protective cover 2 contains a desiccant 3. When the protective cover 2 is placed on the nozzle 127, the desiccant 3 inside the protective cover 2 can effectively dry the delivery chamber 101. Since the nozzle 126 is located inside the delivery chamber 101 and the metering valve stem on the aerosol can is inserted into the nozzle 126, the desiccant 3 can also dry the inside of the nozzle 126 and the metering valve stem on the aerosol can, which can solve the moisture problem from the root and ensure that the drug delivery channel and the suction chamber of the nozzle 127 are always kept dry.

[0082] In this embodiment, to facilitate the placement of the desiccant 3, such as Figure 2 As shown, the protective cover 2 also has a cavity 200. Specifically, a cylindrical structure 4 is set in the center of the protective cover 2. The inside of the cylindrical structure 4 is the cavity 200. The desiccant 3 is installed in the cavity 200 to ensure that the protective cover 2 can be installed and removed normally without damaging the desiccant 3.

[0083] To prevent desiccant 3 from falling out of the cavity 200, such as Figure 3 , Figure 9 As shown, the protective cover 2 is also provided with a limiting rib 400 that can press the desiccant 3 into the cavity 200. In this embodiment, the limiting rib 400 is cross-shaped and has a tube around the limiting rib 400 that can be inserted into the cylindrical structure 4. When the desiccant 3 is placed in the cavity 200, the tube is inserted into the cavity 200, so that the limiting rib 400 presses the desiccant 3.

[0084] In this embodiment, the limiting rib 400 can also be in the shape of a grid or a star shape. The limiting rib 400 can also press the desiccant 3 without relying on the insertion and connection between the tube and the cylindrical structure 4. Instead, the limiting rib 400 can be directly fastened to the cylindrical structure 4 around its perimeter, or the limiting rib 400 can be directly fastened to the circumferential surface of the protective cover 2 around its perimeter. That is, while ensuring that the limiting rib 400 can press the desiccant 3 into the cavity 200, the fixing of the limiting rib 400 can be adjusted as needed.

[0085] In addition, in this embodiment, by using the limiting rib 400 to press the desiccant 3, it is ensured that the desiccant 3 is pressed and fixed, and that the desiccant 3 can contact the delivery cavity 101 as much as possible, so as to ensure the drying effect of the delivery cavity 101.

[0086] In order to ensure that the desiccant 3 can contact the delivery cavity 101 as much as possible, such as Figure 3 As shown, after the desiccant 3 is installed in the cavity 200, there is a certain gap between the outer periphery of the desiccant 3 and the inner wall of the cavity 200, so that an annular channel 6 is formed between the outer periphery of the desiccant 3 and the inner wall of the cavity 200. After the desiccant 3 is placed in the cavity 200, the periphery of the desiccant 3 and the side of the desiccant 3 that is pressed by the limiting rib 400 can be fully released, so that the drying effect of the delivery cavity 101 is better.

[0087] When the side of the desiccant 3 pressed by the limiting rib 400 is sufficient to dry the delivery cavity 101, no gap is needed between the outer periphery of the desiccant 3 and the inner wall of the cavity 200. Alternatively, when the protective cover 2 is deep enough and the side of the desiccant 3 pressed by the limiting rib 400 is sufficient to dry the delivery cavity 101, a separate cavity 200 is not required inside the protective cover 2. In this case, the desiccant 3 can be directly placed at the bottom of the protective cover 2 and then pressed by the limiting rib 400. The inner wall of the protective cover 2 acts as a cylindrical structure 4, and the limiting rib 400 can be directly fastened or snapped onto the inner wall of the protective cover 2, thus achieving both the installation and compression of the desiccant 3.

[0088] In this embodiment, the desiccant 3 can be granular, powdered, or lumpy. When the desiccant 3 is granular or powdered, in order to prevent the desiccant 3 from scattering randomly, the desiccant 3 can be packaged in a mesh bag or breathable packaging bag first, and then the packaged desiccant 3 can be placed in the cavity 200.

[0089] To isolate the receiving cavity 100 and the delivery cavity 101, such as Figure 5 , Figure 6 , Figure 7 , Figure 10 , Figure 11 As shown, the sealing structure includes a fixing plate 102 integral with the outer shell 1, and a sealing plate 103 located above the fixing plate 102. The sealing plate 103 is located on the side of the fixing plate 102 near the receiving cavity 100, and the sealing plate 103 can be close to or away from the receiving cavity 101. When the sealing plate 103 is away from the fixing plate 102, the receiving cavity 100 and the delivery cavity 101 have a certain degree of communication. When the sealing plate 103 is in contact with the fixing plate 102, the receiving cavity 100 and the delivery cavity 101 are completely isolated. To ensure the dryness of the delivery cavity 101, when the protective cover 2 is placed on the suction nozzle 127, the sealing plate 103 is sealed and in contact with the fixing plate 102.

[0090] In this embodiment, since the fixed plate 102 is fixed in position inside the housing 1 and the height of the nozzle 126 is higher than the overall height of the sealing structure, the fixed plate 102 and the nozzle 126 can be designed as one piece. In this case, the mounting port 104 on the fixed plate 102 is seamlessly connected to the outer wall of the nozzle 126. Since the sealing plate 103 needs to be close to or far from the fixing plate 102, the mounting port 104 on the sealing plate 103 is designed to slide and seal with the outer wall of the nozzle 126. When the mounting port 104 on the sealing plate 103 and the outer wall of the nozzle 126 are in sliding and sealing fit, the nozzle 126 can be completely separated from the sealing plate 103 when the sealing plate 103 is at its farthest distance from the fixing plate 102, or the nozzle 126 can still be inserted into the mounting port 104 on the sealing plate 103. When the sealing plate 103 is at its farthest distance from the fixing plate 102, the nozzle 126 is completely separated from the sealing plate 103. In this case, in order to ensure that the nozzle 126 can be accurately inserted into the mounting port 104 on the sealing plate 103 when the sealing plate 103 is close to the fixing plate 102, a chamfer can be made at the end of the nozzle 126 near the sealing plate 103, so that the outer wall of the end of the nozzle 126 near the sealing plate 103 is conical.

[0091] When the fixing plate 102 and the sealing plate 103 cooperate to seal and separate the receiving cavity 100 and the delivery cavity 101, it should be noted that when the fixing plate 102 and the sealing plate 103 are attached, they can cover the entire cross section of the outer shell 1. When this condition is met, and the fixing plate 102 is seamlessly connected to the inner wall of the outer shell 1 on all four sides, a certain gap can be maintained between the sealing plate 103 and the inner wall of the outer shell 1 on all four sides. However, when there is a certain gap between the fixing plate 102 and the inner wall of the outer shell 1, the position on the sealing plate 103 corresponding to the gap needs to maintain a sliding seal with the inner wall of the outer shell 1. Of course, regardless of whether there is a gap at the connection between the fixing plate 102 and the inner wall of the outer shell 1, the sealing plate 103 can slide and seal with the inner wall of the outer shell 1 on all four sides.

[0092] To ensure that the fixing plate 102 and the sealing plate 103 fit together when the protective cover 2 is put on, thereby keeping the delivery cavity 101 sealed, the side of the sealing plate 103 near the fixing plate 102 also has a fixing frame 106 extending into the delivery cavity 101, and the fixing plate 102 also has a clearance opening 128 for the fixing frame 106 to pass through; at the same time, the protective cover 2 and the fixing frame 106 are provided with a plug-in structure. When the protective cover 2 is put on the suction nozzle 127, the protective cover 2 and the fixing frame 106 are plugged in and engaged through the plug-in structure, and the fixing frame 106 is pulled at the same time as the plug-in engagement, thereby driving the sealing plate 103 to move toward the fixing plate 102, so that the sealing plate 103 and the fixing plate 102 are sealed and fitted together.

[0093] Furthermore, such as Figure 2 , Figure 7As shown, the insertion structure includes a push hole 107 on the fixed frame 106 and a push arm 201 on the sealing plate 103. The wall of the push hole 107 has a wedge-shaped surface 108. The height of the end of the wedge-shaped surface 108 near the push arm 201 is lower than the height of the end of the wedge-shaped surface 108 away from the push arm 201. When the protective cover 2 is placed on the suction nozzle 127, the push arm 201 is inserted into the push hole 107. As the protective cover 2 continues to be placed, the push arm 201 continues to be inserted. When the push arm 201 is inserted, it pushes the fixed frame 106 to move towards the delivery cavity 101, thereby pulling the sealing plate 103 closer to the fixed plate 102. When the protective cover 2 is completely closed, the insertion end of the push arm 201 is completely inserted into the push hole 107, and the sealing plate 103 and the fixed plate 102 are sealed and fitted together.

[0094] To ensure smoother movement of the sealing plate 103, two fixing frames 106 can be installed on the sealing plate 103. These two fixing frames 106 are symmetrically arranged along the center of the sealing plate 103, located on either side of the nozzle 126. Simultaneously, two pushing arms 201 are also installed on the protective cover 2, corresponding to the two fixing frames 106. When the protective cover 2 contains a cylindrical structure 4, the pushing arms 201 can be integrated with the cylindrical structure 4; alternatively, the pushing arms 201 can be installed separately on the outside of the cylindrical structure 4.

[0095] In this embodiment, to facilitate the insertion of the push arm 201 into the push hole 107 while simultaneously pushing the fixed frame 106 via the wedge-shaped surface 108, the insertion end of the push arm 201 can be configured as circular or arc-shaped. Alternatively, the insertion end of the push arm 201 can also be configured as an inclined surface that mates with the wedge-shaped surface 108 on the wall of the push hole 107. This design also enables the pushing of the fixed frame 106. That is, as long as the push arm 201 can push the fixed frame 106 while being inserted into the push hole 107, the insertion end of the push arm 201 can be adjusted arbitrarily, which will not be elaborated here.

[0096] To prevent the sealing plate 103 from detaching directly as it moves away from the fixing plate 102, such as Figure 7 , Figure 8As shown, the end of the fixed frame 106 away from the sealing plate 103 also has a limiting buckle A109, and the delivery cavity 101 also has a limiting buckle B120 that engages with the limiting buckle A109. While the limiting buckle A109 and the limiting buckle B120 are engaged, the limiting buckle A109 can slide on the limiting buckle B120, and the sliding direction of the limiting buckle A109 on the limiting buckle B120 is consistent with the reciprocating motion direction of the sealing plate 103. Through the cooperation of the limiting buckle A109 and the limiting buckle B120, it is ensured that the sealing plate 103 will not detach from the fixed plate 102, and the sealing plate 103 can maintain normal sliding, ensuring that the sealing plate 103 and the fixed plate 102 can be sealed and fitted when the protective cover 2 is placed on the suction nozzle 127.

[0097] To enable relative sliding of the limiting latch A109 and limiting latch B120 while they are engaged, the limiting latch A109 consists of locking hooks arranged opposite each other at the extended end of the fixed frame 106. The length between the bent part of the locking hook and the extended end of the fixed frame 106 is not less than the travel distance of the sealing plate 103, and the bending direction of the two locking hooks is towards the central axis of the fixed frame 106. The limiting latch B120 is T-shaped, and the distance between the two locking hooks in the limiting latch A109 is greater than the thickness of the vertical part of the limiting latch B120 and less than the width of the horizontal part of the limiting latch B120. The two locking hooks are positioned so that their hooks are attached to both sides of the horizontal portion of the limiting buckle B120 and both sides of the vertical portion of the limiting buckle B120. During the movement of the fixing frame 106 towards the sealing plate 103, the two locking hooks engage with both sides of the horizontal portion of the limiting buckle B120, effectively preventing the limiting buckle A109 from detaching from the limiting buckle B120. Since the fixing frame 106 is fixed to the limiting buckle A109, and the sealing plate 103 is fixed to the fixing frame 106, the sealing plate 103 is effectively prevented from detaching during movement.

[0098] In order for the protective cover 2 to automatically reset the sealing plate 103 when it is removed from the suction nozzle 127, such as Figure 1 , Figure 5 As shown, a spring mounting hole 122 is also provided on the side of the fixing plate 102 near the sealing plate 103. A spring 121 is installed in the spring mounting hole 122, and the other end of the spring 121 is fixed to the sealing plate 103. When the protective cover 2 is removed from the suction nozzle 127, the push arm 201 exits the push hole 107 on the fixing frame 106, and the fixing frame 106 loses the limitation of the push arm 201. At this time, the spring 121 pushes the sealing plate 103 away from the fixing plate 102 by its own elastic force, so that the sealing plate 103 separates from the fixing plate 102. When the sealing plate 103 resets, it drives the fixing frame 106 to reset. When the fixing frame 106 resets, the limiting buckle A109 moves to the horizontal part of the limiting buckle B120, so that the sealing plate 103 will not fall off when it resets.

[0099] In this embodiment, the spring mounting hole 122 can also be formed on the surface of the sealing plate 103 near the fixing plate 102. In this case, one end of the spring 121 is fixed to the fixing plate 102, and the other end of the spring 121 is installed in the spring mounting hole 122 on the sealing plate 103. At the same time, spring mounting holes 122 can be formed on the opposite surfaces of the fixing plate 102 and the sealing plate 103. In this case, both ends of the spring 121 are respectively installed in the two spring mounting holes 122, and the two ends of the spring 121 do not need to be fixedly installed. This not only makes the installation and removal of the spring 121 more convenient, but also allows the two ends of the spring 121 to be limited through the spring mounting holes 122, so that the spring 121 can be compressed evenly. In order to make the thrust of the sealing plate 103 from the spring 121 more even when it is reset, two springs 121 are installed between the fixing plate 102 and the sealing plate 103, and the two springs 121 are symmetrically arranged with respect to the center of the sealing plate 103.

[0100] To prevent the sealing plate 103 from tilting during movement, such as Figure 5 , Figure 6 , Figure 7 As shown, a positioning post 123 is also provided on the side of the fixing plate 102 near the sealing plate 103, and a sliding hole 124 is provided on the sealing plate 103 for the positioning post 123 to pass through. The sliding hole 124 is slidably engaged with the positioning post 123. Through the engagement of the positioning post 123 and the sliding hole 124, the sealing plate 103 can be guided by the positioning post 123 during movement, making the movement of the sealing plate 103 more stable. In order to further make the movement of the sealing plate 103 more stable, there are two guide posts on the fixing plate 102, and the two guide posts are symmetrically arranged about the center of the fixing plate 102. At this time, there are also two sliding holes 124 on the sealing plate 103 that are slidably engaged with the positioning post 123.

[0101] To ensure a good seal when the sealing plate 103 and the fixing plate 102 are in contact, a sealing ring 125 is also fitted onto the side of the sealing plate 103 closest to the fixing plate 102. The sealing ring 125 is located around the mounting opening 104 on the fixing plate 102, which improves the sealing effect when the sealing plate 103 and the fixing plate 102 are in contact. Of course, in this embodiment, the sealing ring 125 can also be fitted onto the surface of the fixing plate 102 closest to the sealing plate 103, or it can be fitted onto the opposite surfaces of the fixing plate 102 and the sealing plate 103 simultaneously. Alternatively, in this embodiment, the sealing ring 125 can be replaced by a rubber gasket. In this case, the rubber gasket is directly attached to the surface of the fixing plate 102 closest to the sealing plate 103, or it is attached to the surface of the sealing plate 103 closest to the fixing plate 102, or it is attached to the opposite surfaces of the fixing plate 102 and the sealing plate 103 simultaneously. When the sealing ring 125 is replaced by a rubber gasket, the rubber gasket also needs to have an installation port 104 for the nozzle 126 to pass through, but the installation port 104 is matched with the nozzle 126.

[0102] During production, one end of the spring 121 is inserted into the spring mounting hole 122 on the fixed plate 102, and the sealing ring 125 is fitted onto the sealing plate 103. The sealing plate 103 is then mounted above the fixed plate 102 via the sliding hole 124 on the sealing plate 103 and the positioning post 123. The other end of the spring 121 is inserted into the spring mounting hole 122 on the sealing plate 103. During installation, the fixing frame 106 penetrates the fixed plate 102. The clearance opening 128 on the 2 extends into the delivery cavity 101, and the limiting buckle A109 on the fixing frame 106 is fastened to the limiting buckle B120; the aerosol can is installed in the receiving cavity 100, and the valve stem of the metering valve on the aerosol can is inserted into the nozzle 126; finally, the desiccant 3 is installed in the cavity 200, and the insertion tube on the limiting rib 400 is inserted into the cavity 200, so that the limiting rib 400 presses and fixes the desiccant 3 in the cavity 200.

[0103] When using, such as Figure 11 As shown, the protective cover 2 is removed from the suction nozzle 127. At the same time as the protective cover 2 is removed, the push arm 201 exits the push hole 107 on the fixed frame 106, so that the fixed frame 106 is no longer restricted by the push arm 201. At this time, the spring 121 pushes the sealing plate 103 away from the fixed plate 102 through its own elastic force, so that the sealing plate 103 is separated from the fixed plate 102. When the sealing plate 103 resets, it drives the fixed frame 106 to reset. At the same time as the fixed frame 106 resets, the limiting buckle A109 moves to the horizontal part of the limiting buckle B120. At this time, the patient's mouth holds the suction nozzle 127 and presses the aerosol can. The medicine in the aerosol can is sprayed out through the nozzle 126. The sprayed medicine enters the patient's oral cavity through the delivery chamber 101 and the suction nozzle 127.

[0104] After use, such as Figure 10As shown, the protective cover 2 is placed on the suction nozzle 127. At the same time as the protective cover 2 is placed, the push arm 201 is gradually inserted into the push hole 107 on the fixed frame 106. As the protective cover 2 continues to be placed, the push arm 201 continues to be inserted. Through the cooperation of the push arm 201 with the wedge-shaped surface 108 on the inner wall of the push hole 107, the push arm 201 pushes the fixed frame 106 to move towards the delivery cavity 101, thereby pulling the sealing plate 103 closer to the fixed plate 102. The spring 121 is gradually compressed. When the protective cover 2 is completely closed, the insertion end of the push arm 201 is completely inserted into the push hole 107, the spring 121 is completely compressed, and the sealing plate 103 and the fixed plate 102 are sealed and fitted. At this time, the delivery cavity 101 forms a completely sealed space, and the desiccant 3 is exposed in the sealed space, so that the desiccant 3 dries the sealed space. Since the nozzle 126 is located inside the delivery chamber 101 and the metering valve stem on the aerosol can is inserted into the nozzle 126, the desiccant 3 can dry the drug delivery channel of the nozzle 126 and the drug delivery channel of the metering valve stem on the aerosol can while it is in the delivery chamber 101.

[0105] The following comparison uses an existing actuator without desiccant 3 as a control example 1 with the aerosol actuator with drying function provided in this embodiment. Figure 12 , Figure 13 It can be seen that after the control actuator was used with the drug once a day for 20 consecutive days, there was obvious scaling formed on the valve stem, spray orifice, and inner wall of nozzle 126 due to drug moisture absorption. Figure 14 , Figure 15 As can be seen, after the same medication method, the self-made actuator provided in this embodiment has only very slight drug scaling on the valve stem, spray hole and inner wall of nozzle 126, which has a significant improvement effect. Furthermore, the difference between the self-made driver provided in this embodiment and the drug delivery system and related method disclosed in the utility model patent with application number 201880079337.2 is that the desiccant 3 in the self-made driver provided in this embodiment can not only dry the nozzle 126, the spray hole, and the valve stem as a whole, but also dry the delivery chamber 101, the suction nozzle 127, and the protective cover 2, ensuring that drug scale forms in the nozzle 126, the spray hole, the valve stem, the delivery chamber 101, the suction nozzle 127, and the protective cover 2, thereby increasing the possibility of bacterial infection in patients; while the utility model patent with application number 201880079337.2 discloses a drug delivery system and related method in which the desiccant is installed in the protective cap, and the protective cap is directly sealed to the drug nozzle channel, so that the inhalation channel and the inside of the cover are not dried, and the cover only serves to protect against dust and cannot seal moisture.

[0106] 1. Comparison of spray patterns between the driver and the self-made driver provided in this embodiment.

[0107] 1.1 Spray pattern of the control driver

[0108] Table 1-1: Day 1 Comparison Driver Spray Pattern Data

[0109]

[0110]

[0111] Table 1-2: Control Driver Spray Pattern Data on Day 10

[0112]

[0113] Table 1-3: Control Driver Spray Pattern Data on Day 20

[0114]

[0115]

[0116] 1.2 Spray pattern of the self-made driver provided in this embodiment

[0117] Table 2-1: Spray morphology data of the self-made driver on day 1

[0118]

[0119] Table 2-2: Spray morphology data of the self-made driver on day 10

[0120]

[0121]

[0122] Table 2-3: Spray morphology data of the self-made driver on day 20

[0123]

[0124] Table 2-4: Spray morphology data of the self-made driver on day 30

[0125]

[0126]

[0127] According to the spray pattern data of the comparative actuator and the homemade actuator in Tables 1-1 to 2-4, we can see that:

[0128] The control group's budesonide showed a 9.5% decrease in FPF value after 30 days, from 49.9% to 40.4%.

[0129] The control driver, formoterol fumarate, showed a decrease in FPF value from 53.1% to 42.3% after 30 days, a reduction of 10.8%.

[0130] The control driver, glycopyrronium bromide, showed a 7.9% decrease in FPF value after 30 days, from 52.4% to 44.5%.

[0131] The homemade driver of budesonide showed a 2.8% decrease in FPF value after 30 days, from 50.1% to 47.3%.

[0132] The FPF value of the homemade formoterol fumarate decreased from 53.0% to 47.0% after 30 days, a decrease of 6%.

[0133] The FPF value of the homemade driver glycopyrronium bromide decreased from 52.4% to 49.0% after 30 days, a decrease of 3.4%.

[0134] The self-made driver provided in this embodiment significantly improved the FPF values ​​of three API drugs. Furthermore, based on the data above, the median particle size in the MMAD model shows that after 30 days, the particle size increase of the self-made driver was smaller, while the control driver showed a significant increase. It is well known that larger particle sizes lead to poorer therapeutic effects after pulmonary delivery of inhaled medications. Therefore, the self-made driver provided in this embodiment significantly improves the delivery stability of different drugs.

[0135] 2. Compare the driver area data with the self-made driver provided in this embodiment.

[0136] 2.1 Spray area data at a distance of 3cm from the driver's spray point

[0137] Table 3-1: Spray Area Data for Day 1

[0138]

[0139] Table 3-2: Spray area data on day 10

[0140]

[0141] Table 3-3: Spray area data on day 20

[0142]

[0143]

[0144] Table 3-4: Spray area data on day 30

[0145]

[0146] 2.2 Spray area data at a distance of 6cm from the driver sprayer

[0147] Table 4-1: Spray area data for Day 1

[0148]

[0149] Table 4-2: Spray area data on day 10

[0150]

[0151] Table 4-3: Spray area data on day 20

[0152]

[0153]

[0154] Table 4-4: Spray area data on day 30

[0155]

[0156] Based on the data in Tables 3-1 to 4-4, the spray area data of the control driver and the self-made driver at 3cm after 30 days show that the spray area of ​​the control driver decreased from 3.8cm after 30 days. 2 It dropped to 3.0cm 2 It decreased by 0.8cm 2 The homemade driver sprayed an area that increased from 3.8 cm² after 30 days. 2 It dropped to 3.5cm 2 It decreased by 0.3cm 2 .

[0157] The spray area data of the control driver and the homemade driver at 6cm distance after 30 days were compared. The spray area of ​​the control driver increased from 7.7cm to 7.7cm after 30 days. 2 It dropped to 5.8cm 2 It decreased by 1.9cm 2 The homemade driver sprayed an area of ​​8.0 cm² after 30 days. 2 It dropped to 7.4cm 2 It decreased by 0.6cm 2 .

[0158] The self-made driver provided in this embodiment shows a small decrease in spray area at 3 cm and 6 cm, while the control driver shows a more significant decrease. Therefore, it can be seen that the self-made driver provided in this embodiment has good stability in drug delivery.

[0159] 3. Compare the spray plume angle data of the driver with that of the self-made driver provided in this embodiment.

[0160] Table 5-1: Driver Spray Angle Data

[0161]

[0162] According to the data in Table 5-1, the spray angle data of the control driver and the self-made driver at 5.3 cm and 8.3 cm for 30 days shows that the spray angle of the control driver at 5.3 cm decreased from 19.8° to 12.4°, a decrease of 7.4°; and the spray angle at 8.3 cm decreased from 22.6° to 14.7°, a decrease of 7.9°.

[0163] The homemade driver reduced the spray angle from 19.6° to 17.2° at 5.3cm, a decrease of 2.4°, and reduced the spray angle from 22.5° to 19.8° at 8.3cm, a decrease of 2.7°.

[0164] The spray area of ​​the self-made driver provided in this embodiment decreases very little at 5.3 cm and 8.3 cm, while the spray angle of the control driver decreases more significantly. Therefore, it can be seen that the spray angle of the drug delivery provided by the self-made driver in this embodiment has better stability.

[0165] Example 2

[0166] The difference between the aerosol driver with drying function provided in Example 2 and the aerosol driver with drying function provided in Example 1 is that: Figures 16 to 25 As shown, the installation position and installation method of the desiccant 3 are different. Specifically, in this embodiment 2, the desiccant 3 is placed in the delivery cavity 101.

[0167] In this embodiment 2, as Figure 18 As shown, in order to place the desiccant 3 in the delivery cavity 101, a drying shell 5 is installed in the delivery cavity 101, and the desiccant 3 is installed in the drying shell 5. In order to ensure that the desiccant 3 can be fully released, a through hole 500 communicating with the interior is opened on one side, two sides or all four sides of the drying shell 5.

[0168] To facilitate the installation and replacement of the desiccant 3, a groove adapted to the end of the drying housing 5 can be opened at the bottom of the delivery cavity 101, and an opening 129 for inserting the drying housing 5 can be opened on the fixing plate 102. Figure 20As shown, when the drying housing 5 containing desiccant 3 needs to be installed, the drying housing 5 can be inserted into the groove at the bottom of the delivery cavity 101 through the opening 129 on the fixing plate 102, and the upper end of the drying housing 5 is kept inserted into the opening 129 on the fixing plate 102, thereby limiting both ends of the drying housing 5 and realizing the installation of the drying housing 5. Of course, when the drying housing 5 is installed in the above manner, it should be noted that in order to ensure the sealing plate 103 and the fixing plate 102 are sealed and fitted, the drying housing 5 should not be higher than the upper surface of the fixing plate 102 after installation.

[0169] In this embodiment, as Figure 20 , Figure 24 As shown, in order not to affect the spraying of the drug by the nozzle 126, the covering of the protective cover 2, and the movement of the sealing plate 103, the drying housing 5 can be located behind the nozzle 126 or outside the limiting buckle B120 during installation, but the drying housing 5 cannot be located in front of the spray hole of the nozzle 126.

[0170] The aerosol driver with drying function provided in this embodiment 2 is used in the same way as the aerosol driver with drying function provided in embodiment 1. The aerosol driver with drying function provided in this embodiment 2 is assembled in the same way as the aerosol driver with drying function provided in embodiment 1. The only difference is that the drying shell 5 containing the desiccant 3 needs to be installed before the sealing plate 103 is installed.

[0171] The following comparison uses an existing actuator without desiccant 3 as a control example 1 with the aerosol actuator with drying function provided in this embodiment. Figure 12 , Figure 13 It can be seen that after the control device was used with the drug once a day for 20 consecutive days, there was obvious scaling on the valve stem, spray orifice, and inner wall of nozzle 126 due to drug moisture absorption. Figure 26 , Figure 27 As can be seen, the self-made actuator provided in this embodiment, under the same medication administration method, exhibits only very slight drug scaling on the valve stem, nozzle orifice, and inner wall of nozzle 126, demonstrating a significant improvement. Furthermore, the self-made actuator provided in this embodiment differs from the drug delivery system and related methods disclosed in the invention patent application number 201880079337.2 in that the desiccant 3 in the self-made actuator provided in this embodiment can dry the nozzle 126, nozzle orifice, and valve stem as a whole, ensuring that drug scaling does not form inside the nozzle 126, thereby increasing the likelihood of bacterial infection in the patient.

[0172] 1. Comparison of spray patterns between the driver and the self-made driver provided in this embodiment.

[0173] 1.1 Spray pattern of the control driver

[0174] Table 6-1: Spray pattern data of the control driver on day 1

[0175]

[0176] Table 6-2: Spray pattern data of the control driver on day 10

[0177]

[0178] Table 6-3 Spray pattern data of the control driver on day 20

[0179]

[0180] Table 6-4 Spray pattern data of the control driver on day 30

[0181]

[0182]

[0183] 1.2 Spray pattern of the self-made driver provided in this embodiment

[0184] Table 7-1: Spray morphology data of the homemade driver on day 1

[0185]

[0186] Table 7-2: Spray morphology data of the homemade driver on day 10

[0187]

[0188]

[0189] Table 7-3: Spray morphology data of the homemade driver on day 20

[0190]

[0191] Table 7-4: Spray morphology data of the homemade driver on day 30

[0192]

[0193]

[0194] According to the spray pattern data of the comparative actuator and the homemade actuator in Tables 6-1 to 7-4, we can see that:

[0195] The control group's budesonide showed a 9.5% decrease in FPF value after 30 days, from 49.9% to 40.4%.

[0196] The control driver, formoterol fumarate, showed a decrease in FPF value from 53.1% to 42.3% after 30 days, a reduction of 10.8%.

[0197] The control driver, glycopyrronium bromide, showed a 7.9% decrease in FPF value after 30 days, from 52.4% to 44.5%.

[0198] The homemade driver of budesonide showed a 2.8% decrease in FPF value after 30 days, from 50.1% to 47.3%.

[0199] The FPF value of the homemade driver with formoterol fumarate decreased from 53.1% to 47.5% after 30 days, a decrease of 5.6%.

[0200] The FPF value of the homemade driver glycopyrronium bromide decreased from 52.4% to 48.9% after 30 days, a decrease of 3.5%.

[0201] The self-made driver provided in this embodiment significantly improved the FPF values ​​of three API drugs. Furthermore, based on the data above, the median particle size in the MMAD model shows that after 30 days, the particle size increase of the self-made driver was smaller, while the control driver showed a significant increase. It is well known that larger particle sizes lead to poorer therapeutic effects after pulmonary delivery of inhaled medications. Therefore, the self-made driver provided in this embodiment significantly improves the delivery stability of different drugs.

[0202] 2. Compare the driver area data with the self-made driver provided in this embodiment.

[0203] 2.1 Spray area data at a distance of 3cm from the driver's spray point

[0204] Table 8-1: Spray Area Data on Day 1

[0205]

[0206] Table 8-2: Spray area data on day 10

[0207]

[0208]

[0209] Table 8-3: Spray area data on day 20

[0210]

[0211] Table 8-4: Spray area data on day 30

[0212]

[0213] 2.2 Spray area data at a distance of 6cm from the driver sprayer

[0214] Table 9-1: Spray Area Data on Day 1

[0215]

[0216] Table 9-2: Spray area data on day 10

[0217]

[0218] Table 9-3: Spray area data on day 20

[0219]

[0220] Table 9-4: Spray area data on day 30

[0221]

[0222] Based on the data in Tables 8-1 to 9-4, the spray area data of the control driver and the homemade driver at 3cm after 30 days show that the spray area of ​​the control driver decreased from 3.8cm after 30 days. 2 It dropped to 3.0cm 2 It decreased by 0.8cm 2 The homemade driver sprayed an area that increased from 3.8 cm² after 30 days. 2 It dropped to 3.4cm 2 It decreased by 0.4cm. 2 .

[0223] The spray area data of the control driver and the homemade driver at 6cm distance after 30 days were compared. The spray area of ​​the control driver increased from 7.7cm to 7.7cm after 30 days. 2 It dropped to 5.8cm 2 It decreased by 1.9cm 2 The homemade driver sprayed an area of ​​8.5cm after 30 days. 2 It dropped to 7.5cm 2 It decreased by 1.0 cm. 2 .

[0224] The self-made driver provided in this embodiment shows a small decrease in spray area at 3 cm and 6 cm, while the control driver shows a more significant decrease. Therefore, it can be seen that the self-made driver provided in this embodiment has good stability in drug delivery.

[0225] 3. Compare the spray plume angle data of the driver with that of the self-made driver provided in this embodiment.

[0226] Table 10-1: Spray Angle Data

[0227]

[0228]

[0229] According to the data in Table 10-1, the spray angle data of the control driver and the self-made driver at 5.3 cm and 8.3 cm for 30 days shows that the spray angle of the control driver at 5.3 cm decreased from 19.8° to 12.4°, a decrease of 7.4°; and the spray angle at 8.3 cm decreased from 22.6° to 14.7°, a decrease of 7.9°.

[0230] The homemade driver reduced the spray angle from 19.5° to 17.4° at 5.3cm, a decrease of 2.1°, and reduced the spray angle from 22.8° to 19.3° at 8.3cm, a decrease of 3.5°.

[0231] The spray area of ​​the driver provided in this embodiment decreases very little at 5.3 cm and 8.3 cm, while the spray angle of the control driver decreases more significantly. Therefore, it can be seen that the spray angle of the drug delivery provided by the self-made driver in this embodiment has better stability.

[0232] Compare with Example 2

[0233] The difference between the control driver provided in Comparative Example 2 and the aerosol driver with drying function provided in Example 1 is as follows: Figures 28 to 35 As shown, the sealing structure is eliminated, allowing the receiving cavity 100 to communicate with the delivery cavity 101. Correspondingly, the push arm 201 located inside the protective cover 2 is also eliminated. The structure of the desiccant 3 located inside the protective cover 2 is adjusted as follows:

[0234] like Figure 29 As shown, the cylindrical structure 4 on the protective cover 2 is modified into two opposing semi-circular buckles 200', forming an insertion interface 201' between the two semi-circular buckles 200', and a cylindrical shell 202' is inserted into the insertion interface 201'. The inner wall of the cylindrical shell 202' near the end of the protective cover 2 has multiple positioning ribs 204', which are evenly spaced along the circumference of the cylindrical shell 202'. Figure 33 As shown, the desiccant 3 is cylindrical and inserted into the cylindrical shell 202'. Since the inner wall of the cylindrical shell 202' has positioning ribs 204', after the desiccant 3 is inserted into the cylindrical shell 202', an annular channel 6 is formed between the outer surface of the desiccant 3 and the inner wall of the cylindrical shell 202'. The desiccant 3 can be fully released around its perimeter and on the side where it is pressed by the limiting ribs 400.

[0235] To prevent the cylindrical housing 202' from falling out of the insertion interface 201', such as Figure 30 As shown, the outer circular surface of the cylindrical shell 202' is stepped, giving the cylindrical shell 1 a circular stepped surface 205'. The large diameter end and length of the cylindrical shell 202' are adapted to the diameter and depth of the insertion interface 201'. At the same time, protruding ribs 206' that engage with the circular stepped surface 205' are provided on the two semi-circular buckles 200'. When the cylindrical shell 1 is inserted into the insertion interface 201', the protruding ribs 206' on the two semi-circular buckles 200' engage with the circular stepped surface 205' on the cylindrical shell 1, thereby securing the cylindrical shell 1 within the insertion interface 201' and effectively preventing the cylindrical shell 1 from falling off.

[0236] In addition, such as Figure 30 , Figure 34 As shown, a cross-shaped rib 207' is provided at the end of the cylindrical shell 202' away from the protective cover 2, and an annular soft rubber pad 208' is fixed on the side of the cross-shaped rib 207' away from the protective cover 2; a circular boss 209' is also provided on the nozzle 126, which is located around the spray hole on the nozzle 126, and the circular boss 209' cooperates with the annular soft rubber pad 208'. When the protective cover 2 is placed on the suction nozzle 127 of the outer shell 1, the circular boss 209' on the nozzle 126 abuts against the annular soft rubber pad 208', so that the spray hole of the nozzle 126 is sealed and connected with the cylindrical shell 202'.

[0237] During production, the aerosol can is installed in the receiving cavity 100, and the valve stem of the metering valve on the aerosol can is inserted into the nozzle 126. Then, the cylindrical desiccant 3 is inserted into the cylindrical shell 202', and the cylindrical shell 202' is inserted between the two semi-circular buckles 200'. When the protrusion 206' on the semi-circular buckle 200' is aligned with the circular stepped surface 205' on the cylindrical shell 1, the cylindrical shell 202' is locked in place.

[0238] In use, remove the protective cap 2 from the mouthpiece 127, place the mouthpiece 127 in the patient's mouth, and press the aerosol canister. The medication in the aerosol canister will be sprayed out through the nozzle 126, and the sprayed medication will enter the patient's oral cavity through the delivery chamber 101 and the mouthpiece 127. After use, if... Figure 35 As shown, the protective cover 2 is placed on the nozzle 127, and the circular protrusion 209' on the nozzle 126 abuts against the annular soft rubber pad 208', so that the nozzle 126 nozzle orifice is sealed and connected with the cylindrical housing 202'. The cylindrical housing 202', the nozzle 126 and the valve stem of the metering valve on the aerosol can are connected, and the desiccant 3 can fully dry the nozzle 126 and the valve stem of the metering valve on the aerosol can.

[0239] Depend on Figure 36 , Figure 37It can be seen that after the control actuator provided in this comparative example used the drug once a day for 20 consecutive days, there was obvious scaling formed on the valve stem, spray hole and inner wall of nozzle 126 due to drug moisture absorption.

[0240] 1. Compare the spray pattern data of the driver.

[0241] Table 11-1: Day 1 Comparison Driver Spray Pattern Data

[0242]

[0243]

[0244] Table 11-2: Spray morphology data of the control driver on day 10

[0245]

[0246]

[0247] Table 11-3: Spray morphology data of the control driver on day 20

[0248]

[0249] Table 11-4: Spray morphology data of the control driver on day 30

[0250]

[0251]

[0252] According to the spray pattern data of the comparison driver in Tables 11-1 to 11-4:

[0253] The control group's budesonide showed a 5.0% decrease in FPF value after 30 days, from 49.9% to 44.9%.

[0254] The control driver, formoterol fumarate, showed a decrease in FPF value from 53.0% to 43.7% after 30 days, a reduction of 9.3%.

[0255] The control driver, glycopyrronium bromide, showed a 5.2% decrease in FPF value after 30 days, from 52.2% to 47.0%.

[0256] Data from the control drive design shows that the spray particle size increased significantly after 30 days, and the FPF value decreased significantly.

[0257] 2. Compare the driver area data

[0258] 2.1 Comparison of spray area data at a distance of 3cm from the driver sprayer

[0259] Table 12-1: Spray Area Data on Day 1

[0260]

[0261] Table 12-2: Spray area data on day 10

[0262]

[0263]

[0264] Table 12-3: Spray area data on day 20

[0265]

[0266] Table 12-4: Spray area data on day 30

[0267]

[0268] 2.2 Comparison of spray area data at a distance of 6cm from the driver sprayer

[0269] Table 13-1: Spray Area Data on Day 1

[0270]

[0271] Table 13-2: Spray area data on day 10

[0272]

[0273] Table 13-3: Spray area data on day 20

[0274]

[0275] Table 13-4: Spray area data on day 30

[0276]

[0277] According to the data in Tables 12-1 to 13-4, the spray area of ​​the control driver at 3cm increased from 4.2cm to 4.2cm after 30 days. 2 It dropped to 3.3cm 2 It decreased by 0.9cm 2 The control driver sprayed an area of ​​8.0 cm at 6 cm after 30 days. 2 It dropped to 6.3cm 2 It decreased by 1.7cm. 2 .

[0278] The control driver showed a more significant decrease, indicating poorer stability in drug delivery.

[0279] 3. Compare the data on the spray plume angle of the driver.

[0280] Table 14-1: Driver Spray Angle Data

[0281]

[0282] According to the data in Table 14-1, the spray angle data of the control driver at 5.3 cm and 8.3 cm over 30 days showed that the spray angle of the control driver at 5.3 cm decreased from 21.6° to 14.5°, a decrease of 7.1°; and the spray angle at 8.3 cm decreased from 22.6° to 16.5°, a decrease of 6.1°.

[0283] It should be noted that the reference points for 3cm, 6cm, 5.3cm, and 8.3cm in this instruction manual are all based on the nozzle outlet. Furthermore, MMAD in this instruction manual refers to the particle size, and FPF refers to the amount of deposition at the effective site.

[0284] Those skilled in the art should understand that the above embodiments are merely for illustrating the present invention and are not intended to limit the scope of the invention. Those skilled in the art can make other changes or modifications based on the above disclosure, and these changes or modifications still fall within the scope of the present invention.

Claims

1. An aerosol driver with a drying function, characterized in that, include: The outer casing (1) has a sealing structure inside, which divides the interior of the outer casing (1) into a receiving cavity (100) for installing an aerosol can and a delivery cavity (101) for delivering the drug. The outer casing (1) is also equipped with a nozzle (126) connected to the outlet of the metering valve stem on the aerosol can. The nozzle (126) has a spray hole that communicates with the delivery cavity (101). The sealing structure has an installation port (104) that seals with the nozzle (126). The outer casing (1) also has a suction nozzle (127) that communicates with the delivery cavity (101). Desiccant (3), the desiccant (3) is used to dry the delivery chamber (101), the nozzle (126), and the metering valve stem on the aerosol can; and a protective cover (2), the protective cover (2) being used to open or close the delivery cavity (101), and a desiccant (3) being installed in the protective cover (2) or the delivery cavity (101).

2. The aerosol driver with drying function according to claim 1, characterized in that, The protective cover (2) is also provided with a limiting rib (400) for pressing the desiccant (3); preferably, the protective cover (2) is provided with a cavity (200), the desiccant (3) is installed in the cavity (200), and the limiting rib (400) is installed in the opening end of the cavity (200); preferably, an annular channel (6) is formed between the periphery of the desiccant (3) and the inner wall of the cavity (200).

3. The aerosol driver with drying function according to claim 1, characterized in that, The delivery cavity (101) is equipped with a drying shell (5), the desiccant (3) is installed inside the drying shell (5), and the side of the drying shell (5) has a through hole (500) for the release of the desiccant (3).

4. The aerosol driver with drying function according to claim 1, 2, or 3, characterized in that, The desiccant (3) is in granular, powdery, or block form.

5. The aerosol driver with drying function according to claim 2 or 3, characterized in that, The sealing structure includes a fixed plate (102) fixed inside the outer shell (1) and a sealing plate (103) that can be close to or away from the fixed plate (102). When the protective cover (2) is on, the sealing plate (103) is sealed and fitted with the fixed plate (102), and the mounting port (104) on the sealing plate (103) is slidably sealed with the nozzle (126).

6. The aerosol driver with drying function according to claim 5, characterized in that, The sealing plate (103) also has a fixing frame (107) that extends through the fixing plate (102) into the delivery cavity (101). The protective cover (2) and the fixing frame (107) are provided with a plug-in structure. The plug-in structure allows the sealing plate (103) to be pulled to fit the fixing plate (102) while the protective cover (2) is closed.

7. The aerosol driver with drying function according to claim 6, characterized in that, The plug-in structure includes a push hole (107) provided on the fixed frame (107) and a push arm (201) provided on the sealing plate (103). The wall of the push hole (107) has a wedge-shaped surface (108) that cooperates with the push arm (201).

8. The aerosol driver with drying function according to claim 6, characterized in that, The extended end of the fixed frame (107) also has a limiting buckle A (109), and the delivery cavity (101) also has a limiting buckle B (120) that engages with the limiting buckle A (109), and the limiting buckle A (109) can slide on the limiting buckle B (120) along the movement direction of the sealing plate (103).

9. The aerosol driver with drying function according to claim 8, characterized in that, The limiting buckle A (109) consists of two locking hooks arranged opposite each other, and the limiting buckle B (120) is T-shaped, with the two locking hooks in the limiting buckle A (109) respectively hanging on both sides of the limiting buckle B (120).

10. The aerosol driver with drying function according to claim 5, characterized in that, A spring (121) is also installed between the fixing plate (102) and the sealing plate (103); preferably, a spring mounting hole (122) is also provided on the fixing plate (102) or / and the sealing plate (103), and the end of the spring (121) is installed in the spring (121) hole; preferably, a positioning post (123) is also provided on the fixing plate (102), and a sliding hole (124) is also provided on the sealing plate (103) for sliding cooperation with the positioning post (123); preferably, a sealing ring (125) is also provided on the mating surface of the sealing plate (103) or the mating surface of the fixing plate (102).

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