Makeup compositions for treating skin defects

Abstract

To provide a method of treating and concealing a skin defect in a subject.SOLUTION: The present invention provides a method that comprises applying a makeup composition to a skin defect, where the makeup composition comprises silicone and a coloring agent, where the makeup composition simultaneously conceals and treats the skin defect. Makeup compositions and kits for treating and concealing skin defects are also provided.SELECTED DRAWING: None

Description

[Technical field]

[0001] FIELD OF THEINVENTION The present invention relates to a method for treating and concealing skin imperfections in a subject in need thereof by application of a silicone-based makeup composition.The present invention also relates to therapeutic makeup compositions and kits. [Background technology]

[0002] background Makeup compositions are used to enhance or highlight certain facial features, such as eyes or lips.Another important use is to camouflage the appearance of imperfect face or other physical features.Few consumers are blessed with flawless skin, and it is often desirable to hide skin imperfections.For example, adults or teenagers who suffer from acne may wish to apply makeup compositions to hide acne scars and breakouts.

[0003] Consumers do not have makeup compositions designed to treat skin defects, especially scars. In some circumstances, some makeup compositions delay or even worsen the healing process of certain skin defects. Conversely, consumers often use products that help heal skin defects, but these do not hide the defects during the healing process. For example, U.S. Patent No. 5,759,560 (Patent Document 1) discloses a silicone thermoplastic sheet suitable for use in the treatment of dermatological scars, and U.S. Patent No. 6,284,941 (Patent Document 2) discloses a bandage containing a silicone gel for the treatment of skin scars, keloids, wounds or abrasions. Also, U.S. Patent No. 6,159,494 (Patent Document 3) discloses a tape containing a gel from bulbine frutescens for treating post-operative scars. None of these products can simultaneously hide and heal scars.

[0004] Contraction of hypertrophic scars can be increased by applying silicone gel plates or sheets to the scar. Several products are commercially available for this purpose, for example Dow Corning Silastic Sheeting, Cica-Care (Smith & Nephew), Epi-Derm (Biodermis), and Nagosil (Nagor). These products are in the form of molded silicone gel sheets having a thickness of 2 to 4 millimeters. In the treatment of hypertrophic scars, these sheets are placed over the scar and worn for a relatively long period of time, often 3 to 12 months, until the scar is either reduced or eliminated. These products are large, very unsightly, and difficult to handle. Examples of patents disclosing such silicone gel sheets include U.S. Patent No. 5,759,560 (Patent Document 1); U.S. Patent No. 5,891,076 (Patent Document 4); U.S. Patent No. 5,895,656 (Patent Document 5) and U.S. Patent No. 5,919,476 (Patent Document 6). None of these products provide an aesthetic benefit to the skin like a makeup composition.

[0005] Because the healing process for many skin defects, such as severe skin scarring, can take time and can be upsetting to these defects, there is a need for makeup compositions that incorporate effective scar treatment technologies that simultaneously conceal and heal skin defects. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] U.S. Patent No. 5,759,560 [Patent Document 2] U.S. Patent No. 6,284,941 [Patent Document 3] U.S. Patent No. 6,159,494 [Patent Document 4] U.S. Patent No. 5,891,076 [Patent Document 5] U.S. Patent No. 5,895,656 [Patent Document 6] U.S. Patent No. 5,919,476 Summary of the Invention

[0007] In accordance with various aspects and embodiments of the present disclosure, the present invention is directed to makeup compositions, kits, and methods for treating skin defects in a subject in need thereof by application of a high silicone content makeup scar treatment composition.

[0008] In one embodiment, a method for treating and hiding skin defects in a subject comprises applying a makeup composition to the skin defect, the makeup composition comprising at least 5% by weight, 10% by weight, or 20% by weight of silicone and colorant, and simultaneously hiding and treating the skin defect. In another embodiment, the makeup composition is silky smooth, non-greasy, and odorless. In another embodiment, the makeup composition does not comprise an immiscible layer.

[0009] In another embodiment, the makeup composition further comprises a scar-dissolving agent. In one embodiment, the scar-dissolving agent is selected from the group consisting of one or more steroid hormones, collagenases, proteases, oligopolysaccharides, and biologics, or combinations thereof. In one embodiment, the scar-dissolving agent is a steroid hormone. In a preferred embodiment, the steroid hormone is cortisone.

[0010] In another embodiment, the skin defect is an existing scar or a healing wound due to a Caesarean section, plastic surgery, cardiac surgery, a pediatric cleft lip, orthopedic surgery, a burn, a cut, an abrasion, or other trauma.

[0011] In another embodiment, the scar is selected from a keloid scar, a hypertrophic scar, a contracture scar, an acne scar, a chickenpox scar, a skin cancer scar, a dog bite scar, an accident scar, or a surgical scar.

[0012] In another embodiment, the scar is a surgical scar following removal of sutures about 7 to about 14 days after surgery.

[0013] In another embodiment, the makeup composition further provides UV protection.

[0014] In another embodiment, the scar is substantially healed following treatment. In another embodiment, the treatment results in a substantial reduction in the amount and visibility of scar tissue. In one embodiment, the size of the scar is reduced by at least 10%, at least 20%, at least 30%, at least 40%, or at least 50% following treatment.

[0015] In another embodiment, the treatment further provides a soothing or soothing effect to the skin.

[0016] In another embodiment, the makeup composition comprises a pearlescent pigment, hi one embodiment, the pearlescent pigment is titanium mica with iron oxide.

[0017] In another embodiment, the silicone is selected from liquid silicones, oil silicones, wax silicones, resin silicones, or mixtures thereof.

[0018] In another embodiment, the silicone is selected from dimethicone, methicone, trimethicone, cyclomethicone, amodimethicone, trimethylsilylamodimethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, polydimethylsiloxane, polymethylsilsequioxane, and dimethiconol, and mixtures thereof.

[0019] In another embodiment, the amount of makeup composition applied to the skin defect is from about 0.1 to about 10 mL.

[0020] In another embodiment, the viscosity of the silicone is from about 1000 cP to about 1,000,000 cP.

[0021] In another embodiment, the makeup composition is maintained on the skin for at least 1 to 8 hours each day.

[0022] In another embodiment, the makeup composition is applied 1 to 5 times per day for about 14 days to about 120 days.

[0023] In another embodiment, the weight of the silicone ranges from about 5% to about 90% by weight relative to the total weight of the makeup composition.In one embodiment, the weight of the silicone is at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or at least 90% by weight relative to the total weight of the makeup composition.

[0024] In another embodiment, the subject is a human.

[0025] In another embodiment, the present disclosure provides a makeup composition comprising at least 80% by weight of a silicone and a colorant, which when applied to a skin scar of a subject, simultaneously treats the scar on the skin of a subject while camouflaging the scar and providing UV protection. In one embodiment, the makeup composition does not include an immiscible layer.

[0026] In another embodiment, the silicone comprises polydimethylsiloxane.

[0027] In another embodiment, there is provided a scar treatment kit comprising: a) the above-described makeup composition; b) at least one container comprising the makeup composition; and c) at least one applicator.

[0028] In another embodiment, the applicator is a brush, puff, or sponge. [The present invention 1001] A method for treating and concealing a skin defect in a subject, comprising applying a makeup composition to the skin defect, the makeup composition comprising at least 20% by weight of silicone and a colorant, which conceals and simultaneously treats the skin defect. [The present invention 1002] The method of claim 1001, wherein the skin defect is a scar. [The present invention 1003] The method of claim 1002, wherein the scar is selected from a keloid scar, a hypertrophic scar, a contracture scar, an acne scar, and a surgical scar. [The present invention 1004] The method of claim 1002, wherein said scar is a surgical scar following suture removal which begins about 7 to about 14 days after surgery. [The present invention 1005] The method of claim 10, wherein the makeup composition further provides UV protection. [The present invention 1006] The method of claim 1001, wherein said skin is substantially healed following said treatment and scar formation. [The present invention 1007] The method of claim 1002, wherein said treatment substantially reduces the amount and visibility of scar tissue. [The present invention 1008] The method of claim 1002, wherein the size of the scar is reduced following said treatment. [The present invention 1009] The method of claim 1007, wherein the treatment further provides a soothing effect to the skin. [The present invention 1010] The method of claim 10, wherein the makeup composition comprises a pearlescent pigment. [The present invention 1011] The method of claim 10, wherein the pearlescent pigment is a titanic mica containing iron oxide. [The present invention 1012] The method of claim 10, wherein the silicone is selected from a liquid silicone, an oil silicone, a wax silicone, a resin silicone, or a mixture thereof. [The present invention 1013] The method of claim 1001, wherein the silicone is selected from dimethicone, methicone, trimethicone, cyclomethicone, amodimethicone, trimethylsilylamodimethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, polydimethylsiloxane, polymethylsilsequioxane, and dimethiconol, and mixtures thereof. [The present invention 1014] The method of claim 10, wherein the amount of said makeup composition applied to said skin defect is from about 0.1 to about 10 mL. [The present invention 1015] 1001. The method of claim 1001, wherein the viscosity of said silicone is from about 1000 cP to about 1,000,000 cP. [The present invention 1016] 1001. The method of claim 1001, wherein said makeup composition is maintained on said skin for at least 1 to 8 hours each day. [The present invention 1017] 1016. The method of claim 1016, wherein said makeup composition is applied 1 to 5 times a day for about 14 days to about 120 days. [The present invention 1018] 1001. The method according to claim 1001, wherein the amount by weight of silicone is at least 25% relative to the total weight of the makeup composition. [The present invention 1019] The method according to claim 1018, wherein the weight of the silicone is at least 30% relative to the total weight of the makeup composition. [The present invention 1020] The method of claim 10, wherein the subject is a human. [The present invention 1021] The method of claim 10, wherein the makeup composition further comprises cortisone. [The present invention 1022] A makeup composition comprising at least 80% by weight silicone and a colorant, which when applied to a scar on the skin of a subject, simultaneously treats the scar on the skin of the subject, camouflages the scar, and provides UV protection. [The present invention 1023] The makeup composition of claim 1022, wherein the silicone comprises polydimethylsiloxane. [The present invention 1024] A makeup composition according to claim 1022, further comprising cortisone. [The present invention 1025] A method for treating and concealing a skin defect in a subject, comprising applying a makeup composition to the skin defect, the makeup composition comprising at least 20% by weight of silicone, a colorant, and a scar-dissolving agent selected from the group consisting of steroid hormones, collagenase, proteases, oligosaccharides, and biological agents, and combinations thereof, wherein the makeup composition simultaneously conceals and treats the skin defect. [The present invention 1026] 1025. The method of claim 1025, wherein said steroid hormone is cortisone. [The present invention 1027] 1. A method for simultaneously treating and concealing a skin defect in a subject, comprising applying a makeup composition to the skin defect, wherein the makeup composition comprises at least 20% by weight of silicone and a colorant, the colorant depositing a color on the keratinous material that matches the color of the keratinous material, and the makeup composition is not composed of an immiscible layer. [The present invention 1028] The method of claim 1027, wherein the skin defect is a scar. [The present invention 1029] The method of claim 1027, wherein the silicone is selected from a liquid silicone, an oil silicone, a wax silicone, a resin silicone, or a mixture thereof. [The present invention 1030] The method of claim 1027, wherein the subject is a human. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0029] Detailed Description of the Invention definition Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. In case of conflict, the present application, including definitions, will control. Further, unless otherwise required by context, singular terms shall include the plural and plural terms shall include the singular. All publications, patents, and other references mentioned herein are incorporated herein by reference in their entirety as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

[0030] Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods and materials are described below. The materials, methods, and examples are illustrative only and are not intended to be limiting. Other features and advantages of the present disclosure will be apparent from the detailed description, and from the claims.

[0031] To further define this disclosure, the following terms and definitions are provided.

[0032] General definitions The singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. The terms "a" (or "an"), "one or more," and "at least one" are used interchangeably herein. In certain aspects, the term "a" or "an" means "single." In other aspects, the term "a" or "an" includes "two or more" or "plural."

[0033] The term "about" is used herein to mean about, roughly, approximately, or within a region thereof. When the term "about" is used in conjunction with a numerical range, it modifies that range by extending the boundaries above and below the stated numerical values. In general, the term "about" is used herein to adjust a numerical value above and below the stated value with a variance of 10% upward or downward (higher or lower).

[0034] As used herein, the term "and / or" should be considered as a specific disclosure of each of the two specified features or components, whether or not the other is present. Thus, the term "and / or" used in phrases such as "A and / or B" is intended to include "A and B", "A or B", "A" (single), and "B" (single). Similarly, the term "and / or" used in phrases such as "A, B, and / or C" is intended to encompass each of the following aspects: A, B, and C; A, B or C; A or C; A or B; B or C; A and C; A and B; B and C; A (single); B (single); and C (single).

[0035] As used herein, the term "substantially" is used in its ordinary sense, including but not limited to an amount greater than 50 percent.

[0036] Definitions of specific terms The term "skin defect" as used herein is defined as any abnormality or blemish associated with the skin or epidermis. Defects include skin lesions, scars, hyperpigmentation, hypopigmentation, atrophy, burns, trauma, or wounds.

[0037] The term "makeup composition" as used herein is defined as a product containing a colorant capable of depositing color onto a keratinous material, such as human skin or integument, by application to a keratinous material product, such as lipstick, makeup powder, makeup liquid, mineral makeup, eyeliner, foundation, self-tanning agent, or semi-permanent makeup product (tattoo). In one embodiment, the color deposited onto the keratinous material matches the color of the keratinous material.

[0038] The term "immiscible" as used herein is defined as incapable of mixing to form a homogeneous mixture.

[0039] "Steroid hormone" refers to a hormone having a steroid skeleton. Examples of steroid hormones include, but are not limited to, cortisone, clobetasol propionate, flurandrenolide, betamethasone dipropionate, diflorasone diacetate, desoximetasone, halobetasol propionate, fluocinonide, mometasone furoate, mometasone, halcinonide, desoximetasone, fluticasone propionate, triamcinolone acetonide, hydrocortisone valerate, fluocinolone acetonide, prednicarbate, desonide, hydrocortisone, fluocinolone acetonide, hydrocortisone valerate, alclometasone dipropionate, and pharmaceutically acceptable salts thereof.

[0040] As used herein, the term "collagenase" refers to a proteolytic enzyme capable of degrading native collagen.

[0041] The term "protease" as used herein refers to an enzyme that catalyzes the cleavage of peptide bonds in, for example, proteins, polypeptides, oligopeptides, and peptides (collectively, "peptides"). Exemplary proteases include, but are not limited to, serine proteases, cysteine ​​proteases, threonine proteases, aspartic acid proteases, glutamic acid proteases, metalloproteases, asparagine peptide lyases, and the like.

[0042] The term "oligosaccharide" as used herein refers to a molecule composed of multiple sugar units, where these units are linked through glycosidic linkages. As used within this application, the term oligosaccharide also includes higher molecular weight oligomers known as polysaccharides.

[0043] The term "biologic" as used herein refers to biological drugs, including a wide range of products such as vaccines, blood and blood components, allergens, somatic cells, gene therapy, tissues, and proteins. Biologics may be composed of sugars, proteins, nucleic acids, or complex combinations of these substances, and may be living organisms such as cells and tissues. Biologics can be isolated from a variety of sources, such as human, animal, or microbial.

[0044] The term "keloid scar" as used herein is defined as the result of the overgrowth of granulation tissue at the site of a healed skin injury. It may be an overgrowth scar, or an overly aggressive healing response to a wound.

[0045] The term "hypertrophic scar" as used herein is defined as a non-proliferative scar that is a red, raised lump on the skin.

[0046] The term "contracture scar" as used herein refers to the result of a contracture process that occurs in healed scars, often resulting in an undesirable, fixed, rigid scar that may cause functional or cosmetic deformity. Contracture scars are reviewed by Ross Rudolph, Jerry Vande Berg, and H. Paul Ehrlich in Wound Healing: Biochemical and Clinical Aspects, IK Cohen, RF Diegelmann and WJ Lindblad Eds, WB Saunders Company, 96-114 (1992).

[0047] The term "acne scar" as used herein refers to scars formed on skin affected by acne. Acne is often accompanied by scarring (cicatrization). The term "acne" includes mild acne, moderate acne, severe acne, and very severe acne. Mild acne refers to the absence of skin lesions, such as few to a few papules / pustules and nodules. Moderate acne refers to the presence of a few to many papules / pustules, few to a few nodules, and many widespread comedones. Severe acne refers to the presence of many and / or widespread papules / pustules, many persistent or recurrent nodules, large and very widespread comedones, ongoing scarring, persistent purulent and / or serosanguineous drainage from lesions, and the presence of fistulas. Very severe acne also includes conditions called acne congenital, acne fulminant, and acne inverse (follicular atresia triad).

[0048] As used herein, the term "surgical scar" refers to a scar that forms following a surgical procedure.

[0049] As used herein, the term "UV protection" refers to protection against the harmful effects of ultraviolet radiation.

[0050] The terms "color agent" and "coloring agent" as used herein refer to any pigment or dye, or mixture of pigments and / or dyes, suitable for providing sufficient color to the makeup composition. In one embodiment, the coloring agent is used to match the color of the makeup composition to the color of the keratinous material to which the composition is attached.

[0051] The term "silicone" as used herein refers to organosilicon polymers or oligomers of various molecular weights, linear or cyclic, branched or crosslinked, obtained by polymerization and / or polycondensation of suitably functionalized silanes, and consisting essentially of repeating main units in which silicon atoms are bonded to each other through oxygen atoms (siloxane bonds ≡Si-O-Si≡) and optionally substituted hydrocarbon groups are bonded directly to silicon atoms through carbon atoms. The most common hydrocarbon groups are alkyl groups, especially (C1-C 30 ) an alkyl group, in particular a methyl group, a fluoroalkyl group or an aryl group, in particular a phenyl group.

[0052] As used herein, the term "liquid silicone" refers to a silicone compound that is liquid at ambient temperature (25° C.) and atmospheric pressure (760 mmHg).

[0053] The term "silicone oil" as used herein refers broadly to oils that contain at least one silicon atom, specifically a Si-O group.

[0054] The term "silicone wax" as used herein refers to a silicone product that is semi-solid or solid at room temperature. Silicone waxes include substituted long-chain alkyl (C ) dimethicone such as stearyl dimethicone, bisstearyl dimethicone, behenyl dimethicone, or behenoxy dimethicone. 16 ~C 30 Examples of suitable polydimethylsiloxanes include polydimethylsiloxanes having the following structure:

[0055] As used herein, the term "silicone resin" refers to a class of silicone polymers that contain at least two silicone backbones linked by a crosslinking group.

[0056] The term "viscosity" as used herein refers to a measurement of fluid friction. High viscosity materials possess high internal friction and do not flow or spread as easily as low viscosity materials.

[0057] Methods for Treating Skin Defects The present disclosure describes a method for treating and concealing a skin defect in a subject, the method comprising applying a makeup composition to the skin defect, the makeup composition comprising at least 5%, 10%, or 20% by weight of silicone and a colorant, to simultaneously conceal and treat the skin defect.

[0058] In another embodiment, the weight of the silicone ranges from about 5% to about 90% based on the total weight of the makeup composition. In one embodiment, the weight of the silicone ranges from about 5% to about 90%, about 5% to about 85%, about 5% to about 80%, about 5% to about 75%, about 5% to about 70%, about 5% to about 65%, about 5% to about 60%, about 5% to about 55%, about 5% to about 50%, about 5% to about 45%, about 5% to about 40%, about 5% to about 35%, about 5% to about 30%, about 5% to about 25%, about 5% to about 20%, about 5% to about 15%, about 5% to about 20%, about 5% to about 30%, about 5% to about 2 ... %, about 5% to about 10%, about 10% to about 90%, about 15% to about 90%, about 20% to about 90%, about 25% to about 90%, about 30% to about 90%, about 35% to about 90%, about 40% to about 90%, about 45% to about 90%, about 50% to about 90%, about 55% to about 90%, about 60% to about 90%, about 65% to about 90%, about 70% to about 90%, about 75% to about 90%, about 80% to about 90%, and about 85% to about 90%. In one embodiment, the weight of the silicone is at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or at least 90% relative to the total weight of the makeup composition.

[0059] In one embodiment, the composition does not include an immiscible layer.

[0060] In another embodiment, the makeup composition further comprises a scar-dissolving agent. In one embodiment, the scar-dissolving agent is selected from the group consisting of one or more steroid hormones, collagenases, proteases, oligopolysaccharides, and biologics, or combinations thereof. In one embodiment, the scar-dissolving agent is a steroid hormone. In a preferred embodiment, the steroid hormone is cortisone.

[0061] In one embodiment related to this method, the skin defect is any abnormality or injury related to the skin or epidermis.Skin defects include, but are not limited to, skin lesions, scars, hyperpigmentation, hypopigmentation, atrophy, burns, trauma or wounds.In a preferred embodiment, the skin defect is a scar.

[0062] In one embodiment related to the present method, silicone refers to organosilicon polymers or oligomers of various molecular weights, linear or cyclic, branched or crosslinked, obtained by polymerization and / or polycondensation of suitably functionalized silanes, consisting essentially of repeating main units in which silicon atoms are bonded to each other through oxygen atoms (siloxane bonds ≡ Si-O-Si ≡ ) and optionally substituted hydrocarbon groups are bonded directly to silicon atoms through carbon atoms. The most common hydrocarbon groups are alkyl groups, especially (C1-C 30 ) an alkyl group, in particular a methyl group, a fluoroalkyl group or an aryl group, in particular a phenyl group.

[0063] A variety of silicones can be used in the composition and can be chosen from silicone liquids, silicone oils (which may or may not be volatile), silicone waxes, silicone gums, silicone resins, silicone surfactants and / or mixtures thereof.

[0064] In one embodiment, the silicone oil is a compound corresponding to the following general formula (I): TIFF2025024052000001.tif37128In the formula, R1 and R2 are independently C 1~6is alkyl, n is an integer from 3 to 100.

[0065] In one embodiment, the silicone oil is a linear polydimethylsiloxane (PDMS) corresponding to the following general formula (II): TIFF2025024052000002.tif34128 formula, W is -CH3 or -OH; m is an integer from 0 to 2000.

[0066] In one embodiment related to this method, the weight percent of the silicone oil in the makeup composition is about 1% to about 99%, about 1% to about 90%, about 1% to about 80%, about 1% to about 70%, about 1% to about 60%, about 1% to about 50%, about 1% to about 40%, about 1% to about 30%, about 1% to about 20%, about 1% to about 10%, about 1% to about 5%, about 5% to about 99%, about 5% to about 90%, about 5% to about 80%, about 5% to about 70%, about 5% to about 60%, about 5% to about 50%, about 5% to about 40%, about 5% to about 30%, about 5% to about 20%, about 5% to about 10%, about 10% to about 99%, about 10% to about 90%, About 10% to about 80%, about 10% to about 70%, about 10% to about 60%, about 10% to about 50%, about 10% to about 40%, about 10% to about 30%, about 10% to about 20%, about 15% to about 99%, about 15% to about 90%, about 15% to about 80%, about 15% to about 70%, about 15% to about 60%, about 15% to About 50%, about 15% to about 40%, about 15% to about 30%, about 15% to about 20%, about 20% to about 99%, about 20% to about 90%, about 20% to about 80%, about 20% to about 70%, about 20% to about 60%, about 20% to about 50%, about 20% to about 40%, about 20% to about 30%, about 25% to about 99%, About 25% to about 90%, about 25% to about 80%, about 25% to about 70%, about 25% to about 60%, about 25% to about 50%, about 25% to about 40%, about 25% to about 30%, about 30% to about 99%, about 30% to about 90%, about 30% to about 80%, about 30% to about 70%, about 30% to about 60%, about 30% to About 50%, about 30% to about 40%, about 35% to about 99%, about 35% to about 90%, about 35% to about 80%, about 35% to about 70%, about 35% to about 60%, about 35% to about 50%, about 35% to about 40%, about 40% to about 99%, about 40% to about 90%, about 40% to about 80%, about 40% to about 70%, About 40% to about 60%, about 40% to about 50%, about 45% to about 99%, about 45% to about 90%, about 45% to about 80%, about 45% to about 70%, about 45% to about 60%, about 45% to about 50%, about 50% to about 99%, about 50% to about 90%, about 50% to about 80%, about 50% to about 70%, about 50% to About 60%, about 55% to about 99%, about 55% to about 90%, about 55% to about 80%, about 55% to about 70%, about 55% to about 60%, about 60% to about 99%, about 60% to about 90%, about 60% to about 80%, about 60% to about 70%, about 65% to about 99%, about 65% to about 90%, about 65% to about 80%,It may be in the range of about 65% to about 70%, about 70% to about 99%, about 70% to about 90%, about 70% to about 80%, about 75% to about 99%, about 75% to about 90%, about 75% to about 80%, about 80% to about 99%, about 80% to about 90%, about 85% to about 99%, about 85% to about 90%, about 90% to about 99%, about 90% to about 95%, or about 95% to about 99%. In another embodiment, the weight percent of silicone in the makeup composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, or about 99%.

[0067] In one embodiment related to this method, the silicone wax is a silicone product that is semi-solid or solid at room temperature, hi another embodiment, the silicone wax has a melting point in the range of about 25°C to about 135°C.

[0068] In one embodiment related to this method, the silicone wax is a compound corresponding to the following general formula (III): TIFF2025024052000003.tif37128In formula, R1, R2, R3, and R4 are C1 to C 30 Alkyl, C1-C 30 alkoxy, and aryl, each of which is optionally substituted by an ester group; Z is C1~C 30 Alkyl, C1-C 30 Alkoxy, C1-C 30 ester, and aryl; x and y are independently an integer of 0 to 100.

[0069] In one embodiment related to this method, the weight percent of the silicone wax in the makeup composition is about 1% to about 99%, about 1% to about 90%, about 1% to about 80%, about 1% to about 70%, about 1% to about 60%, about 1% to about 50%, about 1% to about 40%, about 1% to about 30%, about 1% to about 20%, about 1% to about 10%, about 1% to about 5%, about 5% to about 99%, about 5% to about 90%, about 5% to about 80%, about 5% to about 70%, about 5% to about 60%, about 5% to about 50%, about 5% to about 40%, about 5% to about 30%, about 5% to about 20%, about 5% to about 10%, about 10% to about 99%, about 10% to about 90%, About 10% to about 80%, about 10% to about 70%, about 10% to about 60%, about 10% to about 50%, about 10% to about 40%, about 10% to about 30%, about 10% to about 20%, about 15% to about 99%, about 15% to about 90%, about 15% to about 80%, about 15% to about 70%, about 15% to about 60%, about 15% to About 50%, about 15% to about 40%, about 15% to about 30%, about 15% to about 20%, about 20% to about 99%, about 20% to about 90%, about 20% to about 80%, about 20% to about 70%, about 20% to about 60%, about 20% to about 50%, about 20% to about 40%, about 20% to about 30%, about 25% to about 99%, About 25% to about 90%, about 25% to about 80%, about 25% to about 70%, about 25% to about 60%, about 25% to about 50%, about 25% to about 40%, about 25% to about 30%, about 30% to about 99%, about 30% to about 90%, about 30% to about 80%, about 30% to about 70%, about 30% to about 60%, about 30% to About 50%, about 30% to about 40%, about 35% to about 99%, about 35% to about 90%, about 35% to about 80%, about 35% to about 70%, about 35% to about 60%, about 35% to about 50%, about 35% to about 40%, about 40% to about 99%, about 40% to about 90%, about 40% to about 80%, about 40% to about 70%, About 40% to about 60%, about 40% to about 50%, about 45% to about 99%, about 45% to about 90%, about 45% to about 80%, about 45% to about 70%, about 45% to about 60%, about 45% to about 50%, about 50% to about 99%, about 50% to about 90%, about 50% to about 80%, about 50% to about 70%, about 50% to About 60%, about 55% to about 99%, about 55% to about 90%, about 55% to about 80%, about 55% to about 70%, about 55% to about 60%, about 60% to about 99%, about 60% to about 90%, about 60% to about 80%, about 60% to about 70%, about 65% to about 99%, about 65% to about 90%, about 65% to about 80%,It may be in the range of about 65% to about 70%, about 70% to about 99%, about 70% to about 90%, about 70% to about 80%, about 75% to about 99%, about 75% to about 90%, about 75% to about 80%, about 80% to about 99%, about 80% to about 90%, about 85% to about 99%, about 85% to about 90%, about 90% to about 99%, about 90% to about 95%, or about 95% to about 99%. In another embodiment, the weight percent of the silicone wax in the makeup composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, or about 99%.

[0070] In one embodiment related to this method, the silicone gum has a viscosity of from 500,000 cSt to 5×10 at 25° C. 7 In another embodiment, the silicone gum does not exhibit a melting point.

[0071] In another embodiment related to this method, the silicone gum is a compound corresponding to the following general formula (IV): TIFF2025024052000004.tif37128In formula, R5, R6, R7, R8, R9, R 10 , R 11 , and R 12 are independently C1-C6 alkyl; Q is C1-C6 alkyl, -OH, and C 2~10 alkenyl; s and t are independently integers from 1 to 5,000.

[0072] In one embodiment related to this method, the silicone gum is present in the makeup composition in an amount by weight of about 1% to about 99%, about 1% to about 90%, about 1% to about 80%, about 1% to about 70%, about 1% to about 60%, about 1% to about 50%, about 1% to about 40%, about 1% to about 30%, about 1% to about 20%, about 1% to about 10%, about 1% to about 5%, about 5% to about 99%, about 5% to about 90%, about 5% to about 80%, about 5% to about 70%, about 5% to about 60%, about 5% to about 50%, about 5% to about 40%, about 5% to about 30%, about 5% to about 20%, about 5% to about 10%, about 10% to about 99%, about 10% to about 90%, about 10% to about 80%, about 10% to about 70%, about 10% to about 60%, about 10% to about 50%, about 10% to about 40%, about 10% to about 30%, about 10% to about 20%, about 15% to about 99%, about 15% to about 90%, about 15% to about 80%, about 15% to about 70%, about 15% to about 60%, about 15% to about 50%, about 15% to about 40%, about 15% to about 30%, about 15% to about 20%, about 20% to about 99%, about 20% to about 90%, about 20% to about 80%, about 20% to about 70%, about 20% to about 60%, about 20% to about 50%, about 20% to about 40%, about 20% to about 30%, about 25% to about 99%, about 25% to 90%, 25% to 80%, 25% to 70%, 25% to 60%, 25% to 50%, 25% to 40%, 25% to 30%, 30% to 99%, 30% to 90%, 30% to 80%, 30% to 70%, 30% to 60%, 30% to About 50%, about 30% to about 40%, about 35% to about 99%, about 35% to about 90%, about 35% to about 80%, about 35% to about 70%, about 35% to about 60%, about 35% to about 50%, about 35% to about 40%, about 40% to about 99%, about 40% to about 90%, about 40% to about 80%, about 40% to about 70%, About 40% to about 60%, about 40% to about 50%, about 45% to about 99%, about 45% to about 90%, about 45% to about 80%, about 45% to about 70%, about 45% to about 60%, about 45% to about 50%, about 50% to about 99%, about 50% to about 90%, about 50% to about 80%, about 50% to about 70%, about 50% to About 60%, about 55% to about 99%, about 55% to about 90%, about 55% to about 80%, about 55% to about 70%, about 55% to about 60%, about 60% to about 99%, about 60% to about 90%, about 60% to about 80%, about 60% to about 70%, about 65% to about 99%, about 65% to about 90%, about 65% to about 80%,It may be in the range of about 65% to about 70%, about 70% to about 99%, about 70% to about 90%, about 70% to about 80%, about 75% to about 99%, about 75% to about 90%, about 75% to about 80%, about 80% to about 99%, about 80% to about 90%, about 85% to about 99%, about 85% to about 90%, about 90% to about 99%, about 90% to about 95%, or about 95% to about 99%. In another embodiment, the weight percent of the silicone gum in the makeup composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, or about 99%.

[0073] In one embodiment related to this method, the silicone resin has the general formula R a Six b O c wherein R is a C1-C6 alkyl group; C 2~6 alkenyl, or phenyl; X is H, OH, a halogen, or C 1~10 alkoxy; a, b, or c are independently a number ranging from 0 to 4. In another embodiment, the silicone resin can be dissolved in a solvent such as polydimethylsiloxane or polyphenylsiloxane oil or cyclomethicone. The silicone resin is modified with an ester group or an alkyl group. In one embodiment, the silicone resin is polymethylsilsesquioxane.

[0074] In one embodiment related to the present method, the silicone resin has a thickness of about 0.001 μm to about 1000 μm, about 0.001 μm to about 900 μm, about 0.001 μm to about 800 μm, about 0.001 μm to about 700 μm, about 0.001 μm to about 600 μm, about 0.001 μm to about 500 μm, about 0.001 μm to about 400 μm, about 0.001 μm to about 300 μm, about 0.001 μm to about 200 μm, about 0.001 μm to about 100 μm, about 0.001 μm to about 90 μm, about 0.001 μm to about 80 μm, about 0.001 μm to about 70 μm, about 0.001 μm to about 60 μm, about 0. 001μm ~ approx. 50μm, approx. 0.001μm ~ approx. 40μm, approx. 0.001μm ~ approx. 30μm, approx. 0.001μm ~ approx. 20μm, approx. 0.00 1μm to about 10μm, about 0.005μm to about 1000μm, about 0.005μm to about 900μm, about 0.005μm to about 800μm, about 0. 005μm~approx. 700μm, approx. 0.005μm~approx. 600μm, approx. 0.005μm~approx. 500μm, approx. 0.005μm~approx. 400μm, approx. 0.005μm~approx. 300μm, approx. 0.005μm~approx. 200μm, approx. 0.005μm~approx. 100μm, approx. 0.005μm~approx. 90μm, approx. 0.005μm to about 80μm, about 0.005μm to about 70μm, about 0.005μm to about 60μm, about 0.005μm to about 50μm, about 0. 005μm~about 40μm, about 0.005μm~about 30μm, about 0.005μm~about 20μm, about 0.005μm~about 10μm, about 0.01 μm ~ approx. 1000 μm, approx. 0.01 μm ~ approx. 900 μm, approx. 0.01 μm ~ approx. 800 μm, approx. 0.01 μm ~ approx. 700 μm, approx. 0.01 μm m ~ approx. 600 μm, approx. 0.01 μm ~ approx. 500 μm, approx. 0.01 μm ~ approx. 400 μm, approx. 0.01 μm ~ approx. 300 μm, approx. 0.01 μm ~ approx. 200μm, about 0.01μm to about 100μm, about 0.01μm to about 90μm, about 0.01μm to about 80μm, about 0.01μm to about 70μm , about 0.01μm to about 60μm, about 0.01μm to about 50μm, about 0.01μm to about 40μm, about 0.01μm to about 30μm, about 0.01 μm ~ approx. 20 μm, approx. 0.01 μm ~ approx. 10 μm, approx. 0.1 μm ~ approx. 1000 μm, approx. 0.1 μm ~ approx. 900 μm, approx. 0.1 μm ~ approx. 80 0μm, about 0.1μm to about 700μm, about 0.1μm to about 600μm, about 0.1μm to about 500μm, about 0.1μm to about 400μm, about 0.1μm to about 300μm, about 0.1μm to about 200μm, about 0.1μm to about 100μm, about 0.1μm to about 90μm, about 0.1μm to about 80μm, about 0.1μm to about 70μm, about 0.1μm to about 60μm, Approximately 0.1μm to approximately 50μm, approximately 0.1μm to approximately 40μm, approximately 0.1μm to approximately 30μm, approximately 0.1μm to approximately 20μm, approximately 0.1μm to approximately 10μm, approximately 0.5μm to approximately 1000μm, approximately 0.5μm to approximately 900μ m, approximately 0.5 μm to approximately 800 μm, approximately 0.5 μm to approximately 700 μm, approximately 0.5 μm to approximately 600 μm, approximately 0.5 μm to approximately 500 μm, approximately 0.5 μm to approximately 400 μm, approximately 0.5 μm to approximately 300 μm, approximately 0.5 μm ~about 200μm, about 0.5μm to about 100μm, about 0.5μm to about 90μm, about 0.5μm to about 80μm, about 0.5μm to about 70μm, about 0.5μm to about 60μm, about 0.5μm to about 50μm, about 0.5μm m ~ about 40μm, about 0.5μm - about 30μm, about 0.5μm - about 20μm, about 0.5μm - about 10μm, about 1μm - about 1000μm, about 1μm - about 900μm, about 1μm - about 800μm, about 1μm - about 70 0μm, about 1μm to about 600μm, about 1μm to about 500μm, about 1μm to about 400μm, about 1μm to about 300μm, about 1μm to about 200μm, about 1μm to about 100μm, about 1μm to about 90μm, about 1μm The particle size is in the range of about 80 μm, about 1 μm to about 70 μm, about 1 μm to about 60 μm, about 1 μm to about 50 μm, about 1 μm to about 40 μm, about 1 μm to about 30 μm, about 1 μm to about 20 μm, about 1 μm to about 10 μm, about 2 μm to about 70 μm, about 3 μm to about 60 μm, about 4 μm to about 50 μm, about 5 μm to about 40 μm, about 5 μm to about 30 μm, about 5 μm to about 20 μm, about 5 μm to about 10 μm, or about 5 μm to about 8 μm.

[0075] In one embodiment related to this method, the weight percent of the silicone resin in the makeup composition is about 1% to about 99%, about 1% to about 90%, about 1% to about 80%, about 1% to about 70%, about 1% to about 60%, about 1% to about 50%, about 1% to about 40%, about 1% to about 30%, about 1% to about 20%, about 1% to about 10%, about 1% to about 5%, about 5% to about 99%, about 5% to about 90%, about 5% to about 80%, about 5% to about 70%, about 5% to about 60%, about 5% to about 50%, about 5% to about 40%, about 5% to about 30%, about 5% to about 20%, about 5% to about 10%, about 10% to about 99%, about 10% to about 90%, about 10% to about 80%, about 10% to about 70%, about 10% to about 60%, about 10% to about 50%, about 10% to about 40%, about 10% to about 30%, about 10% to about 20%, about 15% to about 99%, about 15% to about 90%, about 15% to about 80%, about 15% to about 70%, about 15% to about 60%, about 15% to about 50%, about 15% to about 40%, about 15% to about 30%, about 15% to about 20%, about 20% to about 99%, about 20% to about 90%, about 20% to about 80%, about 20% to about 70%, about 20% to about 60%, about 20% to about 50%, about 20% to about 40%, about 20% to about 30%, about 25% to about 99%, about 25% to 90%, 25% to 80%, 25% to 70%, 25% to 60%, 25% to 50%, 25% to 40%, 25% to 30%, 30% to 99%, 30% to 90%, 30% to 80%, 30% to 70%, 30% to 60%, 30% to About 50%, about 30% to about 40%, about 35% to about 99%, about 35% to about 90%, about 35% to about 80%, about 35% to about 70%, about 35% to about 60%, about 35% to about 50%, about 35% to about 40%, about 40% to about 99%, about 40% to about 90%, about 40% to about 80%, about 40% to about 70%, About 40% to about 60%, about 40% to about 50%, about 45% to about 99%, about 45% to about 90%, about 45% to about 80%, about 45% to about 70%, about 45% to about 60%, about 45% to about 50%, about 50% to about 99%, about 50% to about 90%, about 50% to about 80%, about 50% to about 70%, about 50% to About 60%, about 55% to about 99%, about 55% to about 90%, about 55% to about 80%, about 55% to about 70%, about 55% to about 60%, about 60% to about 99%, about 60% to about 90%, about 60% to about 80%, about 60% to about 70%, about 65% to about 99%, about 65% to about 90%, about 65% to about 80%,It may be in the range of about 65% to about 70%, about 70% to about 99%, about 70% to about 90%, about 70% to about 80%, about 75% to about 99%, about 75% to about 90%, about 75% to about 80%, about 80% to about 99%, about 80% to about 90%, about 85% to about 99%, about 85% to about 90%, about 90% to about 99%, about 90% to about 95%, or about 95% to about 99%. In another embodiment, the weight percent of the silicone resin in the makeup composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, or about 99%.

[0076] In one embodiment related to this method, the silicone composition includes a silicone surfactant. The silicone surfactant also includes hydrophobic silicone and other functional groups. In one embodiment, the silicone surfactant is incorporated into a surface active agent with the polyoxyalkylene portion of the molecule and / or the hydrocarbon portion of the molecule.

[0077] In one embodiment related to this method, the weight percent of the silicone surfactant in the makeup composition is from about 1% to about 99%, from about 1% to about 90%, from about 1% to about 80%, from about 1% to about 70%, from about 1% to about 60%, from about 1% to about 50%, from about 1% to about 40%, from about 1% to about 30%, from about 1% to about 20%, from about 1% to about 10%, from about 1% to about 5%, from about 5% to about 99%, from about 5% to about 90%, from about 5% to about 80%, from about 5% to about 70%, from about 5% to about 60%, from about 5% to about 50%, from about 5% to about 40%, from about 5% to about 30%, from about 5% to about 20%, from about 5% to about 10%, from about 10% to about 99%, from about 10% to about 90%. , about 10% to about 80%, about 10% to about 70%, about 10% to about 60%, about 10% to about 50%, about 10% to about 40%, about 10% to about 30%, about 10% to about 20%, about 15% to about 99%, about 15% to about 90%, about 15% to about 80%, about 15% to about 70%, about 15% to about 60%, about 15% ~50%, ~15%~40%, ~15%~30%, ~15%~20%, ~20%~99%, ~20%~90%, ~20%~80%, ~20%~70%, ~20%~60%, ~20%~50%, ~20%~40%, ~20%~30%, ~25%~99% , about 25% to about 90%, about 25% to about 80%, about 25% to about 70%, about 25% to about 60%, about 25% to about 50%, about 25% to about 40%, about 25% to about 30%, about 30% to about 99%, about 30% to about 90%, about 30% to about 80%, about 30% to about 70%, about 30% to about 60%, about 30% ~50%, ~30%~40%, ~35%~99%, ~35%~90%, ~35%~80%, ~35%~70%, ~35%~60%, ~35%~50%, ~35%~40%, ~40%~99%, ~40%~90%, ~40%~80%, ~40%~70% , about 40% to about 60%, about 40% to about 50%, about 45% to about 99%, about 45% to about 90%, about 45% to about 80%, about 45% to about 70%, about 45% to about 60%, about 45% to about 50%, about 50% to about 99%, about 50% to about 90%, about 50% to about 80%, about 50% to about 70%, about 50% ~ about 60%, about 55% to about 99%, about 55% to about 90%, about 55% to about 80%, about 55% to about 70%, about 55% to about 60%, about 60% to about 99%, about 60% to about 90%, about 60% to about 80%, about 60% to about 70%, about 65% to about 99%, about 65% to about 90%, about 65% to about 80%,It may be in the range of about 65% to about 70%, about 70% to about 99%, about 70% to about 90%, about 70% to about 80%, about 75% to about 99%, about 75% to about 90%, about 75% to about 80%, about 80% to about 99%, about 80% to about 90%, about 85% to about 99%, about 85% to about 90%, about 90% to about 99%, about 90% to about 95%, or about 95% to about 99%. In another embodiment, the weight percent of the silicone surfactant in the makeup composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, or about 99%.

[0078] In one embodiment related to this method, the silicone is selected from dimethicone, methicone, trimethicone, cyclomethicone, amodimethicone, trimethylsilylamodimethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, polydimethylsiloxane, polymethylsilsequioxane, dimethiconol, and mixtures thereof.

[0079] In one embodiment related to this method, the makeup composition further comprises a colorant, which in one embodiment comprises pigments, nacres, and reflective particles, dyes, and mixtures thereof.

[0080] In another embodiment related to this method, the pigment comprises white or colored inorganic or organic particles of any shape that are insoluble in physiological media and are intended to color the composition, hi some embodiments, the pigment is white.

[0081] In other embodiments related to this method, the inorganic pigments include titanium dioxide, such as rutile titanium dioxide pigments, optionally surface treated zirconium oxide, cerium oxide, zinc oxide, iron oxide (black, yellow or red), or chromium oxide, manganese violet, ultramarine blue, chromium hydrate, ferric blue, and metal powders, such as aluminum powder and copper powder.

[0082] In another embodiment related to this method, the organic pigments may be selected from carbon black, D&C type pigments, and lakes based on cochineal carmine, barium, strontium, calcium, and aluminum, as well as organic pigment azo dyes, anthraquinone dyes, indigoid dyes, xanthene dyes, pyrene dyes, quinoline dyes, triphenylmethane dyes, and fluoran dyes.

[0083] In one embodiment related to this method, the dye is a water-soluble dye, such as FD&C Blue No. 11, FD&C Blue No. 12, FD&C Green No. 13, FD&C Red No. 13, FD&C Red No. 140, FD&C Yellow No. 15, FD&C Yellow No. 16, D&C Blue No. 14, D&C Blue No. 19, D&C Green No. 15, D&C Green No. 16, D&C Green No. 18, D&C Orange No. 14, D&C Orange No. 15, D&C Orange No. 110, D&C Orange No. 111, D&C Orange No. 120, D&C Orange No. 130, D&C Orange No. 131, D&C Orange No. 132, D&C Orange No. 133, D&C Orange No. 134, D&C Blue No. 135, D&C Green No. 136, D&C Green No. 137, D&C Green No. 138, D&C Orange No. 139, D&C Orange No. 140, D&C Blue No. 141, D&C Blue No. 142, D&C Blue No. 143, D&C Green No. 144, D&C Green No. 145, D&C Green No. 146, D&C Green No. 147, D&C Green No. 148, D&C Orange No. 149, D&C Orange No. 150, D&C Orange No. 149, D&C Orange No. 141, D&C Orange No. 142, D&C Orange No. 143, D&C Orange No. 144, D&C Orange No. 145, D&C Orange No. 146, D&C 17, FD&C Red No.14, D&C Red No.16, D&C Red No.17, D&C Red No.18, D&C Red No.19, D&C Red No.117, D&C Red No.119, D&C Red No.121, D&C Red No.122, D&C Red No.127, D&C Red No.128, D&C Red No.130, D&C Red No.131, D&C Red N o.134, D&C Red No.139, FD&C Red No.140, D&C Violet No.12, D&C Yellow No.17, Ext. D&C Yellow No.17, D&C Yellow No.18, D&C Yellow No.11-1, D&C Brown No.11, Ext. D&C Violet No.12, D&C Blue No.16 and D&C Yellow No.110. The above dyes are well-known commercially available materials, and their chemical structures are described, for example, in 21 CFR Part 74 (revised April 1, 1988) and CTFA Cosmetic Ingredient Handbook (1988) (published by the Cosmetics, Toiletry and Fragrances Association, Inc.). These publications are incorporated herein by reference.

[0084] The chemical equivalents for each of the above organic dye classes are described in the publication "International Cosmetic Ingredient Dictionary and Handbook" 1997 edition, pp. 371-386 and 524-528 (The Cosmetic, Toiletries and Fragrance Association), which are incorporated by reference into this patent application.

[0085] In another embodiment related to this method, nacre includes any form of colored particles, particularly those produced by certain mollusks within their shells, or alternatively synthesized, which may or may not be iridescent and have color effects via optical interference.

[0086] Examples of nacre include, but are not limited to, pearlescent pigments such as iron oxide coated titanium mica, bismuth oxychloride coated mica, chromium oxide coated titanium mica, and bismuth oxychloride based pearlescent pigments. These pigments may be mica particles with at least two successive layers of metal oxides and / or organic dyes superimposed on the surface. Nacre may more specifically have a yellow, pink, red, bronze, orange, brown, gold, and / or copper color or glitter.

[0087] Examples of nacres that may be incorporated in the composition include, but are not limited to, gold nacres, in particular those sold under the trade names Brilliant gold 212G (Timica), Gold 222C (Cloisonne), Sparkle gold (Timica), Gold 4504 (Chromalite) and Monarch gold 233X (Cloisonne) by Engelhard; bronze nacres, in particular those sold under the trade names Bronze fine (17384) (Colorona) and Bronze (17353) (Colorona) by Merck, and those sold under the trade name Super bronze (Cloisonne) by Engelhard; orange nacres, in particular those sold under the trade names Orange 363C (Cloisonne) and Orange MCR 101 (Cosmica) by Engelhard, and those sold under the trade names Passion orange (Colorona) and Matte (Colorona) by Merck. orange (17449) (Microna); brown nacre, especially under the trade name Nu-antique copper 340XB (Cloisonne) and Brown CL4509 (Chromalite) sold by Engelhard; copper-coloured nacre, especially under the trade name Copper 340A (Timica) sold by Engelhard; red nacre, especially under the trade name Sienna fine (17386) (Colorona); yellow nacre, especially under the trade name Yellow (4502) (Chromalite) sold by Engelhard; golden red nacre, especially under the trade name Sunstone G012 (Gemtone) sold by Engelhard; pink nacre, especially under the trade name Tan opale G005 (Gemtone) sold by Engelhard; golden black nacre, especially under the trade name Nu antique bronze 240 AB (Timica) sold by Engelhard; blue nacre, especially under the trade name Matte sold by Merck. blue (17433) (Microna); silvery white nacre, especially the trade name Xirona Silver sold by Merck;and golden green pink orange nacre, in particular under the trade name Indian summer (Xirona) sold by Merck, and mixtures thereof;

[0088] Additionally, nacre may comprise a borosilicate substrate coated with titanium oxide or polyethylene terephthalate flakes.

[0089] In another embodiment related to this method, the reflective particles comprise particles that, depending on their size, structure, in particular the thickness, physical and chemical properties and surface condition of the layer(s) in which they are made, are able to reflect incident light. This reflection can, if appropriate, be strong enough to create on the surface of the composition or mixture, when applied to a support constituted, excessive gloss spots visible to the naked eye, i.e. more light spots that contrast with the environment by appearing to sparkle.

[0090] In another embodiment related to this method, the reflective particles may be selected so as not to significantly alter the coloring effect produced by the coloring agent with which they are combined, more particularly to optimize this effect in terms of color yield. The reflective particles may more particularly have a yellow, pink, red, bronze, orange, brown, gold and / or copper color or light color. These particles may have various morphologies, in particular platelet or spherical morphologies, in particular spherical morphologies.

[0091] In another embodiment related to this method, the reflective particles, regardless of their morphology, may or may not have a multi-layer structure, and if multi-layered, may, for example, have at least one layer of uniform thickness, particularly of a reflective material.

[0092] In one embodiment, the reflective particles, if they do not have a multilayer structure, may be composed, for example, of metal oxides, particularly synthetically obtained oxides of titanium or iron.

[0093] In another embodiment, when the reflective particles have a multi-layer structure, they can, for example, comprise a natural or synthetic substrate, in particular a synthetic substrate that is at least partially coated with at least one layer of at least one reflective material, in particular at least one metal or metallic material. The substrate may be made of one or more organic and / or inorganic materials.

[0094] More particularly, they may be chosen from glasses, ceramics, graphite, metal oxides, alumina, silica, silicates, in particular aluminosilicates and borosilicates, and synthetic micas, and mixtures thereof.

[0095] Examples of reflective particles include inorganic substrates coated with a metal layer, and may be made from particles including silver-coated borosilicate substrates.

[0096] In one embodiment, the reflective material may include a metal or a layer of a metallic material.

[0097] In another embodiment related to this method, the weight amount of the colorant in the makeup composition is from about 0.01% to about 30%, from about 0.01% to about 25%, from about 0.01% to about 20%, from about 0.01% to about 15%, from about 0.01% to about 10%, from about 0.01% to about 5%, from about 0.01% to about 3%, from about 0.01% to about 2%, from about 0.01% to about 1%, or from about 0.01% to about 10%. ~ about 0.5%, about 0.1% to about 30%, about 0.1% to about 25%, about 0.1% to about 20%, about 0.1% to about 15%, about 0.1% to about 10%, about 0.1% to about 5%, about 0.1% to about 3%, about 0.1% to about 2%, about 0.1% to about 1%, about 0.1% to about 0.5%, about 0.5% to about 30%, about 0.5% to about 25%, about 0.5% to about 20%, about 0.5% to about 15%, about 0.5% to about 10%, about 0.5% to about 5%, about 0.5% to about 3%, about 0.5% to about 2%, about 0.5% to about 1%, about 1% to about 30%, about 1% to about 25%, about 1% to about 20%, about 1% to about 15%, about 1% to about 10%, about 1% to about 5%, about 1% to about 3%, about 1% to about 2%, about 2% to about 30%, about 5% to about 30% , about 5% to about 25%, about 5% to about 20%, about 5% to about 15%, about 5% to about 10%, about 10% to about 30%, about 10% to about 25%, about 10% to about 20%, about 15% to about 30%, about 15% to about 25%, about 15% to about 20%, about 20% to about 30%, about 20% to about 25%, about 25% to about 30%, or about 25% to about 28%.

[0098] In another embodiment related to this method, the makeup composition, when applied to the skin, conceals and simultaneously treats skin imperfections. In one embodiment, the degree of concealment is measured in terms of the "hiding power" or "covering power" of the material. The coverage of the makeup composition can be tested by various methods known in the art and / or described herein. For example, a standard test for measuring the hiding power of a material that dries to form a film is the Dry-Film Coverage Test Method according to ASTM D 6441-05. See ASTM International Designation: D 6441-05 "Standard Test Methods for Measuring the Hiding Power of Powder Coatings", which is incorporated herein by reference in its entirety.

[0099] In one embodiment related to this method, the following formula can be used to measure the degree of hiding: Contrast Ratio (Coverage) (Cw) = 100 x Ro / Rw, where Rw refers to the reflectance of the test makeup composition applied on a white substrate, Ro refers to the reflectance of the test makeup composition applied on a black substrate, and the luminous reflectance is measured by a Konica Minolta handheld spectrophotometer. The method includes drawing the sample onto a polyester film to control the thickness; waiting 15 minutes for the sample to dry, placing the polyester onto a LENETA card, and measuring the reflectance (L* value), Ro (black background), and Rw (white background) using a spectrophotometer. Each LENETA card can be read with three data points on a black background, and this can be repeated for six different LENETA cards. Eighteen data points can be collected and the contrast ratio can be determined. For example, the contrast ratio can be based on the average of these data points. The coverage value can then be normalized based on the solids % of the formula to account for differences in film thickness. A high contrast ratio translates to a film with high coverage. Some embodiments of the disclosure herein provide makeup compositions with a coverage in the range of about 30 to about 200, about 40 to about 200, about 50 to about 200, about 60 to about 200, about 70 to about 200, about 80 to about 200, about 90 to about 200, about 100 to about 200, about 100 to about 190, about 100 to about 180, about 100 to about 170, about 100 to about 160, about 100 to about 150, about 100 to about 140, about 100 to about 130, about 100 to about 120, or about 100 to about 110. Preferably, the coverage of the makeup compositions disclosed herein is about 30, about 50, about 80, about 100, about 150, or about 200.

[0100] In another embodiment related to this method, the makeup composition disclosed herein weakens the phylogenetic process by which scars are formed. In general, after a full-thickness wound occurs by penetration through the epidermis into the dermis layer, it may take several weeks for the epidermis to fully regenerate. The new immature stratum corneum allows an abnormally high level of transepidermal water loss. This dehydration of the stratum corneum signals keratinocytes to produce cytokines, which in turn signal fibroblasts to synthesize and release collagen. Naturally, under hygienic conditions that are far less effective at preventing infection, wound healing is optimized for speed, as opposed to quality of healing. This speed optimization produces excess collagen, which rushes into the scar site and is responsible for many of the undesirable physical and aesthetic properties associated with scarring.

[0101] The makeup compositions disclosed herein provide improved occlusion and hydration to the wound bed. They help the newly formed immature stratum corneum maintain optimal moisture levels. Unlike other dressings, the makeup compositions disclosed herein provide a level of occlusion similar to normal skin and significantly reduce collagen formation at the scar site. Thus, stratum corneum hydration is normalized and undesirable physical and aesthetic properties associated with scarring are minimized. In a preferred embodiment, the makeup composition comprises a significant amount of silicone.

[0102] In another embodiment related to this method, the makeup composition disclosed herein generates a negatively charged electrostatic field due to friction between the composition and the skin, which is believed to aid in the alignment of collagen cells and reduce the appearance of raised scars.

[0103] In another embodiment related to this method, the makeup compositions disclosed herein inhibit the body's natural reaction to increase skin capillaries via hyperemia, thereby reducing the exaggerated blood supply and healing process to the scar site, as well as the apparent intensity and physical characteristics of a fully formed scar.

[0104] The methods disclosed herein should not be limited to any mechanism described herein.

[0105] In another embodiment related to this method, the skin defect is a scar. In one embodiment, the scar is selected from keloid scar, hypertrophic scar, contracture scar, acne scar, and surgical scar. In another embodiment, the scar is a surgical scar after removal of sutures about 7 to about 14 days after surgery. Preferably, the scar is a surgical scar after removal of sutures about 7 days after surgery, about 8 days after surgery, about 9 days after surgery, about 10 days after surgery, about 11 days after surgery, about 12 days after surgery, about 13 days after surgery, or about 14 days after surgery.

[0106] In another embodiment related to this method, the makeup composition further provides UV protection. In one embodiment, the makeup composition blocks both UV-B and UV-A radiation. In one embodiment, the makeup composition has a sun protection factor (SPF) of about 4 to about 60, about 5 to about 60, about 6 to about 60, about 7 to about 60, about 8 to about 60, about 9 to about 60, about 10 to about 60, about 10 to about 50, about 10 to about 40, about 10 to about 30, about 10 to about 25, about 10 to about 20, about 10 to about 19, about 10 to about 18, about 10 to about 17, about 10 to about 16, or about 10 to about 15. In another embodiment, the makeup composition has a sun protection factor (SPF) of about 5, about 10, about 15, about 20, about 25, about 30, about 35, about 40, about 45, about 50, about 55, or about 60.

[0107] In another embodiment related to this method, the makeup composition further comprises one or more sunscreens. Suitable sunscreens are aminobenzoic acid, amyl dimethyl PABA, cinoxate, diethanolamine p-methoxycinnamate, digalloyl trioleate, dioxybenzone, 2-ethoxyethyl p-methoxycinnamate, 4-bis(hydroxypropyl)ethyl aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, ethylhexyl p-methoxycinnamate, 2-ethylhexyl salicylate, glyceryl aminobenzoate ... The active ingredient is selected from aromatic acids, homomenthyl salicylate, homosalate, 3-imidazol-4-ylacrylic acid and ethyl ester, methyl anthranilate, octyl dimethyl PABA, 2-phenylbenzimidazole-5-sulfonic acid and salts, red petrolatum, sulisobenzone, titanium dioxide, triethanolamine salicylate, N,N,N-trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilinium methyl sulfate, and mixtures thereof.

[0108] Suitable sunscreens active in the UV-A and / or UV-B range are p-aminobenzoic acid, oxyethylene (25 mol) p-aminobenzoate, 2-ethylhexyl p-dimethylaminobenzoate, ethyl N-oxypropylene p-aminobenzoate, glycerol p-aminobenzoate, 4-isopropylbenzyl salicylate, 2-ethylhexyl 4-methoxycinnamate, methyl diisopropylcinnamate, isoamyl 4-methoxycinnamate, diethanolamine 4-methoxycinnamate, 3-(4'-trimethylammonium)-benzylidene-bornan-2-one methylsulfate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methyl ... Methoxybenzophenone-5-sulfonate, 2,4-dihydroxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-n-octoxybenzophenone, 2-hydroxy-4-methoxy-4'-methoxybenzophenone-(2-oxobom-3-ylidene)-tolyl-4-sulfonic acid and its soluble salts, 3-(4'-sulfo)benzylidene-bornan-2-one and its soluble salts, 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor, benzene 1,4-di(3-methylidene-10-camphorsulfonic) acid and its salts (Mexoryl SX, U.S. Pat. No. 4,585,597 (Lange et al. Apr.29, 1986)) urocanic acid, 2,4,6-tris[p-(2'-ethylhexyl-1'-oxycarbonyl)-anilino]-1,3,5-triazine, 2-[(p-(tertiobutylamido)anilino]-4,6-bis-[(p-(2'-ethylhexyl-1'-oxycarbonyl)anilino]-1,3,5-triazine, 2,4-bis{[4-(2-ethylhexyloxy)]-2-hydroxy]-phenyl}-6-(4-methoxy-phenyl)-1,3,5-triazine, ("TINOSORB S" sold by Ciba), N-(2 et 4) Polymers of -[(2-oxoboron-3-ylidene)methyl]benzyl]-acrylamide, 1,4-bisbenzimidazolyl-phenylene-3,3',5,5'-tetrasulfonic acid and its salts, benzalmalonate-substituted polyorganosiloxanes, benzotriazole-substituted polyorganosiloxanes (drometrizole trisiloxane), dispersions of 2,2'-methylene-bis-[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol], such as those sold under the trademark MIXXIM BB / 100 (Fairmount Chemical), micronized in dispersed form, such as those sold under the trademark TINOSORB M (Ciba-Geigy), and others. Sunscreens that are suitable for use in the present invention further include solubilized 2,2'-methylene-bis-[6-(2H-benzotriazol-2-yl)-4-(methyl)phenol], such as those sold by FR-A-2,326,405, FR-A-2,440,933, and EP-A-0,114,607, which are hereby expressly incorporated by reference.

[0109] Other dibenzoylmethane sunscreens other than avobenzone include 2-methyldibenzoylmethane, 4-methyldibenzoylmethane, 4-isopropyldibenzoylmethane, 4-tert-butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyldibenzoylmethane, 4,4'-dimethoxydibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane, 2,4-dimethyl-4'-methoxydibenzoylmethane, and 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane.

[0110] In another embodiment related to this method, the makeup composition may further comprise a moisturizer, an emollient, a humectant, a thickener, a skin toner, or a mixture thereof.

[0111] In another embodiment related to this method, the composition according to the present disclosure is generally homogeneous. A uniform distribution of the components is observed. In one embodiment, the composition is a wax-in-oil mixture that is a homogeneous, transparent mixture under warm conditions, and upon cooling, a homogeneous dispersion of wax in oil is formed. In another embodiment, good dispersion of the pigment is observed. In one embodiment, good product flocculation is observed.

[0112] In another embodiment, the makeup compositions disclosed herein remain homogeneous even after application to the skin and / or mucous membranes (at least for several hours).

[0113] In another embodiment, the makeup compositions disclosed herein also exhibit excellent cosmetic properties. They are soft and adhere well to the skin and / or mucous membranes, but not excessively. They are easy to apply and provide a very comfortable feel when applied. In particular, for cosmetic powders, they are easy to compress, disintegrate well, and exhibit good hardness.

[0114] In another embodiment related to this method, the scar is substantially healed following treatment.In another embodiment related to this method, the treatment results in a substantial reduction in the amount and visibility of scar tissue.

[0115] In another embodiment related to this method, the makeup composition further provides a soothing or relief effect to the skin. In another embodiment related to this method, the makeup composition further comprises a soothing agent. Soothing agents include, but are not limited to, vitamin A palmitate; phytelene complex EGX244, a botanical blend of extracts of calendula, chamomile, linden, cornflower, matricaria, and hypericum; allantoin; dipotassium glycyrrhizinate; stearyl glycyrrhizin; bisabo ((3-cyclohexene-1-methanol-∝,4-dimethyl-∝(4-methyl-3-pentenyl)); squalane NF; cetyl esters wax; shea butter; orange roughy oil; hydrogenated phospholipids, and HETESTER™ FAO (C available from Bernel Chemical Company, Englewood, NJ). 12 ~C 15 alcohol octanoate).

[0116] In another embodiment related to this method, the scar is substantially healed after treatment. In another embodiment, the treatment results in a substantial reduction in the amount and visibility of scar tissue. In one embodiment, the size of the scar is reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50% after treatment. The size of the scar can be measured based on the "scar elevation index" at 100x magnification. The scar elevation index is calculated as the scar dermis area (S) divided by the normal dermis area (N), which is based on the dermis height of the adjacent unwounded skin (R. Reid et al., J Plast Reconstr Aesthet Surg. (2007), 60:64-72).

[0117] In another embodiment related to this method, the amount of makeup composition applied to the skin defect is about 0.1 to about 10 mL, about 0.2 to about 10 mL, about 0.3 to about 10 mL, about 0.4 to about 10 mL, about 0.5 to about 10 mL, about 0.6 to about 10 mL, about 0.7 to about 10 mL, about 0.8 to about 10 mL, about 0.9 to about 10 mL, about 1 to about 10 mL, about 2 to about 10 mL, about 3 to about 10 mL, about 4 to about 10 mL, about 5 to about 10 mL, about 6 to about 10 mL, about 7 to about 10 mL, about 8 to about 10 mL, or about 9 to about 10 mL. In another embodiment related to this method, the amount of makeup composition applied to the skin defect is about 0.1 mL, about 0.2 mL, about 0.3 mL, about 0.4 mL, about 0.5 mL, about 0.6 mL, about 0.7 mL, about 0.8 mL, about 0.9 mL, about 1 mL, about 2 mL, about 3 mL, about 4 mL, about 5 mL, about 6 mL, about 7 mL, about 8 mL, about 9 mL, or about 10 mL.

[0118] In another embodiment related to this method, the viscosity of the makeup composition is from about 1,000 cP to about 1,000,000 cP. In one embodiment, the dynamic viscosity of the makeup composition disclosed herein at 25° C. may be measured by a rotational viscometer of the Mettler RM 180 type. The Mettler RM180 instrument (Rheomat) may be equipped with various spindles corresponding to the size order of the viscosity to be measured. For viscosities of 180 to 4,020 cP, the instrument is equipped with spindle 3. For viscosities of 1,000 to 24,000 cP, the instrument is equipped with spindle 4, and for viscosities of 8,000 to 122,000 cP, the instrument is equipped with spindle 5.

[0119] The viscosity is read on the instrument in deviation units (DU). A table attached to the measuring instrument makes it possible to obtain the corresponding value in poise. The rotation speed of the spindle is approximately 200 revolutions per minute.

[0120] When the spindle is set to rotate at a constant drive rotation speed (in this case 200 revolutions per minute), the viscosity value of the composition may change over time until it reaches a constant value. Measurements are taken periodically until a constant measurement value is obtained. The viscosity value that becomes constant over time is the value that is considered to be the dynamic viscosity value of the composition according to the disclosure herein. According to the 75 measurement system, the viscosity measurement is taken after 10 minutes.

[0121] In another embodiment related to this method, the viscosity of the makeup composition is, in particular, about 1,000 to about 1,000,000 cP, about 1,000 to about 900,000 cP, about 1,000 to about 800,000 cP, about 1,000 to about 700,000 cP, about 1,000 to about 600,000 cP, about 1,000 to about 500,000 cP, about 1,000 to about 500,000 cP, about 1,000 to about 400,000 cP, about 1,000 to about 300,000 cP, about 1,000 to about 250,000 cP, about 1,000 to about 200,000 cP, about 1,000 to about 150, 000 cP, about 1,000 to about 125,000 cP, about 1,000 to about 100,000 cP, about 1,000 to about 62,500 cP, about 1,000 to about 50,000 cP, about 1,000 to about 32,000 cP, about 1,000 to about 16,000 cP, about 1,000 to about 10,000 cP, about 1,000 to about 8,000 cP, about 1,000 to about 7,000 cP, about 1,000 to about 6,000 cP, about 1,000 to about 5,000 cP, about 1,000 to about 4,000 cP, about 1,000 to about 3,000 cP, or about 1,000 to about 2,000 cP.

[0122] In another embodiment related to this method, the makeup composition further comprises a gelling agent, which alters the viscosity of the makeup composition.

[0123] In another embodiment related to this method, the makeup composition comprises at least one liquid fatty phase gelling agent. In one embodiment, the liquid fatty phase gelling agent is an inorganic gelling agent. In one particular embodiment, the liquid fatty phase gelling agent is a non-crystalline, non-silicone gelling agent. In particular, the liquid fatty phase gelling agents that can be used in the makeup composition of the invention are chosen from agents that gel by chemical crosslinking and agents that gel by physical crosslinking.

[0124] In another embodiment related to this method, the liquid fatty phase gelling agent by chemical crosslinking is RSiO and RSiO 1.5 Units, and optionally RSiO 0.5 and / or polyorganosiloxanes containing SiO units, in which the radicals R are selected independently of one another from hydrogen, alkyl, such as methyl, ethyl or propyl, aryl, such as phenyl or tolyl, unsaturated aliphatic radicals, such as vinyl, and the ratio of RSiO units to RSiO units is 1.5 The weight ratio of the units ranges from 1 / 1 to 30 / 1.

[0125] The silicone oil-insoluble and swellable polyorganosiloxane is obtained by adding polyorganohydrosiloxane (1) and polyorganosiloxane (2) having an unsaturated aliphatic group, and the amount of hydrogen or unsaturated aliphatic group in (1) and (2) is in the range of 1 to 20 mol % when the polyorganosiloxane is acyclic, and in the range of 1 to 50 mol % when the polyorganosiloxane is cyclic. These polyorganosiloxanes may contain 1 to 40 oxyalkylene groups such as oxypropylene and / or oxyethylene groups.

[0126] Examples of polyorganosiloxanes disclosed herein include, but are not limited to, those sold in the form of KSG6 (Shin-Etsu), Trefil E-505C or Trefil E-506C (Dow Corning), Gransil (Grant Industries (SR-CYC, SR DMF10, SR-DC556)), pre-formed gels KSG15, KSG17, KSG16, KSG18 and KSG21 (Shin-etsu), Gransil SR 5CYC gel, Gransil SR DMF10 gel, Gransil SR DC556 gel, SF 1204 and JK 113 (General Electric), or mixtures thereof.

[0127] In another embodiment related to this method, the liquid fatty phase gelling agent by physical crosslinking is chosen from gelling agents by molecular agitation, hydrogen interactions, dipolar interactions, or a mixture thereof.

[0128] In another embodiment related to this method, the makeup composition comprises a silicone and a colorant. In one embodiment, the ratio of silicone to colorant ranges from about 0.01 to about 99, about 0.1 to about 95, about 1 to about 90, about 5 to about 85, about 10 to about 80, about 15 to about 75, about 20 to about 70, about 25 to about 65, about 30 to about 60, about 35 to about 55, about 40 to about 50, or about 40 to about 45. In another embodiment, the ratio of silicone to colorant is about 0.01, about 0.05, about 0.1, about 0.5, about 1, about 5, about 10, about 15, about 20, about 25, about 30, about 35, about 40, about 45, about 50, about 55, about 60, about 65, about 70, about 75, about 80, about 85, about 90, about 95, or about 99.

[0129] In another embodiment related to this method, the makeup composition disclosed herein is maintained on the skin for at least 1-12 hours, at least 1-11 hours, at least 1-10 hours, at least 1-9 hours, at least 1-8 hours, at least 1-7 hours, at least 1-6 hours, at least 1-5 hours, at least 1-4 hours, or at least 1-3 hours. In another embodiment related to this method, the makeup composition disclosed herein is maintained on the skin for about 1 hour, about 2 hours, about 3 hours, about 4 hours, about 5 hours, about 6 hours, about 7 hours, about 8 hours, about 9 hours, about 10 hours, about 11 hours, or about 12 hours.

[0130] In another embodiment related to this method, the makeup composition disclosed herein is capable of being applied for about 5 days to about 120 days, about 5 days to about 110 days, about 5 days to about 100 days, about 5 days to about 90 days, about 5 days to about 80 days, about 5 days to about 70 days, about 5 days to about 60 days, about 5 days to about 50 days, about 5 days to about 40 days, about 5 days to about 30 days, about 5 days to about 20 days, about 5 days to about 10 days, about 5 days to about 7 days, about 10 days to about 120 days, about 10 days to about 110 days, about 10 days to about 100 days, about 10 days to about 90 days, about 10 days to about 80 days, about 10 days to about 70 days, about 10 days to about 60 days, about 10 days to about 50 days, about 1 It is applied daily for 0 to about 40 days, about 10 to about 30 days, about 10 to about 20 days, about 20 to about 120 days, about 20 to about 110 days, about 20 to about 100 days, about 20 to about 90 days, about 20 to about 80 days, about 20 to about 70 days, about 20 to about 60 days, about 20 to about 50 days, about 20 to about 40 days, about 20 to about 30 days, about 30 to about 120 days, about 40 to about 120 days, about 50 to about 120 days, about 60 to about 120 days, about 70 to about 120 days, about 80 to about 120 days, about 90 to about 120 days, about 100 to about 120 days, or about 110 to about 120 days.

[0131] In another embodiment related to this method, the makeup composition disclosed herein is applied topically to the skin as needed. Typically, the composition is applied topically to the skin 1 to 5 times a day. In one embodiment, the composition is applied topically to the skin 1, 2, 3, 4, or 5 times a day. However, application of the composition may be more or less frequent as prescribed, needed, or desired.

[0132] In another embodiment related to this method, the subject disclosed herein is a mammal. In a preferred embodiment, the subject is a human. In another embodiment, the patient is a human male. In another embodiment, the patient is a human female. In another embodiment, the human is 18 years of age or older.

[0133] In some embodiments related to this method, the method is for veterinary use. In preferred embodiments, the subject is a mammal, such as a non-primate, e.g., rabbit, cow, pig, horse, cat, dog, rat, and a primate, e.g., monkey, e.g., cynomolgus monkey.

[0134] In another embodiment related to this method, the makeup composition of the present disclosure herein is applied to the skin by spraying, spreading, rubbing, or brushing. A preferred route of administration is to massage the makeup composition into the skin with a soft massage, ensuring intimate contact with the skin.

[0135] In another embodiment related to this method, the makeup composition comprises less than 1% or no comedogenic compound.Comedogenic compound as used herein refers to ingredients that tend to clog skin pores.In one embodiment, the makeup composition comprises less than 1% or no any of the following compounds: sodium chloride, wheat germ oil, sodium lauryl sulfate, red algae, octyl stearate, laureth 4, isopropyl myristate, isopropyl isostearate, isocetyl stearate, carrageenan, algae extract, or combinations thereof.

[0136] Make-up Composition In another aspect, the present disclosure provides a makeup composition comprising at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% by weight of silicone and a colorant, which when applied to a scar on the skin of a subject, simultaneously treats the scar on the skin of a subject and camouflages the scar and provides UV protection.

[0137] In one embodiment relating to makeup compositions, silicone broadly refers to organosilicon polymers or oligomers of various molecular weights, linear or cyclic, branched or crosslinked, obtained by polymerization and / or polycondensation of suitably functionalized silanes, essentially consisting of repeating main units in which silicon atoms are bonded to each other via oxygen atoms (siloxane bonds ≡ Si-O-Si ≡ ) and optionally substituted hydrocarbon groups are bonded directly to the silicon atoms via carbon atoms. The most common hydrocarbon groups are alkyl groups, especially (C1-C 30 ) an alkyl group, in particular a methyl group, a fluoroalkyl group or an aryl group, in particular a phenyl group.

[0138] Various silicone compounds can be used in the composition, which can be chosen from silicone liquids, silicone oils (which may or may not be volatile), silicone waxes, silicone gums, silicone resins, silicone surfactants and / or mixtures thereof.

[0139] In another embodiment related to this makeup composition, the silicone oil is a compound corresponding to the following general formula (I): TIFF2025024052000005.tif37128In the formula, R1 and R2 are independently C 1~6 is alkyl; n is an integer from 3 to 100.

[0140] In one embodiment, the silicone oil is a linear polydimethylsiloxane (PDMS) corresponding to the following general formula (II): TIFF2025024052000006.tif34128In formula, W is -CH3 or -OH; m is an integer from 0 to 2000.

[0141] In one embodiment relating to the makeup composition, the amount by weight of silicone oil in the makeup composition is at least 80%, at least 81%, at least 82%, at least 83%, at least 84%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%.

[0142] In one embodiment relating to this makeup composition, the silicone wax is a silicone product that is semi-solid or solid at room temperature, in another embodiment, the silicone wax has a melting point in the range of about 25°C to about 135°C.

[0143] In one embodiment related to this method, the silicone wax is a compound corresponding to the following general formula (III): TIFF2025024052000007.tif37128In formula, R1, R2, R3, and R4 are C1 to C 30 Alkyl, C1-C 30 alkoxy, and aryl, each of which is optionally substituted by an ester group; Z is C1~C 30 Alkyl, C1-C 30 Alkoxy, C1-C 30 ester, and aryl; x and y are independently an integer of 0 to 100.

[0144] In one embodiment relating to the makeup composition, the weight percent of the silicone wax in the makeup composition is at least 80%, at least 81%, at least 82%, at least 83%, at least 84%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%.

[0145] In one embodiment relating to this makeup composition, the silicone gum has a viscosity of 500,000 cSt to 5×10 7 In another embodiment, the silicone gum does not exhibit a melting point.

[0146] In another embodiment related to this makeup composition, the silicone gum is a compound corresponding to the following general formula (IV): TIFF2025024052000008.tif37128In formula, R5, R6, R7, R8, R9, R 10 , R 11 , and R 12 are independently C1-C6 alkyl; Q is C1-C6 alkyl, -OH, and C 2~10 alkenyl; s and t are independently integers from 1 to 5,000.

[0147] In one embodiment relating to the makeup composition, the weight of the silicone gum in the makeup composition is at least 80%, at least 81%, at least 82%, at least 83%, at least 84%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%.

[0148] In one embodiment related to this makeup composition, the silicone resin has the general formula R a Six b O c wherein R is a C1-C6 alkyl group, C 2~6 alkenyl, or phenyl; X is H, OH, Cl, or C 1~10 is an alkoxy; a, b, or c are independently a number ranging from 0 to 4. These resins can be dissolved in solvents such as polydimethylsiloxane or polyphenylsiloxane oils or cyclomethicone. The silicone resin is modified with an ester group or an alkyl group. In one embodiment, the silicone resin is polymethylsilsequioxane.

[0149] In one embodiment of the makeup composition, the silicone resin has a particle size in the range of about 0.01 μm to about 200 μm, about 0.1 μm to about 100 μm, about 0.5 μm to about 90 μm, about 1 μm to about 80 μm, about 2 μm to about 70 μm, about 3 μm to about 60 μm, about 4 μm to about 50 μm, about 5 μm to about 40 μm, about 5 μm to about 30 μm, about 5 μm to about 20 μm, about 5 μm to about 10 μm, or about 5 μm to about 8 μm.

[0150] In one embodiment relating to the makeup composition, the weight percent of the silicone resin in the makeup composition is at least 80%, at least 81%, at least 82%, at least 83%, at least 84%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%.

[0151] In one embodiment related to this makeup composition, the silicone composition comprises a silicone surfactant. The silicone surfactant also comprises hydrophobic silicone and other functional groups. In some embodiments, the silicone surfactant is incorporated into a surface active agent with the polyoxyalkylene portion of the molecule and / or the hydrocarbon portion of the molecule.

[0152] In one embodiment relating to the makeup composition, the weight amount of the silicone surfactant in the makeup composition can be in the range of about 0.1% to about 50%, about 0.5% to about 50%, about 1% to about 50%, about 2% to about 50%, about 5% to about 50%, about 10% to about 50%, about 15% to about 50%, about 20% to about 50%, about 25% to about 50%, about 30% to about 50%, about 35% to about 50%, about 40% to about 50%, or about 45% to about 50%.

[0153] In one embodiment relating to this makeup composition, the silicone is selected from dimethicone, methicone, trimethicone, cyclomethicone, amodimethicone, trimethylsilylamodimethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, polydimethylsiloxane, polymethylsilsequioxane, dimethiconol, and mixtures thereof. In another embodiment, the silicone is polydimethylsiloxane.

[0154] In one embodiment relating to this makeup composition, the makeup composition further comprises a colorant, hi one embodiment, the colorant comprises pigments, nacres, and reflective particles, dyes, and mixtures thereof.

[0155] It should be noted that the tints, sunscreens, and gelling agents described in the Methods section above are also suitable for application in the makeup composition.

[0156] In another embodiment relating to this makeup composition, the makeup composition may further comprise a moisturizer, an emollient, a humectant, a thickener, a toner, or a mixture thereof.

[0157] In another embodiment relating to the makeup composition, the makeup composition is formulated such that when administered to a subject, it will treat the scar and conceal the scar sufficiently to render the scar invisible. Methods for measuring the degree of concealment are described in the Methods section above. In one embodiment, the coverage of the makeup composition is in the range of about 30 to about 200, about 40 to about 200, about 50 to about 200, about 60 to about 200, about 70 to about 200, about 80 to about 200, about 90 to about 200, about 100 to about 200, about 100 to about 190, about 100 to about 180, about 100 to about 170, about 100 to about 160, about 100 to about 150, about 100 to about 140, about 100 to about 130, about 100 to about 120, or about 100 to about 110. Preferably, the coverage of the makeup compositions disclosed herein is about 30, about 50, about 80, about 100, about 150, or about 200.

[0158] In another embodiment, the makeup composition comprises less than 1% or no comedogenic compounds.Comedogenic compounds as used herein refer to ingredients that tend to clog skin pores.In one embodiment, the makeup composition comprises less than 1% or no of the following compounds: sodium chloride, wheat germ oil, sodium lauryl sulfate, red algae, octyl stearate, laureth 4, isopropyl myristate, isopropyl isostearate, isocetyl stearate, carrageenan, algae extract, or combinations thereof.

[0159] In another embodiment, the makeup composition comprises a silicone and a colorant. In one embodiment, the ratio of silicone to colorant ranges from about 0.01 to about 99, about 0.1 to about 95, about 1 to about 90, about 5 to about 85, about 10 to about 80, about 15 to about 75, about 20 to about 70, about 25 to about 65, about 30 to about 60, about 35 to about 55, about 40 to about 50, or about 40 to about 45. In another embodiment, the ratio of silicone to colorant ranges from about 0.01, about 0.05, about 0.1, about 0.5, about 1, about 5, about 10, about 15, about 20, about 25, about 30, about 35, about 40, about 45, about 50, about 55, about 60, about 65, about 70, about 75, about 80, about 85, about 90, about 95, or about 99.

[0160] Scar Treatment Kit In another aspect, there is provided a scar treatment kit comprising: a) a makeup composition as described herein; b) at least one container comprising the makeup composition; and c) at least one applicator. In one embodiment, the applicator in the kit is a brush, a puff, or a sponge.

[0161] In another embodiment relating to the kit, the kit comprises a plurality of compartments for containing a quantity of the makeup composition arranged in rows and columns. In one embodiment, the compartments of the kit are arranged based on the color of the makeup composition. In another embodiment, the shape of the compartment is a circle, a triangle, a rectangle, an oval, a square, a diamond, a trapezoid, or a pentagon. EXAMPLES

[0162] The following examples are provided to facilitate a clearer understanding of certain embodiments of the present invention. It should be understood that the examples are given by way of illustration only. From the above description and examples, those skilled in the art can ascertain the essential features of the present invention, and can make various changes and modifications to the present invention to suit various applications and situations without departing from the spirit and scope thereof. As a result, the present invention is not limited by the illustrative examples described below, but rather is defined by the appended claims.

[0163] Example 1 a. Preparation of Make-up Composition I 65g of polymethylsilsesquioxane, 0.1g of cetyl dimethicone, 1.6g of behenoxy dimethicone, 0.5g of trimethylsiloxysilicate, and 2.8g of polydimethylsiloxane are mixed together. The mixture is ground and sieved to obtain Part A. Then, 10g of titanium dioxide, 0.5g of D&C Red 30, 10.0g of titanium mica, 4.0g of zinc stearate, and 5.5g of talc are mixed, ground, and sieved to obtain Part B. Part A and Part B are mixed and ground until a homogeneous powder is formed. The powder is further sieved to obtain Make-up Composition I, which is packaged in a metal container.

[0164] b. Coverage test Make-up composition I is painted onto a polyester film of control mil thickness. The polyester is placed on a LENETA card. The reflectance Ro (black background) and Rw (white background) are measured using a spectrophotometer. Each LENETA card can be read with three data points on a black background, which can be repeated for six different LENEAT cards. 18 data points are collected and the contrast ratio is determined based on the formula C=100*Ro / Rw.

[0165] c. SPF value Make-up Composition I is tested on five subjects for sun protection (SPF) according to the method described in Federal Register Vol. 46, No. 17, Tuesday Jan. 27, 1981. The SPF result is expected to be about 20.

[0166] d.How to use Makeup composition I (1 g) is applied to the keloid scar of the skin by gentle massage once in the morning and once in the afternoon. The gentle massage ensures that it adheres to the skin. When makeup composition I is applied, the keloid scar is invisible and hidden.

[0167] Example 2 Bunny ears model Using a skin biopsy punch and a dissecting microscope, 7 mm wounds are made on the ventral surface of each ear of four 3 kg New Zealand White rabbits (six wounds per ear). The wounds include complete removal of the epithelium, dermis, and perichondrium. The wounds are covered with polyurethane film until healing is complete (17 days). The wounds on one ear are then treated once a day for 30 days by topical application of makeup composition I of Example 1. The six wounds on the other ear serve as untreated controls. The animals are sacrificed on the 36th day of the experiment.

[0168] Scar tissue is harvested, bisected at the highest point of the scar, and processed for histological analysis using hematoxylin and eosin staining. Scar elevation is quantified by measuring the "scar elevation index" at 100x magnification by an observer blinded to the treatment. Scar elevation index is calculated as the scar dermis area (S) divided by the normal dermis area (N), which is based on the dermis height of the adjacent unwounded skin (R. Reid et al., J Plast Reconstr Aesthet Surg. (2007), 60:64-72).

[0169] The average scar elevation index for control animals (N=20) is expected to be about 1.7, while the average scar elevation index for treated animals (N=19) is expected to be about 1.40.

[0170] Example 3 Table 1 provides the formulations of nine different embodiments.

[0171] [Table 1] *comp. means a makeup composition.

[0172] Example 4 Table 2 provides the formulations of nine different embodiments.

[0173] [Table 2] *comp. means a makeup composition.

[0174] Example 5 Table 3 provides five formulations of make-up compositions containing cortisone.

[0175] [Table 3] *comp. means a makeup composition.

[0176] Example 6 Table 4 provides five formulations of make-up compositions containing cortisone and another scar-dissolving agent.

[0177] [Table 4] *comp. means a makeup composition.

Claims

1. A method for treating and concealing a skin defect in a subject, comprising applying a makeup composition to the skin defect, the makeup composition comprising at least 20% by weight of silicone and a colorant, which conceals and simultaneously treats the skin defect.

2. The method of claim 1 , wherein the skin defect is a scar.

3. 3. The method of claim 2, wherein the scar is selected from a keloid scar, a hypertrophic scar, a contracture scar, an acne scar, and a surgical scar.

4. The method of claim 2, wherein the scar is a post-suture removal surgical scar beginning about 7 to about 14 days after surgery.

5. The method of claim 1 , wherein the makeup composition further provides UV protection.

6. The method of claim 1 , wherein the skin is substantially healed following the treatment and scar formation.

7. 3. The method of claim 2, wherein the treatment substantially reduces the amount and visibility of scar tissue.

8. The method of claim 2, wherein the scar is reduced in size following said treatment.

9. The method of claim 7 , wherein the treatment further provides a soothing effect to the skin.

10. The method of claim 1 , wherein the makeup composition comprises a pearlescent pigment.

11. 11. The method of claim 10, wherein the pearlescent pigment is a titanic mica containing iron oxide.

12. The method of claim 1 , wherein the silicone is selected from a liquid silicone, an oil silicone, a wax silicone, a resin silicone, or a mixture thereof.

13. 2. The method of claim 1, wherein the silicone is selected from dimethicone, methicone, trimethicone, cyclomethicone, amodimethicone, trimethylsilylamodimethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, polydimethylsiloxane, polymethylsilsequioxane, and dimethiconol, and mixtures thereof.

14. The method of claim 1 , wherein the amount of the makeup composition applied to the skin defect is from about 0.1 to about 10 mL.

15. The method of claim 1 , wherein the silicone has a viscosity of from about 1000 cP to about 1,000,000 cP.

16. The method of claim 1, wherein the makeup composition is maintained on the skin for at least 1 to 8 hours each day.

17. The method according to claim 16, wherein the makeup composition is applied 1 to 5 times a day for about 14 days to about 120 days.

18. 2. The method according to claim 1, wherein the weight of silicone is at least 25% relative to the total weight of the makeup composition.

19. 19. The method according to claim 18, wherein the weight of silicone is at least 30% relative to the total weight of the makeup composition.

20. The method of claim 1 , wherein the subject is a human.

21. The method of claim 1 , wherein the makeup composition further comprises cortisone.

22. A makeup composition comprising at least 80% by weight silicone and a colorant, which when applied to a scar on the skin of a subject, treats the scar on the skin of the subject while simultaneously camouflaging the scar and providing UV protection.

23. 23. The makeup composition of claim 22, wherein the silicone comprises polydimethylsiloxane.

24. 23. The makeup composition of claim 22, further comprising cortisone.

25. A method for treating and concealing a skin defect in a subject, comprising applying a makeup composition to the skin defect, the makeup composition comprising at least 20% by weight of silicone, a colorant, and a scar-dissolving agent selected from the group consisting of steroid hormones, collagenase, proteases, oligosaccharides, and biologics, and combinations thereof, wherein the makeup composition simultaneously conceals and treats the skin defect.

26. 26. The method of claim 25, wherein the steroid hormone is cortisone.

27. 1. A method for simultaneously treating and concealing a skin defect in a subject, comprising applying a makeup composition to the skin defect, wherein the makeup composition comprises at least 20% by weight of a silicone and a colorant, the colorant depositing a color on the keratinous material that matches the color of the keratinous material, and the makeup composition is not composed of an immiscible layer.

28. 28. The method of claim 27, wherein the skin defect is a scar.

29. 28. The method of claim 27, wherein the silicone is selected from a liquid silicone, an oil silicone, a wax silicone, a resin silicone, or a mixture thereof.

30. 28. The method of claim 27, wherein the subject is a human.

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