Skin external preparation containing loxoprofen and solubilizer

By incorporating polysorbate 60 or 80 into the external skin preparation, the transdermal absorption of loxoprofen is significantly improved, addressing the limitations of existing formulations and delivering enhanced analgesic and anti-inflammatory effects with improved blood circulation.

JP2025010402AActive Publication Date: 2025-01-20DAIICHI SANKYO HEALTHCARE
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Patent Information

Application Number
JP2024193417
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2019-03-25
Filing Date
2024-11-05
Publication Date
2025-01-20
Estimated Expiration
2040-03-24

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Abstract

To provide a skin external preparation (compounding agent) containing loxoprofen and other active ingredients, the skin external preparation having further improved percutaneous absorbency of loxoprofen.SOLUTION: A skin external preparation contains loxoprofen or a salt thereof, l-menthol, ethanol, tocopherol or a derivative thereof and polysorbate.SELECTED DRAWING: None
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Citation Information

Patent Citations

  • Loxoprofen sodium-containing cataplasm

    JP2013147466A

  • Loxoprofen-containing solid formulation for external use

    JP2015193540A

  • Loxoprofen-containing external preparation composition

    JP2016079180A

  • Pharmaceutical preparation containing loxoprofen

    JP2018021002A

  • Skin preparation containing loxoprofen and a solubilizing agent

    JP7592396B2