Tablet composition

Abstract

To provide a tablet composition which maintains superior gradual dissolvability even when being stored at a high temperature, and is highly heat-resistant and not easily broken.SOLUTION: A tablet composition 10 comprises a component (A) and a component (B) composed of a component (B-1) and a component (B-2), wherein the component (A) is at least one of calcium lactate and calcium hydroxide, the component (B-1) is a lubricant having a melting point of less than 100°C, and the component (B-2) is a lubricant having a melting point of 100°C or more.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a tablet composition.

Background Art

[0002] So far, the slow-dissolving technology has been mainly reported for use in toilet tanks, on-tanks, toilets, etc. For example, Patent Document 1 discloses a solid detergent for a flush toilet in which a solid deodorant insoluble or hardly soluble in water is dispersed in a slow-dissolving agent.

[0003] In recent years, it has been considered to apply the slow-dissolving technology to the field of washing fiber products such as clothes, and solid agents formed by melting a high-melting-point nonionic surfactant or a higher alcohol have been proposed. For example, Patent Document 2 discloses a solid composition for washing treatment containing a water-soluble nonionic surfactant or polyethylene glycol or a copolymer of polyoxyethylene and polyoxypropylene having a melting point of 25°C or higher, a water-insoluble component having a melting point of 50°C or higher, and a functional component. This solid composition for washing treatment is produced by mixing those heated to a temperature equal to or higher than the melting point of each component, pouring the mixture into a mold, and cooling until it solidifies.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] The solid agent is, for example, housed in a washing ball, a washing net, etc., and is put into a washing machine together with the laundry of fiber products for use in washing. However, when using a washing machine with a drying function to perform up to the drying process, a part of the solid agent may dissolve, and there are problems with heat resistance. In addition, when the solid agent is exposed to high temperatures during transportation or storage, the slow solubility may change. Therefore, the solid agent is required to have excellent slow solubility even when stored at high temperatures. Furthermore, when the solid agent cracks during washing, small pieces may fly out from a washing ball or the like and adhere to the textile product. Even if it remains in the washing ball, the surface area becomes small, and the slow solubility may increase excessively. Therefore, the solid agent is required to be difficult to crack during washing.

[0006] An object of the present invention is to provide a tablet composition that has excellent slow solubility even when stored at high temperatures, has good heat resistance, and is difficult to crack.

Means for Solving the Problems

[0007] The present invention has the following aspects. [1] A tablet composition containing component (A) and component (B) composed of component (B-1) and component (B-2), The component (A) is at least one of calcium lactate and calcium hydroxide, The component (B-1) is a lubricant having a melting point of less than 100°C, The component (B-2) is a lubricant having a melting point of 100°C or higher, tablet composition. [2] The component (B-1) is an oily lubricant having a melting point of less than 100°C, The component (B-2) is an inorganic metal salt-based lubricant having a melting point of 100°C or higher, the tablet composition of [1] above. [3] The component (B-1) is one or more selected from carnauba wax, rice wax, hardened oil, sucrose fatty acid ester, and sunflower wax, The component (B-2) is one or more selected from magnesium stearate, calcium stearate, sodium stearyl fumarate, and light anhydrous silicic acid, the tablet composition of [2] above. [4] Further containing component (C), The tablet composition according to any one of [1] to [3] above, wherein the component (C) is an inorganic metal salt containing at least one of magnesium and aluminum. [5] The tablet composition according to [4] above, wherein the component (C) contains at least one selected from synthetic hydrotalcite, magnesium aluminometasilicate, magnesium aluminosilicate, and aluminum hydroxide. [6] The tablet composition according to any one of [1] to [5] above, wherein the mass ratio represented by the component (A) / the component (B) is 0.05 to 2. [Advantages of the Invention]

[0008] According to the present invention, it is possible to provide a tablet composition that is excellent in slow solubility even when stored at a high temperature, has good heat resistance, and is difficult to crack. [Brief Description of the Drawings]

[0009]

Figure 1

Figure 2

Figure 3

[0010] Hereinafter, embodiments of the present invention will be specifically described. However, the present invention is not limited to the following embodiments, and various modifications can be made within the scope of the gist thereof. In this specification and the claims, the numerical range represented by "~" means a numerical range including the numerical values before and after ~ as the lower limit value and the upper limit value. For example, A~B is synonymous with A or more and B or less. The "tablet composition" refers to a solid preparation that retains a constant shape at room temperature (e.g., 25°C) and is less likely to change its shape over time, and examples thereof include tablets, gels, unit doses, etc. In particular, the tablet form is preferred. The "heat resistance" means that when the tablet composition is used for washing textile products using a washing and drying machine, or for washing tableware and cooking utensils (hereinafter sometimes collectively referred to as "tableware") that are kitchen supplies using a dishwasher, the tablet composition is resistant to elution even when exposed to the drying temperature of the washing and drying machine or the dishwasher. The "slow solubility" means that when in contact with water, the entire tablet composition does not dissolve at once, but a part of the surface or the vicinity of the tablet composition dissolves. Specifically, when 12 g of the tablet composition is immersed in water at 15°C for 40 minutes and then the weight of the tablet composition is measured, the weight loss before and after immersion is preferably 0.2 g or more and less than 5.0 g, more preferably 0.5 g or more and 2.5 g or less, and even more preferably 0.8 g or more and less than 2.0 g. In this specification, the slow solubility of the tablet composition transported or stored in a high-temperature environment such as in summer is particularly referred to as the "slow solubility during high-temperature storage".

[0011] The tablet composition of the present invention is a tablet-type solid preparation containing the following component (A) and component (B). The tablet composition preferably further contains component (C) in addition to component (A) and component (B). The tablet composition may further contain components other than component (A), component (B), and component (C) (hereinafter also referred to as "optional components") as necessary, as long as the effects of the present invention are not impaired.

[0012] <(A) component> Component (A) is at least one of calcium lactate and calcium hydroxide. The tablet composition can provide slow solubility during high-temperature storage by having component (A) and component (B-1) described below.

[0013] The content of component (A) is preferably 1 to 25% by mass, more preferably 2 to 20% by mass, and even more preferably 3 to 15% by mass based on the total mass of the tablet composition. If the content of component (A) is at least the above lower limit, the slow solubility during high-temperature storage is further improved. If the content of component (A) is at most the above upper limit, the slow solubility during high-temperature storage is further improved. In addition, the tablet composition is less likely to break during the washing of textile products or the cleaning of tableware.

[0014] <Component (B)> Component (B) consists of component (B-1) and component (B-2). Component (B-1) is a lubricant with a melting point of less than 100°C. Component (B-2) is a lubricant with a melting point of 100°C or higher. That is, component (B) is a lubricant.

[0015] The melting point of component (B-1) is less than 100°C, preferably 60 to 95°C, and more preferably 70 to 90°C. The melting point of component (B-2) is 100°C or higher, preferably 120 to 2000°C, and more preferably 130 to 250°C. The difference in melting point between component (B-1) and component (B-2) is preferably 20°C or higher, more preferably 30°C or higher, and even more preferably 40°C or higher. If the difference in melting point is at least the above lower limit, the slow solubility during high-temperature storage is further improved. The melting point of the lubricant is determined by differential scanning calorimetry. Specifically, using a differential scanning calorimeter, when the temperature is raised from 0°C to 250°C at a heating rate of 2°C / min, the peak temperature of the melting peak is taken as the melting point of the lubricant. When using a commercially available product as the lubricant, for those with catalog values, the catalog value may be adopted as the melting point of the lubricant as a simple measured value.

[0016] (B-1) component is a slow-dissolving component. By containing the (B-1) component in the tablet composition, appropriate slow solubility can be achieved. In addition, by having the above-described (A) component and (B-1) component in the tablet composition, slow solubility during high-temperature storage can be achieved. Furthermore, by containing the (B-1) component in the tablet composition, the hardness increases, making it less likely to crack during the washing of textile products or the cleaning of tableware.

[0017] Examples of the (B-1) component include an oily lubricant with a melting point of less than 100°C, an aqueous lubricant with a melting point of less than 100°C, and the like. Among these, an oily lubricant with a melting point of less than 100°C is preferred. Examples of the oily lubricant with a melting point of less than 100°C include carnauba wax, rice wax, hydrogenated oil, sucrose fatty acid ester, sunflower wax, candelilla wax, rose wax, and the like. Among these, from the perspective of the melting point, carnauba wax, rice wax, hydrogenated oil, sucrose fatty acid ester, and sunflower wax are preferred, and carnauba wax, rice wax, and hydrogenated oil are more preferred. Among them, especially when manufacturing a tablet composition in the form of a tablet, carnauba wax is even more preferred from the perspective of further enhancing the compression moldability (tabletability). (B-1) component may be used alone or in combination of two or more.

[0018] As carnauba wax, known ones can be used. For example, those obtained by purifying natural crude wax by methods such as degumming treatment, deacidification treatment, hydrogenation method, fractional distillation method, column treatment, etc., or unpurified ones can be mentioned. As rice wax, known ones can be used. For example, those separated when purifying rice oil extracted from rice bran can be mentioned. As hydrogenated oil, known ones can be used. For example, hydrogenated castor oil, hydrogenated palm oil, hydrogenated rice oil, hydrogenated coconut oil, hydrogenated soybean oil, etc. can be mentioned. As the sucrose fatty acid ester, a known one can be used, for example, sucrose oleate, sucrose caprylate, sucrose capric acid ester, sucrose laurate, sucrose stearate, sucrose palmitate, sucrose myristate, etc. As the sunflower wax, a known one can be used, for example, the one obtained from sunflower seeds.

[0019] (Component (B-2)) is a component that enhances tableting properties. When the tablet composition contains component (B-2), the tableting properties are improved, and it is less likely to cause tableting problems when manufacturing a tablet composition in the form of a tablet, and the tablet composition can be easily manufactured with high productivity.

[0020] Examples of component (B-2) include inorganic metal salt-based lubricants having a melting point of 100°C or higher. Specifically, magnesium stearate, calcium stearate, sodium stearyl fumarate, light anhydrous silicic acid, hydrous silicon dioxide, talc, sodium lauryl sulfate, etc. are included. Among these, from the viewpoint of further enhancing tableting properties, magnesium stearate, calcium stearate, sodium stearyl fumarate, and light anhydrous silicic acid are preferred, magnesium stearate and calcium stearate are more preferred, and magnesium stearate is even more preferred. (Component (B-2)) may be used alone or in combination of two or more.

[0021] (Component (B)) preferably includes one or more selected from carnauba wax, rice wax, hydrogenated oil, sucrose fatty acid ester, and sunflower wax, and one or more selected from magnesium stearate, calcium stearate, sodium stearyl fumarate, and light anhydrous silicic acid.

[0022] The content of component (B) is preferably 1 to 30% by mass, more preferably 3 to 25% by mass, and even more preferably 6 to 21% by mass based on the total mass of the tablet composition. If the content of component (B) is at least the above lower limit value, the tableting property is further enhanced. If the content of component (B) is at most the above upper limit value, the slow solubility during high-temperature storage is further improved.

[0023] The content of component (B-1) is preferably 0.5 to 29.9% by mass, more preferably 5 to 27% by mass, even more preferably 8 to 25% by mass, and particularly preferably 10 to 20% by mass based on the total mass of the tablet composition. If the content of component (B-1) is at least the above lower limit value, the slow solubility during high-temperature storage of the tablet composition is further improved by the combined use with component (A). In addition, the tablet composition is less likely to break during the washing of textile products or tableware. If the content of component (B-1) is at most the above upper limit value, the slow solubility during high-temperature storage of the tablet composition is further improved by the combined use with component (A).

[0024] The content of component (B-2) is preferably 0.1 to 5% by mass, more preferably 0.2 to 4% by mass, and even more preferably 0.5 to 3% by mass based on the total mass of the tablet composition. If the content of component (B-2) is at least the above lower limit value, the tableting property is further improved, and the tablet composition in the form of tablets can be produced more productively. If the content of component (B-2) is at most the above upper limit value, the tablet composition is less likely to break during the washing of textile products or tableware.

[0025] The total content of component (A) and component (B) (hereinafter, also referred to as “(A + B) amount”) is preferably 10 to 40% by mass, more preferably 15 to 35% by mass, and even more preferably 20 to 30% by mass based on the total mass of the tablet composition. If the (A + B) amount is at least the above lower limit value, the tablet composition is less likely to break during the washing of textile products or tableware. If the (A + B) amount is at most the above upper limit value, the slow solubility during high-temperature storage is further improved.

[0026] (A) component / mass ratio represented by (B) component (hereinafter, also referred to as "A / B ratio") is preferably 0.05 to 2, more preferably 0.07 to 1.5, still more preferably 0.1 to 1, and particularly preferably 0.1 to 0.5. If the A / B ratio is at least the above lower limit value, the slow solubility of the tablet composition during high-temperature storage is further improved. In addition, the tablet composition is less likely to break during washing of fiber products or during washing of tableware. If the A / B ratio is at most the above upper limit value, the slow solubility during high-temperature storage is further improved.

[0027] <(C) component> (C) component is an inorganic metal salt containing at least one of magnesium and aluminum (however, excluding (B-2) component). (C) component is a slow-dissolving component. By containing the (C) component in the tablet composition, the slow solubility during high-temperature storage is further improved by combination with the (A) component. In addition, the hardness of the tablet composition is further increased, and cracking during washing of fiber products or during washing of tableware can be more suppressed.

[0028] Examples of the (C) component include synthetic hydrotalcite, synthetic aluminum silicate, magnesium metaaluminate silicate, magnesium aluminum silicate, aluminum hydroxide, magnesium hydroxide, magnesium aluminum hydroxide, magnesium silicate, magnesium carbonate, magnesium oxide, aluminum oxide, etc. Among these, from the viewpoint of improving the hardness of the tablet composition, synthetic hydrotalcite, magnesium metaaluminate silicate, magnesium aluminum silicate, and aluminum hydroxide are preferred, synthetic hydrotalcite, magnesium metaaluminate silicate, and magnesium aluminum silicate are more preferred, and magnesium metaaluminate silicate is still more preferred. (A) component may be used alone or in combination of two or more. Note that aluminum hydroxide may be crystalline or amorphous. Amorphous aluminum hydroxide is also referred to as "dry aluminum hydroxide gel".

[0029] The content of component (C) is preferably 70% by mass or less, more preferably 30 - 70% by mass, still more preferably 40 - 60% by mass, and particularly preferably 45 - 55% by mass based on the total mass of the tablet composition. If the content of component (C) is at least the above lower limit value, the sustained solubility of the tablet composition during high-temperature storage is further improved by the combined use with component (A). In addition, the tablet composition is less likely to break during the washing of fiber products or the cleaning of tableware. If the content of component (C) is at most the above upper limit value, the sustained solubility of the tablet composition during high-temperature storage is further improved by the combined use with component (A).

[0030] The total content of component (A), component (B) and component (C) (hereinafter also referred to as "(A + B + C) amount") is preferably 10 - 100% by mass, more preferably 40 - 100% by mass, still more preferably 50 - 90% by mass, and particularly preferably 65 - 80% by mass based on the total mass of the tablet composition. If the (A + B + C) amount is at least the above lower limit value, the sustained solubility of the tablet composition during high-temperature storage is further improved. In addition, the tablet composition is less likely to break during the washing of fiber products or the cleaning of tableware. If the (A + B + C) amount is at most the above upper limit value, a powder mixture with excellent tableting properties can be obtained.

[0031] The mass ratio represented by component (C) / ((component (A) + component (B))) (hereinafter also referred to as "C / (A + B) ratio") is preferably 0 - 4.0, more preferably 0.5 - 4.0, still more preferably 1.0 - 3.0, and particularly preferably 2.0 - 3.0. If the C / (A + B) ratio is at least the above lower limit value, the sustained solubility of the tablet composition during high-temperature storage is further improved. If the C / (A + B) ratio is at most the above upper limit value, the sustained solubility of the tablet composition during high-temperature storage is further improved. In addition, the tablet composition is less likely to break during the washing of fiber products or the cleaning of tableware.

[0032] <Optional component> The optional components include, for example, saccharides, antibacterial agents, antifungal agents, deodorants, repellents, ultraviolet absorbers, fluorescent agents, anti-migration agents, fiber surface modifiers, anti-redeposition agents, metal ion scavengers (chelating agents), fragrances, silicone compounds, colorants, thickeners, thinning agents, solubilizers, alkalis, inorganic salts other than component (C), organic acids, antioxidants, preservatives, storage stability improvers, pearlescent agents, extracts, etc. These optional components are known substances, are easily available on the market, and can also be prepared. The optional components may be used alone or in combination of two or more. Note that the total amount of all components constituting the tablet composition is 100% by mass and does not exceed 100% by mass.

[0033] If the tablet composition contains saccharides, the sustained solubility is further improved. In addition, the formability is improved. Examples of saccharides include monosaccharides such as xylose and galactose; disaccharides or higher polysaccharides such as granulated sugar, lactose, sucrose, maltose, fructose, glucose, trehalose, oligosaccharides, and dextrin; sugar alcohols such as mannitol, sorbitol, maltitol, palatinite, lactitol, erythritol, and xylitol. Among these, disaccharides or higher polysaccharides and sugar alcohols are preferred. Among them, from the viewpoint of excellent balance between sustained solubility and formability, mannitol, lactose, sucrose, and oligosaccharides are more preferred, mannitol and lactose are even more preferred, and lactose is particularly preferred. These saccharides may or may not be granulated products. The saccharides may be used alone or in combination of two or more. The content of lactose is not particularly limited as long as the blending purpose can be achieved, but it is preferably 80% by mass or less, more preferably 1 - 50% by mass, and even more preferably 5 - 30% by mass based on the total mass of the tablet composition.

[0034] Examples of the antibacterial agent include alkyltrimethylammonium salts having 12 to 16 carbon atoms (trade names such as "Lipocard C12-37W", "Lipocard C50", "Lipocard C16Cl salt", "Lipocard C16MS salt", etc. manufactured by Lion Specialty Chemicals Co., Ltd.), dialkyldimethylammonium salts (trade names such as "Lipocard 210-80E" manufactured by Lion Specialty Chemicals Co., Ltd., "Carboquat MW50" manufactured by Lonza Co., Ltd., etc.), dialkylmethylpolyammonium propionate (trade name such as "Bardap 26" manufactured by Lonza Co., Ltd., etc.), dichlorosan (trade name such as "Chinosan HP100" manufactured by BASF), triclosan, benzalkonium chloride (trade names such as "Barquat MS100", "Barquat MB80", etc. manufactured by Lonza Co., Ltd.), benzethonium chloride, zinc bis-(2-pyridylthio-1-oxide), 8-hydroxyquinoline, biguanide compounds (trade name such as "Proxel IB" manufactured by Lonza Co., Ltd., etc.), chlorhexidine hydrochloride, polylysine, and the like. The content of the antibacterial agent is not particularly limited as long as the blending purpose can be achieved, but it is preferably less than 10% by mass based on the total mass of the tablet composition.

[0035] Examples of the antifungal agent include Yotor DP95 (compound name: diiodomethyl-p-tolyl sulfone), propynyl iodide butylcarbamate, and the like. Examples of the deodorant include methylglycine diacetic acid (MGDA), aspartic acid diacetic acid (ASDA), isoserine diacetic acid (ISDA), β-alanine diacetic acid (ADAA), serine diacetic acid (SDA), glutamic acid diacetic acid (GLDA), iminodiacetic acid (IDS), hydroxyiminodiacetic acid (HIDS), or salts thereof, zinc ricinoleate, bentonite, dextrin, and the like. Examples of the repellent include known components used as known pest repellents, such as N,N-diethyl-3-methylbenzamide (DEET), ikaridin, and the like. Examples of the ultraviolet absorber include 4-methoxy-4'-tert-butyldibenzoylmethane (trade name "Parsol 1789" manufactured by DSM Nutritional Products Japan Ltd., etc.).

[0036] Examples of the fluorescent agent include 4,4-bis(2-sulfostyryl)biphenyl disodium (trade name "Chinopearl CBS-X" manufactured by BASF, etc.). Examples of the substrate for preventing migration include polyvinylpyrrolidone, etc. Examples of the anti-fading agent include 1,4-bis(3-aminopropyl)piperazine, etc. Examples of the fiber surface modifier include enzymes such as cellulase, amylase, protease, lipase, and keratinase, etc. Examples of the anti-recontamination agent include a water-soluble polymer having at least one repeating unit selected from the group consisting of alkylene terephthalate units and alkylene isophthalate units, and at least one repeating unit selected from the group consisting of oxyalkylene units and polyoxyalkylene units. Specifically, trade name "TexCare SRN-100" (manufactured by Clariant, weight average molecular weight 2000 - 3000), trade name "TexCare SRN-300" (manufactured by Clariant, weight average molecular weight 7000), trade name "Repel-O-Tex Crystal" (manufactured by Rhodia), trade name "Repel-O-Tex QC" (manufactured by Rhodia), etc. Other anti-recontamination agents include alkylene oxide adducts of polyalkyleneimine and alkylene oxide adducts of polyalkyleneamine. Specifically, trade name "Sokalan HP20" (manufactured by BASF), etc. Examples of the metal ion scavenger (chelating agent) include malonic acid, succinic acid, malic acid, diglycolic acid, tartaric acid, citric acid, fumaric acid, etc.

[0037] As the fragrance, those known to be blendable into the treatment agent composition for fiber products can be used without particular limitation. For example, the list of usable fragrance raw materials is described in various literatures such as "Perfume and Flavor Chemicals", Vol.I and II, Steffen Arctander, Allured Pub.Co.(1994), "Synthetic Perfumes - Chemistry and Product Knowledge", by Motokazu Indoh, Chemical Industry Daily Co., Ltd.(1996), "Perfume and Flavor Materials of Natural Origin", Steffen Arctander, Allured Pub.Co.(1994), "Encyclopedia of Scents", edited by the Japan Flavor Association, Asakura Shoten(1989), "Perfumery Material Performance V.3.3", Boelens Aroma Chemical Information Service(1996), "Flower oils and Floral Compounds In Perfumery", Danute Lajaujis Anonis, Allured Pub.Co.(1993), etc. The blending amount of the fragrance is not particularly limited as long as the blending purpose can be achieved, but it is preferably less than 10% by mass based on the total mass of the tablet composition.

[0038] The molecular structure of the silicone compound may be linear, branched, or crosslinked. Also, the silicone compound may be a modified silicone compound, and the modified silicone compound may be modified by one kind of organic functional group or may be modified by two or more kinds of organic functional groups. The silicone compound can be used in the state of an oil, and can also be used in the state of an emulsion dispersed by an arbitrary emulsifier. Specific examples of silicone include dimethyl silicone, polyether-modified silicone, methylphenyl silicone, alkyl-modified silicone, higher fatty acid-modified silicone, methylhydrogen silicone, fluorine-modified silicone, epoxy-modified silicone, carboxy-modified silicone, carbinol-modified silicone, amino-modified silicone, and the like. For example, polyoxyethylene-modified silicone (trade name "SH3775M" etc. manufactured by DuPont - Toray Specialty Materials Co., Ltd.) and the like can be mentioned. The silicone content is not particularly limited as long as the blending purpose can be achieved, but it is preferably less than 10% by mass based on the total mass of the tablet composition.

[0039] Examples of the colorant include general-purpose dyes and pigments such as Acid Red 138, Polar Red RLS, Acid Yellow 203, Acid Blue 9, Blue No. 1, Blue No. 205, Green No. 3, Red No. 106, Yellow No. 203, Turquoise P-GR (all are trade names), and the like. The content of the colorant is not particularly limited as long as the blending purpose can be achieved, but it is preferably 0.00005 to 0.005% by mass based on the total mass of the tablet composition.

[0040] Examples of the organic acid include succinic acid, fumaric acid, malic acid, adipic acid, tartaric acid, benzoic acid, citric acid, pyrrolidonecarboxylic acid, salicylic acid, maleic acid, phthalic acid, glutaric acid, oxalic acid, and the like.

[0041] <Shape> The shape of the tablet composition is not particularly limited, and examples thereof include a shape having a cylindrical portion, a shape having a prismatic portion, and the like.

[0042] When the tablet composition has a shape having a cylindrical portion, the tablet composition may have a shape consisting only of the cylindrical portion, or may have a shape having a cylindrical portion and bulging portions bulging upward and downward from the cylindrical portion.

[0043] When the tablet composition has a shape having a cylindrical portion and a bulging portion, examples of such a tablet composition include Sumitomo square tablets, Sumitomo round tablets, R tablets (standard R tablets), two-step R tablets, and the like. Among these, Sumitomo square tablets and R tablets are preferred. The bulging portions of these tablets may be vertically asymmetric, but are preferably vertically symmetric.

[0044] FIG. 1 is a side view showing an example of a tablet composition 10 having the shape of a Sumitomo square tablet. The tablet composition 10 of this example is a biconvex tablet having a cylindrical portion 11, a first bulging portion 12, and a second bulging portion 13. The diameter of the cylindrical portion 11, that is, the diameter of the top surface and the bottom surface of the cylindrical portion 11 is preferably 15.1 mm or more, more preferably 20 to 50 mm, and even more preferably 25 to 35 mm. If the diameter of the cylindrical portion 11 is equal to or greater than the above lower limit value, accidental ingestion can be further prevented. If the diameter of the cylindrical portion 11 is equal to or less than the above upper limit value, it can be gradually dissolved uniformly until the end. The first bulging portion 12 rises linearly from near the periphery of one end face of the cylindrical portion 11 toward the center of the one end face at a predetermined rising angle θ, and an arbitrary region including the zenith 12A becomes a plane. The second bulging portion 13 rises linearly from near the periphery of the other end face of the cylindrical portion 11 toward the center of the other end face at a predetermined rising angle θ, and an arbitrary region including the zenith 13A becomes a plane. The rising angle θ in the first bulging portion 12 and the rising angle θ in the second bulging portion 13 may be the same or different, and are preferably the same from the viewpoint of tablet strength. The thickness H1 of the tablet composition 10, that is, the sum of the thickness of the cylindrical portion 11 and the maximum thicknesses of the first bulging portion 12 and the second bulging portion 13 is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm. The tablet composition 10 shown in FIG. 1 has a horizontally annular horizontal surface (land portion 14) on the outer periphery of the first bulging portion 12 and a horizontally annular horizontal surface (land portion 15) on the outer periphery of the second bulging portion 13. However, for example, it may not have a land portion, and the peripheral portion of the tablet and the bulging rising portion may be in contact with each other.

[0045] FIG. 2 is a side view showing an example of a tablet composition 20 having the shape of an R tablet. The tablet composition 20 of this example has a cylindrical portion 21, a first bulging portion 22, and a second bulging portion 23, and is a biconvex tablet in which the radius of curvature R of the curve of the surface of each of the first bulging portion 22 and the second bulging portion 23 is constant regardless of the position on the surface of the bulging portion. The diameter of the cylindrical portion 21, that is, the diameter of the top surface and the bottom surface of the cylindrical portion 21, is the same as the diameter of the cylindrical portion 11 of the tablet composition 10 shown in FIG. 1. The first bulging portion 22 bulges from the vicinity of the periphery of one end face of the cylindrical portion 21 toward the center of the one end face. The second bulging portion 23 bulges from the vicinity of the periphery of the other end face of the cylindrical portion 21 toward the center of the other end face. Here, the "radius of curvature of the curve of the surface of the first bulging portion 22" refers to the radius of the circle when the curve drawn by the surface of the first bulging portion 22 is regarded as a part of a circle in the cross section when cutting perpendicularly to the end face of the cylindrical portion 21 so as to pass through the zenith 22A. The "radius of curvature of the curve of the surface of the second bulging portion 23" refers to the radius of the circle when the curve drawn by the surface of the second bulging portion 23 is regarded as a part of a circle in the cross section when cutting perpendicularly to the end face of the cylindrical portion 21 so as to pass through the zenith 23A. The zenith 22A in the first bulging portion 22 is the point located at the highest position with respect to one end face. The zenith 23A in the second bulging portion 23 is the point located at the lowest position with respect to the other end face. The radius of curvature R of the first bulging portion 22 and the radius of curvature R of the second bulging portion 23 may be the same or different, and from the viewpoint of tablet strength, it is preferably the same. The thickness H2 of the tablet composition 20, that is, the sum of the thickness of the cylindrical portion 21 and the maximum thicknesses of the first bulging portion 22 and the second bulging portion 23, is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm. The tablet composition 20 shown in FIG. 2 has a horizontally annular horizontal surface (land portion 24) in a plan view on the outer periphery of the first bulging portion 22 and a horizontally annular horizontal surface (land portion 25) in a plan view on the outer periphery of the second bulging portion 23. However, for example, it may not have a land portion, and the peripheral portion of the tablet and the bulging rising portion may be in contact with each other.

[0046] When the tablet composition has a shape consisting only of a cylindrical portion, the diameter of the cylindrical portion is the same as the diameter of the cylindrical portion 11 of the tablet composition 10 shown in FIG. 1. Also, the height of the cylindrical portion, that is, the thickness of the tablet composition consisting only of the cylindrical portion, is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm. The tablet composition consisting only of a cylindrical portion may be flat. In the case of a flat shape, the aspect ratio (diameter of the cylindrical portion / height H of the cylindrical portion) is preferably 1 to 10, more preferably 1.2 to 5, and even more preferably 1.5 to 2.5.

[0047] Also, when the tablet composition has a shape consisting only of a cylindrical portion, a concave portion may be provided on at least one of the surfaces of the cylindrical portion, specifically, the top surface and the bottom surface of the cylindrical portion. FIG. 3(a) is a perspective view showing an example of a tablet composition 30 having a shape with a concave portion provided on the surface, and FIG. 3(b) is a cross-sectional view of the tablet composition 30 taken along the line A - A'. The tablet composition 30 shown in FIG. 3 is composed only of a cylindrical portion 31, and a concave portion 32 is provided at the center of the top surface 31a of the cylindrical portion 31. Also, the shape of the cross-section along the thickness H3 direction of the tablet composition 30 is a quadrilateral, and its four corners are rounded. In addition, although the top surface and the bottom surface of the tablet composition 30 in the illustrated example are flat, at least one of the top surface and the bottom surface may be a curved surface.

[0048] The diameter of the cylindrical portion 31, that is, the diameter of the top surface 31a and the bottom surface 31b, is preferably 15.1 mm or more, more preferably 20 to 50 mm, and even more preferably 25 to 35 mm. If the diameter of the top surface 31a and the bottom surface 31b is equal to or greater than the above lower limit value, accidental ingestion can be more effectively prevented. If the diameter of the top surface 31a and the bottom surface 31b is equal to or less than the above upper limit value, it can be gradually dissolved uniformly until the end.

[0049] The thickness H3 of the tablet composition 30, that is, the thickness of the cylindrical portion 31, is not particularly limited. For example, it is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm.

[0050] The depth h of the concave portion 32 is preferably 20 to 40% of the thickness H3 of the tablet composition 30, and more preferably 25 to 35%. If the depth h of the concave portion 32 is equal to or greater than the above lower limit value, the hardness of the tablet composition 30 is further increased. If the depth h of the concave portion 32 is equal to or less than the above upper limit value, it can be easily tabletted and formed. The diameter d of the opening of the concave portion 32 is preferably 5 to 25 mm, more preferably 7 to 20 mm, and even more preferably 15 to 20 mm. Although the shape of the opening of the concave portion 32 in the illustrated example is circular, the shape of the opening of the concave portion 32 is not particularly limited and may be polygonal or elliptical. The volume of the concave portion 32 is preferably 5 to 25% of the volume of the tablet composition 30, and more preferably 10 to 20%. If the volume of the concave portion 32 is equal to or greater than the above lower limit value, the sustained solubility of the tablet composition 30 is further improved. If the volume of the concave portion 32 is equal to or less than the above upper limit value, the hardness of the tablet composition 30 is further increased. Note that the concave portion 32 may be formed in a spiral shape toward its center.

[0051] When the tablet composition has a shape with a prismatic portion, the tablet composition may consist only of the prismatic portion or may have a shape with a prismatic portion and bulging portions that bulge upward and downward from the prismatic portion. Also, when the tablet composition has a shape consisting only of a prismatic portion, a concave portion may be provided on the surface of the prismatic portion, specifically, at least one of the top surface and the bottom surface of the prismatic portion.

[0052] Examples of the tablet composition having a prismatic part include a tablet composition having a cylindrical part, in which the cylindrical part is changed to a prismatic part. The diameter of the circumscribed circle of the top or bottom surface of the prismatic part is preferably 15.1 mm or more, more preferably 20 - 50 mm, and even more preferably 25 - 35 mm. If the diameter of the circumscribed circle of the top or bottom surface of the prismatic part is at least the above lower limit value, accidental ingestion can be further prevented. If the diameter of the circumscribed circle of the top or bottom surface of the prismatic part is at most the above upper limit value, it can be gradually dissolved uniformly until the end. The shape of the top or bottom surface of the prismatic part is not particularly limited as long as it is a polygon, and examples include a triangle, a quadrilateral, a pentagon, a hexagon, a heptagon, an octagon, a star-shaped polygon, etc.

[0053] As the shape of the tablet composition, a shape having a cylindrical part is preferred. From the viewpoint of further increasing the hardness of the tablet composition, a shape having a cylindrical part and a bulging part, or a shape in which at least one of the top and bottom surfaces of the cylindrical part is provided with a concave part is more preferred. The shape of a sumi-kakuhei tablet, or a shape in which at least one of the top and bottom surfaces of the cylindrical part is provided with a concave part is even more preferred, and a shape in which at least one of the top and bottom surfaces of the cylindrical part is provided with a concave part is particularly preferred.

[0054] <Weight> The weight per preparation of the tablet composition is preferably 1.5 g or more, more preferably 2 - 20 g, and even more preferably 10 - 15 g. If the weight per preparation is at least the above lower limit value, accidental ingestion can be further prevented. If the weight per preparation is at most the above upper limit value, the hardness of the tablet composition is further increased.

[0055] <Manufacturing method> The tablet composition can be obtained, for example, by tableting a mixture (also referred to as a powder mixture) obtained by mixing component (A), component (B), and, if necessary, one or more of component (C) and optional components. Examples of the tableting method include a method of tableting (compression molding) using a tableting machine having a mortar and a pestle. The tableting conditions are not particularly limited, but the tableting pressure is preferably 20 to 100 kN, more preferably 40 to 60 kN.

[0056] <Function and effect> Since the tablet composition of the present invention described above contains the components (A) and (B) described above, it is excellent in sustained solubility and has good heat resistance even when stored at high temperatures. In addition, since the tablet composition of the present invention has high hardness, it is not easily broken during the washing of textile products or the cleaning of tableware. Moreover, since it is in tablet form, it is also excellent in heat resistance. In particular, the tablet composition in the form of a tablet obtained by compression molding each component is even more excellent in heat resistance.

[0057] <Use> The tablet composition of the present invention can be used together with the object to be washed during the washing treatment by a washing machine or the dishwashing by a dishwasher. That is, the tablet composition is preferably used for washing treatment or dishwashing treatment. When washing and drying the object to be washed using a washing machine (washing and drying machine) or a dishwasher (dishwashing and drying machine) equipped with a drying function, the temperature inside the washing and drying machine or the dishwashing and drying machine becomes high (for example, about 30 to 90 °C) during the drying process. Therefore, when the tablet composition is used in a washing and drying machine or a dishwasher, the tablet composition will be exposed to high temperatures. However, the tablet composition of the present invention has excellent heat resistance and is not easily eluted even when exposed to high temperatures. Therefore, the tablet composition of the present invention is particularly suitable for washing treatment using a washing and drying machine or dishwashing treatment using a dishwashing and drying machine. In the case of washing treatment, examples of the object to be washed include textile products such as clothing (fabrics), dishcloths, towels, sheets, and curtains. The material of the textile product is not particularly limited and may be any of natural fibers such as cotton, silk, and wool, and chemical fibers such as polyester and polyamide. In the case of dishwashing treatment, examples of the object to be washed include utensils directly used for meals such as plates, chopsticks, and spoons; cooking utensils such as pots and kitchen knives. In this specification, these are collectively referred to as "tableware".

[0058] In addition, if the tablet composition of the present invention contains a functional component other than the component (A) in addition to the components (A) and (B), each time it comes into contact with water, a part of the surface of the tablet composition or its vicinity dissolves, and the functional component is gradually released together with the components (A) and (B) contained in the tablet composition, so that the effect of the functional component can be continuously exerted. Examples of the functional component include the optional components described above. For example, if an antibacterial agent, an antifungal agent, a deodorant, etc. are blended in the tablet composition, these functions are imparted not only to the object to be washed but also to the inside of a washing machine or a dishwasher.

[0059] <Usage method> The tablet composition of the present invention can be used as it is or after being housed in a container, tool, or bag. For example, when the tablet composition of the present invention is used for a washing process, the tablet composition can be put inside a commercially available washing product such as a washing ball or a washing net, and these can be put into a washing machine together with the object to be washed for use in washing. As the washing ball, for example, the outer container part of the product named "Eco Washing Ball" manufactured by Ihara Kikuhan Co., Ltd. with the tourmaline inside removed can be used. As the washing net, for example, the product named "Umi. Washing Net" manufactured by Diyouth can be used. When all or almost all of the tablet composition of the present invention has dissolved during washing in these washing products, they can be reused by separately housing and using the tablet composition of the present invention. Washing products such as a washing ball or a washing net containing the tablet composition of the present invention may be placed in a washing machine in advance, or may be placed on top of the object to be washed after the object to be washed is placed in it, and can be placed in the washing machine during all steps of water injection, washing, drainage, rinsing, dehydration, and (depending on the washing machine) drying. After the washing is completed, when taking out the object to be washed from the washing machine, washing products such as a washing ball or a washing net containing the tablet composition of the present invention may be left as they are in the washing machine and can be used as they are during the next washing. When the tablet composition of the present invention is used for dishwashing, it can be used in the same manner as when it is used for washing.

Examples

[0060] Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited by the following description. In this example, "%" indicates "mass%" unless otherwise specified.

[0061] "Raw materials used" (A) component or its substitute, the following compounds were used. · A-1: Calcium lactate (manufactured by Fujifilm Wako Pure Chemical Corporation). · A-2: Calcium hydroxide (manufactured by Fujifilm Wako Pure Chemical Corporation). · A-3: Calcium silicate (manufactured by Kanto Chemical Co., Inc., substitute for component (A)).

[0062] (B) component or its substitute, the following compounds were used. · B-1-1: Carnauba wax (manufactured by Toagosei Co., Ltd., melting point 85 °C, oily lubricant). · B-1-2: Hydrogenated oil (castor oil manufactured by Freund Industry Co., Ltd., melting point 85 °C, oily lubricant). · B-1-3: Rice wax (manufactured by Toagosei Co., Ltd., melting point 80 °C, oily lubricant). · B-1-4: Sucrose fatty acid ester (manufactured by Mitsubishi Chemical Corporation, melting point 80 °C, oily lubricant). · B-1-5: Polyethylene glycol 4000 (manufactured by Sanyo Chemical Industries, Ltd., melting point 55 °C, aqueous lubricant). · B-2-1: Calcium stearate (manufactured by Taihei Chemical Industry Co., Ltd., melting point 147 °C, inorganic metal salt-based lubricant). · B-2-2: Magnesium stearate (manufactured by Taihei Chemical Industry Co., Ltd., melting point 140 °C, inorganic metal salt-based lubricant). · B-2-3: Sodium stearyl fumarate (manufactured by Fujifilm Wako Pure Chemical Corporation, melting point 196 °C, inorganic metal salt-based lubricant). · B-2-4: Light anhydrous silicic acid (manufactured by Freund Industry Co., Ltd., melting point 1713 °C, inorganic metal salt-based lubricant). ·B-2-5: Magnesium stearate (manufactured by Yoneyama Pharmaceutical Co., Ltd., melting point 88°C, inorganic metal salt-based lubricant, substitute for component (B-2)).

[0063] As component (C), the following compounds were used. ·C-1: Magnesium aluminometasilicate (manufactured by Fuji Chemical Industry Co., Ltd.). ·C-2: Magnesium aluminum silicate (manufactured by Fuji Chemical Industry Co., Ltd.). ·C-3: Synthetic hydrotalcite (manufactured by Kyowa Chemical Industry Co., Ltd.). ·C-4: Dried aluminum hydroxide gel (manufactured by Nikko Pharmaceutical Co., Ltd.).

[0064] As optional components, the following compounds were used. · Lactose: Manufactured by Freund Industry Co., Ltd.

[0065] "Measurement and Evaluation" <Evaluation of Heat Resistance> One tablet of the tablet composition was placed in a protective container (the outer container part of the product named "Eco Washing Ball" manufactured by Ihara Enterprise Sales Co., Ltd. with the tourmaline inside removed). The protective container containing the tablet composition was placed in a drum-type washing and drying machine (manufactured by Panasonic Holdings Corporation, product name "NA-VX7600L"), and washed and dried for about 4 hours in the standard course (from water injection to drying, water temperature 15°C, maximum temperature inside the cabinet during drying 80°C). The appearance of the tablet composition after drying was visually observed, and the heat resistance was evaluated based on the following evaluation criteria. ◎, 〇, and △ were considered qualified. (Evaluation Criteria) ◎: Did not melt at all and was not sticky. 〇: Slightly melted and was sticky but at an acceptable level. △: Melted about half and was sticky. ×: Almost completely melted and was significantly sticky.

[0066] <Evaluation of Slow Solubility during High-Temperature Storage> The tablet composition was sealed in an aluminum pouch manufactured by Toppan Co., Ltd. and stored in a constant-temperature bath at 40°C for 30 days. One tablet of the tablet composition after storage was placed in a protective container (the outer container part of the product named "Eco Washing Ball" manufactured by Iihara Enterprise Sales Co., Ltd. with the tourmaline inside removed). A protective container containing the tablet composition was placed in a drum-type washing and drying machine (manufactured by Panasonic Holdings Corporation, model name "NA-VX7600L"), and washed for about 40 minutes on the standard course (from water injection to dehydration, water temperature 15°C). The weight change of the tablet composition before and after washing (weight before washing - weight after washing) was taken as the gradual dissolution amount. The same evaluation was carried out a total of 5 times, and the average gradual dissolution amount was calculated from the 5 gradual dissolution amounts, and the heat resistance was evaluated based on the following evaluation criteria. ◎, 〇, and △ were considered qualified. (Evaluation Criteria) ◎: The average gradual dissolution amount is 0.8 g or more and less than 2.0 g. 〇: The average gradual dissolution amount is 0.5 g or more and less than 0.8 g, or 2.0 g or more and 2.5 g or less. △: The average gradual dissolution amount is 0.2 g or more and less than 0.5 g, or more than 2.5 g and less than 5.0 g. ×: The average gradual dissolution amount is less than 0.2 g, or 5.0 g or more.

[0067] <Evaluation of Cracks> One tablet of the tablet composition was placed in a protective container (the outer container part of the product named "Eco Washing Ball" manufactured by Iihara Enterprise Sales Co., Ltd. with the tourmaline inside removed). A protective container containing the tablet composition was placed in a drum-type washing and drying machine (manufactured by Panasonic Holdings Corporation, model name "NA-VX7600L"), and washed for about 40 minutes on the standard course (from water injection to dehydration, water temperature 15°C). The tablet composition after washing was taken out from the protective container, and the appearance of the tablet composition was visually observed, and the cracks during washing were evaluated based on the following evaluation criteria. 〇 and △ were considered qualified. (Evaluation Criteria) 〇: No cracks were observed. △: Cracks less than 1 cm square occurred. ×: Cracks 1 cm square or larger occurred.

[0068] "Example 1" Based on the formulation composition shown in Table 1, the powders of each component were weighed into a plastic bag so that the total was 200 g, and the plastic bag was shaken by hand 100 times to mix the powders, obtaining a powder mixture. The obtained powder mixture was tabletted using a single-punch tableting machine (manufactured by Fuji Pharmaceutical Machinery Co., Ltd., product name "FY-TPF-100S") with a flat sumi-angle pestle having a diameter of 30 mm for the cylindrical part at a tableting pressure of 50 kN, obtaining a tablet composition having the shape of a sumi-angle flat tablet as shown in Figure 1. The weight per formulation was 12 g. The thickness of the tablet composition was 15 mm, and the rising angle θ of the bulging part was 30°. For the obtained tablet composition, heat resistance, slow solubility during high-temperature storage, and cracking were evaluated. The results are shown in Table 1.

[0069] "Examples 2 to 14" Tablet compositions were produced and various evaluations were carried out in the same manner as in Example 1, except that the formulation composition of each component was changed to the values shown in Tables 1 and 2. The results are shown in Tables 1 and 2.

[0070] "Comparative Examples 1 to 6" Tablet compositions were produced and various evaluations were carried out in the same manner as in Example 1, except that the formulation composition of each component was changed to the values shown in Table 3. The results are shown in Table 3. In addition, when sticking or capping occurred during tableting, it was regarded as a "tableting failure".

[0071]

Table 1

[0072]

Table 2

[0073]

Table 3

[0074] In Tables 1 to 3, the blending amounts (mass %) of each component are all ratios to the total mass per preparation of the tablet composition, and except in cases where specified, the values are shown in terms of pure components. Note that a blank in the blending amount means that the component is not blended (blending amount 0 mass %). Also, in Tables 1 to 3, the “amount of (A + B)” is the total content of component (A) and component (B) with respect to the total mass per preparation. The “amount of (A + B + C)” is the total content of component (A), component (B), and component (C) with respect to the total mass per preparation. The “A / B ratio” is the mass ratio of component (A) to component (B). The “C / (A + B) ratio” is the mass ratio of component (C) to the total content of component (A) and component (B).

[0075] As is clear from Tables 1 and 2, the tablet compositions obtained in each example were excellent in slow solubility even when stored at high temperature, had good heat resistance, and were difficult to crack during washing. On the other hand, as is clear from Table 3, the tablet composition obtained in Comparative Example 1 that did not contain component (A) was inferior in slow solubility during high-temperature storage. The tablet composition obtained in Comparative Example 2 containing calcium silicate as a substitute for component (A) was inferior in slow solubility during high-temperature storage. The tablet composition obtained in Comparative Example 3 that did not contain component (B-1) was inferior in slow solubility during high-temperature storage. Also, it was easy to crack during washing. In the cases of Comparative Examples 4 and 5 where component (B-2) was not used, sticking or capping occurred during tableting, so the tablet composition could not be manufactured. The tablet composition obtained in Comparative Example 6 containing a lubricant with a melting point of less than 100°C as a substitute for component (B-2) was inferior in slow solubility during high-temperature storage. Also, it was easy to crack during washing.

Explanation of Symbols

[0076] 10 Tablet composition 11 Cylindrical part 12 First bulging part 12A Zenith 13 Second bulging part 13A Zenith 14 Land part 15 Land part 20 Tablet composition 21 Cylindrical part 22 First bulging part 22A Zenith 23 Second bulging part 23A Zenith 24 Land part 25 Land part 30 Tablet composition 31 Cylindrical part 31a Top surface 31b Bottom surface 32 Concave part

Claims

1. A tablet composition containing component (A) and component (B) composed of component (B-1) and component (B-2), The component (A) is at least one of calcium lactate and calcium hydroxide, The component (B-1) is a lubricant with a melting point of less than 100 °C, The component (B-2) is a lubricant with a melting point of 100 °C or higher, tablet composition.

2. The component (B-1) is an oily lubricant with a melting point of less than 100 °C, The component (B-2) is an inorganic metal salt-based lubricant with a melting point of 100 °C or higher, the tablet composition according to claim 1.

3. The component (B-1) is one or more selected from carnauba wax, rice wax, hardened oil, sucrose fatty acid ester, and sunflower wax, The component (B-2) is one or more selected from magnesium stearate, calcium stearate, sodium stearyl fumarate, and light anhydrous silicic acid, the tablet composition according to claim 2.

4. Further contains component (C), The component (C) is an inorganic metal salt containing at least one of magnesium and aluminum, the tablet composition according to any one of claims 1 to 3.

5. The component (C) contains at least one or more selected from synthetic hydrotalcite, magnesium aluminometasilicate, magnesium aluminosilicate, and aluminum hydroxide, the tablet composition according to claim 4.

6. The tablet composition according to any one of claims 1 to 3, wherein the mass ratio represented by the component (A) / the component (B) is 0.05 to 2.

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