External preparation composition

Abstract

To provide an external preparation composition which secures excellent stability immediately after production and under high-temperature storage, enhances skin compatibility during application, reduces a sticky sensation on skin after application, and further has a transparent or semi-transparent appearance.SOLUTION: An external preparation composition comprises the following components (A), (B), (C), (D), and (E): (A) at least one selected from sphingosine and derivatives thereof; (B) a dihydric alcohol; (C) a compound having a carboxyl group and having 7 or fewer carbon atoms; (D) an oily agent that is solid at 25°C; and (E) water.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an external preparation composition. [Background technology]

[0002] It has been proposed to incorporate sphingosine into external preparation compositions such as external skin preparations (for example, Patent Documents 1 to 3). Patent Document 1 describes that an external skin preparation containing sphingosines, an acidic compound selected from inorganic acids and organic acids having 5 or less carbon atoms, ceramides, and a compound selected from specific monoalkyl glyceryl ethers and sterols or derivatives thereof has excellent storage stability, moisturizing effect, and usability. Patent Document 2 describes that an oil-in-water emulsion cosmetic containing an emulsion containing sphingosines, an acidic compound selected from inorganic acids and organic acids having 5 or less carbon atoms, and ceramides, and an emulsion containing an oily component selected from polar oils and hydrocarbon oils, and a surfactant, has excellent storage stability. Patent Document 3 describes that an oil-in-water emulsion composition containing an ester oil that is liquid at 25°C, sphingosines, an acidic compound selected from inorganic acids and organic acids having 5 or less carbon atoms, cholesterol or phytosterol, and in which the liquid oily components including the ester oil that is liquid at 25°C account for 5 to 90 mass% of the total amount of the oil phase, can maintain an emulsified state stably for a long period of time even without containing a surfactant, and also has a glossy surface, a good appearance, and an excellent feel when used. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2005-002017 [Patent Document 2] Japanese Patent Application Laid-Open No. 2005-023068 [Patent Document 3] Japanese Patent Application Laid-Open No. 2006-028109 Summary of the Invention [Problem to be solved by the invention]

[0004] However, from an aesthetic point of view, external preparation compositions such as cosmetics are also required to have a transparent or translucent appearance, but the compositions described in the above-mentioned prior art documents have a cloudy appearance due to the inclusion of a large amount of oil. Currently, an external preparation composition containing phytosphingosine or a derivative thereof, which has excellent stability, improved compatibility during application, reduced stickiness, and a transparent or translucent appearance, has not yet been obtained. [Means for solving the problem]

[0005] The present inventors have conducted extensive research focusing on the stability of topical compositions containing sphingosine and at least one of its derivatives, and have found that by using sphingosine and at least one of its derivatives in combination with certain components, it is possible to obtain topical compositions that are excellent in stability immediately after production and during high-temperature storage, have improved compatibility during application, are less sticky, and have a transparent or translucent appearance.

[0006] The present invention provides a composition comprising the following components (A), (B), (C), (D) and (E): (A) at least one of sphingosine and its derivatives (B) Dihydric alcohol (C) Compounds with a carboxyl group and 7 or less carbon atoms (D) Oil solution that is solid at 25°C (E)Water The present invention relates to an external preparation composition containing the compound. [Effects of the Invention]

[0007] The topical composition of this embodiment ensures excellent stability immediately after production and during high-temperature storage, improves compatibility with the skin during application, suppresses sticky feeling on the skin after application, and maintains a transparent or translucent appearance. DETAILED DESCRIPTION OF THE INVENTION

[0008] The topical composition of this embodiment contains, as component (A), at least one of sphingosine and its derivatives. Component (A) is an oil-soluble component present in intercellular lipids and is commonly used as a component of topical compositions such as cosmetics for the purpose of imparting a moisturizing feel. Examples of component (A) include sphingosine represented by the following chemical formula (1), dihydrosphingosine represented by the following chemical formula (2), phytosphingosine represented by the following chemical formula (3), dehydrosphingosine represented by the following chemical formula (4), dehydrophytosphingosine represented by the following chemical formula (5), and sphingadienine represented by the following chemical formula (6).

[0009] [ka]

[0010] Of these, from the viewpoints of improving the moisturizing feeling, suppressing the sticky feeling on the skin after application, and improving compatibility with the skin during application, component (A) preferably contains one or more selected from sphingosine, dihydrosphingosine, phytosphingosine, dehydrosphingosine, and dehydrophytosphingosine, more preferably contains one or more selected from sphingosine and phytosphingosine, and even more preferably contains phytosphingosine.

[0011] Component (A) may be used alone or in combination of two or more. From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, imparting a transparent or translucent appearance, and improving stability immediately after production and during high-temperature storage, the content of component (A) in the topical preparation composition is preferably 0.01% by mass or more, more preferably 0.04% by mass or more, and even more preferably 0.1% by mass or more. Furthermore, from the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, imparting a transparent or translucent appearance, and improving stability immediately after production and during high-temperature storage, the content of component (A) is preferably 0.5% by mass or less, more preferably 0.35% by mass or less, and even more preferably 0.25% by mass or less. The content of component (A) in the topical preparation composition is preferably 0.01 to 0.5% by mass, more preferably 0.04 to 0.35% by mass, and even more preferably 0.1 to 0.25% by mass.

[0012] The dihydric alcohol of component (B) is a compound having two hydroxyl groups in the molecule and is not particularly limited as long as it is one commonly used in topical compositions such as cosmetics. The dihydric alcohol dissolves the above-mentioned component (A) and the below-described component (D), improving stability immediately after production and during high-temperature storage, and imparting a moisturizing feel and a transparent or translucent appearance. Examples of dihydric alcohols include polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,3-propanediol, and pentylene glycol. Among these, component (B) preferably contains one or more selected from dipropylene glycol, 1,3-propanediol, 1,3-butylene glycol, and pentylene glycol, from the viewpoints of reducing stickiness on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage.

[0013] Component (B) may be used alone or in combination of two or more. From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the content of component (B) in the topical preparation composition is preferably 2% by mass or more, more preferably 3.5% by mass or more, and even more preferably 7.4% by mass or more. Furthermore, from the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the content of component (B) is preferably 25% by mass or less, more preferably 20% by mass or less, and even more preferably 16% by mass or less. The content of component (B) in the topical preparation composition is preferably 2 to 25% by mass, more preferably 3.5 to 20% by mass, and even more preferably 7.4 to 16% by mass.

[0014] From the viewpoint of suppressing sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the content ratio (A) / (B) of component (A) to component (B) is preferably 0.0001 or more, more preferably 0.0005 or more, even more preferably 0.001 or more, even more preferably 0.003 or more, and particularly preferably 0.01 or more. Also, from the viewpoint of suppressing sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the ratio (A) / (B) is preferably 0.1 or less, more preferably 0.08 or less, even more preferably 0.06 or less, even more preferably 0.034 or less, and particularly preferably 0.021 or less. The ratio (A) / (B) is preferably from 0.0001 to 0.1, more preferably from 0.0005 to 0.08, even more preferably from 0.001 to 0.06, still more preferably from 0.003 to 0.034, and especially preferably from 0.01 to 0.021.

[0015] Component (C) is a compound having a carboxyl group and 7 or less carbon atoms, examples of which include lactic acid, acetylhydroxyproline, and glycolic acid. Component (C) imparts a moisturizing feeling. From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, it is preferable for component (C) to contain one or more compounds selected from lactic acid and acetylhydroxyproline, and more preferably lactic acid.

[0016] Component (C) may be used alone or in combination of two or more. From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the content of component (C) in the topical preparation composition is preferably 0.005% by mass or more, more preferably 0.012% by mass or more, and even more preferably 0.04% by mass or more. Furthermore, from the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the content of component (C) is preferably 0.2% by mass or less, more preferably 0.12% by mass or less, and even more preferably 0.08% by mass or less. The content of component (C) in the topical preparation composition is preferably 0.005 to 0.2% by mass, more preferably 0.012 to 0.12% by mass, and even more preferably 0.04 to 0.08% by mass.

[0017] From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the content ratio (B) / (C) of component (B) to component (C) is preferably 50 or more, more preferably 90 or more, even more preferably 110 or more, and even more preferably 160 or more. Furthermore, from the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the ratio (B) / (C) is preferably 2000 or less, more preferably 1600 or less, even more preferably 1200 or less, and even more preferably 560 or less. The ratio (B) / (C) is preferably 50 to 2000, more preferably 90 to 1600, even more preferably 110 to 1200, and even more preferably 160 to 560.

[0018] The oil agent that is solid at 25°C (component (D)) is an oil agent that has a melting point higher than 25°C under 1 atmosphere. The melting point can be measured in accordance with Method 3 of the Standards for Cosmetic Ingredients. Note that component (D) does not include sphingosine and its derivatives, which are component (A). Component (D) has the effect of improving stability immediately after production and during high-temperature storage. The oil agent that is solid at 25°C is not particularly limited as long as it is one that is commonly used in topical compositions such as cosmetics, and any oil agent can be used. Examples include higher alcohols having 12 to 22 carbon atoms, higher fatty acids having 12 to 22 carbon atoms, monoalkyl glyceryl ethers having 12 to 22 carbon atoms, hydrocarbons, ester oils, waxes, ceramides, and sterols.

[0019] The higher alcohol having 12 to 22 carbon atoms is preferably one having 14 to 22 carbon atoms, more preferably one having 16 to 18 carbon atoms, such as myristyl alcohol, cetanol, stearyl alcohol, and behenyl alcohol. Of these, it is preferable to include at least one selected from cetanol and stearyl alcohol. The higher fatty acid having 12 to 22 carbon atoms is preferably one having 14 to 22 carbon atoms, more preferably one having 16 to 18 carbon atoms, such as myristic acid, palmitic acid, stearic acid, and behenic acid. Of these, it is preferable to include at least one selected from palmitic acid and stearic acid.

[0020] The monoalkyl glyceryl ether having 12 to 22 carbon atoms preferably contains one or more selected from batyl alcohol and chimyl alcohol. Hydrocarbons include paraffin, petrolatum, ceresin, ozokerite, microcrystalline wax, etc. Among these, paraffin is preferred. Ester oils include myristyl myristate, cholesteryl isostearate, behenyl behenylate, glycerin trimyristate, etc.

[0021] Examples of waxes include beeswax, candelilla wax, carnauba wax, bayberry wax, jojoba wax, lanolin, shellac wax, spermaceti, and Japan wax. As ceramides, one or more types selected from natural ceramides and pseudo-ceramides can be used, and specifically, the ceramides described in JP 2013-53146 A can be used.

[0022] Examples of sterols include cholesterol and phytosterols. Phytosterols are also called phytosterols. From the viewpoints of suppressing sticky feeling on the skin after application, improving compatibility with the skin during application, imparting a transparent or translucent appearance, and improving stability immediately after production and during high-temperature storage, component (D) preferably contains at least one selected from ceramides and sterols, more preferably contains sterols, even more preferably contains at least one selected from cholesterol and phytosterols, and even more preferably contains phytosterol. Component (D) interacts with component (A), contributing to the dissolution of component (A) in the topical composition and making the topical composition transparent or translucent in appearance.

[0023] Component (D) may be used alone or in combination of two or more. From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, imparting a transparent or translucent appearance, and improving stability immediately after production and during high-temperature storage, the content of component (D) in the topical preparation composition is preferably 0.01% by mass or more, more preferably 0.04% by mass or more, even more preferably 0.08% by mass or more, and even more preferably 0.15% by mass or more. Furthermore, from the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, imparting a transparent or translucent appearance, and improving stability immediately after production and during high-temperature storage, the content of component (D) is preferably 0.8% by mass or less, more preferably 0.4% by mass or less, even more preferably 0.26% by mass or less, and even more preferably 0.21% by mass or less. The content of component (D) in the topical composition is preferably 0.01 to 0.8% by mass, more preferably 0.04 to 0.4% by mass, even more preferably 0.08 to 0.26% by mass, and even more preferably 0.15 to 0.21% by mass.

[0024] From the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, making the appearance transparent or translucent, and improving stability immediately after production and during high-temperature storage, the content ratio (A) / (D) of component (A) to component (D) is preferably 0.01 or more, more preferably 0.05 or more, even more preferably 0.1 or more, and even more preferably 0.5 or more. Furthermore, from the viewpoints of suppressing a sticky feeling on the skin after application, improving compatibility with the skin during application, and improving stability immediately after production and during high-temperature storage, the ratio (A) / (D) is preferably 40 or less, more preferably 20 or less, even more preferably 7 or less, and even more preferably 1.4 or less. The ratio (A) / (D) is preferably 0.01 to 40, more preferably 0.05 to 20, even more preferably 0.1 to 7, and even more preferably 0.5 to 1.4. By including a predetermined ratio and amount of component (D) relative to component (A), component (A) dissolves well, making it possible to make the appearance of the topical composition transparent or translucent.

[0025] In addition to the above-mentioned components, the topical composition of this embodiment may contain other components that are commonly used in topical compositions, provided that the effects of this embodiment are not impaired. For example, the topical composition may contain polyhydric alcohols other than component (B), surfactants, water-soluble polymers, oils that are liquid at 25°C, antioxidants, fragrances, preservatives, pH adjusters other than component (C), blood circulation promoters, cooling agents, antiperspirants, disinfectants, skin activators, moisturizers, and refreshing agents.

[0026] Furthermore, from the viewpoint of improving the aesthetic appearance, the topical composition of this embodiment is preferably transparent or translucent, and the content of oil that is liquid at 25°C in the topical composition is preferably 0.4% by mass or less, more preferably 0.3% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.05% by mass or less, and especially preferably 0.01% by mass or less. Furthermore, from the viewpoint of improving the aesthetic appearance, the topical composition of this embodiment is preferably transparent or translucent, and the total content of component (D) and oil that is liquid at 25°C in the topical composition is preferably 1% by mass or less, more preferably 0.8% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, particularly preferably 0.26% by mass or less, and especially preferably 0.21% by mass.

[0027] The topical composition of this embodiment can be produced, for example, by preparing an oil phase mixture and an aqueous phase mixture separately and uniformly emulsifying them. The oil phase mixture can be prepared by heating and stirring components (A), (B), (D), and other oily components at 80 to 90°C and confirming dissolution. The aqueous phase mixture can be prepared by heating and stirring components (C), at least a portion of component (E), and other aqueous components at 80 to 90°C and confirming dissolution. The oil phase mixture is added to the aqueous phase mixture heated to 80 to 90°C, and the mixture is uniformly emulsified to obtain the topical composition of this embodiment.

[0028] The topical composition of this embodiment may be prepared using an emulsification method using a micromixer (described in Japanese Patent No. 5086583). In the micromixer method, first, among components (A) to (E) and optional components used as needed, the oily component and the aqueous component are separately heated and dissolved to prepare an oil phase mixture and an aqueous phase mixture. Next, the oil phase mixture and the aqueous phase mixture are each allowed to flow at a constant flow rate and then merged. After merging, the topical composition of this embodiment is obtained by passing the mixture through pores with a pore size of 0.03 mm or more and 20 mm or less.

[0029] From the viewpoint of improving stability, the topical composition of this embodiment preferably has a pH in the range of 4 to 7, more preferably 4 to 6, and even more preferably 4 to 5. The pH of the topical composition is measured at 25°C using a pH meter (tabletop pH meter F-72, manufactured by HORIBA).

[0030] Furthermore, from the viewpoints of suppressing sticky feeling on the skin after application and improving compatibility with the skin during application, the viscosity of the topical composition of this embodiment at 25°C is preferably 10 to 300 mPa·s. The viscosity of the topical composition can be measured, for example, using a Brookfield viscometer with a No. 4 rotor at 6 rpm for 30 seconds at 25°C. The viscosity of the topical composition of this embodiment at 25°C is more preferably 20 to 200 mPa·s, and even more preferably 30 to 100 mPa·s.

[0031] When the transmittance in the visible light range (300-900 nm) is 15 to 100%, the external preparation composition has a transparent or translucent appearance. Being transparent or translucent can be advantageous in terms of improving the aesthetic appearance. From the viewpoint of improving the aesthetic appearance, the higher the transmittance, the more preferable it is. From the viewpoint of improving the aesthetic appearance, the transmittance in the visible light range is preferably 15 to 100%, more preferably 25 to 100%, and even more preferably 38 to 100%. The transmittance tends to increase as the content of component (D) decreases. The transmittance is measured at 25° C. using a UV-visible spectrophotometer (UV1800, manufactured by Shimadzu Corporation) at a measurement wavelength λ=550 nm using a dispocell (PMMA for near UV, measurement range: 300-900 nm).

[0032] The topical composition of the present invention is preferably an oil-in-water emulsion cosmetic. The topical composition of the present invention can be used, for example, as a lotion, gel, emulsion, serum, cream, etc., and is preferably one or more selected from a lotion, emulsion, and cream, more preferably one or more selected from a lotion and emulsion, and even more preferably a lotion. The topical composition of this embodiment can be taken in an appropriate amount and applied directly to the skin of the face, body, hands, feet, etc. Alternatively, it may be impregnated into a woven fabric, nonwoven fabric, etc. and applied to the skin. By applying the topical composition of this embodiment, it is possible to impart a sufficient moisturizing feeling to the skin without a sticky feeling. Moreover, the topical composition of this embodiment has excellent stability during high-temperature storage and does not deteriorate during storage.

[0033] While the preferred embodiments of the present invention have been described above, the technical scope of the present invention is not limited to the scope of the above-described embodiments. Various modifications and improvements can be made to the above-described embodiments. [Example]

[0034] Next, examples of the present invention will be described, but the present invention is not limited to these examples.

[0035] Each component used in the preparation of the topical composition is listed below along with the name of the raw material and the manufacturer. Component (A) Phytosphingosine (Evonik) Ingredient (B) Pentylene glycol (Symrise) 1,3-Butylene Glycol BG (Kyukyu Alcohol Kogyo Co., Ltd.) Propanediol (Zhangjiagang Meijingrong Chemical Industry Co., Ltd.) Dipropylene glycol (ADEKA) Ingredients (C) Lactic acid (Musashino Chemical Laboratory) Ingredients (D) Cholesterol (wool) (Nippon Fine Chemical Co., Ltd.) Phytosterols (Tama Biochemical Co., Ltd.)

[0036] The topical compositions of the Examples and Comparative Examples were prepared with the compositions (% by mass) shown in Table 1. In preparation, components (A), (B), and (D) were first heated and dissolved at 85°C to prepare a homogeneous oil phase mixture. Next, component (C) was heated and dissolved at 85°C together with a portion of component (E) to prepare a homogeneous aqueous phase mixture. While heated at 85°C, the oil phase mixture and aqueous phase mixture were each flowed at a constant rate under a pressure of 0.2 MPa·s until they merged and passed through pores with a pore size of 0.4 mm to obtain a homogeneous emulsion similar to a lotion. Component (E) was added to the remaining emulsion and mixed homogeneously to obtain each topical preparation composition.

[0037] The obtained topical compositions were examined for stability, compatibility with the skin during application, non-stickiness on the skin after application, pH, and transparency. Measurement methods were as follows.

[0038] The stability immediately after production and after storage at 50°C for one month was measured using the following method. <Stability (immediately after manufacturing)> The appearance of each topical composition immediately after production was visually observed and rated on the following four-point scale. 4: No aggregates. 3: There are a few aggregates. 2: There are obvious aggregates. 1: Unmanufacturable (Oil phase components are not uniformly dissolved when the oil phase mixture is prepared by mixing the oil phase components during manufacturing).

[0039] <Stability (after 1 month storage at 50°C)> Each topical composition was filled in a standard glass container (Mighty Vial No. 7, AS ONE Corporation) at 40 g and stored in a storage cabinet at 50° C. After one month, the appearance of the topical composition in the container was visually observed and rated on the following four-point scale. 4: No agglomerates on the bottom of the storage container. 3: A small amount of aggregates was observed on the bottom of the storage container, which quickly disappeared when the container was shaken by hand. 2: A small amount of aggregates was observed on the bottom of the storage container, and did not disappear even when the storage container was shaken by hand. 1: A large amount of aggregates (sediments) was observed on the bottom of the storage container. For any stability, a rating of "3" or higher is considered acceptable.

[0040] <Skin absorption during application> Three expert evaluators applied 0.1 g of each topical composition to the back of the hand and massaged it in, and then performed a sensory evaluation of how well the topical composition blended with the skin during the massage, based on the following criteria. The evaluation results in the table are the total scores of three expert evaluators. 5: Clearly familiar. 4: It fits well. 3: Fairly familiar. 2: Not very familiar. 1: Not familiar A rating of "9" or higher for compatibility with the skin during application is considered acceptable, indicating that the topical composition is compatible with the skin and provides a sufficient feeling of moisture.

[0041] <No sticky feeling on skin after application> Three expert evaluators applied 0.1 g of each topical composition to the back of the hand, massaged it in, and then touched the skin immediately after massaging to perform a sensory evaluation according to the following criteria. The evaluation results in the table are the total scores of three expert evaluators. 5: There is no obvious stickiness. 4: No sticky feeling. 3: Almost no stickiness. 2: Slightly sticky feeling. 1: Sticky feeling. A rating of "9" or higher for the lack of stickiness on the skin after application is considered acceptable.

[0042] <ph> Immediately after production, the pH of each topical composition was measured at 25°C using a tabletop pH meter F-72 manufactured by HORIBA.

[0043] <Transparency> The topical composition was filled into a cell, and the transparency was measured immediately after production and after storage at 50°C for 1 month using the following measuring device. Device name: UV-visible spectrophotometer (UV1800, manufactured by Shimadzu Corporation) Measurement wavelength: λ=550nm Disposable cell: PMMA for near UV (measurement range: 300-900nm) As with the stability test described above, the transparency was measured immediately after production and after storage at 50°C for one month. The results were expressed as transmittance (%).

[0044] The results obtained are summarized in Table 1 below, along with the compositions.

[0045] [Table 1]

[0046] The topical composition of the example contains all of the components (A) to (E), and therefore has excellent stability, improves compatibility with the skin during application, and reduces stickiness. As shown in Comparative Examples 1 to 3, when any of Component (A), Component (B), and Component (C) was not contained, the evaluation of <Stability immediately after production> was rated "1: Unproduction possible," and the topical composition could not be produced. Furthermore, since production was not possible, the subsequent evaluations were rated "Unevaluable."

[0047] Tables 2 and 3 below show examples of lotion formulations.

[0048] [Table 2]

[0049] [Table 3]

[0050] Table 4 below shows an example of a lotion formulation.

[0051] [Table 4]

[0052] Table 5 below shows an example of a cream formulation.

[0053] [Table 5]

[0054] The topical composition of the present invention, whether in the form of a lotion, emulsion, or cream, ensures excellent stability immediately after production and during high-temperature storage, improves compatibility with the skin during application, suppresses sticky feeling on the skin after application, and maintains a transparent or translucent appearance.< / ph>

Claims

1. The following components (A), (B), (C), (D), and (E): (A) at least one of sphingosine and its derivatives (B) Dihydric alcohol (C) Compounds having a carboxyl group and 7 or less carbon atoms (D) An oil solution that is solid at 25°C (E) Water An external preparation composition comprising:

2. The topical composition according to claim 1, wherein the component (C) comprises at least one selected from the group consisting of lactic acid and acetylhydroxyproline.

3. The topical composition according to claim 2, wherein the component (D) comprises at least one selected from cholesterol and phytosterol.

4. 4. The topical composition according to claim 2, wherein the content of component (A) in the topical composition is 0.01 to 0.5% by mass.

5. 4. The topical composition according to claim 2, wherein the content of component (B) in the topical composition is 2 to 25% by mass.

6. 4. The topical composition according to claim 2, wherein the content of component (C) in the topical composition is 0.005 to 0.2% by mass.

7. 4. The topical composition according to claim 2, wherein the content of the component (D) in the topical composition is 0.01 to 0.8% by mass.

8. 6. The topical composition according to claim 5, wherein the mass ratio of component (A) to component (B) ((A) / (B)) is 0.0001 to 0.

1.

9. 7. The topical composition according to claim 6, wherein the mass ratio of component (B) to component (C) ((B) / (C)) is 50 to 2,000.

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