Liquid agent packaging body production fixture and liquid agent packaging body production method

Abstract

To provide a liquid agent packaging body production fixture and a liquid agent packaging body production method which can keep the vertical dimensions of a horizontal seal part within a specified range.SOLUTION: A liquid agent packaging body production fixture 2 is formed with a through hole 6. An inside face of the through hole 6 has a flat face 6b straightly extending in a vertical direction. A liquid agent packaging body production method includes: a vertical seal step of overlapping both widthwise edges of a belt-like film, further heat-sealing the same into a vertical seal part, and forming a cylindrical body 20 extending vertically; a horizontal seal step of heat-sealing the cylindrical body 20 in a horizontal direction, and providing the cylindrical body 20 with a horizontal seal part 24; a liquid agent filling step of filling a liquid agent into the cylindrical body 20 closed at a bottom by the horizontal seal part 24; an air blowing step of positioning the cylindrical body 20 to the through hole 6, and blowing air between the flat face 6b and the cylindrical body 20; and a cutting step of cutting the horizontal seal part 24 in a state where the downward movement of the cylindrical body 20 and the blowing of the air are stopped.SELECTED DRAWING: Figure 6

Description

[Technical field]

[0001] The present invention relates to a manufacturing jig for a liquid drug package and a manufacturing method for a liquid drug package. [Background technology]

[0002] Patent Document 1 below discloses a preparation kit 100 for a multi-component liquid composition, as shown in Fig. 8. This preparation kit 100 includes a composite liquid package 104 consisting of a plurality of liquid packages 102 containing the components of the liquid composition, and an outer bag 106 that contains the composite liquid package 104.

[0003] As shown in Fig. 9, the liquid agent package 102 is a "pillow flat bag" manufactured by vertically sealing a sheet of film back to back to form a cylinder, horizontally sealing the film at a predetermined interval, and then cutting the film, and the liquid agent is contained inside the "pillow flat bag". The liquid agent package 102 has a vertical seal portion 108, an upper horizontal seal portion 110, a lower horizontal seal portion 112, and a liquid agent storage portion 114 provided between the upper horizontal seal portion 110 and the lower horizontal seal portion 112. Note that a through opening 116 may be provided in the upper horizontal seal portion 110 for the purpose of convenience when the upper horizontal seal portions 110 of the multiple liquid agent packages 102 are stacked and heat-pressurized to form the composite liquid agent package 104.

[0004] Such a liquid agent package can be manufactured by a vertical pillow packaging method, which includes a vertical sealing step of overlapping and heat-sealing both widthwise end portions of a strip-shaped film to form a vertically extending cylindrical body, a horizontal sealing step of heat-sealing the cylindrical body along a horizontal direction perpendicular to the vertical direction to provide a horizontal seal portion on the cylindrical body, a liquid agent filling step of filling the cylindrical body whose lower part is closed by the horizontal seal portion with a liquid agent, and a cutting step of cutting the horizontal seal portion.

[0005] Since the vertical pillow packaging method is a continuous method, when focusing on two liquid agent packages (a downstream liquid agent package and an upstream liquid agent package) that are manufactured in succession, in the horizontal sealing process performed to form the horizontal seal portion interposed between the two packages, the upper horizontal seal portion of the downstream liquid agent package and the lower horizontal seal portion of the upstream liquid agent package are formed simultaneously. That is, the lower horizontal seal has already been formed through the horizontal sealing process and the liquid material filling process, and the downstream liquid agent package is filled with liquid agent inside, but the upper opening of the downstream liquid agent package that is open at the top (upstream side) is heat sealed to form a horizontal seal portion (interposed between the two packages), and in the cutting process performed thereafter, the horizontal seal portion is cut to separate the downstream liquid agent package into the upper horizontal seal portion and the upstream liquid agent package into the lower horizontal seal portion, and the two packages are simultaneously separated.

[0006] When preparing a multi-component liquid composition using the preparation kit, the multiple liquid packages constituting the composite liquid package are crushed in the outer bag. This causes the lower horizontal seal of each liquid package to be opened, causing the liquid to flow out of each liquid package into the outer bag. The multiple liquid packages are then mixed in the outer bag to prepare the multi-component liquid composition. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] International Publication No. 2020 / 158238 Summary of the Invention [Problem to be solved by the invention]

[0008] When manufacturing a liquid agent package, it is important that the vertical dimensions (hereinafter also referred to as "vertical width") of the lower horizontal seal portion and the upper horizontal seal portion after the cutting process are within a specified range. However, since the vertical width of the lower horizontal seal portion and the vertical width of the upper horizontal seal portion are determined by the cutting position in the cutting process, even if the width of the horizontal seal portion formed in the horizontal sealing process is controlled to a specified dimension, if the cutting position deviates from the specified position, it is not possible to form the lower horizontal seal portion and the upper horizontal seal portion having the specified vertical width. Furthermore, deviation in the cutting position causes the following problems.

[0009] That is, if the vertical dimension (length) of the lower horizontal seal part is too large, a large pressing force is required to open the horizontal seal part of the liquid agent package, making it difficult to open the liquid agent package. On the other hand, if the vertical dimension (length) of the lower horizontal seal part is too small, the liquid agent package may be unintentionally torn. In addition, if the vertical width of the upper horizontal seal part is too small, or if the horizontal seal part is cut obliquely in the cutting process and the upper horizontal seal part is tilted, poor heat sealing or misalignment is likely to occur when multiple liquid agent packages are integrated into a composite liquid agent package by heat sealing. Therefore, the vertical dimensions of the lower horizontal seal part and the upper horizontal seal part of the liquid agent package must be within a specified range.

[0010] The object of the present invention is to provide a manufacturing tool for a liquid agent packaging body and a manufacturing method for a liquid agent packaging body that can prevent misalignment of the cutting position and keep the vertical dimensions of the lower horizontal seal portion and the upper horizontal seal portion within a specified range. [Means for solving the problem]

[0011] According to the present invention, there is provided the following manufacturing tool for a liquid drug package that solves the above-mentioned problems. "A manufacturing jig for liquid drug packaging, A through hole extending in the vertical direction is formed, The inner surface of the through hole has a flat surface that extends straight along the up-down direction.

[0012] A pair of flat surfaces may be provided, and the pair of flat surfaces may be disposed at positions facing each other. The inner surface of the through hole has an inclined surface that extends downward from the upper portion of the through hole, and the flat surface preferably extends downward from the lower end of the inclined surface. The through hole is rectangular when viewed in the vertical direction, and four inclined surfaces are provided downward from the four sides of the upper edge of the through hole, and four flat surfaces are provided downward from the lower ends of the four inclined surfaces. It is preferable that the inclined surface is curved convexly toward the inside of the through hole. It is preferable that when air is blown between the flat surface of the through hole and the multiple liquid agent packages connected in the vertical direction, the multiple liquid agent packages are guided along the flat surface.

[0013] Furthermore, according to the present invention, there is provided the following method for producing a liquid drug package that solves the above problems. "A method for manufacturing a liquid drug package, comprising: a vertical sealing step of overlapping and heat-sealing both widthwise ends of the strip of film to form a vertically sealed portion, thereby forming a tubular body extending in the vertical direction; a lateral sealing step of heat-sealing the cylindrical body along a lateral direction perpendicular to a vertical direction to provide a lateral seal portion on the cylindrical body; a liquid agent filling step of filling the cylindrical body, the lower portion of which is closed by the transverse seal portion, with a liquid agent; an air blowing step of positioning the cylindrical body in the through hole of the manufacturing jig for the liquid agent package as described above, and blowing air between the flat surface and the cylindrical body; and cutting the transverse seal portion while stopping the downward movement of the cylindrical body and the air blowing.

[0014] In the air blowing step, it is preferable to blow air between the surface of the cylindrical body not having the vertical seal portion and the flat surface. In the air blowing step, it is preferable to blow air from above downward. Effect of the Invention

[0015] According to the present invention, when a cylindrical body is positioned in a through hole of a manufacturing jig for liquid drug packaging and air is blown between the flat surface and the cylindrical body, the pressure between the flat surface and the cylindrical body decreases, and the cylindrical body is attracted to the flat surface. Therefore, the cylindrical body can be guided so as to extend in the vertical direction by the flat surface of the manufacturing jig for liquid drug packaging. Therefore, the horizontal seal portion can be cut after the cylindrical body is positioned at a predetermined cutting position, so that the vertical dimensions of the upper horizontal seal portion and the lower horizontal seal portion can be kept within a predetermined range. [Brief description of the drawings]

[0016] [Figure 1] 1A is a plan view of a manufacturing jig according to the present invention, FIG. 1B is a front view of the jig shown in FIG. 1A, and FIG. 1C is a side view of the jig shown in FIG. [Diagram 2] Schematic diagram of a vertical pillow packaging machine. [Diagram 3] Schematic diagram of a strip of film. [Figure 4] FIG. [Diagram 5] 1 is a schematic diagram of a cylindrical body having a plurality of horizontal seal portions spaced apart in the vertical direction. [Figure 6] (a) Schematic diagram showing a cylindrical body positioned in the through hole of the manufacturing jig shown in Figure 1; (b) Schematic diagram showing a state in which air is blown between the flat surface of the through hole of the manufacturing jig shown in Figure 1 and the cylindrical body; (c) Plan view of the jig with the area where air is blown from the air nozzle shown hatched. [Figure 7] FIG. [Figure 8] Schematic diagram of a kit for preparing a multi-component liquid composition. [Figure 9] FIG. 9 is a schematic diagram of the liquid agent package shown in FIG. 8. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] Dental adhesive compositions such as dental adhesives are multi-component liquid compositions. During dental treatment, a required amount of dental adhesive composition is prepared and used each time by mixing multiple liquids. In the preparation kit for multi-component liquid composition disclosed in Patent Document 1, when the amount of each liquid packaged in multiple liquid packages is set to a single-use amount, not only is the preparation operation simplified, but there is also the advantage that the amount of dental adhesive composition that is discarded unused can be reduced. When producing such a kit suitable for single use, the amount of liquid packaged in each liquid package is small, for example, 0.01 to 1 ml, so the size of the liquid package is inevitably small, and becomes a rectangular bag with a length of about 20 mm and a width of about 10 mm.

[0018] The present inventors have recognized that when a liquid agent package for use in a single-use kit is manufactured by a vertical pillow packaging method, it is difficult to control the cutting position in the cutting process, and cutting cannot be performed at a predetermined position, resulting in a high rate of defective products. The present inventors believe that the cause of the above problem is that, after a horizontal sealing process for forming a lower horizontal seal portion, a liquid agent filling process, and a horizontal sealing process for forming an upper horizontal seal portion are performed, a connected body in which a plurality of (uncut) liquid agent packages filled with a liquid agent and horizontally sealed at the lower and upper sides are connected in the vertical direction is difficult to control the posture due to the weight when sent downstream, because the force generated by the distortion of the film caused by the above-mentioned multiple processes is relatively large compared to the weight of the connected body. Thus, the present inventors have intensively studied a method for controlling the posture of the connected body being sent out so that the planned cutting position in the horizontal seal portion coincides with the actual cutting position.

[0019] As a result, it was discovered that a through hole extending in the vertical direction is formed upstream of the cutting section where the cutting process takes place, and the inner surface of the through hole is formed using a jig with a flat surface that extends straight along the vertical direction. By passing the connector through the through hole and blowing air between the flat surface of the through hole and the connector, the posture of the connector can be controlled and sent out, making it possible to cut at the intended cutting position with a high probability, and thus completing the present invention.

[0020] Hereinafter, a manufacturing jig for a liquid agent package and a manufacturing method for a liquid agent package according to the present invention will be described with reference to the drawings.

[0021] First, referring to Fig. 7, the liquid agent package which is the object of the liquid agent package manufacturing method according to the present invention will be described. The liquid agent package 26 is a flat pillow bag in which the liquid agent serving as the raw material of the multi-component liquid composition is liquid-tightly sealed, and has an upper transverse seal portion 26a, a lower transverse seal portion 26b, and a liquid agent storage portion 26c provided between the upper transverse seal portion 26a and the lower transverse seal portion 26b. The liquid agent is liquid-tightly held inside the liquid agent storage portion 26c. In addition, a circular through opening 26d is provided near the center of the upper transverse seal portion 26a for the purpose of facilitating stacking the upper transverse seal portions 26a of the multiple liquid agent packages 26 and heat-pressing them to form a composite liquid agent package.

[0022] Next, a manufacturing jig for liquid drug packages according to the present invention will be described with reference to Fig. 1. A manufacturing jig 2 for liquid drug packages (hereinafter simply referred to as "jig 2") is used to control the attitude of a connected body consisting of multiple liquid drug packages connected in the vertical direction when the connected body is pushed out and moved to a position where a cutting process is performed when manufacturing liquid drug packages by the vertical pillow packaging method, and includes a guide section 4 for guiding the connected body. A through hole 6 extending in the vertical direction is formed in the guide section 4, so that the guided connected body can pass through the inside of the through hole 6.

[0023] The inner surface of the through hole 6 has an inclined surface 6a and a flat surface 6b. The inclined surface 6a extends from the upper portion of the through hole 6 downwardly and inwardly of the through hole 6. The inclined surface 6a in this embodiment extends from the upper edge of the through hole 6. However, the inclined surface 6a only needs to extend from the upper portion of the through hole 6, and does not necessarily have to extend from the upper edge of the through hole 6. The flat surface 6b extends straight in the vertical direction from the lower end of the inclined surface 6a. It is important that the guide portion 4 has the flat surface 6b, and does not necessarily have to have the inclined surface 6a.

[0024] Although it is sufficient that each of the inclined surface 6a and the flat surface 6b is provided one by one, it is preferable that each of them is provided in pairs. When each of the inclined surface 6a and the flat surface 6b is provided in pairs, it is preferable that the pair of inclined surfaces 6a is provided at positions facing each other, and the pair of flat surfaces 6b is also provided at positions facing each other. As shown in FIG. 1(a), the through hole 6 of this embodiment is rectangular when viewed in the vertical direction, and four inclined surfaces 6a are provided downward from the four sides of the upper edge of the through hole 6. In addition, four flat surfaces 6b are provided downward from the four inclined surfaces 6a.

[0025] As shown in Fig. 1, the inclined surface 6a in this embodiment is curved convexly toward the inside of the through hole 6. This allows multiple liquid agent packages connected in the vertical direction to be smoothly guided to the flat surface 6b provided below the inclined surface 6a. The inclined surface 6a does not have to be curved. In other words, the inclined surface 6a may be a flat surface that extends from the upper part of the through hole 6 downwardly and inclined toward the inside of the through hole 6.

[0026] The jig 2 also includes a supported portion 8 that is supported by an appropriate support (not shown). The supported portion 8 in this embodiment extends substantially horizontally from the upper portion of the guide portion 4. The supported portion 8 is provided with a through hole 8a for passing the support. The through hole 8a may be, for example, an elongated hole (slot hole). The shape of the supported portion 8 is not limited to the shape shown in the drawings, and may be changed as appropriate depending on the shape of the support. Any shape may be adopted for the supported portion 8 as long as the support can fix the jig 2 in a predetermined position by supporting the supported portion 8.

[0027] The jig 2 can be made of a suitable synthetic resin material or a suitable metal material. However, it is preferable that the jig 2 is made of a synthetic resin material that is easy to mold.

[0028] The dimensions of the jig 2 are appropriately changed depending on the dimensions of the liquid package to be manufactured, but it is preferable that the length of the through hole 6 in the thickness direction (left-right direction in Figs. 1(a), 6(a) and 6(b)) is 0.5 to 20.0 mm longer than the maximum thickness of the liquid package, the length in the horizontal direction (up-down direction in Fig. 1(a) and left-right direction in Fig. 1(c)) is 0.5 to 2.0 mm longer than the length of the liquid package in the horizontal direction (left-right direction in Fig. 7), and the length in the height direction (up-down direction in Figs. 1(b) and (c) and Figs. 6(a) and (b)) is the length of 1 to 5 liquid packages. By setting the above dimensions, it is easy to obtain the effect of guiding multiple connected liquid packages.

[0029] Next, a method for manufacturing the liquid drug package will be described. This manufacturing method can be carried out, for example, by using a vertical pillow packaging machine 10 shown in Fig. 2. A film roll 14, in which a strip-shaped film 12 serving as the material for the liquid drug package is wound into a cylindrical shape, is attached to this vertical pillow packaging machine 10, and the liquid drug package is manufactured while appropriately feeding out the film 12 from the film roll 14.

[0030] The film 12 is a laminated structure. The layer (inner layer) located on the inside when the film 12 is formed into a liquid drug package is made of a resin with high heat-welding properties (having heat-sealing properties) that serves as a sealant material. The layer (outer layer) located on the outside when the film 12 is formed into a liquid drug package can be made of a resin with low heat-welding properties (having no heat-sealing properties), an inorganic material, or a composite of both. The film 12 may have an intermediate layer between the inner layer and the outer layer to further enhance its functionality.

[0031] (Vertical sealing process) In this embodiment, first, a vertical sealing step is carried out in which both widthwise end portions of the strip-shaped film 12 are overlapped and heat-sealed to form vertically sealed portions, thereby forming a tubular body extending in the vertical direction.

[0032] Specifically, film 12 is pulled out from film roll 14 attached to vertical pillow packaging machine 10, and is intermittently moved via a plurality of direction change rollers (not shown) to vertical sealing process execution section 16 (see FIG. 2) of vertical pillow packaging machine 10. In the vertical sealing process, while film 12 is moved from top to bottom, the overlapping portion of one widthwise end portion 12a (see FIG. 3) of film 12 and the other widthwise end portion 12b (see FIG. 3) of film 12 are heat-sealed in vertical sealing process execution section 16. As a result, as shown in FIG. 4, both widthwise end portions 12a, 12b of film 12 are overlapped and heat-sealed to form vertical seal portion 18, and a tubular body 20 extending in the vertical direction can be formed.

[0033] (Horizontal sealing process) After the vertical sealing process is performed, a horizontal sealing process is performed in which the tubular body 20 is heat-sealed along a horizontal direction perpendicular to the up-down direction to provide a horizontal seal portion in the tubular body 20. As shown in FIG. 2, the horizontal sealing process execution unit 22 of the vertical pillow packaging machine 10 is disposed below the vertical sealing process execution unit 16.

[0034] In the transverse sealing process, the cylindrical body 20, which moves intermittently from above to below, is heat-sealed intermittently along the transverse direction by the transverse sealing process execution unit 22. By performing the transverse sealing process, as shown in FIG. 5, a plurality of transverse seal parts 24 can be provided in the cylindrical body 20 at intervals in the vertical direction. In addition, a plurality of packages 26 are formed by the plurality of transverse seal parts 24. Note that FIG. 5 is a schematic diagram of a cylindrical body provided with a plurality of transverse seal parts at intervals in the vertical direction, and is actually obtained by repeating the cycle of "transverse sealing process -> (described later) liquid material filling process" at least twice or more, and is also a schematic diagram of a connected body in which a plurality of (uncut) liquid agent packages 26 are connected in the vertical direction. The space between the transverse seal parts 24 in the connected body is a liquid agent storage section 26c filled with a predetermined amount of liquid agent (not shown). Focusing on one liquid agent storage section 26c, the upper portion of the horizontal seal portion 24 below the liquid agent storage section 26c becomes the lower horizontal seal portion 26b of the liquid agent packaging body 26, and the lower portion of the horizontal seal portion 24 above the liquid agent storage section 26c becomes the upper horizontal seal portion 26a of the liquid agent packaging body 26.

[0035] The transverse sealing process can be performed together with the intermittent downward movement of the cylindrical body 20. That is, the time during which the transverse sealing process is performed (for example, 1.4 seconds) may overlap with the time during which the cylindrical body 20 is moving (for example, 0.8 seconds). However, the time during which the transverse sealing process is performed and the time during which the cylindrical body 20 is moving do not have to be the same length of time. The intermittent downward movement of the cylindrical body 20 (and the intermittent feeding of the film 12 from the film roll 14) can be performed using a film feeding device, but it is preferable to use a movable heat sealer such as a so-called box motion type as the heat sealer performing the transverse sealing process, and to move the cylindrical body 20 downward while sandwiched by the heat sealer by a distance equivalent to the length of one liquid agent package 26. After the movement, the heat sealer releases the sandwiching of the cylindrical body 20 and returns to its original position so that the next transverse seal can be performed.

[0036] (Liquid filling process) While the transverse sealing process is performed intermittently, a liquid agent filling process is performed between the transverse sealing processes, in which a liquid agent is filled into the tubular body 20 whose lower part is closed by the transverse sealing section 24. That is, while heat sealing to form the upper transverse sealing section 26a is not being performed, a predetermined amount of liquid agent is filled by the liquid agent filling machine 28 into the package 26 whose lower part is closed by the transverse sealing section 24 (the upper part of the transverse sealing section 24 becomes the lower transverse sealing section 26b) provided in the immediately preceding sealing process. Then, by performing the transverse sealing process after filling the package 26 with the liquid agent, the upper part of the package 26 filled with the liquid agent can be closed by the transverse sealing section 24.

[0037] (Air blowing process) After the lateral sealing step and the liquid agent filling step are performed, the cylindrical body 20 is positioned in the through hole 6 of the jig 2, and an air blowing step is performed in which air is blown between the flat surface 6b of the through hole 6 and the cylindrical body 20. As shown in Fig. 2, the jig 2 is disposed below the lateral sealing step performing unit 22. In addition, an air nozzle 30 for blowing air between the cylindrical body 20 is disposed between the lateral sealing step performing unit 22 and the jig 2.

[0038] FIG. 6(a) shows an example of the cylindrical body 20 before the air blowing process is performed. After the horizontal sealing process and the liquid agent filling process are performed, the film 12 is distorted by the heat sealing, so that the posture of the cylindrical body 20 is difficult to stabilize, as shown in FIG. 6(a). That is, the cylindrical body 20 may not extend straight from above to below. In particular, when the amount of liquid agent filled in the packaging body 26 is small (that is, when the mass of the cylindrical body 20 is small), the posture stabilization effect due to the weight of the cylindrical body 20 is difficult to occur, so the influence of the distortion of the film 12 is likely to be noticeable. If the posture of the cylindrical body 20 is not stable, the position of the cylindrical body 20 with respect to the cutting process execution unit 32 will be shifted from the predetermined cutting position in the cutting process described below.

[0039] Therefore, in order to stabilize the posture of the cylindrical body 20, an air blowing process is performed. In the air blowing process of this embodiment, the cylindrical body 20 is positioned in the through hole 6 of the jig 2, and air is blown between the flat surface 6b of the through hole 6 and the cylindrical body 20 in the direction indicated by the arrow A1 using the air nozzle 30 as shown in FIG. 6(b). Then, the pressure between the flat surface 6b and the cylindrical body 20 decreases, and the cylindrical body 20 is attracted to the flat surface 6b, and the cylindrical body 20 moves in the direction indicated by the arrow A2 in FIG. 6(b). Therefore, the flat surface 6b of the jig 2 can guide the cylindrical body 20 so that it extends in the vertical direction. As a result, the cylindrical body 20 can be positioned at a predetermined cutting position.

[0040] Although not shown, the air nozzle 30 is connected to an air pump (air supply source) via a flow path such as a tube. As described later, it is preferable to stop the air blowing when performing the cutting process, but since it is difficult to stabilize the air flow rate if the air pump is turned on and off in accordance with the timing at which the air blowing is stopped, it is preferable to turn on and off the air supplied to the air nozzle 30 by switching the flow path with the air pump always on.

[0041] In the air blowing step, it is preferable to blow air between the surface of the cylindrical body 20 without the vertical seal portion 18 and the flat surface 6b. The surface without the vertical seal portion 18 allows air to flow more smoothly, so the pressure between the flat surface 6b and the cylindrical body 20 is more likely to decrease, and since the surface is flatter than the surface with the vertical seal portion 18, the posture of the cylindrical body 20 is more stable. From the viewpoint of effectiveness, as shown in FIG. 6(c), the air blowing port 30a of the air nozzle 30 is a rectangular opening having a length equivalent to the length of the through hole 6 (in the vertical direction in FIG. 1(a)) and a width equivalent to half the inclination width of the inclined surface 6a (in the horizontal direction in FIG. 1(a)), and is preferably disposed above the through hole 6 so that the projection 30b of the air blowing port 30a (the portion shown by hatching in FIG. 6(c)) overlaps with the inclined surface 6a.

[0042] In addition, in the air blowing step, it is advantageous to blow air from above downward. As described above, the vertical seal section 18 and the horizontal seal section 24 are formed by heat sealing. Therefore, if there are locally melted areas remaining in the vertical seal section 18 and the horizontal seal section 24, the molten material of the film 12 will adhere to the blade of the cutting process execution section 32 when the cutting process described below is executed. In this regard, if air is blown from above downward in the air blowing step, the air will hit the cylindrical body 20 even after the cylindrical body 20 has passed through the jig 2, improving the cooling effect. Therefore, the molten material of the film 12 is prevented from adhering to the blade of the cutting process execution section 32.

[0043] The flow rate of the blown air is determined based on the posture stabilization effect. 3 / s) is calculated by multiplying the cross-sectional area (m 2 The linear velocity (m / hr) divided by the linear velocity (m / hr) is preferably 5 to 50 (m / s), and more preferably 10 to 40 (m / s).

[0044] Furthermore, in the jig 2 of this embodiment, an inclined surface 6a is provided that extends downward from the upper portion of the through hole 6 at an angle toward the inside of the through hole 6, so that air can be smoothly introduced between the flat surface 6b of the through hole 6 and the cylindrical body 20.

[0045] (cutting process) After the air blowing step is performed, the cutting step is performed to cut the horizontal seal portion 24 while the downward movement of the cylindrical body 20 and the air blowing are stopped. As shown in FIG. 2, the cutting step performing unit 32 of the vertical pillow packaging machine 10 is disposed below the jig 2. The cutting step is performed while the movement of the cylindrical body 20 moving from top to bottom is stopped so that the horizontal seal portion 24 can be cut at a predetermined position. In addition, in order to prevent vibration of the cylindrical body 20 caused by the air blowing, the air blowing is stopped in the cutting step. Then, by performing the cutting step in the cutting step performing unit 32, a liquid agent package 26 as shown in FIG. 7 can be manufactured.

[0046] As described above, when the cylindrical body 20 is positioned in the through hole 6 of the jig 2 and air is blown between the flat surface 6b and the cylindrical body 20, the pressure between the flat surface 6b and the cylindrical body 20 decreases, and the cylindrical body 20 is drawn to the flat surface 6b. Therefore, the flat surface 6b of the jig 2 can guide the cylindrical body 20 so that it extends in the vertical direction. Therefore, the horizontal seal portion 24 can be cut after the cylindrical body 20 is positioned at a predetermined cutting position, so that the horizontal seal portion 24 can be reliably cut at the intended cutting position 27 (see FIG. 5), and the vertical dimensions of the upper horizontal seal portion 26a and the lower horizontal seal portion 26b can be kept within a predetermined range.

[0047] The effect of the present invention is remarkable when the amount of liquid agent filled in the package 26 is small as described above. Therefore, from the viewpoint of high effectiveness, the manufacturing method according to the present invention is suitably applied to the manufacture of liquid agent packages in which the amount of liquid agent per package is 0.005 to 5 ml, particularly 0.01 to 1 ml.

[0048] The liquid agent package 26 thus manufactured can be suitably used in a kit for preparing a multi-component liquid composition. In the liquid agent package 26, the vertical dimension of the horizontal seal portion 24 is within a predetermined range as described above, and therefore the liquid agent package 26 can be opened by applying a predetermined pressing force. [Explanation of symbols]

[0049] 2: Jig 4: Guide section 6:Through hole 6a: Inclined surface 6b: Flat surface 8: Supported part 8a:Through hole 10: Vertical pillow packaging machine 12:Film 14: Film roll 16: Vertical sealing process execution department 18: Vertical seal section 20: Cylindrical body 22: Horizontal sealing process execution unit 24: Horizontal seal section 26: Packaging 30: Air nozzle 30a: Air outlet 30b: Air outlet projection 32: Cutting process execution unit 100: Adjustment kit 102: Liquid drug packaging body 104: Composite liquid packaging body 106: Outer bag 108: Vertical seal part 110: Upper horizontal seal part 112: Lower horizontal seal part 114: Liquid storage section 116: Through hole

Claims

1. A manufacturing jig for a liquid drug package, comprising: A through hole extending in the vertical direction is formed, The inner surface of the through hole has a flat surface that extends straight along the vertical direction.

2. The liquid agent packaging manufacturing jig according to claim 1 , wherein a pair of the flat surfaces are provided, and the pair of flat surfaces are disposed in positions facing each other.

3. The inner surface of the through hole has an inclined surface that extends downward from an upper portion of the through hole and is inclined toward the inside of the through hole, The liquid agent package manufacturing jig according to claim 1 , wherein the flat surface extends downward from a lower end of the inclined surface.

4. The through hole has a rectangular shape when viewed in the vertical direction, The inclined surfaces are provided in four portions extending downward from four sides of the upper edge of the through hole, The liquid agent packaging manufacturing jig according to claim 3 , wherein the flat surfaces are four in number and are provided downward from lower ends of the four inclined surfaces.

5. The manufacturing jig for a liquid agent package according to claim 3 , wherein the inclined surface is curved convexly toward an inside of the through hole.

6. 2. The liquid agent packaging manufacturing jig according to claim 1, wherein when air is blown between a flat surface of the through hole and a plurality of liquid agent packaging bodies connected in the vertical direction, the plurality of liquid agent packaging bodies are guided along the flat surface.

7. A method for producing a liquid drug package, comprising the steps of: a vertical sealing step of overlapping and heat-sealing both widthwise ends of the strip of film to form a vertically sealed portion, thereby forming a tubular body extending in the vertical direction; a horizontal sealing step of heat-sealing the cylindrical body along a horizontal direction perpendicular to the up-down direction to provide a horizontal seal portion on the cylindrical body; a liquid agent filling step of filling the cylindrical body, the lower portion of which is closed by the transverse seal portion, with a liquid agent; an air blowing step of positioning the cylindrical body in the through hole of the manufacturing jig for the liquid agent package according to claim 1 and blowing air between the flat surface and the cylindrical body; a cutting step of cutting the transverse seal portion while the downward movement of the cylindrical body and the air blowing are stopped.

8. The method for producing a liquid agent package according to claim 7 , wherein in the air blowing step, air is blown into a gap between a surface of the cylindrical body that does not have the vertical seal portion and the flat surface.

9. The method for producing a liquid agent package according to claim 7 , wherein the air is blown from above downward in the air blowing step.

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