Crystallization tank for production of ectoine

Abstract

The utility model relates to crystallization equipment technical field, concretely relates to a kind of ectoine production crystallization tank, including tank body. Concentrated liquid feed inlet and ethanol adding port are set on the tank body, ethanol feed inlet is connected with the spraying device in tank body, jacket is set on the outside of tank body, the jacket includes upper jacket and lower jacket, the volume of upper jacket and lower jacket is consistent, the upper side of the upper side of upper jacket is medium inlet, the lower side of the other side is medium outlet, the lower side of the lower side of lower jacket is medium inlet, the upper side of the other side is medium outlet, flow monitoring instrument and control valve are installed on the water inlet pipeline of jacket, temperature monitoring instrument is installed on the water outlet pipeline of jacket. The utility model can realize the uniform addition of ethanol on the one hand, and can realize the more stable control to the temperature in tank body on the other hand, so as to help ectoine better crystallization, help to ensure better crystal form and purity, positively affect product quality.

Description

Technical Field

[0001] This utility model relates to the field of crystallization equipment technology, specifically to an ectoine production crystallization tank. Background Technology

[0002] Ectoin (tetrahydromethylpyrimidine carboxylic acid) is an important biocompatible compound with broad application prospects in cosmetics, pharmaceuticals, food and other fields. The market demand for high-purity ectoin is showing a continuous growth trend.

[0003] Existing ectoine is mainly prepared by biological fermentation, which uses the method of fermenting genetically engineered Escherichia coli. The resulting ectoine fermentation broth can be further purified by filtration, crystallization and other techniques to obtain pure ectoine.

[0004] Crystallization is a key step in the production of ectoine. Reasonable process and parameter control are crucial to improving product yield and ensuring product quality. Long-term practice has shown that adding small molecule alcohols, such as ethanol, can promote ectoine crystallization and effectively improve the crystallization yield, while also playing a positive role in improving product quality.

[0005] Industrial crystallization tanks are generally large, such as 10m³. 3 Due to its large volume, controlling the temperature within the tank during production is quite difficult, and uniform temperature control is crucial to product quality. Therefore, this invention proposes an ectoine crystallization tank, which plays a positive and effective role in ensuring product quality through the uniform addition of small molecule alcohols and further refined temperature control. Utility Model Content

[0006] The purpose of this invention is to address the shortcomings of the existing technology by providing an ectoine production crystallization tank that allows for rapid mixing of ethanol and materials, and enables precise temperature control to control product quality.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: an ectoine production crystallization tank, comprising a tank body, a concentrated liquid inlet provided on the tank body, a jacket provided on the outside of the tank body, a discharge port provided at the bottom of the tank body, and support legs provided around the bottom of the tank body. The tank body is also provided with an ethanol addition port, which is connected to a spray device inside the tank body. The jacket includes an upper jacket and a lower jacket, the upper jacket (31) and the lower jacket have the same volume. A first medium inlet is provided above one side of the upper jacket, a first medium outlet is provided below the other side of the upper jacket, a second medium inlet is provided below one side of the lower jacket, and a second medium outlet is provided above the other side of the lower jacket.

[0008] Furthermore, the tank is equipped with a stirring mechanism, which includes a stirring motor fixed above the tank and connected to a stirring paddle in the tank. A support is provided at the bottom inside the tank, and the bottom of the stirring paddle is supported by the support. A PTFE scraper is fixed around the stirring paddle and contacts the inner wall of the tank.

[0009] Furthermore, the concentrate inlet is connected to the concentrate feed pipe, and a concentrate feed pump is installed on the concentrate feed pipe; the ethanol addition port is connected to the ethanol feed pipe, and an ethanol feed pump is installed on the ethanol feed pipe; the outlet is connected to the outlet pipe, and a third control valve is installed on the outlet pipe.

[0010] Furthermore, a seed crystal addition port and an observation port are provided on the top of the tank.

[0011] Furthermore, the spraying device includes a spray pipe connected to an ethanol addition port, the spray pipe being fixedly connected to the inner wall of the tank via a fixing pipe, and spray heads being evenly distributed below the spray pipe.

[0012] Furthermore, the jacket is connected to a circulating water pipeline, which includes a first circulating water inlet pipe, a second circulating water inlet pipe, a first circulating water outlet pipe, and a second circulating water outlet pipe; the first circulating water inlet pipe is connected to a first medium inlet pipe, and the second circulating water inlet pipe is connected to a second medium inlet pipe; the first circulating water outlet pipe is connected to a first medium outlet pipe, and the second circulating water outlet pipe is connected to a second medium outlet pipe.

[0013] Furthermore, the first circulating water inlet pipe is equipped with a first control valve and a first flow indicator transmitter, the second circulating water inlet pipe is equipped with a second control valve and a second flow indicator transmitter; the first circulating water outlet pipe is equipped with a first temperature indicator transmitter, and the second circulating water outlet pipe is equipped with a second temperature indicator transmitter.

[0014] Furthermore, the first flow indicator transmitter, the second flow indicator transmitter, the first temperature indicator transmitter, and the second temperature indicator transmitter are respectively connected to the field PLC, and the field PLC is connected to the first control valve and the second control valve.

[0015] The beneficial effects of this invention are as follows: On the one hand, this invention can achieve uniform addition of ethanol, and on the other hand, it can achieve more stable temperature control in the tank, which helps ectoine to crystallize better, helps to ensure better crystal form and purity, and plays a positive role in ensuring product quality. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the tank structure of this utility model;

[0017] Figure 2 This is a schematic diagram of the overall structure of this utility model;

[0018] Figure 3 This is a top view schematic diagram of the spraying device of this utility model.

[0019] The names corresponding to each mark in the diagram:

[0020] 1. Tank body; 11. Support legs; 12. Concentrate inlet; 13. Ethanol inlet; 14. Discharge outlet; 15. Seed crystal inlet; 16. Observation port; 2. Stirring mechanism; 21. Stirring motor; 22. Support; 23. Stirring paddle; 24. PTFE scraper; 3. Jacket; 31. Upper jacket; 311. First medium inlet; 312. First medium outlet; 32. Lower jacket; 321. Second medium inlet; 322. Second medium outlet; 4. Spraying device; 41. Spray pipe; 42. Fixing rod; 43. Spray head; 5. 51. Concentrate feed pipe; 6. Ethanol feed pipe; 61. Ethanol feed pump; 7. Circulating water pipe; 71. First circulating water inlet pipe; 711. First control valve; 712. First flow indicator transmitter; 72. Second circulating water inlet pipe; 721. Second control valve; 722. Second flow indicator transmitter; 73. First circulating water outlet pipe; 731. First temperature indicator transmitter; 74. Second circulating water outlet pipe; 741. Second temperature indicator transmitter; 8. Discharge pipe; 81. Third control valve. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model are within the protection scope of the present utility model.

[0022] Embodiments of this utility model:

[0023] like Figure 1-3 As shown, the crystallization tank in this embodiment includes a tank body 1, with a support leg 11 at the bottom of the tank body 1. A stirring mechanism 2 is provided in the tank body 1, and the stirring mechanism 2 includes a stirring motor 21. The stirring motor 21 is fixedly installed above the tank body 1 and is connected to the stirring paddle 23. A support 22 is provided at the bottom of the tank body 1. The lower part of the rotating shaft of the stirring paddle 23 is supported by the support 22 (bridge arch shape, which does not affect the discharge). PTFE scrapers 24 are fixedly installed on both sides of the stirring paddle 23 and are in contact with the inner wall of the tank body 1.

[0024] A concentrate inlet 12 and an ethanol addition port 13 are provided above the tank body 1. The concentrate inlet 12 is connected to the concentrate inlet pipe 5, and a concentrate feed pump 51 is provided on the concentrate inlet pipe 5. The ethanol addition port 13 is connected to the ethanol inlet pipe 6, and an ethanol feed pump 61 is provided on the ethanol inlet pipe 6. The ethanol inlet is connected to a spray device 4 inside the tank body 1. The spray device 4 includes a spray pipe 41. The ethanol inlet is connected to the spray pipe 41. The spray pipe 41 is fixedly connected to the inner side wall of the tank body 1 by a fixing rod 42. Spray heads 43 are evenly distributed below the spray pipe 41. In this embodiment, the concentrate feed pump 51 is a screw pump, and the ethanol feed pump 61 is a peristaltic pump.

[0025] A discharge port 14 is provided at the bottom of the tank body 1, and the discharge port 14 is connected to the discharge pipe 8. A third control valve 81 is provided on the discharge pipe 8. A seed crystal addition port 15 and an observation port 16 are provided above the tank body 1. In this embodiment, the third control valve 81 is a gate valve.

[0026] A jacket 3 is provided on the outside of the tank body 1. The jacket 3 includes an upper jacket 31 and a lower jacket 32, which have the same volume. A first medium inlet 311 is provided on the upper side of the upper jacket 31, and a first medium outlet 312 is provided on the lower side of the other side of the upper jacket 31. A second medium inlet 321 is provided on the lower side of the lower jacket 32, and a second medium outlet 322 is provided on the upper side of the other side of the lower jacket 32. A circulating water pipe 7 is also provided, which includes a first circulating water inlet pipe 71 and a second circulating water inlet pipe 72. Pipe 71 is connected to the first medium inlet 311, and a first control valve 711 and a first flow indicator transmitter 712 are installed on the first circulating water inlet pipe 71; the second circulating water inlet pipe 72 is connected to the second medium inlet 321, and a second control valve 721 and a second flow indicator transmitter 722 are installed on the second circulating water inlet pipe 72; it also includes a first circulating water outlet pipe 73 and a second circulating water outlet pipe 74, and a first temperature indicator transmitter 731 is installed on the first circulating water outlet pipe 73, and a second temperature indicator transmitter 741 is installed on the second circulating water outlet pipe 74.

[0027] In this embodiment, a field PLC is provided. The stirring motor 21, the concentrate feed pump 51 and the ethanol feed pump 61 are all connected to the field PLC. The first temperature indicator transmitter 731, the second temperature indicator transmitter 741, the first flow indicator transmitter 712 and the second flow indicator transmitter 722 are all connected to the field PLC. The field PLC is connected to the first control valve 711 and the second control valve 721.

[0028] The principle of this utility model is as follows:

[0029] In use, under stirring conditions, ectoine concentrate is added to tank 1 through concentrate inlet 12, and ethanol is added to tank 1 by spraying through ethanol inlet. In this invention, a screw pump is used to achieve continuous and stable delivery of concentrate, and a peristaltic pump is used to deliver ethanol. Both screw pump and peristaltic pump are existing mature equipment and have certain metering functions, so they will not be described in detail.

[0030] In the above process, ectoine concentrate is added first, followed by ethanol. The spray device 4 facilitates rapid mixing of ethanol. During crystallization, temperature control is critical, requiring continuous and stable temperature changes in tank 1. In this invention, the upper jacket 31 and lower jacket 32 ​​are used to achieve more stable temperature control in tank 1. The temperatures monitored on the first circulating water outlet pipe 73 and the second circulating water outlet pipe 74 are averaged to obtain the temperature in tank 1 (since the temperature decreases relatively slowly during crystallization, such as 5℃ / h, the temperature on the circulating water outlet pipe can be considered the temperature of the material in tank 1). Then, by controlling the opening and flow rate of the control valves on the first circulating water inlet pipe 71 and the second circulating water inlet pipe 72 (the flow rates in the first and second circulating water inlet pipes 71 and 72 are equal), stable temperature control is achieved, which helps to obtain a product with better crystal form (after the temperature reaches the required crystallization temperature, it is allowed to stand for crystallization) and helps to control product quality.

Claims

1. An ectoine production crystallization tank, comprising a tank body (1), a concentrate inlet (12) provided on the tank body (1), a jacket (3) provided on the outside of the tank body (1), a discharge outlet (14) provided at the bottom of the tank body (1), and support legs (11) provided around the bottom perimeter of the tank body (1), characterized in that: The tank (1) is also provided with an ethanol addition port (13), which is connected to the spray device (4) inside the tank (1); the jacket (3) includes an upper jacket (31) and a lower jacket (32), the upper jacket (31) and the lower jacket (32) have the same volume, a first medium inlet (311) is provided above one side of the upper jacket (31), a first medium outlet (312) is provided below the other side of the upper jacket (31), a second medium inlet (321) is provided below one side of the lower jacket (32), and a second medium outlet (322) is provided above the other side of the lower jacket (32). The jacket is connected to the circulating water pipe (7), which includes a first circulating water inlet pipe (71), a second circulating water inlet pipe (72), a first circulating water outlet pipe (73), and a second circulating water outlet pipe (74). The first circulating water inlet pipe (71) is connected to the first medium inlet (311), the second circulating water inlet pipe (72) is connected to the second medium inlet (321), the first circulating water outlet pipe (73) is connected to the first medium outlet (312), and the second circulating water outlet pipe (74) is connected to the second medium outlet (322).

2. The ectoine production crystallization tank according to claim 1, characterized in that: The tank (1) is provided with a stirring mechanism (2), which includes a stirring motor (21). The stirring motor (21) is fixed above the tank (1). The stirring motor (21) is connected to the stirring paddle (23) in the tank (1). A support (22) is provided at the bottom inside the tank (1). The bottom of the stirring paddle (23) is supported by the support (22). A PTFE scraper (24) is fixed around the stirring paddle (23). The PTFE scraper (24) is in contact with the inner wall of the tank (1).

3. The ectoine production crystallization tank according to claim 1, characterized in that: The concentrate inlet (12) is connected to the concentrate feed pipe (5), and a concentrate feed pump (51) is installed on the concentrate feed pipe (5); the ethanol addition port (13) is connected to the ethanol feed pipe (6), and an ethanol feed pump (61) is installed on the ethanol feed pipe (6); the outlet (14) is connected to the outlet pipe (8), and a third control valve (81) is installed on the outlet pipe (8).

4. The ectoine production crystallization tank according to claim 1, characterized in that: The tank (1) is provided with a seed crystal addition port (15) and an observation port (16) on the top.

5. The ectoine production crystallization tank according to claim 1, characterized in that: The spraying device (4) includes a spray pipe (41), which is connected to the ethanol addition port (13). The spray pipe (41) is fixedly connected to the inner wall of the tank (1) through a fixed pipe. Spray heads (43) are evenly distributed below the spray pipe (41).

6. The ectoine production crystallization tank according to claim 1, characterized in that: The first circulating water inlet pipe (71) is equipped with a first control valve (711) and a first flow indicator transmitter (712), the second circulating water inlet pipe (72) is equipped with a second control valve (721) and a second flow indicator transmitter (722); the first circulating water outlet pipe (73) is equipped with a first temperature indicator transmitter (731), and the second circulating water outlet pipe (74) is equipped with a second temperature indicator transmitter (741).

7. The ectoine production crystallization tank according to claim 6, characterized in that: The first flow indicator transmitter (712), the second flow indicator transmitter (722), the first temperature indicator transmitter (731), and the second temperature indicator transmitter (741) are respectively connected to the field PLC, and the field PLC is connected to the first control valve (711) and the second control valve (721).

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