A high-precision F18 radiopharmaceutical automatic sampling device

Abstract

This utility model relates to the field of radiopharmaceutical sampling technology and discloses a high-precision automatic sampling device for F18 radiopharmaceuticals, comprising: a sampling chamber, wherein a sampler for extracting and transporting the drug is disposed on the inner side of the sampling chamber; a feeding side chamber, disposed on the outer side of the sampling chamber, wherein a sealed channel is provided between the feeding side chamber and the sampling chamber; a feeding block, located inside the feeding side chamber, wherein an electric slide rail is provided between the sampling chamber and the feeding side chamber, and the feeding block is disposed on the electric slide rail; and several slots, wherein several fixing components are disposed on the inner side of the slots. By setting the fixing components, this application allows the device to adapt to bottles of different sizes and keep the bottles vertically and stably fixed. This design effectively adapts to bottles of various sizes, solves the problem of frequent replacement of the feeding rack in the prior art, improves the applicability and flexibility of the sampling device, increases sampling efficiency, and simplifies the operation steps.

Description

Technical Field

[0001] This utility model relates to the field of radiopharmaceutical sampling technology, and in particular to a high-precision F18 radiopharmaceutical automatic sampling device. Background Technology

[0002] F18, or fluorine-18, is a radioactive isotope that is an important radiolabeling material used in medical imaging, particularly in positron emission tomography (PET). When fluorine-18 binds to deoxyglucose molecules, the resulting compound can be used to assess and diagnose various diseases, including tumors, brain diseases, and cardiovascular diseases.

[0003] When processing and analyzing radiopharmaceutical samples containing fluorine-18, automated sampling devices are generally required. In existing automated sampling devices, the sampling process for F18 radiopharmaceuticals requires the vials to first be placed on a feed rack, and then precisely transported to the sampler via a conveyor system for extraction and transport. However, since the feed rack is only compatible with one size of vial, it is necessary to manually change the feed rack to match different sample containers when dealing with different sizes of vials. This design limitation leads to several significant problems: First, frequent feed rack changes increase operational complexity and preparation time, greatly affecting the overall sampling efficiency; second, in tasks requiring the processing of vials of multiple sizes, batch processing is required, reducing the flexibility and response speed of the equipment, making the entire experimental or production process more time-consuming and inefficient. Therefore, the existing fixed-size feed rack design is poorly adaptable to diverse application scenarios, limiting the efficient operation of automated sampling systems. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a high-precision automatic sampling device for F18 radiopharmaceuticals.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A high-precision F-type radiopharmaceutical automatic sampling device includes: a sampling chamber, on the inside of which a sampler for extracting and transporting the drug is disposed; a feeding side chamber, disposed on the outside of the sampling chamber, with a sealed channel between the feeding side chamber and the sampling chamber; a feeding block, located inside the feeding side chamber, on which an electric slide rail is provided between the sampling chamber and the feeding side chamber; and several slots for holding drug bottles, the slots being formed on the feeding block, with several fixing members disposed on the inner side of the slots for fixing the drug bottles.

[0007] As a preferred technical solution of this utility model, the fixing component includes: a cavity disposed inside the feed block; a sliding plate slidably connected inside the cavity; a fixing plate, one side of which is fixed to the sliding plate, and the other side of which extends into the slot; a storage bag and several springs, all disposed between the sliding plate and the inner side of the cavity, and the storage bag is provided with electrorheological fluid.

[0008] As a preferred embodiment of this utility model, a protective cover is fixed to the top of the feed block, and a through-hole corresponding to the slot is provided on the protective cover. A fastening rope is provided inside the protective cover around the through-hole.

[0009] As a preferred embodiment of this utility model, the bottom and sidewalls of the feed block are provided with an isolation layer.

[0010] As a preferred embodiment of this utility model, the fixing plate is provided with an inclined surface facing the side wall of the medicine bottle.

[0011] As a preferred technical solution of this utility model, all the fixing plates located in the same slot are arranged in a circumferential array.

[0012] This utility model has the following beneficial effects:

[0013] 1. Improved compatibility: By setting up a feeding block and fixing parts, the fixing plate can adaptively adjust its position according to the size of the medicine bottle and keep the medicine bottle vertical and stable. This design can effectively adapt to medicine bottles of various sizes, solve the problem of frequent feeding rack replacement in the existing technology, improve the applicability and flexibility of the sampling device, and also improve the sampling efficiency.

[0014] 2. Improved stability: By setting up a fixing component, the fixing plate can keep the medicine bottle in a vertical position at all times. This allows the sampling needle of the sampler to be stably inserted into the bottle during sampling, which improves the accuracy of sampling and reduces sampling errors caused by the instability of the medicine bottle.

[0015] 3. Simplified operation process: By setting up fixing parts, the staff only needs to put all the medicine bottles into the slots and apply an electric field to the electrorheological fluid to fix all the medicine bottles at the same time. This reduces the need for manual intervention and simplifies the operation steps. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of a high-precision F18 radiopharmaceutical automatic sampling device proposed in this utility model.

[0017] Figure 2 This is a three-dimensional cross-sectional view of the feed block;

[0018] Figure 3 for Figure 2 Enlarged view of the structure at point A.

[0019] In the diagram: 1 Sampling chamber, 2 Feed side chamber, 3 Sealed channel, 4 Sampler, 5 Electric slide rail, 6 Feed block, 7 Slot, 8 Fixing plate, 9 Slide plate, 10 Cavity, 11 Spring, 12 Storage bag, 13 Electrorheological fluid, 14 Protective cover, 15 Penetration port, 16 Fastening rope, 17 Isolation layer. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0021] Reference Figure 1-3 A high-precision F18 radiopharmaceutical automatic sampling device includes a sampling chamber 1, a feed side chamber 2, and a feed block 6. A sampler 4 for extracting and transporting the drug is installed inside the sampling chamber 1. The sampler 4 generally consists of an injection needle, a drive mechanism, and sensors. When the sample is transported to the bottom of the sampler 4, the sampler 4 moves down, and the injection needle inserts into the drug vial to extract the sample. This device is prior art and is not considered an innovation of this application; therefore, it will not be described in detail here. The feed side chamber 2 is located at the sampling... Outside chamber 1, a sealed channel 3 is provided between the feed side chamber 2 and the sampling chamber 1. During feeding, the sealed channel 3 is closed, which can isolate the radioactive contamination in the sampling chamber 1 and play a protective role. The feed block 6 is located inside the feed side chamber 2. An electric slide rail 5 is provided between the sampling chamber 1 and the feed side chamber 2. The feed block 6 is placed on the electric slide rail 5. The electric slide rail 5 is used to transport the feed block 6 and the medicine bottle into the sampling chamber 1. Several slots 7 are opened on the feed block 6. The slots 7 are used to place the medicine bottle.

[0022] The inner side of the slot 7 is provided with several fixing components for fixing the medicine bottle. Specifically, the fixing components include: a cavity 10, which is disposed inside the feed block 6; a slide plate 9, which is slidably connected inside the cavity 10; a fixing plate 8, which has an inclined surface facing the side wall of the medicine bottle. When the medicine bottle is placed, the inclined surface can squeeze the fixing plate 8, causing the fixing plate 8 to move towards the cavity 10. One side of the fixing plate 8 is fixed to the slide plate 9, and the other side of the fixing plate 8 extends into the interior of the slot 7. All the fixing plates 8 located in the same slot 7 are arranged in a circumferential array, which can disperse the force applied to the medicine bottle and ensure that the medicine bottle is firmly fixed; a storage bag 12 and several springs 11 are disposed between the slide plate 9 and the inner side of the cavity 10. The storage bag 12 can deform to store... Both sides of the bag 12 and both ends of the spring 11 are fixed to the side wall of the slide plate 9 and the inside of the cavity 10, respectively. The storage bag 12 is equipped with an electrorheological fluid 13. Specifically, the electrorheological fluid 13 is a smart material whose viscosity can be rapidly changed under the action of an external electric field. In the absence of an electric field, this fluid usually behaves like an ordinary liquid or semi-solid with low viscosity. However, when an electric field of sufficient strength is applied, the particles in the fluid will align along the direction of the electric field to form a solid-like structure, causing its viscosity to increase sharply. Two parallel electrode plates are arranged inside the feed block 6. The two electrode plates are respectively connected to the positive and negative ends of the high voltage power supply. The electric field generated when the power is applied can act on the electrorheological fluid 13, causing its state to change.

[0023] Furthermore, a protective cover 14 is fixed to the top of the feed block 6. The protective cover 14 is provided with a through-hole 15 corresponding to the slot 7. The through-hole 15 is used to place medicine bottles. A fastening rope 16 is provided inside the protective cover 14 around the through-hole 15 so that the through-hole 15 can be adapted to medicine bottles of different sizes. An isolation layer 17 is provided on the bottom and side wall of the feed block 6. Both the isolation layer 17 and the protective cover 14 are used to reduce the influence of the external electric field on the electrorheological fluid 13.

[0024] The specific working principle of this utility model is as follows:

[0025] During operation, the operator first places all the medicine bottles into the slot 7. During placement, the bottom and side walls of the medicine bottles will press against the fixing plate 8, causing it to move towards the cavity 10. When the medicine bottle moves to its limit position, the fixing plate 8 can initially fix the medicine bottle under the elastic force of the spring 11, and keep the medicine bottle in a vertical position. This ensures that the sampling needle of the sampler 4 can be stably inserted into the bottle during sampling. After all the medicine bottles are placed, the operator applies an electric field to the feed block 6. Under the action of the electric field, the state of the electrorheological liquid 13 changes from liquid to solid, thus stably fixing the medicine bottles. Then, the feed side chamber 2 is closed, the sealing channel 3 is opened, and the electric slide rail 5 is activated, so that the medicine bottles can move sequentially under the sampler 4 for sampling. This design allows the device to adapt to medicine bottles of different sizes, improving the flexibility and applicability of operation, and also improving sampling efficiency.

[0026] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A high precision F18 radiopharmaceutical auto-sampling device, characterized by, include: A sampling chamber (1) is provided inside the sampling chamber (1) for extracting and transporting drugs; A feed side chamber (2) is located outside the sampling chamber (1), and a sealed channel (3) is provided between the feed side chamber (2) and the sampling chamber (1); The feed block (6) is located inside the feed side chamber (2). An electric slide rail (5) is provided between the sampling chamber (1) and the feed side chamber (2). The feed block (6) is set on the electric slide rail (5). Several slots (7) are provided for placing medicine bottles. The slots (7) are opened on the feed block (6). Several fixing members are provided on the inner side of the slots (7) for fixing the medicine bottles.

2. The high-precision F18 radiopharmaceutical automatic sampling device according to claim 1, characterized in that, The fastener includes: A cavity (10) is provided inside the feed block (6); The slide plate (9) is slidably connected inside the cavity (10); A fixing plate (8) is fixed on one side to a sliding plate (9), and the other side of the fixing plate (8) extends into the interior of a slot (7); The storage bag (12) and several springs (11) are both disposed between the slide plate (9) and the inside of the cavity (10), and the storage bag (12) is provided with electrorheological fluid (13).

3. The high-precision F18 radiopharmaceutical automatic sampling device according to claim 2, characterized in that, The top of the feed block (6) is fixed with a protective cover (14), and the protective cover (14) is provided with a through hole (15) corresponding to the slot (7). A fastening rope (16) is provided inside the protective cover (14) around the through hole (15).

4. The high-precision F18 radiopharmaceutical automatic sampling device according to claim 3, characterized in that, The bottom and sidewalls of the feed block (6) are provided with an isolation layer (17).

5. The high precision F18 radiopharmaceutical automatic sampling device according to claim 2, characterized in that, The fixing plate (8) has an inclined surface facing the side wall of the medicine bottle.

6. The high precision F18 radiopharmaceutical automatic sampling device according to claim 5, characterized in that, All the fixing plates (8) located in the same slot (7) are arranged in a circumferential array.

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