Mouse intragastric liquid medicine constant temperature emulsification device

Abstract

The utility model discloses a mouse gavage liquid medicine constant temperature emulsification device relates to liquid medicine constant temperature emulsification technical field. This mouse gavage liquid medicine constant temperature emulsification device contains device main part, and the middle part of device main part is provided with emulsion tank, and the top of emulsion tank is provided with sealed transmission cover, and the top of sealed transmission cover is provided with drive unit, and the spiral shape of screw disc produces the fluid power of going up when rotating, can promote the initiative of the sediment particle and wall surface adhesion particle, then towards the central stirring axle concentration, makes the particle of bottom deposition to be able to repeatedly pass through emulsification head, strengthens emulsification effect, eliminates the concentration difference of liquid medicine upper and lower layers, and through eccentric wheel makes the eccentric motion of rotating arm, thereby makes the swing of the oscillation type of limiting head, promotes the rotation of rotating connection base of limiting tooth, and drive screw disc carries out the differential rotation to stirring axle, further promotes the full exchange of upper layer and lower layer liquid medicine in emulsification chamber.

Description

Technical Field

[0001] This utility model relates to the field of constant temperature emulsification technology of drug solutions, specifically a constant temperature emulsification device for drug solutions used in oral gavage of mice. Background Technology

[0002] In the drug solutions used for gavage in laboratory mice, multiphase drug solutions are prone to stratification and precipitation. Even after ordinary stirring, there may still be local uneven concentrations. Emulsification devices can make drug particles and oil droplets evenly dispersed in the solvent, ensuring that the drug concentration of each drop of drug solution is consistent. This avoids the situation where the concentration is high at the beginning and low at the end of the gavage or local overdose, and ensures that the dosage of drugs administered to each group of mice is uniform. The constant temperature emulsification device is a type of laboratory equipment that can mix and emulsify multiphase drug solutions at a constant temperature to form a uniform and stable dispersion system.

[0003] Regarding the problems existing in the current technology: Most existing equipment relies solely on the stirring shaft to rotate the emulsifying head. The sediment particles at the bottom tend to adhere to the inner wall of the container or accumulate at the bottom of the chamber, making them difficult to capture by the emulsifying head. Unemulsified sediment particles can lead to differences in concentration between the upper and lower layers of the drug solution, resulting in inaccurate drug dosage during gavage and directly reducing the reliability of experimental data. Furthermore, when faced with a continuous and stable emulsification speed, sediment particles are prone to aggregate under centrifugal force, hindering the circulation of the drug solution within the emulsification chamber. Insufficient exchange between the upper and lower layers of the drug solution further exacerbates the stratification and sedimentation problems, reducing the overall stability of the drug solution. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a constant-temperature emulsification device for oral medication in mice, which solves the problem of uneven emulsification.

[0005] To achieve the above objectives, this utility model is implemented through the following technical solution: a constant temperature emulsification device for mouse gavage includes a device body, an emulsification tank is provided in the middle of the device body, a sealing transmission cover is provided at the top of the emulsification tank, and a drive unit is provided at the top of the sealing transmission cover.

[0006] Preferably, the emulsifying tank includes an emulsifying chamber, a heating jacket is fixedly connected to the outer surface of the emulsifying chamber, a stirring shaft is provided inside the emulsifying chamber, the top end of the stirring shaft passes through the sealing transmission cover and is fixedly connected to the output end of the drive unit, a plurality of emulsifying heads are fixedly connected to the outer surface of the stirring shaft, and two spiral disks are provided inside the emulsifying chamber, the top ends of the two spiral disks are fixedly connected to the bottom end of the sealing transmission cover.

[0007] Preferably, the two spiral disks are arranged around the stirring shaft, and the upper surface of the spiral disks is inclined toward the stirring shaft.

[0008] Preferably, the sealing transmission cover includes a sealing cover, and a reduction transmission chamber is rotatably connected to the inner side of the sealing cover. The bottom end of the reduction transmission chamber is fixedly connected to the top of two spiral discs.

[0009] Preferably, the deceleration transmission chamber includes a fixed guide arm, which is rotatably connected to the outer surface of the stirring shaft. The top end of the fixed guide arm extends to the outer side of the top end of the sealing cover. The outer surface of the fixed guide arm is fixedly connected to the inside of the sealing cover. An eccentric wheel is fixedly connected to the outer surface of the stirring shaft below the fixed guide arm.

[0010] Preferably, a rotating arm is rotatably sleeved on the outer surface of the eccentric wheel, and both ends of the rotating arm are rotatably connected to limit heads. A guide support arm is rotatably connected to the outer surface of the stirring shaft, and the support arm is located below the rotating arm.

[0011] Preferably, the two limiting heads are slidably connected to the fixed guide arm and the guide support arm, respectively.

[0012] Preferably, the bottom end of the guide support arm is rotatably connected to a rotating connecting base, the outer surface of the rotating connecting base is rotatably connected to the inner side of the sealing cover, and a plurality of limiting teeth are fixedly connected to the outer side of the top end of the rotating connecting base, the plurality of limiting teeth being adapted to the limiting head.

[0013] This utility model provides a spiral disc and a reduction gearbox. Compared with the prior art, it has the following advantages: 1. This is a constant-temperature emulsification device for mouse gavage medication. The spiral shape of the spiral disk generates upward fluid force during rotation, which can actively lift the sediment particles at the bottom of the cavity and the particles attached to the wall. Then, the particles are concentrated towards the stirring shaft in the middle by the inclined angle of the upper side of the spiral disk, so that the sediment particles at the bottom can pass through the emulsification head again, which can enhance the emulsification effect, strengthen the circulation flow, and eliminate the concentration difference between the upper and lower layers of the medication.

[0014] 2. This is a constant-temperature emulsification device for mouse gavage medication. An eccentric wheel creates a power path as the stirring shaft rotates, allowing the rotating arm to move eccentrically under the eccentric wheel. With a fixed guide arm defining the sliding path of a limiting head at one end, the limiting head near the guide support arm oscillates. This movement between the limiting teeth causes the limiting head to rotate, driving the rotating connecting base to rotate. This, in turn, drives the spiral disk connected to the rotating connecting base to rotate differentially relative to the stirring shaft. This disrupts the fluid balance within the emulsification chamber, further promoting the full exchange of medication between the upper and lower layers, preventing circulation obstruction, particle agglomeration, and medication stratification, and extending the medication stabilization time. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a cross-sectional view of the internal structure of the emulsification tank of this utility model; Figure 3 This is a schematic diagram of the sealing transmission cover structure of this utility model; Figure 4 This is a cross-sectional view of the gearbox assembly of this utility model; Figure 5 This is an exploded view of the speed reduction transmission compartment structure of this utility model.

[0016] In the diagram: 1. Drive unit; 2. Sealed transmission cover; 21. Sealed cover; 22. Reduction transmission chamber; 221. Fixed guide arm; 222. Eccentric wheel; 223. Limiting head; 224. Rotating arm; 225. Guide support arm; 226. Rotary connecting base; 227. Limiting teeth; 3. Emulsifying tank; 31. Emulsifying chamber; 32. Heating jacket; 33. Stirring shaft; 34. Emulsifying head; 35. Spiral disc; 4. Main body of the device. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0018] Please see Figures 1 to 5 This utility model provides a technical solution: a constant temperature emulsification device for mouse gavage medication, which includes a device body 4, an emulsification tank 3 in the middle of the device body 4, a sealing transmission cover 2 at the top of the emulsification tank 3, and a drive unit 1 at the top of the sealing transmission cover 2.

[0019] The main body 4 of the device serves as the core mounting carrier, the emulsification tank 3 is the core cavity for emulsifying the drug solution, the sealed transmission cover 2 is sealed on the top of the emulsification tank 3 to ensure a stable internal working environment, and the drive unit 1 is fixed on the top of the sealed transmission cover 2. After starting, it provides power output to the entire device and drives the operation of subsequent components.

[0020] Please see Figure 2 The emulsifying tank 3 includes an emulsifying chamber 31. A heating jacket 32 ​​is fixedly connected to the outer surface of the emulsifying chamber 31. A stirring shaft 33 is provided inside the emulsifying chamber 31. The top end of the stirring shaft 33 passes through the sealing transmission cover 2 and is fixedly connected to the output end of the drive unit 1. Several emulsifying heads 34 are fixedly connected to the outer surface of the stirring shaft 33. Two spiral discs 35 are provided inside the emulsifying chamber 31. The top ends of the two spiral discs 35 are fixedly connected to the bottom end of the sealing transmission cover 2.

[0021] The emulsification chamber 31 is used to contain the liquid to be treated. The heating jacket 32 ​​on its outer surface generates heat after being energized, maintaining the liquid in the emulsification chamber 31 at a set constant temperature to avoid temperature fluctuations affecting the properties of the liquid. After the drive unit 1 is started, it drives the stirring shaft 33 inside the emulsification chamber 31 to rotate. Multiple emulsification heads 34 on the outer surface of the stirring shaft 33 rotate with the shaft to perform preliminary emulsification and stirring of the liquid. At the same time, the two spiral disks 35 surrounding the stirring shaft 33 in the emulsification chamber 31 cooperate to complete the circulation and sedimentation of the liquid under the subsequent power action.

[0022] Two spiral disks 35 surround the stirring shaft 33. The upper surface of the spiral disks 35 is inclined toward the stirring shaft 33. The spiral shape of the spiral disks 35 generates upward fluid force when rotating, which can actively lift the sediment particles at the bottom of the cavity and the particles attached to the wall. Then, through the inclined angle of the upper side of the spiral disks 35, they are concentrated toward the stirring shaft 33 in the middle, so that the sediment particles at the bottom can pass through the emulsification head 34 again, which enhances the emulsification effect, strengthens the circulation flow, and eliminates the concentration difference between the upper and lower layers of the liquid.

[0023] Please see Figure 3 The sealing transmission cover 2 includes a sealing cover 21, and a reduction transmission chamber 22 is rotatably connected to the inner side of the sealing cover 21. The bottom end of the reduction transmission chamber 22 is fixedly connected to the top of two spiral discs 35.

[0024] The sealing cover 21 serves to seal and support, and the deceleration transmission chamber 22, which is rotatably connected to its inner side, is a key intermediate structure for power transmission. The bottom end of the deceleration transmission chamber 22 is fixedly connected to the top of the two spiral disks 35, which can transmit its own rotational power to the spiral disks 35, driving the spiral disks 35 to move synchronously, providing a power basis for sedimentation and liquid circulation.

[0025] Please see Figures 4 to 5 The reduction gearbox 22 includes a fixed guide arm 221, which is rotatably connected to the outer surface of the stirring shaft 33. The top end of the fixed guide arm 221 extends to the outer side of the top end of the sealing cover 21. The outer surface of the fixed guide arm 221 is fixedly connected to the inside of the sealing cover 21. An eccentric wheel 222 is fixedly connected to the outer surface of the stirring shaft 33 below the fixed guide arm 221.

[0026] A rotating arm 224 is rotatably mounted on the outer surface of the eccentric wheel 222. Both ends of the rotating arm 224 are rotatably connected to limit heads 223. A guide support arm 225 is rotatably connected to the outer surface of the stirring shaft 33. The support arm 225 is located below the rotating arm 224.

[0027] The fixed guide arm 221 inside the reduction gearbox 22 is fixed inside the sealing cover 21 and is rotatably connected to the stirring shaft 33. It provides support for the stirring shaft 33 and defines its own position. When the stirring shaft 33 rotates, the eccentric wheel 222 on its outer surface rotates synchronously with the shaft. The eccentric wheel 222 converts its own eccentric rotational motion into the swinging power of the rotating arm 224 through the rotating arm 224 sleeved on its outer surface. At the same time, the guide support arm 225 on the outer surface of the stirring shaft 33 provides support and motion guidance for the other end of the rotating arm 224.

[0028] The two limiting heads 223 are slidably connected to the fixed guide arm 221 and the guide support arm 225, respectively.

[0029] The limiting heads 223 at both ends of the rotating arm 224 slide on the side close to the fixed guide arm 221 and the guide support arm 225, respectively. The fixed guide arm 221 limits the sliding trajectory of one limiting head 223, so that the rotating arm 224, driven by the eccentric wheel 222, drives the other limiting head 223 to perform regular oscillating swing, completing the conversion of power form, and preparing for the subsequent differential rotation of the spiral disk 35.

[0030] The bottom end of the guide support arm 225 is rotatably connected to a rotating connecting base 226. The outer surface of the rotating connecting base 226 is rotatably connected to the inner side of the sealing cover 21. Several limiting teeth 227 are fixedly connected to the outer side of the top of the rotating connecting base 226. The several limiting teeth 227 are adapted to the limiting head 223.

[0031] The rotating connecting base 226 can rotate inside the sealing cover 21. Several limiting teeth 227 on the outer side of its top end are adapted to the oscillating limiting head 223. When the limiting head 223 oscillates, it alternately meshes with the limiting teeth 227, pushing the rotating connecting base 226 to rotate slowly. The rotating connecting base 226 drives the deceleration transmission chamber 22 connected to it, which in turn drives the spiral disk 35 to rotate at a different speed than the stirring shaft 33, forming differential motion.

[0032] Please see Figures 1 to 5 At work, First, the emulsified drug solution is injected into the emulsification chamber 31 of the emulsification tank 3. The sealing transmission cover 2 is then tightened to ensure a seal. The constant temperature parameters of the heating jacket 32 ​​are set according to the drug solution stability requirements. After the temperature stabilizes, the drive unit 1 is started. The drive unit 1 drives the stirring shaft 33 to rotate, so that the emulsification head 34 performs preliminary emulsification and stirring of the drug solution. At the same time, the stirring shaft 33 distributes power through the reduction transmission chamber 22. Through the cooperation of the eccentric wheel 222, the rotating arm 224, the limiting head 223 and the limiting teeth 227, the spiral disk 35 is driven to rotate at a different speed than the stirring shaft 33. The spiral disk 35 uses the spiral shape to generate upward fluid force, lifting the sediment particles at the bottom of the chamber and the particles attached to the wall towards the stirring shaft 33, so that they are re-emulsified by the emulsification head 34. Throughout the process, the heating jacket 32 ​​maintains a constant temperature for the drug solution. The differentially rotating spiral disk 35 promotes full exchange between the upper and lower layers of the drug solution, avoids particle agglomeration and stratification, and finally forms a uniform and stable drug solution to meet the precise dosage requirements for oral administration to mice.

[0033] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0034] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, the phrase "comprising an element defined as..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0035] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A constant-temperature emulsification device for a drug solution administered via gavage to mice, comprising a main body (4), characterized in that: The device body (4) is provided with an emulsifying tank (3) in the middle, and a sealing transmission cover (2) is provided at the top of the emulsifying tank (3), and a drive unit (1) is provided at the top of the sealing transmission cover (2). The emulsifying tank (3) includes an emulsifying chamber (31), a heating jacket (32) is fixedly connected to the outer surface of the emulsifying chamber (31), a stirring shaft (33) is provided inside the emulsifying chamber (31), the top end of the stirring shaft (33) passes through the sealing transmission cover (2) and is fixedly connected to the output end of the drive unit (1), a number of emulsifying heads (34) are fixedly connected to the outer surface of the stirring shaft (33), and two spiral discs (35) are provided inside the emulsifying chamber (31), the top ends of the two spiral discs (35) are fixedly connected to the bottom end of the sealing transmission cover (2).

2. The constant-temperature emulsification device for mouse gavage solution according to claim 1, characterized in that: Two spiral disks (35) are arranged around the stirring shaft (33), with the upper surface of the spiral disks (35) inclined toward the stirring shaft (33).

3. The constant-temperature emulsification device for mouse gavage solution according to claim 2, characterized in that: The sealing transmission cover (2) includes a sealing cover (21), and a deceleration transmission chamber (22) is rotatably connected to the inside of the sealing cover (21). The bottom end of the deceleration transmission chamber (22) is fixedly connected to the top of two spiral discs (35).

4. The constant-temperature emulsification device for mouse gavage solution according to claim 3, characterized in that: The reduction gearbox (22) includes a fixed guide arm (221), which is rotatably connected to the outer surface of the stirring shaft (33). The top end of the fixed guide arm (221) extends to the outer side of the top end of the sealing cover (21). The outer surface of the fixed guide arm (221) is fixedly connected to the inside of the sealing cover (21). An eccentric wheel (222) is fixedly connected to the outer surface of the stirring shaft (33) below the fixed guide arm (221).

5. The constant-temperature emulsification device for mouse gavage solution according to claim 4, characterized in that: The outer surface of the eccentric wheel (222) is rotatably fitted with a rotating arm (224), and both ends of the rotating arm (224) are rotatably connected to a limit head (223). The outer surface of the stirring shaft (33) is rotatably connected to a guide support arm (225), and the support arm (225) is located below the rotating arm (224).

6. The constant-temperature emulsification device for mouse gavage solution according to claim 5, characterized in that: The two limiting heads (223) are slidably connected to the fixed guide arm (221) and the guide support arm (225), respectively.

7. The constant-temperature emulsification device for mouse gavage solution according to claim 6, characterized in that: The bottom end of the guide support arm (225) is rotatably connected to a rotating connecting base (226). The outer surface of the rotating connecting base (226) is rotatably connected to the inner side of the sealing cover (21). A number of limiting teeth (227) are fixedly connected to the outer side of the top of the rotating connecting base (226). The number of limiting teeth (227) are adapted to the limiting head (223).

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