A BNCT mouse irradiation device without anesthesia

Abstract

The utility model discloses a kind of BNCT mouse irradiation devices without anesthesia, including disc body, sliding assembly is installed on disc body, detachably installed with mouse fixer on sliding assembly, mouse fixer includes head fixing assembly and tail fixing assembly for limiting mouse activity, fixed shaft is vertically arranged on disc body, bracket is installed on fixed shaft, the end portion of bracket is located above mouse fixer and is provided with reversible folding connecting plate. Mouse head and neck are fixed by the fastening screw of mouse fixer, mouse tail is fixed by clamping groove, mouse can be irradiated subsequently without anesthesia, avoid anesthetics to influence BNCT treatment effect;By round multi-arm sliding rail clamping disc, multiple mouse fixers can be assembled, one mouse is placed in each fixer, reasonably divide area, avoid multiple mice confusion;By adjusting the position of mouse fixer on sliding rail and turning L-shaped connecting plate, multiple mice can be irradiated at different parts simultaneously, convenient operation, save experimental time.

Description

Technical Field

[0001] This utility model relates to the field of experimental equipment technology, specifically to a BNCT mouse irradiation device that does not require anesthesia. Background Technology

[0002] Boron neutron capture therapy (BNCT) is a novel radiotherapy technique that utilizes the interaction between neutrons and boron to precisely target cancer cells. BNCT-related biological experiments are crucial for evaluating treatment efficacy, optimizing treatment regimens, and exploring its effects on normal tissues. Biological experiments typically require the establishment of animal models. Mice are widely used as research subjects. BNCT-related biological experiments generally require irradiating specific sites on mice after anesthesia; however, anesthetic drugs can suppress the immune system, respiratory function, and circulatory function of mice, potentially affecting the evaluation of BNCT's therapeutic effect. In practice, because biological experiments require statistical analysis of results from multiple samples and may irradiate different sites on mice, there is a need for a mouse irradiation device that does not require anesthesia for BNCT. Utility Model Content

[0003] The purpose of this invention is to solve the problems mentioned above in the background art and to propose a BNCT mouse irradiation device that does not require anesthesia.

[0004] The objective of this utility model can be achieved through the following technical solutions:

[0005] An anesthesia-free BNCT mouse irradiation device includes a disc body with a sliding assembly mounted on it. A mouse restraint is detachably mounted on the sliding assembly. The mouse restraint includes a head restraint assembly and a tail restraint assembly for restricting mouse movement. A fixing shaft is vertically arranged on the disc body, and a bracket is mounted on the fixing shaft. A flip-up and foldable connecting plate is provided at the end of the bracket above the mouse restraint. A through hole is provided on the connecting plate.

[0006] As a further embodiment of this utility model: the head fixing component and the tail fixing component can be combined to form a breathable container.

[0007] As a further embodiment of this utility model: the head fixing component includes a fixing cover and a fastening screw, the tail fixing component includes a fixing cylinder, the fixing cover is detachably embedded in the front opening of the fixing cylinder, the fastening screw is vertically disposed on the fixing cover, and the fastening screw is threadedly connected to the fixing cover.

[0008] As a further embodiment of this utility model: a strip-shaped opening is provided at the front end of the fixed cylinder near the fastening screw along the length direction of the fixed cylinder, the fastening screw can slide along the strip-shaped opening, and the fixed cover is fastened and limited to the fixed cylinder by the fastening screw.

[0009] As a further embodiment of this utility model: a vent hole is provided at the end of the fixed cover, and a through groove is provided at the end of the fixed cylinder away from the fixed cover.

[0010] As a further embodiment of this utility model: the sliding component includes a rectangular slide rail and a slot, the slot can slide on the rectangular slide rail, the rectangular slide rail is fixed to the disc body, and the slot is fixed to the fixed cylinder.

[0011] As a further embodiment of this utility model: the number of sliding components is multiple, and one end of the multiple sliding components is arranged in a ring at equal intervals with the circular center of the disc body as the center point.

[0012] As a further embodiment of this invention, the number of the mouse fixator and the connecting plate is also multiple.

[0013] As a further embodiment of this utility model: the connecting plate is L-shaped and can be rotated upwards by 180°.

[0014] As a further embodiment of this invention: the connecting plate is made of boron-containing polyethylene, which can be used to shield neutron irradiation.

[0015] The beneficial effects of this invention are as follows: The mouse head and neck are secured by the screws of the mouse restraint device, and the mouse tail is secured by the slot. Subsequent irradiation can be performed on the mouse without anesthesia, avoiding the influence of anesthetics on the BNCT treatment effect. Multiple mouse restraint devices can be assembled using the circular multi-arm slide rail mounting plate, with one mouse placed in each device, rationally dividing the area and preventing confusion among multiple mice. By adjusting the position of the mouse restraint device on the slide rail and flipping the L-shaped connecting plate, irradiation of different parts of multiple mice can be achieved simultaneously, making operation convenient and saving experimental time. Attached Figure Description

[0016] The present invention will be further described below with reference to the accompanying drawings.

[0017] Figure 1 This is a schematic diagram of the structure of this utility model;

[0018] Figure 2 , 3 4 is a schematic diagram of the structure of the mouse fixation device of this utility model;

[0019] Figure 5 This is a schematic diagram of the structure of this utility model, showing multiple rectangular slide rails arranged in a ring.

[0020] Figure 6 This is a schematic diagram of the connecting plate of this utility model.

[0021] In the diagram: 1. Disc body; 2. Rectangular slide rail; 3. Slot; 4. Mouse restraint; 5. Connecting plate; 6. Star-shaped disc; 7. Fixing cylinder; 8. Fixing cover; 9. Fastening screw; 10. Cylindrical hollow roller; 11. Bolt; 12. Side hole; 13. Through hole; 16. Fixing shaft; 17. Groove. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0023] Example 1, please refer to Figures 1-6 As shown, this utility model is a BNCT mouse irradiation device that does not require anesthesia, including a disc body 1. A sliding component is installed on the disc body 1. A mouse restraint 4 is detachably installed on the sliding component. The mouse restraint 4 includes a head restraint component and a tail restraint component for restricting the movement of the mouse. The head restraint component and the tail restraint component can be combined to form a breathable container.

[0024] A fixed shaft 16 is vertically arranged on the disc body 1, and a bracket is installed on the fixed shaft 16. The end of the bracket is located above the mouse fixation device 4 and is provided with a flip-able and foldable connecting plate 5. A through hole 13 is opened on the connecting plate 5.

[0025] Example 2, please refer to Figures 1-6 As shown, this utility model is a BNCT mouse irradiation device that does not require anesthesia, including a disc body 1. A sliding component is installed on the disc body 1. A mouse restraint 4 is detachably installed on the sliding component. The mouse restraint 4 includes a head restraint component and a tail restraint component for restricting the movement of the mouse. The head restraint component and the tail restraint component can be combined to form a breathable container.

[0026] A fixed shaft 16 is vertically arranged on the disc body 1, and a bracket is installed on the fixed shaft 16. The end of the bracket is located above the mouse fixation device 4 and is provided with a flip-able and foldable connecting plate 5. A through hole 13 is opened on the connecting plate 5.

[0027] The head fixing assembly includes a fixing cover 8 and a fastening screw 9. The tail fixing assembly includes a fixing cylinder 7. The fixing cover 8 is detachably embedded in the front opening of the fixing cylinder 7. The fastening screw 9 is vertically arranged on the fixing cover 8 and is threadedly connected to the fixing cover 8.

[0028] The front opening of the fixing cylinder 7 is provided with a strip-shaped opening along the length of the fixing cylinder 7 near the fastening screw 9. The fastening screw 9 can slide along the strip-shaped opening, and the fixing cover 8 is fastened and limited to the fixing cylinder 7 by the fastening screw 9.

[0029] A vent hole is provided at the end of the fixed cover 8, and a through groove 17 is provided at the end of the fixed cylinder 7 away from the fixed cover 8.

[0030] Example 3, please refer to Figures 1-6 As shown, this utility model is a BNCT mouse irradiation device that does not require anesthesia, including a disc body 1. A sliding component is installed on the disc body 1. A mouse restraint 4 is detachably installed on the sliding component. The mouse restraint 4 includes a head restraint component and a tail restraint component for restricting the movement of the mouse. The head restraint component and the tail restraint component can be combined to form a breathable container.

[0031] A fixed shaft 16 is vertically arranged on the disc body 1, and a bracket is installed on the fixed shaft 16. The end of the bracket is located above the mouse fixation device 4 and is provided with a flip-able and foldable connecting plate 5. A through hole 13 is opened on the connecting plate 5.

[0032] The head fixing assembly includes a fixing cover 8 and a fastening screw 9. The tail fixing assembly includes a fixing cylinder 7. The fixing cover 8 is detachably embedded in the front opening of the fixing cylinder 7. The fastening screw 9 is vertically arranged on the fixing cover 8 and is threadedly connected to the fixing cover 8.

[0033] The front opening of the fixing cylinder 7 is provided with a strip-shaped opening along the length of the fixing cylinder 7 near the fastening screw 9. The fastening screw 9 can slide along the strip-shaped opening, and the fixing cover 8 is fastened and limited to the fixing cylinder 7 by the fastening screw 9.

[0034] A vent hole is provided at the end of the fixed cover 8, and a through groove 17 is provided at the end of the fixed cylinder 7 away from the fixed cover 8.

[0035] The sliding component includes a rectangular slide rail 2 and a slot 3. The slot 3 can slide on the rectangular slide rail 2. The rectangular slide rail 2 is fixed to the disc body 1, and the slot 3 is fixed to the fixed cylinder 7.

[0036] In another embodiment, there are multiple sliding components, with one end of each component arranged in a ring at equal intervals around the circular center of the disc 1. There are also multiple mouse restraints 4 and connecting plates 5.

[0037] In another embodiment, the connecting plate 5 is L-shaped and can be flipped upwards by 180°.

[0038] In another embodiment, the connecting plate 5 is made of boron-containing polyethylene and can be used to shield against neutron irradiation.

[0039] In another embodiment, a fixed shaft 16 is fixedly connected to the circular multi-arm slide rail clamping plate. The fixed shaft 16 is provided with a limiting ring. The star-shaped disk 6 has a circular through groove at its center. The diameter of the fixed shaft 16 is slightly smaller than the diameter of the circular through groove. The fixed shaft 16 passes through the circular through groove at the center of the star-shaped disk 6 and is clamped at the limiting ring on the fixed shaft 16.

[0040] Each connecting arm of the star-shaped disk 6 is fixed with a cylindrical hollow roller 10 at its end, which is used to connect the L-shaped connecting plate 5 of the mouse shielding device. The bolt 11 passes through the two side holes 12 of the L-shaped connecting plate 5 and the cylindrical hollow roller 10 for fixing. The L-shaped connecting plate 5 can be rotated upwards by 180°.

[0041] The disc body 1 is a circular multi-arm slide rail clamping disc.

[0042] The mouse restraint 4 is located between the circular multi-arm slide rail clamping plate and the L-shaped connecting plate 5.

[0043] Multiple rectangular slide rails 2 are fixedly connected to the circular multi-arm slide rail mounting plate. The mouse restraint 4 is connected to the rectangular slide rails 2 through slots 3 and can move freely back and forth. The number of slots 3 is the same as the number of rectangular slide rails 2.

[0044] The mouse restraint 4 consists of a fixing cylinder 7 and a fixing cover 8. The fixing cover 8 has a round hole 14 for maintaining air circulation. The fastening screw 9 fixes the mouse's head and neck, and the mouse's tail passes through the groove 17 of the fixing cylinder 7 for fixation.

[0045] The L-shaped connecting plate 5 has a through hole 13 for irradiating specific parts of the mouse. By moving the mouse restraint 4 back and forth, the position of the through hole 13 relative to the mouse restraint 4 can be adjusted to irradiate specific parts of the mouse.

[0046] The L-shaped connecting plate 5 is made of boron-containing polyethylene and can be used to shield neutron irradiation.

[0047] After treating the mice according to the experimental requirements, loosen the fastening screw 9, remove the fastening screw 9 and the fixing cover 8, and place each mouse into the corresponding mouse restraint 4. Multiple mice can be irradiated at the same time in one experiment, saving experimental time and cost. Then, replace the fixing cover 8, use the fastening screw 9 to fix the head and neck of the mouse, and fix the mouse tail through the groove 17 of the fixing tube 7 to prevent the mouse from moving.

[0048] The fixed cover 8 has a round hole 14 to maintain air circulation and prevent the mouse from suffocating.

[0049] Multiple rectangular slide rails 2 are fixedly connected to a circular multi-arm slide rail mounting plate. Mouse restrainers 4 are connected to the rectangular slide rails 2 via slots 3 and can move freely back and forth. The number of slots 3 and mouse restrainers 4 is the same as the number of rectangular slide rails 2. Each mouse restrainer 4 holds one mouse, with independent space, avoiding interference with neutron beam irradiation due to mice being too close together.

[0050] The L-shaped connecting plate 5 is made of boron-containing polyethylene and can be used to shield neutron irradiation. It has through holes 13 for irradiating specific areas of the mouse. By moving the mouse restraint 4 back and forth, the position of the through holes 13 relative to the mouse restraint 4 can be adjusted to irradiate specific areas of the mouse. Flipping the L-shaped connecting plate 5 to a horizontal position allows for whole-body irradiation of the mouse.

[0051] The working principle and usage process of this utility model are as follows: Loosen the fastening screw 9, remove the fastening screw 9 and the fixing cover 8, put each mouse into the corresponding mouse fixation device 4, fix the mouse's head, neck and tail to prevent the mouse from moving; then, move the mouse fixation device 4 back and forth according to the irradiation area, adjust the positional relationship between the through hole 13 on the L-shaped connecting plate 5 and the mouse fixation device 4, or flip the L-shaped connecting plate 5 to a horizontal position for whole-body irradiation.

[0052] The foregoing has provided a detailed description of one embodiment of the present invention, but the description is merely a preferred embodiment and should not be construed as limiting the scope of the present invention. All equivalent variations and improvements made within the scope of the claims of the present invention should still fall within the scope of the claims of the present invention.

Claims

1. A non-anesthesia-free BNCT mouse irradiation device, comprising a disc (1), characterized in that, A sliding assembly is installed on the disc body (1), and a mouse restrainer (4) is detachably installed on the sliding assembly. The mouse restrainer (4) includes a head restraint assembly and a tail restraint assembly for restricting the movement of the mouse. A flip-up and foldable connecting plate (5) is provided above the mouse restrainer (4), and a through hole (13) is provided on the connecting plate (5).

2. The BNCT mouse irradiation device without anesthesia according to claim 1, characterized in that, The head fixing component and the tail fixing component can be combined to form a breathable container.

3. The BNCT mouse irradiation device without anesthesia according to claim 2, characterized in that, The head fixing assembly includes a fixing cover (8) and a fastening screw (9). The tail fixing assembly includes a fixing cylinder (7). The fixing cover (8) is detachably embedded in the front opening of the fixing cylinder (7). The fastening screw (9) is vertically arranged on the fixing cover (8) and is threadedly connected to the fixing cover (8).

4. The BNCT mouse irradiation device without anesthesia according to claim 3, characterized in that, The front end opening of the fixed cylinder (7) is provided with a strip-shaped opening along the length direction of the fixed cylinder (7) near the fastening screw (9). The fastening screw (9) can slide along the strip-shaped opening. The fixed cover (8) is fastened and limited to the fixed cylinder (7) by the fastening screw (9).

5. The BNCT mouse irradiation device without anesthesia according to claim 3, characterized in that, The fixed cover (8) has a vent hole at its end, and the fixed cylinder (7) has a through groove (17) at the end away from the fixed cover (8).

6. The BNCT mouse irradiation device without anesthesia according to claim 3, characterized in that, The sliding component includes a rectangular slide rail (2) and a slot (3). The slot (3) can slide on the rectangular slide rail (2). The rectangular slide rail (2) is fixed to the disc body (1), and the slot (3) is fixed to the fixed cylinder (7).

7. A non-anesthesia-free BNCT mouse irradiation device according to any one of claims 1 or 6, characterized in that, The number of sliding components is multiple, and one end of the multiple sliding components is arranged in a ring at equal intervals with the circular center of the disc (1).

8. The BNCT mouse irradiation device without anesthesia according to claim 7, characterized in that, The number of mouse fixation devices (4) and connecting plates (5) is also multiple.

9. The BNCT mouse irradiation device without anesthesia according to claim 1, characterized in that, The connecting plate (5) is L-shaped and can be rotated 180° upwards.

10. The BNCT mouse irradiation device without anesthesia according to claim 9, characterized in that, The connecting plate (5) is made of boron-containing polyethylene and can be used to shield neutron irradiation.

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