An extrusion device for doxorubicin hydrochloride liposomes

Abstract

The utility model relates to extrusion technical field for doxorubicin hydrochloride liposome production, especially for a kind of extrusion device for doxorubicin hydrochloride liposome, including bucket body, the top of bucket body is provided with bucket cover, the top of bucket cover is provided with feed inlet, the outside of the connecting place of bucket cover and bucket body is provided with sealing ring, the bottom of bucket body is fixedly connected with conical cylinder, the bottom of conical cylinder is fixedly connected with extrusion cylinder, connecting ring is provided in extrusion cylinder, the outside of connecting ring is provided with quick-release assembly for quick replacement and fixed. The utility model is rotated by rotating block and makes second fixed block and first fixed block align, subsequently rotates cam handle and drives cam, pivot in cam and the fixed rod connected with pivot rotate together, when cam rotates to certain angle, it will be tightly pressed second fixed block by the shape of second fixed block and first fixed block, so that second fixed block and first fixed block are fixed to limit fixing ring in opening, this structure design is simple, and it is convenient to operate.

Description

Technical Field

[0001] This utility model relates to the field of extrusion technology for the production of doxorubicin hydrochloride liposomes, and in particular to an extrusion device for doxorubicin hydrochloride liposomes. Background Technology

[0002] Doxorubicin hydrochloride liposomes often refer to doxorubicin hydrochloride liposome injection. Its active ingredient is doxorubicin hydrochloride, an anthracycline cytotoxic antibiotic extracted from the culture medium of *Streptomyces porphyria* var. *panthenium*. It is mainly used for patients with AIDS-related Kaposi's sarcoma who have extensive skin, mucous membrane, and visceral diseases. Doxorubicin hydrochloride liposomes are one of the important drugs in the treatment of this type of disease and are commonly used in clinical medicine. The production of doxorubicin hydrochloride liposomes requires multiple processing steps, including extrusion processing, which requires the use of extrusion equipment.

[0003] In the current technology, a filter membrane is required for the final extrusion process. However, filter membrane clogging is a common problem in the extrusion process, requiring frequent shutdowns for replacement, which affects continuous production. The filter membrane replacement process in the existing equipment is cumbersome, requiring the tightening of multiple bolts, and the sealing ring is prone to misalignment, leading to leakage. This is especially inconvenient in aseptic operation. Utility Model Content

[0004] This utility model addresses the shortcomings of existing technologies by providing the following technical solution:

[0005] An extrusion device for doxorubicin hydrochloride liposomes includes a barrel body, a barrel cover at the top of the barrel body, a feed inlet at the top of the barrel cover, a sealing ring at the connection between the barrel cover and the barrel body, a conical cylinder fixedly connected to the bottom of the barrel body, an extrusion cylinder fixedly connected to the bottom of the conical cylinder, a connecting ring inside the extrusion cylinder, and a quick-release assembly for quick replacement and fixation on the outside of the connecting ring.

[0006] As an improvement to the above technical solution, the quick-release assembly includes an opening on one side of the connecting ring, a rotating block is rotatably connected to one end of the opening, a locking block is fixedly connected to the inner side of the rotating block, a second fixing block is fixedly connected to the other end of the rotating block, and a locking groove adapted to the locking block is provided on the outer side of the opening.

[0007] As an improvement to the above technical solution, the other end of the opening is fixedly connected to a first fixing block, a fixing rod is rotatably connected inside the first fixing block, the other end of the fixing rod is fixedly connected to the outside of the rotating shaft, the rotating shaft is rotatably connected inside the cam, and a cam handle is fixedly connected to the outside of the cam.

[0008] As an improvement to the above technical solution, a fixing ring is slidably connected inside the opening, and a filter membrane is disposed inside the fixing ring.

[0009] As an improvement to the above technical solution, a support frame is fixedly connected to the top of the bucket lid, a motor is fixedly connected to the middle of the support frame, a rotating rod is fixedly connected to the output end of the motor, filter screens are symmetrically arranged on the outer side of the rotating rod, and scrapers are arranged on the outer side of the filter screens.

[0010] As an improvement to the above technical solution, a plurality of first flow pipes are uniformly arranged inside the barrel, a first inlet is fixedly connected to the top outer side of the barrel, a first outlet is fixedly connected to the bottom outer side of the barrel, and a first temperature sensor is arranged on the outer side of the barrel.

[0011] As an improvement to the above technical solution, a chamber is opened on the inner side of the conical cylinder, a plurality of second flow pipes are evenly arranged inside the conical cylinder, a second inlet is fixedly connected to the top outer side of the conical cylinder, a second outlet is fixedly connected to the bottom outer side of the conical cylinder, and a second temperature sensor is arranged on the outer side of the conical cylinder.

[0012] The beneficial effects of this utility model are:

[0013] When the filter membrane needs to be replaced, the opening can be exposed by rotating the rotating block, making it easy to slide and install or remove the fixing ring and filter membrane. After the fixing ring is installed, the rotating block is rotated in the opposite direction to make the locking block on the inside of the rotating block engage with the locking groove on the outside of the opening to limit and fix the fixing ring. The second fixing block at one end of the rotating block is aligned with the first fixing block at one end of the opening. Then, the cam handle is rotated to drive the cam, rotating shaft and fixing rod to rotate together. When the fixing rod is locked in the first and second fixing blocks, the cam is rotated again. When the cam rotates to a certain angle, its shape will press against the second fixing block, fixing the second fixing block together with the first fixing block, thereby limiting and fixing the filter membrane in the fixing ring in the opening. This structure is simple in design, easy to operate, and takes less time, which can effectively improve production efficiency. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the structure of the first temperature sensor in this utility model;

[0016] Figure 3 This is a schematic diagram of the structure of the filter screen in this utility model;

[0017] Figure 4 This is a schematic diagram of the filter membrane structure in this utility model;

[0018] Figure 5 This is a schematic diagram of the quick-release component in this utility model.

[0019] Reference numerals: 1. Barrel body; 2. Barrel lid; 3. Motor; 4. Support frame; 5. Feed inlet; 6. Sealing ring; 7. First inlet; 8. First outlet; 9. Conical cylinder; 10. Extrusion cylinder; 11. Second outlet; 12. Second inlet; 13. Second temperature sensor; 14. First temperature sensor; 15. Rotating rod; 16. Filter screen; 17. First flow tube; 18. Second flow tube; 19. Chamber; 20. Fixing ring; 21. Filter membrane; 22. Connecting ring; 23. Opening; 24. Slot; 25. First fixing block; 26. Fixing rod; 27. Rotating shaft; 28. Cam; 29. ​​Cam handle; 30. Rotating block; 31. Locking block; 32. Second fixing block; 33. Scraper. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this utility model clearer, the following provides a more detailed description of the utility model. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of the utility model.

[0021] Please refer to Figures 1-5 An extrusion device for doxorubicin hydrochloride liposomes includes a barrel body 1, a barrel cover 2 at the top of the barrel body 1, a feed inlet 5 at the top of the barrel cover 2, a sealing ring 6 on the outside of the connection between the barrel cover 2 and the barrel body 1, a conical cylinder 9 fixedly connected to the bottom of the barrel body 1, an extrusion cylinder 10 fixedly connected to the bottom of the conical cylinder 9, a connecting ring 22 inside the extrusion cylinder 10, and a quick-release assembly for quick replacement and fixation on the outside of the connecting ring 22.

[0022] Specifically, after the barrel body 1 and the barrel cover 2 are connected by a snap-fit, the sealing performance is enhanced by the sealing ring 6 set at the connection. The solution is added into the barrel body 1 through the feed port 5. After the solution undergoes a filtration in the barrel body 1, it flows into the conical cylinder 9 and the extrusion cylinder 10 for final extrusion. The quick-release assembly can speed up the replacement process and reduce the number of replacement steps.

[0023] Please refer to Figures 1-5 The quick-release assembly includes an opening 23 on one side of the connecting ring 22. One end of the opening 23 is rotatably connected to a rotating block 30. A locking block 31 is fixedly connected to the inner side of the rotating block 30. The other end of the rotating block 30 is fixedly connected to a second fixing block 32. A slot 24 adapted to the locking block 31 is provided on the outer side of the opening 23. The other end of the opening 23 is fixedly connected to a first fixing block 25. A fixing rod 26 is rotatably connected inside the first fixing block 25. The other end of the fixing rod 26 is fixedly connected to the outer side of the rotating shaft 27. The rotating shaft 27 is rotatably connected inside the cam 28. A cam handle 29 is fixedly connected to the outer side of the cam 28. A fixing ring 20 is slidably connected inside the opening 23. A filter membrane 21 is provided inside the fixing ring 20.

[0024] Specifically, the rotating block 30 is an arc-shaped block that fits the opening 23. By rotating the rotating block 30, the locking block 31 on the inner side of the rotating block 30 engages with the locking groove 24 on the outer side of the opening 23 to limit and fix the fixing ring 20. The engagement of the locking block 31 and the locking groove 24 also improves the sealing performance and prevents leakage. It also aligns the second fixing block 32 at one end of the rotating block 30 with the first fixing block 25 at one end of the opening 23. Then, rotating the cam handle 29 drives the cam 28, the rotating shaft 27, and the fixing rod 26 together. As the fixed rod 26 is engaged in the first fixed block 25 and the second fixed block 32, the cam 28 continues to rotate. When the cam 28 rotates to a certain angle, its shape will press against the second fixed block 32, so that the second fixed block 32 and the first fixed block 25 are firmly squeezed and fixed by the fixed rod 26, thereby limiting and fixing the filter membrane 21 in the fixed ring 20 in the opening 23. The solution is squeezed out through the microporous filter membrane 21. This structure is simple in design, easy to operate, and takes less time, which can effectively improve production efficiency.

[0025] Please refer to Figures 1-5 A support frame 4 is fixedly connected to the top of the bucket lid 2. A motor 3 is fixedly connected to the middle of the support frame 4. A rotating rod 15 is fixedly connected to the output end of the motor 3. A filter screen 16 is symmetrically arranged on the outside of the rotating rod 15. A scraper 33 is arranged on the outside of the filter screen 16.

[0026] Specifically, the motor 3 drives the rotating rod 15 at its output end to rotate. When the rotating rod 15 rotates, it drives the filter screen 16 symmetrically arranged on its outer side to rotate together to collect larger impurities in the solution, so that the filtered solution continues to flow downwards for easy extrusion. At the same time, when the filter screen 16 rotates, the scraper 33 on its outer side will also rotate and move along with it and continuously scrape the inner wall of the barrel 1 to prevent impurities in the solution from sticking to the inner wall.

[0027] Please refer to Figures 1-5 A plurality of first flow pipes 17 are evenly arranged inside the barrel body 1. A first inlet 7 is fixedly connected to the top outer side of the barrel body 1, and a first outlet 8 is fixedly connected to the bottom outer side of the barrel body 1. A first temperature sensor 14 is arranged on the outer side of the barrel body 1.

[0028] Specifically, a constant temperature medium is injected through the first inlet 7 and flows into the first flow pipe 17, and flows out through the first outlet 8. The medium is recycled and reused through an externally installed recycling device. The temperature of the medium in the first flow pipe 17 can be detected by the first temperature sensor 14, so that the temperature of the solution is maintained within a certain range when it is filtered for the first time in the tank 1.

[0029] Please refer to Figures 1-5A chamber 19 is provided on the inner side of the conical cylinder 9. Several second flow pipes 18 are evenly arranged inside the conical cylinder 9. A second inlet 12 is fixedly connected to the top of the outer side of the conical cylinder 9. A second outlet 11 is fixedly connected to the bottom of the outer side of the conical cylinder 9. A second temperature sensor 13 is provided on the outer side of the conical cylinder 9.

[0030] Specifically, the chambers 19 inside the conical cylinder 9 are also conical, and the inner walls of the conical cylinder 9 are smooth. The space of the chambers 19 gradually narrows, creating a pre-pressure effect on the solution to be extruded. This can break up large liposome aggregates, allowing the solution to flow more evenly to the filter membrane 21, thereby reducing the pressure on the filter membrane 21, extending the life of the filter membrane 21, and improving the success rate of single extrusion. Similarly, a constant temperature medium is injected through the second inlet 12 and flows into the second flow tube 18, and flows out through the second outlet 11. The medium is recycled and reused through an externally installed recovery device. The temperature of the medium in the second flow tube 18 can be detected by the second temperature sensor 13, so that the temperature of the solution is maintained in a lower range than that in the first flow tube 17 when it is extruded in the conical cylinder 9, maximizing the protection of drug activity and improving extrusion efficiency and quality.

[0031] The above embodiments are only used to illustrate the technical solution of this utility model, and are not intended to limit it.

Claims

1. An extrusion apparatus for doxorubicin hydrochloride liposomes, comprising a barrel body (1), a barrel cover (2) provided on the top of the barrel body (1), a feed inlet (5) provided on the top of the barrel cover (2), and a sealing ring (6) provided on the outer side of the connection between the barrel cover (2) and the barrel body (1), characterized in that: A conical cylinder (9) is fixedly connected to the bottom of the barrel (1), and an extrusion cylinder (10) is fixedly connected to the bottom of the conical cylinder (9). A connecting ring (22) is provided inside the extrusion cylinder (10), and a quick-release assembly for quick replacement and fixation is provided on the outside of the connecting ring (22).

2. The extrusion apparatus for doxorubicin hydrochloride liposomes according to claim 1, characterized in that: The quick-release assembly includes an opening (23) on one side of the connecting ring (22), a rotating block (30) is rotatably connected to one end of the opening (23), a locking block (31) is fixedly connected to the inner side of the rotating block (30), a second fixing block (32) is fixedly connected to the other end of the rotating block (30), and a slot (24) adapted to the locking block (31) is provided on the outer side of the opening (23).

3. The extrusion apparatus for doxorubicin hydrochloride liposomes according to claim 2, characterized in that: The other end of the opening (23) is fixedly connected to the first fixing block (25), and a fixing rod (26) is rotatably connected inside the first fixing block (25). The other end of the fixing rod (26) is fixedly connected to the outside of the rotating shaft (27), and the rotating shaft (27) is rotatably connected inside the cam (28). A cam handle (29) is fixedly connected to the outside of the cam (28).

4. The extrusion apparatus for doxorubicin hydrochloride liposomes according to claim 3, characterized in that: A fixing ring (20) is slidably connected inside the opening (23), and a filter membrane (21) is disposed inside the fixing ring (20).

5. The extrusion apparatus for doxorubicin hydrochloride liposomes according to claim 1, characterized in that: A support frame (4) is fixedly connected to the top of the bucket lid (2), a motor (3) is fixedly connected to the middle of the support frame (4), a rotating rod (15) is fixedly connected to the output end of the motor (3), a filter screen (16) is symmetrically arranged on the outside of the rotating rod (15), and a scraper (33) is arranged on the outside of the filter screen (16).

6. The extrusion apparatus for doxorubicin hydrochloride liposomes according to claim 1, characterized in that: A plurality of first flow pipes (17) are uniformly arranged inside the barrel (1). A first inlet (7) is fixedly connected to the top outer side of the barrel (1). A first outlet (8) is fixedly connected to the bottom outer side of the barrel (1). A first temperature sensor (14) is arranged on the outer side of the barrel (1).

7. The extrusion apparatus for doxorubicin hydrochloride liposomes according to claim 1, characterized in that: The conical cylinder (9) has a chamber (19) on its inner side. Several second flow pipes (18) are evenly arranged inside the conical cylinder (9). A second inlet (12) is fixedly connected to the top of the outer side of the conical cylinder (9). A second outlet (11) is fixedly connected to the bottom of the outer side of the conical cylinder (9). A second temperature sensor (13) is arranged on the outer side of the conical cylinder (9).

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