Spot type ventilation clean system

Abstract

To provide a spot type humidification / ventilation clean system that enables population control for environmental microbes in a local space.SOLUTION: A spot type ventilation clean system comprises, in a local space where a person is seated in front of a desk, a partition board that is a transparent acrylic board capable of being placed on a table, a humidification unit that sprays mist above the partition board, and a ventilation unit that allows ventilation of the space below the partition board. The system controls population of microbes originating from pathogen-infected persons through a combination of humidification, ventilation, antibacterial treatment, and filtration.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a spot ventilation cleaning system for controlling the population of microorganisms derived from pathogen-infected individuals existing in a local space by efficiently combining hygiene management techniques such as humidification, ventilation, antibacterial treatment, and filtration, and further promoting the activation of the body's defense function of the pathogen-infected individual itself to control the spread of infectious diseases.

Background Art

[0002] In recent years, countermeasures against various unknown infectious diseases have become an urgent issue, and comprehensive measures are desired. As important preventive methods for infectious diseases, wearing masks, face masks, face shields, and using disinfectants such as ethanol, sodium hypochlorite, sodium alkylbenzene sulfonate, and benzalkonium chloride, various measures related to hygiene management are required (Non-Patent Document 1).

[0003] In addition, as natural-derived components, generally speaking, volatile components derived from plants are known to have an attenuating effect on bacteria and viruses or to act as disinfectants, and are called phytoalexins. Since they are known to have functions such as activating the immune system and relaxing mentally, their importance as forest bathing has also been pointed out (Non-Patent Documents 2, 3, 4).

[0004] Furthermore, as countermeasures against pathogenic microorganisms, the development of vaccines is also underway. Generally, live vaccines and vaccines in which the functions of microorganisms are inactivated are the mainstream. In recent years, new methods such as RNA vaccines and DNA vaccines that utilize the genetic information of microorganisms, as well as plant-derived vaccines that are expressed in plants by utilizing genetic information, have emerged (Non-Patent Documents 5, 6, 7, 8). These vaccines mainly aim to selectively induce IgG that has a specific effect on the target pathogenic microorganism.

[0005] On the other hand, nasal vaccines are known as vaccines that induce secretory IgA, which is weak in titer but effective against pathogenic microorganisms (Non-Patent Documents 5 and 9). It has been suggested that a similar antigen uptake system by M cells is also observed in the nasal mucosa and the airway mucosa (Non-Patent Documents 10 and 11).

[0006] In the activation of the immune system in the airway, it is known that bacterial-derived Heat shock protein 65 (HSP65), particularly HSP65 derived from Mycobacterium leprae, has an immune activation effect (Non-Patent Documents 12 and 13). On the other hand, attempts have also been made to develop vaccines against Mycobacterium tuberculosis that utilize these effects (Non-Patent Documents 14 and 15). Thus, in the mucosal system, it has been suggested that HSP60 and HSP65 may regulate biological defense by having cell-binding or adjuvant-like activities.

[0007] In terms of the hard surface, hygiene management systems that utilize bactericidal and antiviral functions using ultraviolet rays (UV-C, UV222nm) (Non-Patent Documents 16, 17, 18) (Patent Document 1), silver ions (Patent Document 2), radical reactions (Patent Document 3), plasma discharge (Patent Document 4), etc., which have been conventionally utilized, have also become widespread, and the need to use these efficiently is assumed. Also, it has been clarified that a humidity of 40 - 60% is important for an indoor environment that is less susceptible to virus infection. Also, it has been clarified that a humidity of 40 - 60% is important for an indoor environment that is less susceptible to virus infection (Non-Patent Document 19).

[0008] When looking at the symbiotic relationship between animals and bacteria, in recent years, the relationship between the indigenous microbiota and the physiological functions and pathologies of the host has been rapidly becoming clear. For example, more than 1,000 species and over 40 trillion intestinal bacteria inhabit the human intestinal tract, forming a complex intestinal ecosystem, and it is known that they interact with the host's tissues and contribute to maintaining health. Therefore, when the balance of these intestinal ecosystems is disrupted, so-called dysbiosis leads to the onset of various diseases (Non-Patent Documents 20, 21, 22), and the need for probiotics and prebiotics that control the intestine has been recognized.

[0009] In addition, the inventors have succeeded in developing probiotics that affect the living body of animals by utilizing thermophilic Bacillus flora, which is one of the extreme environment microorganisms that are difficult to grow in the normal temperature region. In particular, as livestock such as chickens, pigs, and cows, fish, and rodents as model animals, mice and rats, it has been suggested that the intestinal microbiota can be controlled and that it may have a beneficial effect on the living body at that time (Patent Documents 5, 6, Non-Patent Documents 22, 23).

Prior Art Documents

Patent Documents

[0010]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

Patent Document 6

Non-Patent Documents

[0011] Non-Patent Document 1 https: / / www.mhlw.go.jp / stf / seisakunitsuite / bunya / syoudoku_00001.html Non-Patent Document 2 Tokin, Boris Petrovich, Keizo Kanzaki, "The Mysterious Power of Plants = Phytontcide: Exploring the Mystery of Trees That Kill Microorganisms", Kodansha <Bluebacks B-424>, 1984 Non-Patent Document 3 https: / / www.fo-society.jp / therapy / expe.html Non-Patent Document 4 http: / / www.fc.chiba-u.jp / research / naturetherapy / Non-Patent Document 5 22nd Meeting of the Vaccination and Vaccine Subcommittee of the Research and Development, Production, and Distribution Division of the Council for Health Science Policy, December 25, 2019, "Regarding Vaccine Research and Development", https: / / www.mhlw.go.jp / content / 10906000 / 000580437.pdf Non-Patent Document 6 DNA Vaccine, https: / / ja.wikipedia.org / wiki / DNAワクチン Non-Patent Document 7 RNA Vaccine, https: / / www.t.utokyo.ac.jp / shared / press / data / setnws_201710121450382322891478_608693.pdf Non-Patent Document 8 Plant-Derived Vaccine, https: / / www.mt-pharma.co.jp / ir / meeting / pdf / presen170927_M.pdf Non-Patent Document 9 Nasal Vaccine, https: / / www.amed.go.jp / news / release_20190104.html Non-Patent Document 10 Shunsuke Kimura, Mami Mutoh, Meri Hisamoto, Hikaru Saito, Shun Takahashi, Takanori Asakura, Makoto Ishii, Yutaka Nakamura, Junichiro Iida, Koji Hase, Toshihiko Iwanaga. Airway M cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease. Frontiers in Immunology (2019) DOI:10.3389 / fimmu.2019.01323

Non-Patent Document 11

Non-Patent Document 12

Non-Patent Document 13

Non - Patent Document 14

Non - Patent Document 15

Non-Patent Document 16

Non-Patent Document 17

Non-Patent Document 18

Non-Patent Document 19

Non-Patent Document 20

Non - Patent Document 21

Non - Patent Document 22

Non - Patent Document 23

Summary of the Invention

Problems to be Solved by the Invention

[0012] Generally, when these hygiene management technologies are used alone, efficient operation through cooperation is left to consumers. The key lies in controlling the hygiene management space that could not be utilized before through a combined approach.

[0013] One of the basic countermeasures is to emphasize indoor ventilation, etc. However, it is extremely difficult to control ventilation within the space under any conditions. Also, when conversations have to be held without increasing the distance between people facing each other, currently, masks, ordinary face shields, etc. are used, but in reality, they still carry a certain potential for pathogen exposure.

[0014] Moreover, for disinfectants, it is possible to control by disinfecting fixed contaminated parts. For UV irradiation, etc., sterilization and virus killing are possible for the irradiated area. However, since the source of infection is humans, it is not necessarily effective, especially against direct infection through exhalation. When droplets are directly exposed to non-infected individuals, even if skin surface disinfection is possible with these methods, what can be controlled through gargling, etc. is only the nasal mucosa and part of the pharynx. There is no other way to remove pathogens that have already been inhaled into the lungs through breathing than through the body's defense reaction.

[0015] However, if no appropriate vaccine has been developed, it will depend on the activation of self-immunity, and efficient control will be difficult.

[0016] Furthermore, even if there is a vaccine, it does not have a 100% effect, and there are individual differences. In order to enhance the function of the vaccine, the original host's immune system must be healthy. At present, research and development that captures the synergistic effects with drugs, nutritional agents, supplements, etc. to draw out the effects of the vaccine has not been progressing easily. Means to solve

[0017] To solve these problems, a simple ventilation system that can create an air curtain spot by spot is necessary. Also, in the relationship between humidity and virus infection, which has been pointed out as important in recent years, it is extremely important to maintain a local humidity of 40 - 60%.

[0018] Therefore, in the local space under the condition of sitting in front of a desk, even if people are facing each other directly or wearing a face shield, there is a simple and effective air curtain containing humidity, and even if there are pathogenic bacteria or pathogenic viruses, a system that can remove them by residential ventilation is necessary.

[0019] Furthermore, if existing systems such as air purifiers can be utilized and efficiently spot-ventilated by simple suction, the versatility will be further expanded.

[0020] Also, after providing an area with less exposure to people, it is necessary to utilize ultraviolet rays, etc. to sterilize or suppress viruses, and to circulate efficiently ventilated and purified air.

[0021] Also, by utilizing phytochides derived from forests, etc., and combining the sterilization or virus suppression effects of phytochides themselves, synergistic effects can be expected by utilizing immune activation functions, or aromatherapy-like relaxation effects, etc.

[0022] Furthermore, by exposing cell membrane / wall components, heat shock protein (HSP), or lantibiotics derived from microorganisms that can stimulate the immune system via the nasal and respiratory tracts, the entire mucosal system can be activated, and the intestinal flora can be improved together with probiotics and prebiotics to enhance the overall body defense function. As application examples of the materials of the microorganisms to be sprayed, fermented products containing thermophilic bacteria (NITE International Deposit Number: BP-863) and thermophilic bacteria complex (ATCC International Deposit Number: PTA-1773) have been suggested to induce the expression of interferon, a cytokine involved in the defense against viral infection, after improving the intestinal flora (Journal of Bioscience and Bioengineering, 114(5):500-505, 2012; the Gene Expression Omnibus (GEO) database (access ID: GSE37732)). In addition, effects such as skin wound healing and allergy suppression have been confirmed at the field level. It is expected that the combined use of these heat shock proteins derived from microorganisms may enhance the activation effect on the immune system.

[0023] The globally well-known hygiene hypothesis (Strachan DP. Hayfever, hygiene, and household size. BMJ 299:1259-1260, 1989) is a hypothesis that shows that differences in the exposure to environmental factors during infancy lead to differences in the subsequent incidence of allergies, and that a non-hygienic environment reduces the subsequent incidence of allergies. This hypothesis is now widely recognized, and a lot of data supporting this hypothesis has been accumulated, and its relationship with many diseases has also been pointed out. That is, it implies that it is important to construct an environment in which animals can coexist with the environmental microbiota. Therefore, the exposure to cell membrane / wall components, heat shock protein (HSP), or lantibiotics derived from microorganisms is important.

[0024] Therefore, a system is provided that controls the population of microorganisms derived from pathogen-infected individuals present in a local space by efficiently combining hygiene management techniques such as humidification, ventilation, antibacterial treatment, and filtration.

[0025] In addition, a spot ventilation cleaning system is provided that controls the spread of infectious diseases by also promoting the function of activating the body's defense function of the pathogen-infected individual itself.

[0026] That is, the means is a partition plate, which is a transparent acrylic plate that can be installed on a desk, in a local space under the condition of sitting in front of a desk, a humidification unit by mist spraying above the partition plate, and a ventilation unit that enables ventilation of the space below the partition plate, and controls the population of microorganisms derived from pathogen-infected individuals by combining humidification, ventilation, antibacterial treatment, and filtration. In addition, a HEPA filter unit is joined to the humidification unit and the ventilation unit to improve purification performance. An ultraviolet irradiation filter unit is joined to the ventilation unit to improve sterilization and antiviral performance. By spraying Lantibiotic derived from fermented microorganisms, the environmental microbial flora in the space is controlled and the direct biological defense performance in the living body is improved. By spraying volatile components derived from plants, the environmental microbial flora in the space is controlled and the direct biological defense performance in the living body is improved.

Effects of the Invention

[0027] The present invention is a system aimed at controlling the spread of infectious diseases by efficiently combining hygiene management techniques such as humidification, ventilation, anti-pathogen, and filtration to control the population of microorganisms derived from pathogen-infected individuals present in a local space, and also promoting the function of activating the body's defense function of the pathogen-infected individual itself.

[0028] This makes it possible to control pathogens in cases where face-to-face contact with people is essential and wearing masks is not possible, preventing the remaining discharged virus from floating in the air, thus enabling comprehensive control and solving conventional problems. In addition, the present invention not only efficiently combines humidity, ventilation, anti-pathogens, and filtration, but also utilizes the immunostimulating function and relaxation function of plant-derived phytocides, and improves the immunostimulating function by spraying cell membrane / wall components, heat shock protein (HSP), or lantibiotics derived from microorganisms. It is expected to enhance the value of existing technologies in this regard.

Brief Description of the Drawings

[0029]

Figure 1

Figure 2

Figure 3

Modes for Carrying Out the Invention

[0030] Next, embodiments of the present invention will be described, but the present invention is not limited to these embodiments.

[0031] The desktop spot-type clean ventilation system of the present invention aims to locally achieve a humidity condition of 40 - 60%, which is relatively effective in pathogen infection. At the same time, local ventilation is realized.

[0032] Furthermore, by implementing these ventilations including HEPA filters, ultraviolet irradiation, etc., the purified air is circulated.

[0033] By spraying a combination of phytic acid derived from plants and cell membrane / wall components, heat shock protein (HSP), or lantibiotics derived from microorganisms, it becomes possible to enhance the body's defense function.

Example

[0034] As described in FIGS. 1 and 2, on a tabletop, install a partition plate made of a transparent acrylic plate, and equip a humidification unit with a humidification spray port on the upper part of the 1-3. unit humidification pipe capable of humidification. This enables efficient humidification. In the 1-2. humidification unit, depending on the cost and required functions, a HEPA filter, as well as phytic acid components derived from plants, environmentally symbiotic preparations, specifically cell membrane / wall components, heat shock protein (HSP), or lantibiotics derived from microorganisms, can be added. Also, to enable room ventilation, equip a 2-2. ventilation unit at the lower part of the 0. partition plate (from the 2-1. suction port to the 2-3. ventilation unit pipe). This enables room ventilation. Pathogens sucked in by such ventilation are killed locally by irradiation with ultraviolet light at a pre-stage through the HEPA filter, so that they can be removed doubly through the filter.

[0035] As UV222nm has been proven to be relatively safe for the human body as ultraviolet light, ensure that no ultraviolet light leaks from the device and at least an air flow is generated. The air ventilation speed is assumed to be 0.35 m3 / s or less as the assumed maximum suction value. Ideally, it should be set so that the air in 1 m3 inside the tabletop is ventilated in about 3 minutes. This is expected to make it relatively easier to manage customers when used in food and beverage establishments such as cafeterias and restaurants. Note that since this system is solely aimed at removing droplets floating in the air, there may be pathogens adhering to the partition plate or falling on the tabletop, so it is necessary to disinfect with a disinfectant that can surely sterilize and remove viruses.

[0036] Also, as shown in FIG. 3, it is expected that by using it in combination with a conventional system, ventilation with purified air and other immune activation functions and relaxation functions can be imparted.

Industrial Applicability

[0037] The system is expected to be used in indoor areas where people can talk, such as dining tables and conference rooms in homes, indoor areas where people can gather, food service facilities, medical institutions, blood donation vehicles, and medical examination boxes that are expected to be developed and popularized in the future.

Explanation of Signs

[0038] 0. Partition board 1-1. Humidifying spray port 1-2. Humidifying unit 1-3. Humidifying unit piping 2-1. Suction port 2-2. Ventilation unit 2-3. Ventilation unit piping

Deposit Number

[0039] BP-863(NITE)

[0040] PTA-1773(ATCC)

Claims

**Claim 1** In a local space under the condition of sitting in front of a desk, a partition plate which is a transparent acrylic plate that can be installed on the desk, a humidifying unit by mist spraying on the upper part of the partition plate, and a ventilation unit at the lower part of the partition plate to enable ventilation of the space, and controlling the population of microorganisms derived from pathogen-infected individuals by combining humidification, ventilation, antibacterial, and filtration. A spot-type ventilation cleaning system characterized by this. **Claim 2** The spot-type ventilation cleaning system according to claim 1, characterized in that a HEPA filter unit is joined to the humidifying unit and the ventilation unit to improve purification performance. **Claim 3** The spot-type ventilation cleaning system according to any one of claims 1 to 2, characterized in that an ultraviolet irradiation filter unit is joined to the ventilation unit to improve sterilization and antiviral performance. **Claim 4** The spot-type ventilation cleaning system according to any one of claims 1 to 3, characterized in that by spraying lantibiotic derived from fermented microorganisms, the environmental microbial flora in the space is controlled and the direct biological defense performance in the living body is improved. **Claim 5** The spot-type ventilation cleaning system according to any one of claims 1 to 4, characterized in that by spraying volatile components derived from plants, the environmental microbial flora in the space is controlled and the direct biological defense performance in the living body is improved.

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